IL135989A0 - Processes for the production of multivesicular liposomes - Google Patents
Processes for the production of multivesicular liposomesInfo
- Publication number
- IL135989A0 IL135989A0 IL13598998A IL13598998A IL135989A0 IL 135989 A0 IL135989 A0 IL 135989A0 IL 13598998 A IL13598998 A IL 13598998A IL 13598998 A IL13598998 A IL 13598998A IL 135989 A0 IL135989 A0 IL 135989A0
- Authority
- IL
- Israel
- Prior art keywords
- processes
- emulsion
- production
- multivesicular liposomes
- multivesicular
- Prior art date
Links
- 239000002502 liposome Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 238000009295 crossflow filtration Methods 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 230000003068 static effect Effects 0.000 abstract 1
- 239000007762 w/o emulsion Substances 0.000 abstract 1
- 239000008307 w/o/w-emulsion Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65G—TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING OR TIPPING, SHOP CONVEYOR SYSTEMS OR PNEUMATIC TUBE CONVEYORS
- B65G67/00—Loading or unloading vehicles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65G—TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING OR TIPPING, SHOP CONVEYOR SYSTEMS OR PNEUMATIC TUBE CONVEYORS
- B65G2814/00—Indexing codes relating to loading or unloading articles or bulk materials
- B65G2814/03—Loading or unloading means
- B65G2814/0397—Loading or unloading means for ships
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6585697P | 1997-11-14 | 1997-11-14 | |
PCT/US1998/024261 WO1999025319A1 (en) | 1997-11-14 | 1998-11-13 | Production of multivesicular liposomes |
Publications (1)
Publication Number | Publication Date |
---|---|
IL135989A0 true IL135989A0 (en) | 2001-05-20 |
Family
ID=22065597
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL13598998A IL135989A0 (en) | 1997-11-14 | 1998-11-13 | Processes for the production of multivesicular liposomes |
IL135989A IL135989A (en) | 1997-11-14 | 2000-05-05 | Processes for the production of multivesicular liposomes |
IL193778A IL193778A0 (en) | 1997-11-14 | 2008-08-31 | Multivesicular liposomes particle compositions |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL135989A IL135989A (en) | 1997-11-14 | 2000-05-05 | Processes for the production of multivesicular liposomes |
IL193778A IL193778A0 (en) | 1997-11-14 | 2008-08-31 | Multivesicular liposomes particle compositions |
Country Status (10)
Country | Link |
---|---|
US (3) | US20020039596A1 (de) |
EP (1) | EP1030652B1 (de) |
JP (2) | JP4575592B2 (de) |
AT (1) | ATE554748T1 (de) |
AU (5) | AU752802C (de) |
CA (1) | CA2309548A1 (de) |
ES (1) | ES2384094T3 (de) |
IL (3) | IL135989A0 (de) |
NZ (1) | NZ504188A (de) |
WO (1) | WO1999025319A1 (de) |
Families Citing this family (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001005373A1 (en) * | 1999-07-15 | 2001-01-25 | Inex Pharmaceuticals Corp. | Methods and apparatus for preparation of lipid vesicles |
US6495166B1 (en) * | 1999-11-12 | 2002-12-17 | Alkermes Controlled Therapeutics Inc. | Apparatus and method for preparing microparticles using in-line solvent extraction |
DE60026571T2 (de) * | 1999-11-19 | 2006-12-14 | MGI Pharma Biologics, Inc., Lexington | Durchflussverfahren zur herstellung von mikropartikeln |
US20050037086A1 (en) * | 1999-11-19 | 2005-02-17 | Zycos Inc., A Delaware Corporation | Continuous-flow method for preparing microparticles |
