IL136442A0 - Triazolo-pyridazine derivatives as ligands for gaba receptors - Google Patents
Triazolo-pyridazine derivatives as ligands for gaba receptorsInfo
- Publication number
- IL136442A0 IL136442A0 IL13644299A IL13644299A IL136442A0 IL 136442 A0 IL136442 A0 IL 136442A0 IL 13644299 A IL13644299 A IL 13644299A IL 13644299 A IL13644299 A IL 13644299A IL 136442 A0 IL136442 A0 IL 136442A0
- Authority
- IL
- Israel
- Prior art keywords
- triazolo
- ligands
- pyridazine derivatives
- gaba receptors
- gaba
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9801233.9A GB9801233D0 (en) | 1998-01-21 | 1998-01-21 | Therapeutic agents |
GBGB9821517.1A GB9821517D0 (en) | 1998-10-02 | 1998-10-02 | Therapeutic agents |
PCT/GB1999/000103 WO1999037644A1 (en) | 1998-01-21 | 1999-01-13 | Triazolo-pyridazine derivatives as ligands for gaba receptors |
Publications (1)
Publication Number | Publication Date |
---|---|
IL136442A0 true IL136442A0 (en) | 2001-06-14 |
Family
ID=26312988
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL13644299A IL136442A0 (en) | 1998-01-21 | 1999-01-13 | Triazolo-pyridazine derivatives as ligands for gaba receptors |
Country Status (24)
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2315763A1 (en) * | 1998-01-21 | 1999-07-29 | Merck Sharp & Dohme Limited | Triazolo-pyridazine derivatives as ligands for gaba receptors |
GB9929685D0 (en) | 1999-12-15 | 2000-02-09 | Merck Sharp & Dohme | Therapeutic agents |
GB0017543D0 (en) | 2000-07-17 | 2000-09-06 | Merck Sharp & Dohme | Therapeutic agents |
WO2005058860A1 (ja) * | 2003-12-19 | 2005-06-30 | Ube Industries, Ltd. | 4−置換又は非置換テトラヒドロピラン−4−カルボン酸化合物又はそのエステル化合物の製法 |
EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス,インコーポレイティド | ムスカリン性受容体調節による神経発生 |
AU2006304787A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by PDE inhibition |
CA2625210A1 (en) * | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
EA015754B1 (ru) * | 2005-12-21 | 2011-12-30 | Янссен Фармацевтика, Н.В. | Триазолопиридазины в качестве модуляторов тирозинкиназы |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
EP2377531A2 (en) | 2006-05-09 | 2011-10-19 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
EP2026813A2 (en) | 2006-05-09 | 2009-02-25 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
US7998971B2 (en) | 2006-09-08 | 2011-08-16 | Braincells Inc. | Combinations containing a 4-acylaminopyridine derivative |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
EP2123619A1 (de) | 2008-05-20 | 2009-11-25 | Bayer Schering Pharma AG | Neue [F-18]-Markierte L-Glutaminsäure-und L-Glutaminderivate (II), ihre Verwendung sowie Verfahren zu ihrer Herstellung |
PT2328414E (pt) * | 2008-08-29 | 2014-03-17 | Concert Pharmaceuticals Inc | Derivados de triazol-piridazina substituídos |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
WO2011005520A1 (en) | 2009-06-23 | 2011-01-13 | Concert Pharmaceuticals, Inc. | Deuterium-modified triazolo-pyridazine derivatives as gaba-a receptor modulators |
AU2010276537B2 (en) | 2009-07-27 | 2015-04-16 | Gilead Sciences, Inc. | Fused heterocyclic compounds as ion channel modulators |
US9089531B2 (en) | 2010-09-28 | 2015-07-28 | The Regents Of The University Of California | GABA agonists in the treatment of disorders associated with metabolic syndrome and GABA combinations in treatment or prophylaxis of type I diabetes |
TWI510480B (zh) | 2011-05-10 | 2015-12-01 | Gilead Sciences Inc | 充當離子通道調節劑之稠合雜環化合物 |
