BR0007810A - Processo de preparação de compostos bicìclicos e aplicação desse processo para preparação de um composto inibidor de ice - Google Patents

Processo de preparação de compostos bicìclicos e aplicação desse processo para preparação de um composto inibidor de ice

Info

Publication number
BR0007810A
BR0007810A BR0007810-7A BR0007810A BR0007810A BR 0007810 A BR0007810 A BR 0007810A BR 0007810 A BR0007810 A BR 0007810A BR 0007810 A BR0007810 A BR 0007810A
Authority
BR
Brazil
Prior art keywords
preparation
ice
application
compound
compounds
Prior art date
Application number
BR0007810-7A
Other languages
English (en)
Other versions
BR0007810B1 (pt
Inventor
Veronique Crocq
Patrick Roussel
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of BR0007810A publication Critical patent/BR0007810A/pt
Publication of BR0007810B1 publication Critical patent/BR0007810B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Patente de Invenção: "PROCESSO DE PREPARAçãO DE COMPOSTOS BICìCLICOS E APLICAçãO DESSE PROCESSO PARA PREPARAçãO DE UM COMPOSTO INIBIDOR DE ICE". A invenção tem por objeto um processo de preparação dos compostos de fórmula (1), na qual R = H, alquila, arila ou aralquila, contendo até 18 átomos de carbono e a função amina pode ser livre ou protegida, a partir de um composto de fórmula (IA), caracterizado pelo fato da ciclização ser feita em meio básico e em presença de um derivado de ácido fosfónico, notadamente POCI~ 3~ OU POBr~ 3~ e a aplicação desse processo como etapa intermediária para a preparação de um composto inibidor da enzima de conversão da interleuquina 1-beta (ICE).
BRPI0007810-7A 1999-01-12 2000-01-11 processo de preparação de compostos bicìclicos, uso do referido processo para preparação de inibidor de enzima de conversão de interleuquina 1-beta, bem como os referidos compostos. BR0007810B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9900227A FR2788276B1 (fr) 1999-01-12 1999-01-12 NOUVEAU PROCEDE DE PREPARATION DE COMPOSES BICYCLIQUES ET L'APPLICATION DE CE PROCEDE COMME ETAPE INTERMEDIAIRE POUR LA PREPARATION D'UN COMPOSE INHIBITEUR DE L'ENZYME DE CONVERSION DE L'INTERLEUKINE 1-BETA (ice)
FR9900227 1999-01-12
PCT/FR2000/000041 WO2000042061A1 (fr) 1999-01-12 2000-01-11 Procede de preparation de composes bicycliques et l'application de ce procede pour la preparation d'un compose inhibiteur de ice

Publications (2)

Publication Number Publication Date
BR0007810A true BR0007810A (pt) 2001-11-06
BR0007810B1 BR0007810B1 (pt) 2011-08-23

Family

ID=9540778

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0007810-7A BR0007810B1 (pt) 1999-01-12 2000-01-11 processo de preparação de compostos bicìclicos, uso do referido processo para preparação de inibidor de enzima de conversão de interleuquina 1-beta, bem como os referidos compostos.

Country Status (24)

Country Link
US (1) US6512111B1 (pt)
EP (1) EP1144436B1 (pt)
JP (1) JP4601826B2 (pt)
KR (1) KR100797349B1 (pt)
CN (1) CN1240710C (pt)
AT (1) ATE263780T1 (pt)
AU (1) AU774752B2 (pt)
BR (1) BR0007810B1 (pt)
CA (1) CA2359964C (pt)
DE (1) DE60009658T2 (pt)
DK (1) DK1144436T3 (pt)
ES (1) ES2215020T3 (pt)
FR (1) FR2788276B1 (pt)
HK (1) HK1045316B (pt)
HU (1) HU230062B1 (pt)
IL (2) IL144227A0 (pt)
NO (1) NO328110B1 (pt)
NZ (1) NZ512908A (pt)
PL (1) PL196993B1 (pt)
PT (1) PT1144436E (pt)
SI (1) SI1144436T1 (pt)
TW (1) TWI222443B (pt)
WO (1) WO2000042061A1 (pt)
ZA (1) ZA200105550B (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6703500B2 (en) 1998-08-19 2004-03-09 Vertex Pharmaceuticals, Incorporated Method of preparing bicyclic intermediates from piperazic acid or an ester thereof useful in the manufacture of caspase inhibitors
US6559304B1 (en) 1998-08-19 2003-05-06 Vertex Pharmaceuticals Incorporated Method for synthesizing caspase inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
NZ204130A (en) * 1982-05-12 1986-03-14 Hoffmann La Roche Bicyclic heterocyclic compounds and pharmaceutical compositions

