IL138899A0 - Amidene derivatives and pharmaceutical compositions containing the same - Google Patents

Amidene derivatives and pharmaceutical compositions containing the same

Info

Publication number
IL138899A0
IL138899A0 IL13889999A IL13889999A IL138899A0 IL 138899 A0 IL138899 A0 IL 138899A0 IL 13889999 A IL13889999 A IL 13889999A IL 13889999 A IL13889999 A IL 13889999A IL 138899 A0 IL138899 A0 IL 138899A0
Authority
IL
Israel
Prior art keywords
amidene
derivatives
same
pharmaceutical compositions
compositions containing
Prior art date
Application number
IL13889999A
Other languages
English (en)
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Publication of IL138899A0 publication Critical patent/IL138899A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
IL13889999A 1998-04-10 1999-04-09 Amidene derivatives and pharmaceutical compositions containing the same IL138899A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP11623398 1998-04-10
JP23786998 1998-08-25
PCT/JP1999/001900 WO1999052895A1 (fr) 1998-04-10 1999-04-09 Composes d'amidine

Publications (1)

Publication Number Publication Date
IL138899A0 true IL138899A0 (en) 2001-11-25

Family

ID=26454606

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13889999A IL138899A0 (en) 1998-04-10 1999-04-09 Amidene derivatives and pharmaceutical compositions containing the same

Country Status (23)

Country Link
US (2) US6562828B1 (fr)
EP (1) EP1070714B1 (fr)
KR (1) KR100416111B1 (fr)
CN (1) CN1305470A (fr)
AR (1) AR015269A1 (fr)
AT (1) ATE272630T1 (fr)
AU (1) AU752588B2 (fr)
BR (1) BR9910122A (fr)
CA (1) CA2327488A1 (fr)
CO (1) CO5021130A1 (fr)
DE (1) DE69919149D1 (fr)
HU (1) HUP0101137A3 (fr)
ID (1) ID28266A (fr)
IL (1) IL138899A0 (fr)
NO (1) NO20005083L (fr)
NZ (1) NZ508101A (fr)
PE (1) PE20000422A1 (fr)
PL (1) PL343424A1 (fr)
RU (1) RU2201927C2 (fr)
SG (1) SG74717A1 (fr)
SK (1) SK15072000A3 (fr)
TR (1) TR200002904T2 (fr)
WO (1) WO1999052895A1 (fr)