NO3175985T3 (US06828322-20041207-C00025.png) | 2011-07-01 | 2018-04-28 | ||
TW201837023A (zh) | 2011-07-01 | 2018-10-16 | 美商基利科學股份有限公司 | 作為離子通道調節劑之稠合雜環化合物 |
GB201321745D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
WO2017151617A1 (en) | 2016-02-29 | 2017-09-08 | Dana-Farber Cancer Institute, Inc. | Stapled intracellular-targeting antimicrobial peptides to treat infection |
CN107344936B (zh) * | 2016-05-06 | 2022-06-03 | 上海赛默罗生物科技有限公司 | 三唑哒嗪类衍生物、其制备方法、药物组合物和用途 |
JP7305614B2 (ja) | 2017-07-19 | 2023-07-10 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | 抗生物質耐性細菌感染症の処置のための安定化抗菌ペプチド |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1080712A (en) * | 1976-09-22 | 1980-07-01 | Jay D. Albright | Hypotensive agents |
US4230705A (en) * | 1976-09-22 | 1980-10-28 | American Cyanamid Company | 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazines and their uses in treating anxiety |
US4112095A (en) | 1976-10-07 | 1978-09-05 | American Cyanamid Company | 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazine hypotensive agents |
PH12424A (en) | 1976-10-26 | 1979-02-15 | American Cyanamid Co | Method of treating anxiety in mammals |
US4260755A (en) | 1979-10-31 | 1981-04-07 | American Cyanamid Company | Novel 6-phenyl and substituted 6-phenyl-1,2,4-triazolo[4,3-b]pyridazines |
US4260756A (en) * | 1979-11-15 | 1981-04-07 | American Cyanamid Company | 6- And 8-heteroaryl-1,2,4-triazolo[4,3-b]pyridazines |
FI81350C (fi) | 1982-01-18 | 1990-10-10 | Lepetit Spa | Analogfoerfarande foer framstaellning av nya, farmakologiskt aktiva 6-substituerade s-triatsolo/3,4-a/ ftalazinderivat. |
IT1194310B (it) | 1983-07-12 | 1988-09-14 | Lepetit Spa | Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti |
US4654343A (en) * | 1985-10-31 | 1987-03-31 | American Cyanamid Company | N-substituted-N[3-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]alkanamides, carbamates and ureas |
SK9399A3 (en) * | 1996-07-25 | 2000-04-10 | Merck Sharp & Dohme | Substituted triazolo-pyridazine derivatives as ligands for gaba receptors |
CA2315763A1 (en) * | 1998-01-21 | 1999-07-29 | Merck Sharp & Dohme Limited | Triazolo-pyridazine derivatives as ligands for gaba receptors |
-
1999
- 1999-01-13 CA CA002315763A patent/CA2315763A1/en not_active Abandoned
- 1999-01-13 HU HU0100575A patent/HUP0100575A3/hu unknown
- 1999-01-13 EA EA200000783A patent/EA002755B1/ru not_active IP Right Cessation
- 1999-01-13 EP EP99901025A patent/EP1049696A1/en not_active Withdrawn
- 1999-01-13 SK SK1092-2000A patent/SK10922000A3/sk unknown
- 1999-01-13 YU YU43800A patent/YU43800A/sh unknown
- 1999-01-13 NZ NZ504870A patent/NZ504870A/xx unknown
- 1999-01-13 US US09/582,589 patent/US6579875B1/en not_active Expired - Fee Related
- 1999-01-13 KR KR1020007007937A patent/KR20010034257A/ko not_active Application Discontinuation
- 1999-01-13 CN CN99802249A patent/CN1110498C/zh not_active Expired - Fee Related
- 1999-01-13 GE GEAP19995511A patent/GEP20032868B/en unknown
- 1999-01-13 PL PL99341652A patent/PL341652A1/xx not_active Application Discontinuation
- 1999-01-13 MX MXPA00007135A patent/MXPA00007135A/es unknown
- 1999-01-13 CZ CZ20002691A patent/CZ290883B6/cs not_active IP Right Cessation
- 1999-01-13 AU AU20657/99A patent/AU748737B2/en not_active Ceased
- 1999-01-13 IL IL13644299A patent/IL136442A0/xx unknown
- 1999-01-13 JP JP2000528565A patent/JP2002501066A/ja not_active Withdrawn