WO2001083594A1 (fr) * | 2000-04-28 | 2001-11-08 | Tanabe Seiyaku Co., Ltd. | Procede de preparation d'une microsphere |
ATE275625T1 (de) * | 2000-07-19 | 2004-09-15 | Technodop Ltd Soc De Droit Irl | Kulturraum und bioreaktor zur ausserkörperlichen tierzellenkultur |
US6471995B1 (en) * | 2000-09-27 | 2002-10-29 | Alkermes Controlled Therapeutics, Inc. Ii | Apparatus and method for preparing microparticles using liquid-liquid extraction |
JP4709367B2 (ja) * | 2000-10-19 | 2011-06-22 | テルモ株式会社 | 無菌的なリポソームの製造方法 |
EP1306127B2 (de) † | 2001-10-26 | 2011-09-07 | OctoPlus PolyActive Sciences B.V. | Verfahren zur Herstellung von gereinigten Partikeln |
US20030180348A1 (en) * | 2002-03-22 | 2003-09-25 | Levinson R. Saul | Transcellular drug delivery system |
US20040082521A1 (en) * | 2002-03-29 | 2004-04-29 | Azaya Therapeutics Inc. | Novel formulations of digitalis glycosides for treating cell-proliferative and other diseases |
US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
US20050271731A1 (en) * | 2002-09-11 | 2005-12-08 | Akira Suzuki | Process for the production of microspheres and unit therefor |
JP2006508126A (ja) * | 2002-11-06 | 2006-03-09 | アザヤ セラピューティクス インコーポレイティッド | 薬学的製剤のタンパク質安定化されたリポソーム製剤 |
PT1592416E (pt) * | 2003-02-07 | 2009-04-03 | Prometic Biosciences Inc | Ácidos gordos, glicéridos e análogos com cadeia de comprimento médio como estimulantes da eritropoiese |
BE1016051A5 (nl) | 2004-05-18 | 2006-02-07 | Utexbel Nv | Insectenwerende behandeling van textiel. |
AU2009249584B2 (en) | 2008-05-19 | 2014-03-20 | Otsuka America Pharmaceutical, Inc. | Method and apparatus for preparing a solution of a shear sensitive material |
JP5371030B2 (ja) * | 2008-05-23 | 2013-12-18 | 国立大学法人 筑波大学 | ベシクルの製造方法、この製造方法によって得られるベシクルおよびベシクルを製造するためのw/o/wエマルション |
JP5107220B2 (ja) * | 2008-12-11 | 2012-12-26 | 三菱重工業株式会社 | 燃料供給装置及びガスタービン |
US8822610B2 (en) | 2008-12-22 | 2014-09-02 | ATRP Solutions, Inc. | Control over controlled radical polymerization processes |
US8815971B2 (en) | 2008-12-22 | 2014-08-26 | ATRP Solutions, Inc. | Control over controlled radical polymerization processes |
WO2010121307A1 (en) * | 2009-04-21 | 2010-10-28 | The University Of Queensland | Complex emulsions |
US9783628B2 (en) | 2009-04-23 | 2017-10-10 | ATRP Solutions, Inc. | Dual-mechanism thickening agents for hydraulic fracturing fluids |
US8173750B2 (en) | 2009-04-23 | 2012-05-08 | ATRP Solutions, Inc. | Star macromolecules for personal and home care |
US20120100207A1 (en) * | 2009-07-02 | 2012-04-26 | Konica Minolta Holdings, Inc. | Process for producing liposomes by two-step emulsification method utilizing outer aqueous phase containing specific dispersing agent, process for producing liposome dispersion or dry powder thereof using the process for producing liposomes, and liposome dispersion or dry powder thereof produced thereby |
JP5741442B2 (ja) | 2009-11-20 | 2015-07-01 | コニカミノルタ株式会社 | リポソームの製造方法 |
CN104997634A (zh) | 2010-04-09 | 2015-10-28 | 帕西拉制药有限公司 | 用于配制大直径合成膜囊泡的方法 |
US9770414B2 (en) | 2010-05-13 | 2017-09-26 | Pacira Pharmaceuticals, Inc. | Sustained release formulation of methotrexate as a disease-modifying antirheumatic drug (DMARD) and an anti-cancer agent |
ES2770575T3 (es) * | 2010-10-28 | 2020-07-02 | Pacira Pharmaceuticals Inc | Formulación de liberación sostenida de un fármaco antiinflamatorio no esteroideo |