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EP1122252A4 (fr) * 1998-10-16 2002-06-26 Takeda Chemical Industries Ltd Composes azotes hererocycliques condenses; procede de fabrication et agents les renfermant
US6262088B1 (en) 1998-11-19 2001-07-17 Berlex Laboratories, Inc. Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
US6350761B1 (en) 1999-07-30 2002-02-26 Berlex Laboratories, Inc. Benzenamine derivatives as anti-coagulants
US20020065303A1 (en) * 2000-02-01 2002-05-30 Bing-Yan Zhu Bivalent phenylene inhibitors of factor Xa
EP1268452A1 (fr) * 2000-03-24 2003-01-02 Millenium Pharmaceuticals, Inc. Inhibteurs aminosulfonyles bicycliques du facteur xa
EP1268432A1 (fr) * 2000-03-24 2003-01-02 Millenium Pharmaceuticals, Inc. Inhibiteurs du facteur xa sous forme d'isoquinolone
US20040048780A1 (en) * 2000-05-10 2004-03-11 The Trustees Of Columbia University In The City Of New York Method for treating and preventing cardiac arrhythmia
US8022058B2 (en) 2000-05-10 2011-09-20 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US7393652B2 (en) * 2000-05-10 2008-07-01 The Trustees Of Columbia University In The City Of New York Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
US20040229781A1 (en) * 2000-05-10 2004-11-18 Marks Andrew Robert Compounds and methods for treating and preventing exercise-induced cardiac arrhythmias
US6489125B1 (en) * 2000-05-10 2002-12-03 The Trustees Of Columbia University In The City Of New York Methods for identifying chemical compounds that inhibit dissociation of FKBP12.6 binding protein from type 2 ryanodine receptor
US20060293266A1 (en) * 2000-05-10 2006-12-28 The Trustees Of Columbia Phosphodiesterase 4D in the ryanodine receptor complex protects against heart failure
US7879840B2 (en) * 2005-08-25 2011-02-01 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US7718644B2 (en) * 2004-01-22 2010-05-18 The Trustees Of Columbia University In The City Of New York Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
CA2416384A1 (fr) * 2000-07-17 2003-01-16 Takeda Chemical Industries, Ltd. Derives de sulfonate, leur production et utilisation
DE10110325A1 (de) * 2001-03-03 2002-09-05 Merck Patent Gmbh Phenylderivate 2
CA2473236A1 (fr) 2002-01-10 2003-07-24 Neurogen Corporation Ligands recepteurs de l'hormone de concentration de la melanine: 2-(4-benzyl-piperazine-1-ylmethyl)- substitue et analogues de 2-(4-benzyl-diazepan-1-ylmethyl)-1h-benzoimidazole
AU2003235895A1 (en) * 2002-05-09 2003-11-11 Mochida Pharmaceutical Co., Ltd. Process for producing 1-(4-pyridyl)-4-piperidone
US7544678B2 (en) * 2002-11-05 2009-06-09 The Trustees Of Columbia University In The City Of New York Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
US20070004736A1 (en) * 2002-11-22 2007-01-04 Keiji Kubo Imidazole derivative, process for producing the same, and use
AU2003302238A1 (en) 2002-12-03 2004-06-23 Axys Pharmaceuticals, Inc. 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
JP2007525165A (ja) 2003-03-07 2007-09-06 トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク タイプ１ライアノジン受容体に基づく方法
EP1479676A1 (fr) * 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH Dérivés de benzimidazole en tant qu'inhibiteurs du facteur Xa
US7741341B2 (en) * 2003-05-19 2010-06-22 Sanofi-Aventis Deutschland Gmbh Benzimidazole-derivatives as factor Xa inhibitors
US7378409B2 (en) * 2003-08-21 2008-05-27 Bristol-Myers Squibb Company Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity
JP4355917B2 (ja) 2003-10-29 2009-11-04 信越化学工業株式会社 含窒素有機化合物、レジスト材料及びパターン形成方法
US8710045B2 (en) * 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
DE102004016605A1 (de) * 2004-04-03 2005-10-20 Merck Patent Gmbh Thiocarbamoylproline
TWI396686B (zh) * 2004-05-21 2013-05-21 Takeda Pharmaceutical 環狀醯胺衍生物、以及其製品和用法
FR2870846B1 (fr) 2004-05-25 2006-08-04 Sanofi Synthelabo Derives de tetrahydroisoquinolylsulfonamides, leur preparation et leur utilisation en therapeutique
NZ552501A (en) * 2004-08-11 2010-03-26 Kyorin Seiyaku Kk Novel cyclic aminobenzoic acid derivative
JP4900238B2 (ja) 2005-02-02 2012-03-21 味の素株式会社 新規ベンズアミジン化合物
EP1862464A4 (fr) * 2005-03-23 2010-08-25 Kyorin Seiyaku Kk Nouveau derive acide aminophenylalcanoique cyclique
US7709516B2 (en) * 2005-06-17 2010-05-04 Endorecherche, Inc. Helix 12 directed non-steroidal antiandrogens
US7704990B2 (en) * 2005-08-25 2010-04-27 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
EP1790646A1 (fr) * 2005-11-24 2007-05-30 Sanofi-Aventis Derives de Isoquinoline et Benzo[h]Isoquinoline, leur preparation et leur utilisation en thérapeutique en tant qu'antagonistes du recepteur de l'histamine H3.
US20080186971A1 (en) * 2007-02-02 2008-08-07 Tarari, Inc. Systems and methods for processing access control lists (acls) in network switches using regular expression matching logic
KR20110036833A (ko) * 2008-07-11 2011-04-11 아지노모토 가부시키가이샤 아미딘 유도체
AR080374A1 (es) 2010-03-05 2012-04-04 Sanofi Aventis Procedimiento para la preparcion de 2-(ciclohexilmetil)-n-(2-((2s)-1-metilpirrolidin-2-il) etil)- 1,2,3,4-tetrahidroisoquinolin-7- sulfonamida
KR101499696B1 (ko) * 2013-10-16 2015-03-09 한국식품연구원 젓갈 유래 엔테로코쿠스속 미생물 및 이를 이용하여 s-아데노실-l-메티오닌을 대량 생산하는 방법
CN103965113A (zh) * 2014-05-06 2014-08-06 四川大学 1-羟乙基-2-取代苯氧甲基苯并咪唑类化合物及其制备方法
SG11202003005PA (en) * 2017-10-04 2020-04-29 Japan Tobacco Inc Nitrogen-containing heteroaryl compound, and pharmaceutical use thereof

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Also Published As

Publication number Publication date
EP1070714A4 (fr) 2002-10-30
HUP0101137A2 (hu) 2001-10-28
TR200002904T2 (tr) 2001-02-21
CA2327488A1 (fr) 1999-10-21
PL343424A1 (en) 2001-08-13
ID28266A (id) 2001-05-10
WO1999052895A1 (fr) 1999-10-21
CO5021130A1 (es) 2001-03-27
NZ508101A (en) 2002-12-20
ATE272630T1 (de) 2004-08-15
BR9910122A (pt) 2001-10-16
RU2201927C2 (ru) 2003-04-10
KR20010042606A (ko) 2001-05-25
SG74717A1 (en) 2000-08-22
AU752588B2 (en) 2002-09-26
AR015269A1 (es) 2001-04-18
SK15072000A3 (sk) 2001-08-06
EP1070714A9 (fr) 2005-10-19
US6562828B1 (en) 2003-05-13
US20040006099A1 (en) 2004-01-08
NO20005083D0 (no) 2000-10-09
NO20005083L (no) 2000-12-08
CN1305470A (zh) 2001-07-25
EP1070714A1 (fr) 2001-01-24
EP1070714B1 (fr) 2004-08-04
DE69919149D1 (de) 2004-09-09
AU3167799A (en) 1999-11-01
HUP0101137A3 (en) 2003-03-28
PE20000422A1 (es) 2000-05-19
KR100416111B1 (ko) 2004-01-31

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