Also Published As

Publication number Publication date
NO20013435L (no) 2001-08-27
FR2788276A1 (fr) 2000-07-13
PL196993B1 (pl) 2008-02-29
EP1144436B1 (fr) 2004-04-07
ATE263780T1 (de) 2004-04-15
CA2359964A1 (fr) 2000-07-20
DK1144436T3 (da) 2004-08-02
HK1045316A1 (en) 2002-11-22
DE60009658D1 (de) 2004-05-13
EP1144436A1 (fr) 2001-10-17
FR2788276B1 (fr) 2001-02-16
TWI222443B (en) 2004-10-21
HU230062B1 (hu) 2015-06-29
ES2215020T3 (es) 2004-10-01
PL348919A1 (en) 2002-06-17
KR20010101468A (ko) 2001-11-14
IL144227A (en) 2006-12-31
IL144227A0 (en) 2002-05-23
AU3052400A (en) 2000-08-01
ZA200105550B (en) 2002-07-25
AU774752B2 (en) 2004-07-08
BR0007810B1 (pt) 2011-08-23
CA2359964C (fr) 2010-04-20
NO328110B1 (no) 2009-12-07
KR100797349B1 (ko) 2008-01-22
HK1045316B (zh) 2006-09-29
NZ512908A (en) 2003-07-25
SI1144436T1 (en) 2004-06-30
CN1240710C (zh) 2006-02-08
HUP0202665A2 (hu) 2002-12-28
CN1343218A (zh) 2002-04-03
JP2002534533A (ja) 2002-10-15
NO20013435D0 (no) 2001-07-11
DE60009658T2 (de) 2005-03-24
WO2000042061A1 (fr) 2000-07-20
US6512111B1 (en) 2003-01-28
HUP0202665A3 (en) 2004-12-28
JP4601826B2 (ja) 2010-12-22
PT1144436E (pt) 2004-08-31

Similar Documents

Publication Publication Date Title
DK1120388T3 (da) Anvendelse af pyrazolderivater som nitrifikationsinhibitor
BRPI0621668B8 (pt) composição ácida para limpar superfícies de metal ou ligas que são suscetíveis à corrosão, solução de uso aquosa e método para limpar superfícies de metal que são suscetíveis à corrosão
BRPI0414738A (pt) derivados de ácido acético substituìdos
PT1757610E (pt) Derivado de pirimidina condensada e inibidor da xantina oxidase
ATE236176T1 (de) Neue substrate zur detektion von mikrobiellen metaboliten
BG106939A (en) Method for the preparation of citalopram
WO2001087898A3 (de) N- (2-pyrimidinyl) (thio)phosphorsäuretriamide, verfahren zu ihrer herstellung, und deren verwendung als mittel zur regulierung bzw. hemmung der enzymatischen harnstoff-hydrolyse
CA2433840A1 (en) Inhibitors of adp-ribosyl transferases, cyclases, and hydrolases, and uses thereof
GEP20074256B (en) Novel benzothiadiazine, process for their preparation and pharmaceutical compositions containing
BR0007810A (pt) Processo de preparação de compostos bicìclicos e aplicação desse processo para preparação de um composto inibidor de ice
EP1414955A4 (en) COMPOSITIONS FOR IMPROVED CATALYSIS RAPPORTEUR DEPOSITION
PT91607A (pt) Process for the preparation of substituted beta-diketones and of pharmaceutical compositions containing them
DE3368050D1 (en) Pyridine derivatives, process for their preparation and pharmaceutical compositions containing them
EP1010701A4 (en) PROCESS FOR THE PREPARATION OF 3-CEPHEM COMPOUNDS
AR029324A1 (es) Procedimiento de preparacion de compuestos biciclicos y aplicacion de este procedimiento como etapa intermedia para la preparacion de un compuesto inhibidor de la enzima que convierte interleuquina 1-beta (ice)
BRPI0413057A (pt) processo para preparação de imipenem
ZA200702878B (en) Derivatives of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl]phosphonic acid and method of making them
BR9811481A (pt) Processo para a preparação de derivados de 1,3-diazo-spiro(4,4) non-1- en-04-ona e intermediários de 1-ciano-1-acil amino ciclo-pentano
MA29315B1 (fr) Nouveaux derives d'aminoacides phosphiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
TH43868A (th) อนุพันธ์ของไซโคลอัลคิลอะมิโนเมทิลเพอโรลิดีน
BR0309930A (pt) Derivados do ácido dihidroxihexanóico, seus intermediários e métodos de produção
BR9917603A (pt) Método para a preparação do citalopram

Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 23/08/2011, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 20A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2548 DE 05-11-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.