BR9811481A - Processo para a preparação de derivados de 1,3-diazo-spiro(4,4) non-1- en-04-ona e intermediários de 1-ciano-1-acil amino ciclo-pentano - Google Patents

Processo para a preparação de derivados de 1,3-diazo-spiro(4,4) non-1- en-04-ona e intermediários de 1-ciano-1-acil amino ciclo-pentano

Info

Publication number
BR9811481A
BR9811481A BR9811481-6A BR9811481A BR9811481A BR 9811481 A BR9811481 A BR 9811481A BR 9811481 A BR9811481 A BR 9811481A BR 9811481 A BR9811481 A BR 9811481A
Authority
BR
Brazil
Prior art keywords
formula
compound
preparation
transformed
diazo
Prior art date
Application number
BR9811481-6A
Other languages
English (en)
Other versions
BR9811481B1 (pt
Inventor
Csaba Huszar
Attila Kis-Tamas
Attila Nemeth
Zsuzsanna Nad
Zoltan Makovi
Antal Gajary
Endre Kollar
Peter Aranyosi
Karoly Gy Re
Istvan Meszaros
Zsuzsanna Csetrine Hari
Attila Supic
Ilona Dervalicsne
Katalin Dubovszki
Lajosne Pali
Agnes Kunsztne Karasz
Erzsebet Bognar
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of BR9811481A publication Critical patent/BR9811481A/pt
Publication of BR9811481B1 publication Critical patent/BR9811481B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"PROCESSO PARA A PREPARAçãO DE DERIVADOS DE 1,3-DIAZO-SPIRO (4,4) NON-1-EN-4-ONA E INTERMEDIáRIOS DE 1-CIANO-1-ACIL AMINO CICLOPENTANO" Processo para a preparação de compostos de fórmula geral (I), onde R significa um átomo de hidrogênio, ou um grupo alquila C~ 1-6~, ou um grupo aralquila C~ 7-12~ ou um grupo fenila, caracterizado pelo fato de a) o composto de fórmula (III) ser reagido com um composto de fórmula (IV) onde X significa um átomo de halogênio ou um grupo alcoxila C~ 1-5~ ou um grupo hidroxila e o composto de fórmula (II) resultante ser transformado, em um meio reacional com pH acima de 7, no composto de fórmula (I), ou b) o composto de fórmula (III) ser reagido com um anidrido de fórmula geral (V) e o composto de fórmula (II) resultante ser transformado, em um meio reacional com pH acima de 7, no composto de fórmula geral (I), ou c) um composto de fórmula (II) ser transformado, em um meio reacional, com pH acima de 7, no composto de fórmula (I), e, se desejado, os compostos resultantes de fórmula (I), antes ou após a separação, serem transformados em sais de adição ácida, ou os compostos de fórmula (I) serem liberados a partir de seus sais de adição ácida. Desse modo é revelado um processo para a preparação de intermediários úteis na síntese de antagonistas da angiotensina II.
BRPI9811481-6A 1997-07-25 1998-07-22 processo para a preparação de derivados de 1,3-diazo-spiro (4,4) non-1-en-4-ona e intermediários de 1-ciano-1-acil amino ciclopentano. BR9811481B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HUP9701295A HU218680B (hu) 1997-07-25 1997-07-25 Eljárás 1,3-diaza-spiro[4,4]non-1-én-4-on-származékok előállítására és 1-ciano-1-(acil-amino)-ciklopentán intermedierek
PCT/HU1998/000068 WO1999005120A1 (en) 1997-07-25 1998-07-22 Process for the preparation of 1,3-diaza-spiro (4.4) non-1-en-4-one derivatives and 1-cyano-1-acylaminocyclopentane intermediates

Publications (2)

Publication Number Publication Date
BR9811481A true BR9811481A (pt) 2000-09-19
BR9811481B1 BR9811481B1 (pt) 2010-10-05

Family

ID=89995421

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9811481-6A BR9811481B1 (pt) 1997-07-25 1998-07-22 processo para a preparação de derivados de 1,3-diazo-spiro (4,4) non-1-en-4-ona e intermediários de 1-ciano-1-acil amino ciclopentano.

