IL142893A0 - Fused polyclic heterocyclic compounds and pharmaceutical compositions containing the same - Google Patents
Fused polyclic heterocyclic compounds and pharmaceutical compositions containing the sameInfo
- Publication number
- IL142893A0 IL142893A0 IL14289399A IL14289399A IL142893A0 IL 142893 A0 IL142893 A0 IL 142893A0 IL 14289399 A IL14289399 A IL 14289399A IL 14289399 A IL14289399 A IL 14289399A IL 142893 A0 IL142893 A0 IL 142893A0
- Authority
- IL
- Israel
- Prior art keywords
- compositions containing
- same
- polyclic
- fused
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/16—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Input Circuits Of Receivers And Coupling Of Receivers And Audio Equipment (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19107398A | 1998-11-12 | 1998-11-12 | |
US37083799A | 1999-08-09 | 1999-08-09 | |
US40136499A | 1999-09-21 | 1999-09-21 | |
PCT/US1999/027054 WO2000027846A2 (en) | 1998-11-12 | 1999-11-12 | Crf receptor antagonists and methods relating thereto |
Publications (1)
Publication Number | Publication Date |
---|---|
IL142893A0 true IL142893A0 (en) | 2002-04-21 |
Family
ID=27392849
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14289399A IL142893A0 (en) | 1998-11-12 | 1999-11-12 | Fused polyclic heterocyclic compounds and pharmaceutical compositions containing the same |
Country Status (17)
Country | Link |
---|---|
US (1) | US6514982B1 (no) |
EP (1) | EP1129091B1 (no) |
JP (1) | JP2002529465A (no) |
KR (1) | KR20010080990A (no) |
CN (1) | CN1217945C (no) |
AT (1) | ATE225349T1 (no) |
AU (1) | AU755552B2 (no) |
CA (1) | CA2350642A1 (no) |
DE (1) | DE69903333T2 (no) |
DK (1) | DK1129091T3 (no) |
ES (1) | ES2180338T3 (no) |
HK (1) | HK1038926B (no) |
IL (1) | IL142893A0 (no) |
NO (1) | NO20012194L (no) |
NZ (1) | NZ510955A (no) |
PT (1) | PT1129091E (no) |
WO (1) | WO2000027846A2 (no) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002529465A (ja) * | 1998-11-12 | 2002-09-10 | ニューロクライン バイオサイエンシーズ, インコーポレイテッド | Crfレセプターアンタゴニストおよびcrfレセプターアンタゴニストに関する方法 |
US6531475B1 (en) | 1998-11-12 | 2003-03-11 | Neurocrine Biosciences, Inc. | CRF receptor antagonists and methods relating thereto |
EP1293213A1 (en) * | 2000-02-14 | 2003-03-19 | Japan Tobacco Inc. | Preventives/remedies for postoperative stress |
JP2003533530A (ja) | 2000-05-18 | 2003-11-11 | ニューロクライン バイオサイエンシーズ, インコーポレイテッド | Crfレセプターアンタゴニスト |
AU3958902A (en) | 2000-11-03 | 2002-05-27 | Neurocrine Biosciences Inc | Crf receptor antagonists and methods relating thereto |
CA2432148C (en) | 2000-12-28 | 2011-01-18 | Ono Pharmaceutical Co., Ltd. | Tri-heterocyclic compounds and a pharmaceutical comprising them as an active ingredient |
EP1345938A1 (en) | 2000-12-28 | 2003-09-24 | Neurocrine Biosciences, Inc. | Tricyclic crf receptor antagonists |
EP1383498B1 (en) * | 2001-04-30 | 2006-03-15 | Glaxo Group Limited | Crf receptor antagonists |
AU2002257939B2 (en) * | 2001-05-21 | 2006-08-24 | Neurocrine Inc | Tri-and tetraaza-acenaphthylen derivatives as CRF receptor antagonists |
GB0117395D0 (en) * | 2001-07-17 | 2001-09-05 | Glaxo Group Ltd | Chemical compounds |
US7273871B2 (en) | 2001-07-17 | 2007-09-25 | Sb Pharmco Puerto Rico Inc. | Phenyl-5,6,6A,7,8,9-hexahydro-4H-1,4,9-triaza-phenalene derivatives as CRF antagonists |
EP2335700A1 (en) | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
CN100422186C (zh) | 2003-06-25 | 2008-10-01 | 小野药品工业株式会社 | 吡唑并嘧啶化合物的甲磺酸盐、其结晶及其制备方法 |
US20060024661A1 (en) * | 2003-07-30 | 2006-02-02 | The Regents Of The University Of California | Modulation of CRF potentiation of NMDA receptor currents via CRF receptor 2 |