US9587064B2 (en) | 2010-12-08 | 2017-03-07 | ATRP Solutions, Inc. | Salt-tolerant star macromolecules |
RU2577683C2 (ru) | 2010-12-27 | 2016-03-20 | Терумо Кабусики Кайся | Липосомная композиция и способ ее получения |
EP2672958A1 (de) | 2011-02-08 | 2013-12-18 | Halozyme, Inc. | Zusammensetzung und lipidformulierung eines hyaluronan-abbauenden enzym und seine verwendung zur behandlung von benigner prostatahyperplasie |
JP5889279B2 (ja) | 2011-03-25 | 2016-03-22 | テルモ株式会社 | 持続徐放性リポソーム組成物およびその製造方法 |
CA2871820C (en) | 2012-05-10 | 2020-11-03 | Painreform Ltd. | Depot formulations of a hydrophobic active ingredient and methods for preparation thereof |
JP5314794B2 (ja) * | 2012-08-27 | 2013-10-16 | 三菱重工業株式会社 | 燃料供給装置及びガスタービン |
EP2890760A4 (de) | 2012-08-30 | 2016-10-12 | Atrp Solutions Inc | Doppelmechanismus-verdickungsmittel für hydraulische frackingfluide |
WO2014046191A1 (ja) | 2012-09-21 | 2014-03-27 | テルモ株式会社 | 局所麻酔薬持続徐放性リポソーム製剤 |
US20140093952A1 (en) * | 2012-10-02 | 2014-04-03 | David Serway | Bioreactor Tangential Flow Perfusion Filter System |
US10711238B2 (en) | 2012-10-02 | 2020-07-14 | Repligen Corporation | Method for proliferation of cells within a bioreactor using a disposable pumphead and filter assembly |
CA2899349C (en) | 2013-02-04 | 2021-09-21 | ATRP Solutions, Inc. | Salt-tolerant star macromolecules |
WO2015036046A1 (en) * | 2013-09-13 | 2015-03-19 | N.V. Nutricia | Improved process for preparing infant formula using a static mixer |
US10583397B2 (en) | 2014-05-13 | 2020-03-10 | Amgen Inc. | Process control systems and methods for use with filters and filtration processes |
ES2820226T3 (es) | 2014-05-15 | 2021-04-20 | Insmed Inc | Métodos para tratar infecciones pulmonares micobacterianas no tuberculosas |
CN107075015B (zh) | 2014-07-03 | 2019-08-23 | 派诺聚合物技术公司 | 表面活性剂-相容性星形大分子 |
US9439864B2 (en) * | 2014-07-07 | 2016-09-13 | Antriabio, Inc. | Solvent extraction from biodegradable microparticles |
WO2016010840A1 (en) * | 2014-07-16 | 2016-01-21 | Novartis Ag | Method of encapsulating a nucleic acid in a lipid nanoparticle host |
US11633699B2 (en) | 2014-08-11 | 2023-04-25 | Osaka University | Dialyzer, liposome producing apparatus, and liposome producing method |
ES2727137T3 (es) | 2014-08-28 | 2019-10-14 | Halozyme Inc | Terapia combinada con una enzima de degradación de hialuronano y un inhibidor de puntos de control inmunitario |
JP6316182B2 (ja) | 2014-12-19 | 2018-04-25 | 富士フイルム株式会社 | リポソームの製造方法及びリポソーム製造装置 |
EP3142656B1 (de) * | 2015-01-21 | 2018-10-17 | Pacira Pharmaceuticals, Inc. | Multivesikuläre liposomformulierungen von tranexamsäure |
WO2016177741A1 (en) | 2015-05-04 | 2016-11-10 | Eth Zurich | Method for preparing transmembrane ph-gradient vesicles |
EP3317448B1 (de) | 2015-06-30 | 2021-09-08 | Tela Bio, Inc. | Ecke-steppstich muster |
EP3324882B1 (de) | 2015-07-21 | 2023-10-25 | Tela Bio, Inc. | Nachgiebigkeitskontrolle von nähten in trägermaterialien |
US9820843B2 (en) | 2016-04-26 | 2017-11-21 | Tela Bio, Inc. | Hernia repair grafts having anti-adhesion barriers |
CN109983013A (zh) | 2016-11-18 | 2019-07-05 | 帕西拉制药有限公司 | 美洛昔康锌复合物微粒多囊脂质体制剂及其制备方法 |
WO2018160026A1 (ko) * | 2017-03-02 | 2018-09-07 | 단디바이오사이언스 주식회사 | 면역활성물질을 포함하는 다중도메인캡슐, 이의 제조방법, 및 이를 포함하는 면역조절 조성물 |
KR102069680B1 (ko) * | 2017-03-02 | 2020-01-23 | 단디바이오사이언스 주식회사 | 면역억제인자 제어물질을 포함하는 다중도메인캡슐, 이의 제조방법, 및 이를 포함하는 면역조절 조성물 |
