IL139697A - Nitric oxide synthase inhibitors, pharmaceutical compositions comprising them and process for their preparation - Google Patents
Nitric oxide synthase inhibitors, pharmaceutical compositions comprising them and process for their preparationInfo
- Publication number
- IL139697A IL139697A IL13969799A IL13969799A IL139697A IL 139697 A IL139697 A IL 139697A IL 13969799 A IL13969799 A IL 13969799A IL 13969799 A IL13969799 A IL 13969799A IL 139697 A IL139697 A IL 139697A
- Authority
- IL
- Israel
- Prior art keywords
- preparation
- pharmaceutical compositions
- nitric oxide
- oxide synthase
- synthase inhibitors
- Prior art date
Links
- 239000000236 nitric oxide synthase inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- CSYSULGPHGCBQD-UHFFFAOYSA-N s-ethylisothiouronium diethylphosphate Chemical compound CCSC(N)=N.CCOP(O)(=O)OCC CSYSULGPHGCBQD-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9811599.1A GB9811599D0 (en) | 1998-05-30 | 1998-05-30 | Nitric oxide synthase inhibitors |
| PCT/EP1999/003583 WO1999062875A1 (en) | 1998-05-30 | 1999-05-27 | Nitric oxide synthase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL139697A0 IL139697A0 (en) | 2002-02-10 |
| IL139697A true IL139697A (en) | 2005-12-18 |
Family
ID=10832929
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13969799A IL139697A (en) | 1998-05-30 | 1999-05-27 | Nitric oxide synthase inhibitors, pharmaceutical compositions comprising them and process for their preparation |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US6355689B1 (cs) |
| EP (1) | EP1084104B1 (cs) |
| JP (1) | JP3839256B2 (cs) |
| KR (1) | KR20010043920A (cs) |
| CN (1) | CN1218940C (cs) |
| AP (1) | AP1382A (cs) |
| AT (1) | ATE245142T1 (cs) |
| AU (1) | AU757042B2 (cs) |
| BR (1) | BR9910849A (cs) |
| CA (1) | CA2333322C (cs) |
| CZ (1) | CZ297473B6 (cs) |
| DE (1) | DE69909625T2 (cs) |
| DK (1) | DK1084104T3 (cs) |
| EA (1) | EA003026B1 (cs) |
| EE (1) | EE04149B1 (cs) |
| ES (1) | ES2203147T3 (cs) |
| GB (1) | GB9811599D0 (cs) |
| HU (1) | HUP0102472A3 (cs) |
| ID (1) | ID26790A (cs) |
| IL (1) | IL139697A (cs) |
| IS (1) | IS2442B (cs) |
| NO (1) | NO20006044L (cs) |
| NZ (1) | NZ508222A (cs) |
| PL (1) | PL194784B1 (cs) |
| PT (1) | PT1084104E (cs) |
| RS (1) | RS49984B (cs) |
| SK (1) | SK18052000A3 (cs) |
| TR (1) | TR200003539T2 (cs) |
| WO (1) | WO1999062875A1 (cs) |
| ZA (1) | ZA200006847B (cs) |
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| JP4205340B2 (ja) | 2000-03-24 | 2009-01-07 | ファルマシア コーポレーション | 酸化窒素シンターゼ阻害剤として有用なアミジノ化合物およびその塩 |
| US7012098B2 (en) | 2001-03-23 | 2006-03-14 | Pharmacia Corporation | Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers |
| WO2003022309A1 (fr) * | 2001-09-10 | 2003-03-20 | Ono Pharmaceutical Co., Ltd. | Remedes pour maladies allergiques |
| US20030109522A1 (en) * | 2001-09-24 | 2003-06-12 | Manning Pamela T. | Ophthalmologic treatment methods using selective iNOS inhibitors |
| EP1506040A2 (en) * | 2002-05-16 | 2005-02-16 | Pharmacia Corporation | Selective inos inhibitors for the treatment of respiratory diseases and conditions |
| EP1505972A2 (en) * | 2002-05-16 | 2005-02-16 | Pharmacia Corporation | A selective inos inhibitor and a pde inhibitor in combination for the treatment of respiratory diseases |
| EP1528921A2 (en) * | 2002-08-02 | 2005-05-11 | Pharmacia Corporation | Methods for treatment and prevention of gastrointestinal conditions |
| US20060247216A1 (en) * | 2002-10-25 | 2006-11-02 | Haj-Yehia Abdullah I | Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments |
| WO2004050084A2 (en) * | 2002-11-29 | 2004-06-17 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Ace-inhibitors having antioxidant and nitricoxid-donor activity |
| TWI328009B (en) | 2003-05-21 | 2010-08-01 | Glaxo Group Ltd | Quinoline derivatives as phosphodiesterase inhibitors |
| GB0316212D0 (en) * | 2003-07-10 | 2003-08-13 | Glaxo Group Ltd | Novel compounds |
| GB0316290D0 (en) | 2003-07-11 | 2003-08-13 | Glaxo Group Ltd | Novel compounds |