WO2005013997A1 (en) * | 2003-08-12 | 2005-02-17 | F. Hoffmann-La Roche Ag | Spiro-substituted tetrahydroquinazolines as corticotropin releasing factor (cfr) antagonists |
ES2303130T3 (es) * | 2003-12-22 | 2008-08-01 | Sb Pharmco Puerto Rico Inc. | Antagonistas del receptor de crf y metodos relacionados con ellos. |
DK1718608T3 (da) | 2004-02-20 | 2013-10-14 | Boehringer Ingelheim Int | Virale polymeraseinhibitorer |
WO2005087775A1 (ja) * | 2004-03-15 | 2005-09-22 | Ono Pharmaceutical Co., Ltd. | 三環式複素環化合物およびその化合物を有効成分として含有する医薬組成物 |
WO2006031322A2 (en) * | 2004-08-09 | 2006-03-23 | Research Development Foundation | Determination of the 3d-structure of an extracellular domain of a b1 g-protein coupled receptor by nmr analysis |
BRPI0807868A2 (pt) | 2007-02-01 | 2013-10-15 | Astrazeneca Ab | Composto ou um sal farmaceuticamente aceitável ou n-óxido do mesmo, composição farmacêutica, uso de um composto ou um sal farmaceuticamente aceitável ou n-óxido, método para o tratamento de um ser humano ou animal que sofre um câncer, e, processo para preparar um composto ou um sal farmaceuticamente aceitável ou n-óxido do mesmo |
EP2414359A1 (en) * | 2009-03-31 | 2012-02-08 | ArQule, Inc. | Peri-fused pyrazolo-pyrimidine compounds |
EP2440558B1 (en) | 2009-06-08 | 2015-04-01 | Takeda Pharmaceutical Company Limited | Dihydropyrrolonaphtyridinone compounds as inhibitors of jak |
KR20120124428A (ko) * | 2009-12-30 | 2012-11-13 | 아르퀼 인코포레이티드 | 치환된 피롤로-아미노피리미딘 화합물 |
CN113416191A (zh) * | 2021-04-27 | 2021-09-21 | 西安交通大学 | 一种合成三环骨架2-吡啶酮/2-吡啶亚胺类化合物的方法 |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4605642A (en) | 1984-02-23 | 1986-08-12 | The Salk Institute For Biological Studies | CRF antagonists |
US5013737A (en) * | 1988-02-22 | 1991-05-07 | American Cyanamid Company | 2,4,8-Trisubstituted-3H,6H-1,4,5A,8A-tetraazaacenaphtylene-3,5-(4H)-diones and 2,4-8-trisubstituted-4,5-dihydro-5-thioxo-3H,6H-1,4,5A,8A-tetrazaacenaphthylen-3-ones |
US4904658A (en) | 1988-04-15 | 1990-02-27 | American Cyanamid Company | Substituted-6H,8H-pyrimido-[1,2,3-cd]purine-8,10-(9H)-diones and substituted-6H,10H-pyrimido[1,2-cd]purin-10-ones |
US5063245A (en) | 1990-03-28 | 1991-11-05 | Nova Pharmaceutical Corporation | Corticotropin-releasing factor antagonism compounds |
FR2692893B1 (fr) | 1992-06-24 | 1994-09-02 | Sanofi Elf | Dérivés alkylamino ramifiés du thiazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent. |
JP2781661B2 (ja) | 1992-12-17 | 1998-07-30 | フアイザー・インコーポレイテツド | Crfアンタゴニストとしての置換ピラゾール |
WO1994013643A1 (en) | 1992-12-17 | 1994-06-23 | Pfizer Inc. | Pyrazoles and pyrazolopyrimidines having crf antagonist activity |
TW336932B (en) | 1992-12-17 | 1998-07-21 | Pfizer | Amino-substituted pyrazoles |
JP2895961B2 (ja) * | 1992-12-17 | 1999-05-31 | フアイザー・インコーポレイテツド | Crfアンタゴニストとしてのピロロピリミジン |
TW370529B (en) * | 1992-12-17 | 1999-09-21 | Pfizer | Pyrazolopyrimidines |
WO1995010506A1 (en) | 1993-10-12 | 1995-04-20 | The Du Pont Merck Pharmaceutical Company | 1n-alkyl-n-arylpyrimidinamines and derivatives thereof |
TW530047B (en) | 1994-06-08 | 2003-05-01 | Pfizer | Corticotropin releasing factor antagonists |
CN1056611C (zh) * | 1994-06-16 | 2000-09-20 | 美国辉瑞有限公司 | 吡唑并吡啶和吡咯并吡啶,其用途和用于制备它们的中间体 |
KR100256707B1 (ko) | 1995-05-12 | 2000-05-15 | 해피 페너 | 데아자푸린 유도체; 새로운 부류의 crf1 특이 리간드 |
FR2735777B1 (fr) | 1995-06-21 | 1997-09-12 | Sanofi Sa | Derives de 4-phenylaminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant |
AU725254B2 (en) | 1996-03-26 | 2000-10-12 | Du Pont Pharmaceuticals Company | Aryloxy- and arylthio- fused pyridines and pyrimidines and derivatives |
US6326368B1 (en) | 1996-03-27 | 2001-12-04 | Dupont Pharmaceuticals Company | Aryloxy- and arylthiosubstituted pyrimidines and triazines and derivatives thereof |