- 1999-01-13 BR BR9906905-9A patent/BR9906905A/pt not_active IP Right Cessation
- 1999-01-13 EE EEP200000430A patent/EE200000430A/xx unknown
- 1999-01-13 WO PCT/GB1999/000103 patent/WO1999037644A1/en not_active Application Discontinuation
-
2000
- 2000-06-16 IS IS5540A patent/IS5540A/is unknown
- 2000-07-20 NO NO20003730A patent/NO315516B1/no not_active IP Right Cessation
- 2000-07-21 HR HR20000492A patent/HRP20000492A2/hr not_active Application Discontinuation
- 2000-08-07 BG BG104671A patent/BG104671A/xx unknown
-
2003
- 2003-06-17 US US10/463,075 patent/US6828322B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CZ290883B6 (cs) | 2002-11-13 |
US6579875B1 (en) | 2003-06-17 |
CN1110498C (zh) | 2003-06-04 |
NZ504870A (en) | 2002-11-26 |
CN1288465A (zh) | 2001-03-21 |
EA002755B1 (ru) | 2002-08-29 |
EA200000783A1 (ru) | 2000-12-25 |
HRP20000492A2 (en) | 2000-12-31 |
EE200000430A (et) | 2001-12-17 |
PL341652A1 (en) | 2001-04-23 |
EP1049696A1 (en) | 2000-11-08 |
IS5540A (is) | 2000-06-16 |
WO1999037644A1 (en) | 1999-07-29 |
HUP0100575A2 (hu) | 2001-09-28 |
CZ20002691A3 (cs) | 2000-12-13 |
BR9906905A (pt) | 2000-10-10 |
US20040063714A1 (en) | 2004-04-01 |
NO315516B1 (no) | 2003-09-15 |
HUP0100575A3 (en) | 2003-03-28 |
KR20010034257A (ko) | 2001-04-25 |
US6828322B2 (en) | 2004-12-07 |
CA2315763A1 (en) | 1999-07-29 |
AU748737B2 (en) | 2002-06-13 |
NO20003730L (no) | 2000-09-20 |
NO20003730D0 (no) | 2000-07-20 |
GEP20032868B (en) | 2003-01-27 |
JP2002501066A (ja) | 2002-01-15 |
YU43800A (sh) | 2002-12-10 |
MXPA00007135A (es) | 2002-11-07 |
AU2065799A (en) | 1999-08-09 |
SK10922000A3 (sk) | 2001-03-12 |
BG104671A (en) | 2001-05-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUP0100575A3 (en) | Triazolo-pyridazine derivatives as ligands for gaba receptors | |
AU2002232768A1 (en) | Benzimidazole and pyridylimidazole derivatives as ligands for GABA receptors | |
AP2003002818A0 (en) | Benzimidazole and pyridylimidazole derivatives as ligands for gaba receptors | |
AU2002215100A1 (en) | Imidazo-pyrimidine derivatives as ligands for gaba receptors | |
IL141226A0 (en) | 1h-imidazopyridine derivatives | |
PL345540A1 (en) | Thiobenzimidazole derivatives | |
GB0027773D0 (en) | Gaba B receptors | |
SG71898A1 (en) | Benzosulfone derivatives | |
AP2001002071A0 (en) | Phenyl yanthine derivatives | |
GB9809664D0 (en) | a-Ketoamide derivatives | |
AU2217200A (en) | 2-amino-9-alkylpurines: gaba brain receptor ligands | |
PL349354A1 (en) | Substituted phenethylamine derivatives | |
AU5047399A (en) | Tetrahydroindolone derivatives as gabaaalpha5 ligands for enhancing cognition | |
EG23802A (en) | 2-Phenylpyran-4-one derivatives | |
GB9815542D0 (en) | Bicyclohexane derivatives | |
GB9827729D0 (en) | Thieno-indole derivatives | |
ZA976591B (en) | Substituted triazolo-pyridazine derivatives as ligands for gaba receptors | |
ZA993845B (en) | Triazolo-pyridazine derivatives as ligands for gaba receptors. | |
EP1061912A4 (en) | PHENANTHROFURANDERIVATE | |
IL139276A0 (en) | Cyclohexenondioxthio chromanoyl derivatives | |
HK1042478A1 (zh) | 2-氧代-2h-喹啉衍生物 | |
AU2653499A (en) | Oxo-dipyridoimidazole-carboxamides: gaba brain receptor ligands | |
TW353304U (en) | Improved structure for accessories | |
AU2002241137A1 (en) | Imidazo-pyrimidine derivatives as ligands for gaba receptors | |
CZ2000554A3 (cs) | Substituované 4-oxonaftyridin-3-karboxamidy jako ligandy mozkových receptorů GABA |