| US20050203082A1 (en) * | 2003-08-13 | 2005-09-15 | Hsu Chung Y. | Combination therapy with inhibitors of inducible nitric oxide synthase and alkylating agents |
| AR049384A1 (es) | 2004-05-24 | 2006-07-26 | Glaxo Group Ltd | Derivados de purina |
| TWI307630B (en) | 2004-07-01 | 2009-03-21 | Glaxo Group Ltd | Immunoglobulins |
| GB0418045D0 (en) | 2004-08-12 | 2004-09-15 | Glaxo Group Ltd | Compounds |
| JP5281291B2 (ja) | 2005-01-10 | 2013-09-04 | グラクソ グループ リミテッド | 新規化合物 |
| PE20100741A1 (es) | 2005-03-25 | 2010-11-25 | Glaxo Group Ltd | COMPUESTOS DERIVADOS DE 3,4-DIHIDROPIRIMIDO[4,5-d]PIRIMIDIN-2(1H)-ONA COMO INHIBIDORES DE QUINASA p38 |
| AR053346A1 (es) | 2005-03-25 | 2007-05-02 | Glaxo Group Ltd | Compuesto derivado de 8h -pirido (2,3-d) pirimidin -7 ona 2,4,8- trisustituida composicion farmaceutica y uso para preparar una composicion para tratamiento y profilxis de una enfermedad mediada por la quinasa csbp/ rk/p38 |
| JPWO2007000884A1 (ja) * | 2005-06-29 | 2009-01-22 | 国立大学法人金沢大学 | 骨・関節疾患の予防・治療剤およびそのスクリーニング方法 |
| GB0514809D0 (en) | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
| PE20071068A1 (es) | 2005-12-20 | 2007-12-13 | Glaxo Group Ltd | Acido 3-(4-{[4-(4-{[3-(3,3-dimetil-1-piperidinil)propil]oxi}fenil)-1-piperidinil]carbonil}-1-naftalenil)propanoico o propenoico, sales de los mismos, como antagonistas de los receptores h1 y h3 |
| EA200801997A1 (ru) | 2006-04-20 | 2009-04-28 | Глаксо Груп Лимитед | Новые соединения |
| GB0611587D0 (en) | 2006-06-12 | 2006-07-19 | Glaxo Group Ltd | Novel compounds |
| PL2046787T3 (pl) | 2006-08-01 | 2011-10-31 | Glaxo Group Ltd | Związki pirazolo[3,4-b]pirydynowe i ich zastosowanie jako inhibitory PDE4 |
| AU2007354255A1 (en) * | 2006-11-09 | 2008-12-04 | University Of Maryland, Baltimore | Use of 5,6-dimethylxanthenone-4-acetic acid as an antimicrobial agent |
| PE20081889A1 (es) | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | Indol carboxamidas como inhibidores de ikk2 |
| US20110160249A1 (en) | 2008-05-23 | 2011-06-30 | Schaab Kevin Murray | 5-lipoxygenase-activating protein inhibitor |
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| US20120035247A1 (en) | 2009-03-19 | 2012-02-09 | Merck Sharp & Dohme Corp. | RNA Interference Mediated Inhibition of Signal Transducer and Activator of Transcription 6 (STAT6) Gene Expression Using Short Interfering Nucleic Acid (siNA) |
| WO2010107952A2 (en) | 2009-03-19 | 2010-09-23 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF CONNECTIVE TISSUE GROWTH FACTOR (CTGF) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| JP2012520685A (ja) | 2009-03-19 | 2012-09-10 | メルク・シャープ・エンド・ドーム・コーポレイション | 低分子干渉核酸（ｓｉＮＡ）を用いたＧＡＴＡ結合タンパク質３（ＧＡＴＡ３）遺伝子発現のＲＮＡ干渉媒介性阻害 |
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| EP2411516A1 (en) | 2009-03-27 | 2012-02-01 | Merck Sharp&Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF APOPTOSIS SIGNAL-REGULATING KINASE 1 (ASK1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
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| JP2012521762A (ja) | 2009-03-27 | 2012-09-20 | メルク・シャープ・エンド・ドーム・コーポレイション | 低分子干渉核酸（ｓｉＮＡ）を用いた神経成長因子β鎖（ＮＧＦβ）遺伝子発現のＲＮＡ干渉媒介性阻害 |
| AR076373A1 (es) | 2009-04-24 | 2011-06-08 | Glaxo Group Ltd | N-pirazolil carboxamidas como inhibidores de canales de calcio |
| EP2421834A1 (en) | 2009-04-24 | 2012-02-29 | Glaxo Group Limited | Pyrazole and triazole carboxamides as crac channel inhibitors |
| TWI562992B (en) | 2009-04-30 | 2016-12-21 | Glaxo Group Ltd | Indazole derivative, pharmaceutical composition thereof, and use thereof as inhibitors of kinase activity |
| JP2013512879A (ja) | 2009-12-03 | 2013-04-18 | グラクソ グループ リミテッド | Ｐｉ３キナーゼの阻害剤としてのベンズピラゾール誘導体 |
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| EP2512438B1 (en) | 2009-12-16 | 2017-01-25 | 3M Innovative Properties Company | Formulations and methods for controlling mdi particle size delivery |
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| ES2602972T3 (es) | 2010-09-08 | 2017-02-23 | Glaxosmithkline Intellectual Property Development Limited | Derivados de indazol para su uso en el tratamiento de infección por virus de la gripe |
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| US9394281B2 (en) | 2014-03-28 | 2016-07-19 | Calitor Sciences, Llc | Substituted heteroaryl compounds and methods of use |
| CR20160529A (es) | 2014-05-12 | 2017-01-02 | Glaxosmithkline Intellectual Property (No 2) Ltd | Composiciones farmacéuticas para tratar enfermedades infecciosas |
| JP2018527362A (ja) | 2015-09-11 | 2018-09-20 | サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． | 置換されたヘテロアリール化合物および使用方法 |
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| GB9127376D0 (en) * | 1991-12-24 | 1992-02-19 | Wellcome Found | Amidino derivatives |
| DE4310202A1 (de) | 1992-03-30 | 1993-10-07 | Ciba Geigy | µ-Ketoimidoester als Stabilisatoren für chlorhaltige Polymerisate |
| US5281627A (en) | 1992-05-28 | 1994-01-25 | Cornell Research Foundation, Inc. | Substituted arginines and substituted homoarginines and use thereof |
| US5585402A (en) | 1992-12-23 | 1996-12-17 | Glaxo Wellcome Inc. | Nitric oxide synthase inhibitors |
| US5364881A (en) | 1993-11-15 | 1994-11-15 | The Medical College Of Wisconsin Research Foundation, Inc. | S-alkyl-isothioureido-amino acids and use thereof |
| KR100430207B1 (ko) | 1994-06-15 | 2004-07-19 | 더 웰컴 파운데이션 리미티드 | 효소억제제 |
| FR2727111B1 (fr) | 1994-11-21 | 1997-01-17 | Hoechst Lab | Nouveaux analogues soufres d'aminoacides, leur procede de preparation et leurs applications comme medicaments |
| MY117948A (en) * | 1997-01-13 | 2004-08-30 | Glaxo Group Ltd | Nitride oxide synthase inhibitors. |
-
1998
- 1998-05-30 GB GBGB9811599.1A patent/GB9811599D0/en not_active Ceased
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1999
- 1999-05-27 ID IDW20002495A patent/ID26790A/id unknown
- 1999-05-27 JP JP2000552087A patent/JP3839256B2/ja not_active Expired - Fee Related
- 1999-05-27 CN CNB998068578A patent/CN1218940C/zh not_active Expired - Fee Related
- 1999-05-27 RS YUP-746/00A patent/RS49984B/sr unknown
- 1999-05-27 AU AU43671/99A patent/AU757042B2/en not_active Ceased
- 1999-05-27 AP APAP/P/2000/001998A patent/AP1382A/en active
- 1999-05-27 DK DK99926397T patent/DK1084104T3/da active
- 1999-05-27 PL PL344368A patent/PL194784B1/pl unknown
- 1999-05-27 WO PCT/EP1999/003583 patent/WO1999062875A1/en active IP Right Grant
- 1999-05-27 EA EA200001122A patent/EA003026B1/ru not_active IP Right Cessation
- 1999-05-27 NZ NZ508222A patent/NZ508222A/xx unknown
- 1999-05-27 TR TR2000/03539T patent/TR200003539T2/xx unknown
- 1999-05-27 CZ CZ20004450A patent/CZ297473B6/cs not_active IP Right Cessation
- 1999-05-27 AT AT99926397T patent/ATE245142T1/de not_active IP Right Cessation
- 1999-05-27 KR KR1020007013451A patent/KR20010043920A/ko not_active Ceased
- 1999-05-27 US US09/701,473 patent/US6355689B1/en not_active Expired - Lifetime
- 1999-05-27 BR BR9910849-6A patent/BR9910849A/pt not_active Application Discontinuation
- 1999-05-27 DE DE69909625T patent/DE69909625T2/de not_active Expired - Lifetime
- 1999-05-27 EE EEP200000716A patent/EE04149B1/xx not_active IP Right Cessation
- 1999-05-27 ES ES99926397T patent/ES2203147T3/es not_active Expired - Lifetime
- 1999-05-27 SK SK1805-2000A patent/SK18052000A3/sk unknown
- 1999-05-27 CA CA002333322A patent/CA2333322C/en not_active Expired - Fee Related
- 1999-05-27 PT PT99926397T patent/PT1084104E/pt unknown
- 1999-05-27 IL IL13969799A patent/IL139697A/xx not_active IP Right Cessation
- 1999-05-27 HU HU0102472A patent/HUP0102472A3/hu unknown
- 1999-05-27 EP EP99926397A patent/EP1084104B1/en not_active Expired - Lifetime
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2000
- 2000-11-21 IS IS5723A patent/IS2442B/is unknown
- 2000-11-22 ZA ZA200006847A patent/ZA200006847B/en unknown
- 2000-11-29 NO NO20006044A patent/NO20006044L/no not_active Application Discontinuation
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2001
- 2001-11-26 US US09/994,969 patent/US6495606B1/en not_active Expired - Fee Related
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