US6107300A (en) | 1996-03-27 | 2000-08-22 | Dupont Pharmaceuticals | Arylamino fused pyrimidines |
ZA973884B (en) * | 1996-05-23 | 1998-11-06 | Du Pont Merck Pharma | Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders |
WO1998003510A1 (en) | 1996-07-24 | 1998-01-29 | Du Pont Pharmaceuticals Company | AZOLO TRIAZINES AND PYRIMIDINES |
WO1998005661A1 (en) | 1996-08-06 | 1998-02-12 | Pfizer Inc. | Substituted pyrido- or pyrimido-containing 6,6- or 6,7-bicyclic derivatives |
TW477787B (en) | 1996-08-27 | 2002-03-01 | Pfizer | Pyrido six-membered nitrogen-containing cyclic ring derivatives having corticotropin releasing factor antagonist activity and pharmaceutical composition containing same |
ES2273369T3 (es) * | 1996-08-28 | 2007-05-01 | Pfizer Inc. | Derivados 6,5 heterobiciclicos sustituidos. |
JP2001502300A (ja) | 1996-09-16 | 2001-02-20 | デュポン ファーマシューティカルズ カンパニー | ピラジノン類およびトリアジノン類およびその誘導体類 |
FR2754258B1 (fr) | 1996-10-08 | 1998-12-31 | Sanofi Sa | Derives d'aminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant |
US5760225A (en) | 1996-11-15 | 1998-06-02 | Neurogen Corporation | Certain pyrazole derivatives as corticotropin-releasing factor receptor CRF1 specific ligands |
US5723608A (en) | 1996-12-31 | 1998-03-03 | Neurogen Corporation | 3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands |
US6187777B1 (en) | 1998-02-06 | 2001-02-13 | Amgen Inc. | Compounds and methods which modulate feeding behavior and related diseases |
JP2002529465A (ja) * | 1998-11-12 | 2002-09-10 | ニューロクライン バイオサイエンシーズ, インコーポレイテッド | Crfレセプターアンタゴニストおよびcrfレセプターアンタゴニストに関する方法 |
-
1999
- 1999-11-12 JP JP2000581024A patent/JP2002529465A/ja active Pending
- 1999-11-12 KR KR1020017005924A patent/KR20010080990A/ko not_active Application Discontinuation
- 1999-11-12 ES ES99960363T patent/ES2180338T3/es not_active Expired - Lifetime
- 1999-11-12 DK DK99960363T patent/DK1129091T3/da active
- 1999-11-12 US US09/439,840 patent/US6514982B1/en not_active Expired - Lifetime
- 1999-11-12 AT AT99960363T patent/ATE225349T1/de not_active IP Right Cessation
- 1999-11-12 CA CA002350642A patent/CA2350642A1/en not_active Abandoned
- 1999-11-12 IL IL14289399A patent/IL142893A0/xx unknown
- 1999-11-12 WO PCT/US1999/027054 patent/WO2000027846A2/en not_active Application Discontinuation
- 1999-11-12 PT PT99960363T patent/PT1129091E/pt unknown
- 1999-11-12 EP EP99960363A patent/EP1129091B1/en not_active Expired - Lifetime
- 1999-11-12 CN CN998131717A patent/CN1217945C/zh not_active Expired - Fee Related
- 1999-11-12 DE DE69903333T patent/DE69903333T2/de not_active Expired - Lifetime
- 1999-11-12 AU AU17258/00A patent/AU755552B2/en not_active Ceased
- 1999-11-12 NZ NZ510955A patent/NZ510955A/xx unknown
-
2001
- 2001-05-03 NO NO20012194A patent/NO20012194L/no not_active Application Discontinuation
-
2002
- 2002-01-29 HK HK02100690.1A patent/HK1038926B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69903333D1 (de) | 2002-11-07 |
PT1129091E (pt) | 2003-02-28 |
WO2000027846A3 (en) | 2000-11-16 |
KR20010080990A (ko) | 2001-08-25 |
ES2180338T3 (es) | 2003-02-01 |
NO20012194D0 (no) | 2001-05-03 |
HK1038926A1 (en) | 2002-05-10 |
AU755552B2 (en) | 2002-12-12 |
NO20012194L (no) | 2001-05-03 |
WO2000027846A2 (en) | 2000-05-18 |
DK1129091T3 (da) | 2002-11-04 |
EP1129091A2 (en) | 2001-09-05 |
US6514982B1 (en) | 2003-02-04 |
HK1038926B (zh) | 2003-07-18 |
CN1217945C (zh) | 2005-09-07 |
NZ510955A (en) | 2003-01-31 |
JP2002529465A (ja) | 2002-09-10 |
ATE225349T1 (de) | 2002-10-15 |
CA2350642A1 (en) | 2000-05-18 |
AU1725800A (en) | 2000-05-29 |
CN1328559A (zh) | 2001-12-26 |
DE69903333T2 (de) | 2003-08-07 |
EP1129091B1 (en) | 2002-10-02 |
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