IL140861A - Dioxolane pentanoic acid and processes for the preparation thereof - Google Patents

Dioxolane pentanoic acid and processes for the preparation thereof

Info

Publication number
IL140861A
IL140861A IL14086199A IL14086199A IL140861A IL 140861 A IL140861 A IL 140861A IL 14086199 A IL14086199 A IL 14086199A IL 14086199 A IL14086199 A IL 14086199A IL 140861 A IL140861 A IL 140861A
Authority
IL
Israel
Prior art keywords
acid
amino
formula
dioxolane
methyl ester
Prior art date
Application number
IL14086199A
Other languages
English (en)
Other versions
IL140861A0 (en
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of IL140861A0 publication Critical patent/IL140861A0/xx
Publication of IL140861A publication Critical patent/IL140861A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
IL14086199A 1998-07-15 1999-06-01 Dioxolane pentanoic acid and processes for the preparation thereof IL140861A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9294498P 1998-07-15 1998-07-15
PCT/US1999/014957 WO2000003981A2 (en) 1998-07-15 1999-07-01 Preparation of (s)-2-amino-6,6-dimethoxyhexanoic acid methyl ester via novel dioxolanes

Publications (2)

Publication Number Publication Date
IL140861A0 IL140861A0 (en) 2002-02-10
IL140861A true IL140861A (en) 2004-06-01

Family

ID=22235899

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14086199A IL140861A (en) 1998-07-15 1999-06-01 Dioxolane pentanoic acid and processes for the preparation thereof

Country Status (9)

Country Link
US (3) US6166227A (ko)
EP (1) EP1121351A4 (ko)
JP (1) JP2002520389A (ko)
KR (1) KR20010071895A (ko)
AU (1) AU753189B2 (ko)
CA (1) CA2337194A1 (ko)
HU (1) HUP0105151A3 (ko)
IL (1) IL140861A (ko)
WO (1) WO2000003981A2 (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6162913A (en) * 1998-07-15 2000-12-19 Bristol-Myers Squibb Co. Preparation of [4S-(4α,7α,10aβ)]-4-amino-octahydro-5-oxo-7H-pyrido[2,1 -b] [1,3]thiazepine-7-carboxylic acid, methyl ester and salts thereof via novel disulfides
HUP0105151A3 (en) * 1998-07-15 2004-11-29 Bristol Myers Squibb Co Preparation of (s)-2-amino-6,6-dimethoxyhexanoic acid methyl ester via novel dioxolanes
FR2813054B1 (fr) * 2000-08-21 2002-11-15 Faure Bertrand Equipements Sa Systeme pour vehicule, comportant un dispositif de commande adapte pour faire fonctionner un actionneur selectivement en fonction d'une valeur mesuree par un dispositif de mesure dispose dans un siege
US6620600B2 (en) 2000-09-15 2003-09-16 Bristol-Myers Squibb Co. Enzymatic resolution of aryl and thio-substituted acids
DE10155065A1 (de) * 2001-11-09 2003-05-22 Degussa Verfahren zur Kristallisation von Oxonorleucinacetal

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS596297B2 (ja) * 1977-11-09 1984-02-10 相互薬工株式会社 新規アミドオキシム誘導体
US4397677A (en) * 1979-11-29 1983-08-09 Velsicol Chemical Corporation Dioxolane substituted 2,6-dinitroanilines
DE3043159C2 (de) * 1980-11-15 1982-12-09 Degussa Ag, 6000 Frankfurt Cyclische Acetale des Glutaminsäure-γ-semialdehyds, Verfahren zu deren Herstellung und ihre Verwendung
DE3043252C2 (de) * 1980-11-15 1982-12-02 Degussa Ag, 6000 Frankfurt Cyclische Acetale von N-Acylglutaminsäure -γ- semialdehyden, Verfahren zu deren Herstellung und ihre Verwendung
NL8403487A (nl) * 1984-11-15 1986-06-02 Stamicarbon Werkwijze voor de enzymatische scheiding van dl-alfa-aminozuuramides.
US4591601A (en) * 1985-04-12 1986-05-27 Mcneilab, Inc. Anticonvulsant dioxolane methane sulfamates
ATE82326T1 (de) * 1987-08-17 1992-11-15 Novo Industri As Verfahren zur herstellung von organischen chemischen verbindungen.
EP0383403A1 (en) * 1989-02-16 1990-08-22 Stamicarbon B.V. Process for preparation of organic chemicals
US5508272A (en) * 1993-06-15 1996-04-16 Bristol-Myers Squibb Company Compounds containing a fused bicycle ring and processes therefor
US5463051A (en) * 1993-09-27 1995-10-31 Schering Corporation Process for preparing benzazepine intermediates for the synthesis of D1 antagonists
US5332826A (en) * 1993-10-13 1994-07-26 Eastman Kodak Company Process for preparing aminoacetonitriles in one vessel
JPH10295392A (ja) * 1997-04-22 1998-11-10 Kanegafuchi Chem Ind Co Ltd Ｌ−アルリジンアセタールの製造方法
US6133002A (en) 1997-09-25 2000-10-17 Dsm N.V. Process for preparing optically active 2-amino-ω-oxoalkanoic acid derivatives
NL1007113C2 (nl) * 1997-09-25 1999-03-26 Dsm Nv Werkwijze voor de bereiding van optisch actieve 2-amino-omega- oxoalkaanzuurderivaten.
JPH11140076A (ja) * 1997-11-04 1999-05-25 Dai Ichi Pure Chem Co Ltd Ｎ−アシル−α−アミノアジピン酸−γ−セミアルデヒドエチレンアセタール
JP3679231B2 (ja) * 1997-11-04 2005-08-03 第一化学薬品株式会社 光学活性α−アミノアジピン酸−γ−セミアルデヒドエチレンアセタール
US6340752B1 (en) * 1998-01-06 2002-01-22 Bristol-Myers Squibb Co. Deprotection and recrystallization processes
JP3638425B2 (ja) * 1998-01-29 2005-04-13 第一化学薬品株式会社 光学活性α−アミノアジピン酸−γ−セミアルデヒドエチレンアセタールの製造方法
US6174711B1 (en) * 1998-07-05 2001-01-16 Mitsubishi Gas Chemical Company Method for producing L-allysine acetal
WO2000004179A1 (en) * 1998-07-15 2000-01-27 Bristol-Myers Squibb Company Stereoselective reductive amination of ketones
HUP0105151A3 (en) * 1998-07-15 2004-11-29 Bristol Myers Squibb Co Preparation of (s)-2-amino-6,6-dimethoxyhexanoic acid methyl ester via novel dioxolanes
HUP0104996A2 (hu) * 1998-09-03 2002-04-29 Bristol-Myers Squibb Co. Enzimes oxidatív dezaminálási eljárás