WO2018160027A1 (ko) * | 2017-03-02 | 2018-09-07 | 단디바이오사이언스 주식회사 | 면역억제인자 제어물질을 포함하는 다중도메인캡슐, 이의 제조방법, 및 이를 포함하는 면역조절 조성물 |
US11590262B2 (en) | 2018-03-09 | 2023-02-28 | Tela Bio, Inc. | Surgical repair graft |
EP3773505A4 (de) | 2018-03-30 | 2021-12-22 | Insmed Incorporated | Verfahren zur kontinuierlichen herstellung von liposomalen arzneimittelprodukten |
CN108636122B (zh) * | 2018-06-22 | 2023-05-23 | 南京航空航天大学 | 一种多膜蒸馏组件与压缩机等压降排布系统及工作方法 |
WO2020145415A1 (ko) * | 2019-01-07 | 2020-07-16 | 부산대학교 산학협력단 | 혈관-뇌장벽 투과성을 증진시키는 w/o/w형 트리올레인 에멀전을 이용한 약물 전달 플랫폼 |
US11446130B2 (en) | 2019-03-08 | 2022-09-20 | Tela Bio, Inc. | Textured medical textiles |
CN110179752B (zh) * | 2019-05-31 | 2024-02-20 | 常州吾合生物医药有限责任公司 | 高浓度布比卡因多囊脂质体及其制备工艺、配液系统 |
EP4087540A4 (de) * | 2020-01-06 | 2024-01-10 | Pacira Pharmaceuticals Inc | Behandlung von schmerzen in verbindung mit einem kaiserschnitt mit zusammensetzung aus liposomalen anästhetika mit verzögerter freisetzung |
WO2021141963A1 (en) * | 2020-01-10 | 2021-07-15 | Pacira Pharmaceuticals, Inc. | Treatment of pain by subarachnoid administration of sustained-release liposomal anesthetic compositions |
WO2021141959A1 (en) | 2020-01-10 | 2021-07-15 | Pacira Pharmaceuticals, Inc. | Treatment of pain by administration of sustained-release liposomal anesthetic compositions |
CA3167217A1 (en) | 2020-01-13 | 2021-07-22 | Durect Corporation | Sustained release drug delivery systems with reduced impurities and related methods |
EP4274573A1 (de) | 2021-01-11 | 2023-11-15 | Pacira Pharmaceuticals, Inc. | Behandlung von hüftschmerzen mit liposomalen anästhesiezusammensetzungen mit verzögerter freisetzung |
WO2022159564A1 (en) | 2021-01-22 | 2022-07-28 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
US11357727B1 (en) | 2021-01-22 | 2022-06-14 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
US11278494B1 (en) | 2021-01-22 | 2022-03-22 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
US11033495B1 (en) | 2021-01-22 | 2021-06-15 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
US20220304932A1 (en) * | 2021-01-22 | 2022-09-29 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
WO2022197899A2 (en) | 2021-03-19 | 2022-09-22 | Pacira Pharmaceuticals, Inc. | Treatment of pain in pediatric patients by administration of sustained-release liposomal anesthetic compositions |
CN117999100A (zh) * | 2021-10-14 | 2024-05-07 | 帕西拉制药有限公司 | 地塞米松的多囊脂质体制剂 |
US11918565B1 (en) | 2022-11-03 | 2024-03-05 | Pacira Pharmaceuticals, Inc. | Treatment of post-operative pain via sciatic nerve block with sustained-release liposomal anesthetic compositions |
Family Cites Families (171)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3684251A (en) | 1970-09-08 | 1972-08-15 | Us Army | Apparatus for continuous emulsification |
US3946994A (en) | 1974-04-10 | 1976-03-30 | Petrolite Corporation | System for producing emulsions |
IT1015665B (it) | 1974-07-04 | 1977-05-20 | Snam Progetti | Metodo per la preparazione in con tinuo di emulsioni acqua olio ed apparecchiatura adatta allo scopo |
CH588887A5 (de) * | 1974-07-19 | 1977-06-15 | Battelle Memorial Institute | |
US4113765A (en) | 1975-03-21 | 1978-09-12 | Standard Oil Company (Indiana) | Continuous process for sulfonating alkyl aromatics |
US4897308A (en) * | 1975-06-30 | 1990-01-30 | L'oreal | Compositions comprising aqueous dispersions of lipid spheres |