Country Status (12)

Country Link
US (1) US6211382B1 (pt)
EP (1) EP0998463B1 (pt)
JP (1) JP4322420B2 (pt)
AT (1) ATE236132T1 (pt)
AU (1) AU8553798A (pt)
BR (1) BR9811481B1 (pt)
CA (1) CA2297189C (pt)
DE (1) DE69812957T2 (pt)
ES (1) ES2193548T3 (pt)
HU (1) HU218680B (pt)
NO (1) NO315157B1 (pt)
WO (1) WO1999005120A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101704788B (zh) * 2009-11-12 2011-09-07 苏州雅本化学股份有限公司 2-丁基-1,3-二氮杂螺环[4.4]壬烷-1-烯-4-酮的制备方法
JP6202935B2 (ja) * 2013-08-21 2017-09-27 株式会社東芝 原子炉圧力容器
ES2947570T3 (es) * 2016-03-15 2023-08-11 Astellas Pharma Inc Comprimido

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5270317A (en) * 1990-03-20 1993-12-14 Elf Sanofi N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present
FR2681067B1 (fr) 1991-09-10 1993-12-17 Elf Sanofi Derives heterocycliques n-substitues, leur preparation, les compositions pharmaceutiques en contenant.
US5541209A (en) 1994-08-22 1996-07-30 Bristol-Myers Squibb Company Method of treating or preventing cardiac arrhythmia employing an N-substituted heterocyclic derivative
AU5843996A (en) * 1995-05-31 1996-12-18 Ihara Chemical Industry Co. Ltd. Phenylalkanamide derivatives and agrohorticultural bacterici des
CA2196263C (en) * 1996-02-09 2004-10-26 Barry Jackson Process for the preparation of 4-oxoimidazolinium salts
JP4153040B2 (ja) * 1996-04-02 2008-09-17 バイエル・アクチエンゲゼルシヤフト 有害生物防除剤及び除草剤としての置換されたフェニルケトエノール
US6162922A (en) * 1998-01-30 2000-12-19 Bristol-Myers Squibb Co. Method for preparing N-substituted heterocyclic derivatives using a phase-transfer catalyst
DE19912383A1 (de) * 1998-03-27 1999-09-30 Degussa Verfahren zur Herstellung von cyclischen 4-Oxoamidinen
US5910595A (en) * 1998-06-26 1999-06-08 Salsbury Chemicals, Inc. Process for preparing oximidazoles

Also Published As

Publication number Publication date
DE69812957T2 (de) 2003-12-04
DE69812957D1 (de) 2003-05-08
JP4322420B2 (ja) 2009-09-02
HU218680B (hu) 2000-10-30
NO315157B1 (no) 2003-07-21
NO20000344D0 (no) 2000-01-24
AU8553798A (en) 1999-02-16
BR9811481B1 (pt) 2010-10-05
JP2001510830A (ja) 2001-08-07
US6211382B1 (en) 2001-04-03
EP0998463A1 (en) 2000-05-10
EP0998463B1 (en) 2003-04-02
CA2297189C (en) 2007-08-28
ES2193548T3 (es) 2003-11-01
HU218680A (en) 2000-10-28
HU9701295D0 (en) 1997-09-29
WO1999005120A1 (en) 1999-02-04
ATE236132T1 (de) 2003-04-15
CA2297189A1 (en) 1999-02-04
NO20000344L (no) 2000-03-22

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Legal Events

Date Code Title Description
B25G Requested change of headquarter approved
B25D Requested change of name of applicant approved

Owner name: SANOFI-AVENTIS (FR)

Free format text: ALTERADO DE: SANOFI-SYNTHELABO

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 05/10/2010, OBSERVADAS AS CONDICOES LEGAIS.

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 05.10.2020