Also Published As

Publication number Publication date
AU753189B2 (en) 2002-10-10
AU4852899A (en) 2000-02-07
EP1121351A2 (en) 2001-08-08
JP2002520389A (ja) 2002-07-09
WO2000003981A2 (en) 2000-01-27
US6166227A (en) 2000-12-26
EP1121351A4 (en) 2003-05-02
KR20010071895A (ko) 2001-07-31
HUP0105151A2 (hu) 2002-04-29
US6248882B1 (en) 2001-06-19
IL140861A0 (en) 2002-02-10
US6329542B1 (en) 2001-12-11
WO2000003981A3 (en) 2000-09-28
HUP0105151A3 (en) 2004-11-29
WO2000003981A8 (en) 2001-06-28
CA2337194A1 (en) 2000-01-27

Similar Documents

Publication Publication Date Title
EP0215335B1 (en) Process for preparing n-/1(s)-ethoxycarbonyl-3-phenylpropyl/-l-alanyl-l-proline
US6294560B1 (en) Synthesis of clasto-lactacystin β-lactone and analogs thereof
Hashiguchi et al. Stereoselective synthesis of sperabillins and related compounds
EP1392656A2 (en) Process for preparing chiral diol sulfones and dihydroxy acid hmg coa reductase inhibitors
KR20080017475A (ko) 과지질혈증성 병태의 치료를 위한 콜레스테롤 흡수억제제로서의 신규한 2-아제티디논 유도체
KR20060129275A (ko) 콜레스테롤 흡수 저해 활성을 가진 디페닐아제티디논유도체
KR20080033265A (ko) 고지혈성 병태의 치료를 위한 콜레스테롤 흡수억제제로서의 신규한 2-아제티디논 유도체
Tomiyama et al. Synthesis and biological activity of novel carbacyclins having bicyclic substituents on the. omega.-chain
US6248882B1 (en) Preparation of (s)-2-amino-6,6-dimethoxyhexanoic acid methyl ester via novel dioxolanes
EP1021407A1 (en) Synthesis of clasto-lactacystin beta-lactone and analogs thereof
US5449778A (en) Cyclic amino acids and derivatives thereof
Eriksson et al. Solution structure of a dilithiumamide/diethylzinc heterocomplex that catalyzes asymmetric alkylation reactions
KR100551503B1 (ko) 5-아미노-3-카복시메틸-4-시아노-2-티오펜카르복실산의 산업적 합성 방법, 및 라넬산의 이가염 및 이의 수화물의 합성에의 적용
JPH06145148A (ja) 新規ベンズアゼピノン誘導体
MXPA01000252A (en) Preparation of (s)-2-amino-6,6-dimethoxyhexanoic acid methyl ester via novel dioxolanes
AU766558B2 (en) Preparation of (4S-(4alpha,7alpha,10Abeta))-4-amino-octahydro-5-oxo-7H- pyrido(2,1-B)(1,3)thiazepine-7-carboxylic acid, methyl ester and salts thereof via novel disulfides
US5543526A (en) 1-amino-4-(1H-imidazole)- aminobutaneboronic acid derivatives, their preparation and use as synthetic intermediates
US5322963A (en) Method for preparing α-amino-β, δ-diol derivatives
NZ502077A (en) Crystalline roxifiban
EP3956332B1 (en) Diasteroselective process for the preparation of thiol- or disulfide-containing maytansinoid esters and intermediates thereof
IL113544A (en) Active peptide and its preparation
JP3207184B2 (ja) 抗生物質ｍｉ４３−３７ｆ１１の製造方法および製造中間体
Pohl et al. Diastereoselective side‐chain alkylation of (prolinolylmethyl) oxazoles and‐oxadiazoles
KR0140323B1 (ko) 광활성α-아미노산의 제조방법
RU2254338C1 (ru) Способ получения 2,2-диметил-4-алкокси-5,5-диметил-1,3,2-оксазасилолов

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees