IL136835A - Use of alkyl hydrogen fumarates for treating psoriasis, psoriatic arthritis, neurodermatitis and enteritis regionalis crohn - Google Patents

Use of alkyl hydrogen fumarates for treating psoriasis, psoriatic arthritis, neurodermatitis and enteritis regionalis crohn

Info

Publication number
IL136835A
IL136835A IL13683598A IL13683598A IL136835A IL 136835 A IL136835 A IL 136835A IL 13683598 A IL13683598 A IL 13683598A IL 13683598 A IL13683598 A IL 13683598A IL 136835 A IL136835 A IL 136835A
Authority
IL
Israel
Prior art keywords
neurodermatitis
psoriatic arthritis
treating psoriasis
alkyl hydrogen
hydrogen fumarates
Prior art date
Application number
IL13683598A
Other languages
English (en)
Other versions
IL136835A0 (en
Original Assignee
Fumapharm Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fumapharm Ag filed Critical Fumapharm Ag
Publication of IL136835A0 publication Critical patent/IL136835A0/xx
Publication of IL136835A publication Critical patent/IL136835A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
IL13683598A 1998-03-31 1998-12-08 Use of alkyl hydrogen fumarates for treating psoriasis, psoriatic arthritis, neurodermatitis and enteritis regionalis crohn IL136835A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19814358A DE19814358C2 (de) 1998-03-31 1998-03-31 Verwendung von Alkylhydrogenfumaraten zur Behandlung von Psoriasis, psoriatischer Arthritis, Neurodermitis und Enteritis regionalis Crohn
PCT/EP1998/007956 WO1999049858A1 (fr) 1998-03-31 1998-12-08 Utilisation de fumarates d'hydrogene d'alkyle pour le traitement du psoriasis, de la polyarthrite psoriasique, de la nevrodermite et de l'enterite regionale

Publications (2)

Publication Number Publication Date
IL136835A0 IL136835A0 (en) 2001-06-14
IL136835A true IL136835A (en) 2005-05-17

Family

ID=7863089

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13683598A IL136835A (en) 1998-03-31 1998-12-08 Use of alkyl hydrogen fumarates for treating psoriasis, psoriatic arthritis, neurodermatitis and enteritis regionalis crohn

Country Status (26)