US4078052A (en) * | 1976-06-30 | 1978-03-07 | The United States Of America As Represented By The Secretary Of Health, Education And Welfare | Large unilamellar vesicles (LUV) and method of preparing same |
US4086257A (en) * | 1976-10-12 | 1978-04-25 | Sears Barry D | Phosphatidyl quaternary ammonium compounds |
CH624011A5 (de) * | 1977-08-05 | 1981-07-15 | Battelle Memorial Institute | |
US4235871A (en) * | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
US4310506A (en) * | 1979-02-22 | 1982-01-12 | California Institute Of Technology | Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species |
DE2909906A1 (de) | 1979-03-14 | 1980-10-02 | Bayer Ag | Verfahren zur kontinuierlichen herstellung von mikrokapseln |
US4235587A (en) * | 1979-04-09 | 1980-11-25 | Honeywell Inc. | Flame responsive control circuit |
JPS55153713A (en) | 1979-05-02 | 1980-11-29 | Kureha Chem Ind Co Ltd | Pharmaceutical preparation of ribosome containing active substance |
JPS6127918Y2 (de) | 1979-11-07 | 1986-08-19 | ||
US4394372A (en) * | 1980-12-22 | 1983-07-19 | The Procter & Gamble Company | Process for making lipid membrane structures |
US4420398A (en) * | 1981-08-13 | 1983-12-13 | American National Red Cross | Filteration method for cell produced antiviral substances |
US4454083A (en) | 1981-12-21 | 1984-06-12 | Appleton Papers Inc. | Continuous microencapsulation |
US4522803A (en) * | 1983-02-04 | 1985-06-11 | The Liposome Company, Inc. | Stable plurilamellar vesicles, their preparation and use |
US5387410A (en) * | 1983-03-18 | 1995-02-07 | Mallinckrodt, Inc. | Method for enhancing magnetic resonance with compositions containing paramagnetic elements carried by liposomes |
US5169637A (en) | 1983-03-24 | 1992-12-08 | The Liposome Company, Inc. | Stable plurilamellar vesicles |
US4588578A (en) | 1983-08-08 | 1986-05-13 | The Liposome Company, Inc. | Lipid vesicles prepared in a monophase |
US5186941A (en) | 1983-05-06 | 1993-02-16 | Vestar, Inc. | Vesicle formulation for the controlled release of therapeutic agents |
JPH0768117B2 (ja) | 1983-05-06 | 1995-07-26 | ベスター・インコーポレイテツド | 薬剤放出調整用小胞製剤 |
FR2548043A1 (fr) | 1983-06-14 | 1985-01-04 | Saint Gobain Vitrage | Procede et dispositif pour la fabrication par coulee d'une couche optiquement homogene transparente a partir d'un melange de composants |
US4725442A (en) | 1983-06-17 | 1988-02-16 | Haynes Duncan H | Microdroplets of water-insoluble drugs and injectable formulations containing same |
US4622219A (en) | 1983-06-17 | 1986-11-11 | Haynes Duncan H | Method of inducing local anesthesia using microdroplets of a general anesthetic |
US4478824A (en) * | 1983-08-08 | 1984-10-23 | Franco Robert S | Method for altering red blood cell function and survival |
JPS60100516A (ja) | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
US4599227A (en) * | 1983-11-07 | 1986-07-08 | Wisconsin Alumni Research Foundation | Injectable pharmaceutical preparation for the induction of multiple follicular growth |
US4888115A (en) | 1983-12-29 | 1989-12-19 | Cuno, Incorporated | Cross-flow filtration |
US4599342A (en) | 1984-01-16 | 1986-07-08 | The Procter & Gamble Company | Pharmaceutical products providing enhanced analgesia |
US4744989A (en) | 1984-02-08 | 1988-05-17 | E. R. Squibb & Sons, Inc. | Method of preparing liposomes and products produced thereby |