Country Link
US (1) US6277882B1 (fr)
EP (1) EP1059920B1 (fr)
JP (1) JP3527890B2 (fr)
CN (1) CN1150898C (fr)
AT (1) ATE219936T1 (fr)
AU (1) AU745281B2 (fr)
BG (1) BG64744B1 (fr)
BR (1) BRPI9815772B8 (fr)
CA (1) CA2283915C (fr)
CZ (1) CZ291788B6 (fr)
DE (2) DE19814358C2 (fr)
DK (1) DK1059920T3 (fr)
EE (1) EE04702B1 (fr)
ES (1) ES2179551T3 (fr)
HK (1) HK1035134A1 (fr)
HU (1) HU228848B1 (fr)
IL (1) IL136835A (fr)
NO (1) NO327750B1 (fr)
NZ (1) NZ505341A (fr)
PL (1) PL191803B1 (fr)
PT (1) PT1059920E (fr)
RS (1) RS49658B (fr)
RU (1) RU2197233C2 (fr)
SK (1) SK285187B6 (fr)
TR (1) TR200001829T2 (fr)
WO (1) WO1999049858A1 (fr)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19839566C2 (de) * 1998-08-31 2002-01-17 Fumapharm Ag Muri Verwendung von Fumarsäurederivaten in der Transplantationsmedizin
DE19853487A1 (de) 1998-11-19 2000-05-25 Fumapharm Ag Muri Verwendung von Dialkylfumaraten
JP2004523511A (ja) * 2001-01-12 2004-08-05 フーマファーム アーゲー フマル酸アミド類
DE10101307A1 (de) * 2001-01-12 2002-08-01 Fumapharm Ag Muri Fumarsäurederivate als NF-kappaB-Inhibitor
DE10217314A1 (de) * 2002-04-18 2003-11-13 Fumapharm Ag Muri Carbocyclische und Oxacarboncyclische Fumarsäure-Oligomere
BRPI0410805A (pt) * 2003-09-09 2006-06-27 Fumapharm Ag uso de derivados do ácido fumárico para tratamento da insuficiência cardìaca e asma
DE10360869A1 (de) * 2003-09-09 2005-04-07 Fumapharm Ag Verwendung von Fumarsäurederivaten zur Therapie der Herzinsuffizienz, der Hyperkeratose und von Asthma
DE14172398T1 (de) 2004-10-08 2015-01-08 Forward Pharma A/S Gesteuerte Freisetzung von pharmazeutischen Zusammensetzungen mit Fumarinsäureester
US20080004344A1 (en) * 2004-11-10 2008-01-03 Aditech Pharma Ab Novel Salts of Fumaric Acid Monoalkylesters and Their Pharmaceutical Use
EP1915387B1 (fr) * 2005-07-07 2010-01-20 Aditech Pharma AG Nouveaux esters de glucopyranose et esters de glucofuranose d'alkyl-fumarates et leur utilisation pharmaceutique
US20080227847A1 (en) * 2005-07-07 2008-09-18 Aditech Pharma Ab Novel Salts of Fumaric Acid Monoalkylesters and Their Pharmaceutical Use
WO2007042034A1 (fr) * 2005-10-07 2007-04-19 Aditech Pharma Ab Compositions pharmaceutiques a liberation controlee comportant un ester de l'acide fumarique
WO2007042035A2 (fr) * 2005-10-07 2007-04-19 Aditech Pharma Ab Therapie de combinaison pour le traitement d'un trouble auto-immun et/ou inflammatoire et de conditions associees
HRP20220902T3 (hr) 2007-02-08 2022-10-14 Biogen Ma Inc. Pripravci i njihova upotreba u liječenju multiple skleroze
EP3135282A1 (fr) * 2007-02-08 2017-03-01 Biogen MA Inc. Neuroprotection dans des maladies démyélinisantes
DK2334378T3 (da) 2008-08-19 2014-07-07 Xenoport Inc Prodrugs af methylhydrogenfumarat, farmaceutiske sammensætninger deraf og fremgangsmåder til anvendelse
PT2564839T (pt) 2009-01-09 2016-07-14 Forward Pharma As Formulação farmacêutica compreendendo um ou mais ésteres de ácido fumárico numa matriz de erosão
HUE036085T2 (hu) 2011-06-08 2018-06-28 Biogen Ma Inc Nagy tisztaságú és kristályos dimetil-fumarát elõállítására szolgáló eljárás
RU2014125430A (ru) 2011-11-24 2015-12-27 Синтон Бв Контролируемое высвобождение частиц, содержащих диметилфумарат
US9504679B2 (en) 2011-12-19 2016-11-29 Bjoern Colin Kahrs Pharmaceutical compositions comprising glitazones and Nrf2 activators
US20130158077A1 (en) 2011-12-19 2013-06-20 Ares Trading S.A. Pharmaceutical compositions
CN114146079A (zh) 2012-02-07 2022-03-08 比奥根玛公司 含有富马酸二甲酯的药物组合物
MX2014009511A (es) 2012-02-07 2014-10-24 Xenoport Inc Compuestos de fumarato de morfolinoalquilo, composiciones farmaceuticas y metodos de uso.
KR101449114B1 (ko) * 2012-08-21 2014-10-13 바이오스펙트럼 주식회사 푸마르산을 유효성분으로 포함하는 항염 조성물
US10945984B2 (en) 2012-08-22 2021-03-16 Arbor Pharmaceuticals, Llc Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects
AU2013305684B2 (en) * 2012-08-22 2016-11-24 Xenoport, Inc. Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof
US20140171504A1 (en) 2012-12-14 2014-06-19 Georgia Regents Research Institute, Inc. Methods of Treating Sickle Cell Disease and Related Disorders Using Fumaric Acid Esters
US20140179779A1 (en) 2012-12-21 2014-06-26 Biogen Idec Ma Inc. Deuterium Substituted Fumarate Derivatives
HUE040044T2 (hu) 2013-03-14 2019-02-28 Alkermes Pharma Ireland Ltd Fumarátok prodrugjai, és azok alkalmazása különbözõ betegségek kezelésében
US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
WO2014160633A1 (fr) 2013-03-24 2014-10-02 Xenoport, Inc. Compositions pharmaceutiques de fumarate de diméthyle
US9302977B2 (en) 2013-06-07 2016-04-05 Xenoport, Inc. Method of making monomethyl fumarate
WO2014205392A1 (fr) 2013-06-21 2014-12-24 Xenoport, Inc. Co-cristaux de diméthyl fumarate
AU2014314231A1 (en) 2013-08-26 2016-03-03 Fwp Ip Aps Pharmaceutical composition containing dimethyl fumarate for administration at a low daily dose
TW201516020A (zh) 2013-09-06 2015-05-01 Xenoport Inc （ｎ，ｎ－二乙基胺甲醯基）甲基（２ｅ）丁－２－烯－１，４－二酸甲酯之晶形、合成方法及用途
WO2015042294A1 (fr) 2013-09-18 2015-03-26 Xenoport, Inc. Compositions de nanoparticules de fumarate de diméthyle
US9604922B2 (en) 2014-02-24 2017-03-28 Alkermes Pharma Ireland Limited Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases
US9999672B2 (en) 2014-03-24 2018-06-19 Xenoport, Inc. Pharmaceutical compositions of fumaric acid esters
US20170319548A1 (en) * 2014-09-12 2017-11-09 Tobira Therapeutics, Inc. Cenicriviroc combination therapy for the treatment of fibrosis
WO2016061393A1 (fr) 2014-10-15 2016-04-21 Xenoport, Inc. Composés de fumarate, compositions pharmaceutiques et procédés d'utilisation
SG11201705124QA (en) 2015-02-08 2017-07-28 Alkermes Pharma Ireland Ltd Monomethylfumarate prodrug compositions
ES2826825T3 (es) 2015-03-27 2021-05-19 Symbionyx Pharmaceuticals Inc Composiciones y métodos para el tratamiento de la psoriasis
WO2017060400A1 (fr) 2015-10-07 2017-04-13 Neurovive Pharmaceutical Ab Métabolites protégés à base d'acide carboxylique pour le traitement des maladies liées à des dysfonctions mitochondriales
CN105496804A (zh) * 2015-12-25 2016-04-20 知识产权全资有限公司 用于处理头发以及治疗头部牛皮藓的配方及其试剂盒和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2530372A1 (de) * 1975-07-08 1977-01-13 Walter Dr Schweckendiek Pharmazeutische zubereitungen zur behandlung von psoriasis
DE2621214C3 (de) * 1976-05-13 1981-11-12 Koronis Gmbh Chemisch-Pharmazeutische Praeparate, 5441 Sassen Verwendung von Stabilisatoren in Arzneimitteln mit Fumarsäuremonoäthylester und desen Mineralsalzen
DE3127432A1 (de) * 1981-07-11 1983-02-03 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von fumarsaeuremonoester
US5242905A (en) * 1987-09-04 1993-09-07 Dexter Chemical Corporation Pharmaceutical compositions for the treatment of psoriasis
US5214196A (en) * 1987-09-04 1993-05-25 Dexter Chemical Corporation Diethyl ester of di-glycyl fumaramide
US5424332A (en) * 1987-10-19 1995-06-13 Speiser; Peter P. Pharmaceutical composition and process for the production thereof
US4959389A (en) * 1987-10-19 1990-09-25 Speiser Peter P Pharmaceutical preparation for the treatment of psoriatic arthritis
DE8714143U1 (de) * 1987-10-23 1988-03-24 Werler Kunststoffwerke GmbH & Co, 4760 Werl Sitz- und/oder Liegemöbel
DE3834794A1 (de) * 1988-10-12 1990-04-19 F Schielein Oral zu verabreichendes mittel zur behandlung von psoriasis
WO1992012952A1 (fr) * 1991-01-18 1992-08-06 Dexter Chemical Corporation Derives d'acide malique et compositions pour le traitement du psoriasis
US5407772A (en) * 1993-11-30 1995-04-18 Xerox Corporation Unsaturated polyesters
US5972363A (en) * 1997-04-11 1999-10-26 Rohm And Haas Company Use of an encapsulated bioactive composition

Also Published As

Publication number Publication date
RS49658B (sr) 2007-09-21
JP2002509883A (ja) 2002-04-02
NZ505341A (en) 2002-04-26
HU228848B1 (en) 2013-06-28
TR200001829T2 (tr) 2000-11-21
US6277882B1 (en) 2001-08-21
BRPI9815772B1 (pt) 2016-02-10
CZ20003086A3 (cs) 2000-11-15
CZ291788B6 (cs) 2003-05-14
CN1284870A (zh) 2001-02-21
ATE219936T1 (de) 2002-07-15
DE19814358C2 (de) 2002-01-17
BG64744B1 (bg) 2006-02-28
AU2159399A (en) 1999-10-18
BG104566A (en) 2001-01-31
HK1035134A1 (en) 2001-11-16
CA2283915C (fr) 2002-12-03
DK1059920T3 (da) 2002-10-14
BRPI9815772B8 (pt) 2021-07-06
NO327750B1 (no) 2009-09-14
AU745281B2 (en) 2002-03-21
EP1059920A1 (fr) 2000-12-20
DE59804704D1 (de) 2002-08-08
CN1150898C (zh) 2004-05-26
PL341240A1 (en) 2001-03-26
RU2197233C2 (ru) 2003-01-27
SK7922000A3 (en) 2001-01-18
EE200000440A (et) 2001-12-17
NO20002872L (no) 2000-06-06
IL136835A0 (en) 2001-06-14
WO1999049858A1 (fr) 1999-10-07
EP1059920B1 (fr) 2002-07-03
HUP0103234A2 (hu) 2002-01-28
YU32000A (sh) 2002-03-18
HUP0103234A3 (en) 2003-11-28
BRPI9815772A (pt) 2000-11-21
CA2283915A1 (fr) 1999-09-30
DE19814358A1 (de) 1999-10-07
NO20002872D0 (no) 2000-06-06
SK285187B6 (sk) 2006-08-03
PT1059920E (pt) 2002-11-29
ES2179551T3 (es) 2003-01-16
PL191803B1 (pl) 2006-07-31
JP3527890B2 (ja) 2004-05-17
EE04702B1 (et) 2006-10-16

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Legal Events

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MM9K Patent not in force due to non-payment of renewal fees