US5141674A (en) | 1984-03-08 | 1992-08-25 | Phares Pharmaceutical Research N.V. | Methods of preparing pro-liposome dispersions and aerosols |
DE3585967D1 (de) | 1984-03-08 | 1992-06-11 | Phares Pharma Holland | Liposombildende zusammensetzung. |
US4610868A (en) | 1984-03-20 | 1986-09-09 | The Liposome Company, Inc. | Lipid matrix carriers for use in drug delivery systems |
DE3421865A1 (de) | 1984-06-13 | 1985-12-19 | Bayer Ag, 5090 Leverkusen | Kontinuierliche herstellung von mikrokapseldispersionen |
US5077056A (en) * | 1984-08-08 | 1991-12-31 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
DE3432718C1 (de) * | 1984-09-06 | 1986-05-22 | Biotest Pharma GmbH, 6000 Frankfurt | Verfahren zur Herstellung einer Loesung von Milch- und/oder Kolostralimmunglobulinen |
US4761288A (en) | 1984-09-24 | 1988-08-02 | Mezei Associates Limited | Multiphase liposomal drug delivery system |
US4788001A (en) * | 1985-04-02 | 1988-11-29 | Dow Corning Corporation | Oil-in-water emulsion |
GB2176715A (en) | 1985-06-27 | 1987-01-07 | Apv Int Ltd | Beer filtration |
US5292701A (en) * | 1985-08-29 | 1994-03-08 | W. R. Grace & Co.-Conn. | High pore volume and pore diameter aluminum phosphate and method of making the same |
IE58981B1 (en) * | 1985-10-15 | 1993-12-15 | Vestar Inc | Anthracycline antineoplastic agents encapsulated in phospholipid micellular particles |
EP0225130B1 (de) | 1985-11-22 | 1991-10-30 | Takeda Chemical Industries, Ltd. | Liposomzusammensetzung |
US5244678A (en) | 1986-01-14 | 1993-09-14 | Ire-Celltarg S.A. | Pharmaceutical composition containing a local anesthetic and/or centrally acting analgesic encapsulated in liposomes |
JPH0751496B2 (ja) | 1986-04-02 | 1995-06-05 | 武田薬品工業株式会社 | リポソ−ムの製造法 |
DE3776966D1 (de) | 1986-05-20 | 1992-04-09 | Wako Pure Chem Ind Ltd | Funktionelle gruppen tragende liposome und verfahren zu deren herstellung. |
US5204112A (en) * | 1986-06-16 | 1993-04-20 | The Liposome Company, Inc. | Induction of asymmetry in vesicles |
US5147134A (en) | 1986-08-21 | 1992-09-15 | Petrolite Corporation | Process for the continuous production of high-internal-phase-ratio emulsions |
US4877619A (en) | 1986-08-25 | 1989-10-31 | Vestar, Inc. | Liposomal vesicles for intraperitoneal administration of therapeutic agents |
US4776991A (en) * | 1986-08-29 | 1988-10-11 | The United States Of America As Represented By The Secretary Of The Navy | Scaled-up production of liposome-encapsulated hemoglobin |
US4781871A (en) * | 1986-09-18 | 1988-11-01 | Liposome Technology, Inc. | High-concentration liposome processing method |
US4752425A (en) * | 1986-09-18 | 1988-06-21 | Liposome Technology, Inc. | High-encapsulation liposome processing method |
US4844620A (en) | 1986-11-24 | 1989-07-04 | Petrolite Corporation | System for producing high-internal-phase-ratio emulsion products on a continuous basis |
US4781831A (en) * | 1986-12-19 | 1988-11-01 | Goldsmith Robert L | Cross-flow filtration device with filtrate flow conduits and method of forming same |
US4920016A (en) * | 1986-12-24 | 1990-04-24 | Linear Technology, Inc. | Liposomes with enhanced circulation time |
US5723147A (en) * | 1987-02-23 | 1998-03-03 | Depotech Corporation | Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride |
GB8704171D0 (en) | 1987-02-23 | 1987-04-01 | Clayton Found Res | Multivesicular liposomes |
DK86988A (da) | 1987-02-25 | 1988-08-26 | Takeda Chemical Industries Ltd | Liposompraeparat og anvendelse deraf |
JP2666345B2 (ja) | 1987-04-16 | 1997-10-22 | 武田薬品工業株式会社 | リポソーム製剤およびその製造法 |
US5069936A (en) * | 1987-06-25 | 1991-12-03 | Yen Richard C K | Manufacturing protein microspheres |
JP2877160B2 (ja) * | 1987-07-29 | 1999-03-31 | ザ リポソーム カンパニー,インコーポレイテッド | 粒子のサイズによる分離方法 |
CA1337273C (en) | 1987-07-29 | 1995-10-10 | Robert P. Lenk | Method for size separation of particles |
IE63518B1 (en) | 1987-11-18 | 1995-05-03 | Vestar Inc | Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes |
US5807572A (en) * | 1988-02-18 | 1998-09-15 | Depotech Corporation | Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride |
DE68901733T2 (de) * | 1988-03-04 | 1993-03-25 | Takeda Chemical Industries Ltd | Liposom-zusammensetzung. |
US5948441A (en) * | 1988-03-07 | 1999-09-07 | The Liposome Company, Inc. | Method for size separation of particles |
US5261903A (en) * | 1988-04-11 | 1993-11-16 | M.D. Inc. | Composite anesthetic article and method of use |
MX9203504A (es) * | 1988-04-20 | 1992-07-01 | Liposome Co Inc | Complejo agente: lipido activo de alta proporcion. |
US5576017A (en) | 1988-05-30 | 1996-11-19 | Depotech Corporation | Heterovesicular liposomes |
US5422120A (en) * | 1988-05-30 | 1995-06-06 | Depotech Corporation | Heterovesicular liposomes |
US4937078A (en) | 1988-08-26 | 1990-06-26 | Mezei Associates Limited | Liposomal local anesthetic and analgesic products |
IL91664A (en) | 1988-09-28 | 1993-05-13 | Yissum Res Dev Co | Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release |
BE1001869A3 (fr) * | 1988-10-12 | 1990-04-03 | Franz Legros | Procede d'encapsulation liposomiale d'antibiotiques aminoglucosidiques, en particulier de la gentamycine. |
US4921853A (en) * | 1988-11-14 | 1990-05-01 | Michigan State University | Method for producing analgesia in mammals |
US4908463A (en) | 1988-12-05 | 1990-03-13 | Ethyl Corporation | Aluminoxane process |
US5049392A (en) | 1989-01-18 | 1991-09-17 | The Liposome Company, Inc. | Osmotically dependent vesicles |
US4956290A (en) * | 1989-03-27 | 1990-09-11 | Phillips Petroleum Company | Large scale process for the purification of alcohol oxidase |
US5364632A (en) | 1989-04-05 | 1994-11-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Medicinal emulsions |
US5227170A (en) * | 1989-06-22 | 1993-07-13 | Vestar, Inc. | Encapsulation process |
FR2651680B1 (fr) * | 1989-09-14 | 1991-12-27 | Medgenix Group Sa | Nouveau procede de preparation de microparticules lipidiques. |
US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
US5225212A (en) | 1989-10-20 | 1993-07-06 | Liposome Technology, Inc. | Microreservoir liposome composition and method |
US5227165A (en) | 1989-11-13 | 1993-07-13 | Nova Pharmaceutical Corporation | Liposphere delivery systems for local anesthetics |
US5334381A (en) | 1989-12-22 | 1994-08-02 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
US5580575A (en) | 1989-12-22 | 1996-12-03 | Imarx Pharmaceutical Corp. | Therapeutic drug delivery systems |
NZ237464A (en) | 1990-03-21 | 1995-02-24 | Depotech Corp | Liposomes with at least two separate chambers encapsulating two separate biologically active substances |
US5246707A (en) * | 1990-04-26 | 1993-09-21 | Haynes Duncan H | Sustained release delivery of water-soluble bio-molecules and drugs using phospholipid-coated microcrystals, microdroplets and high-concentration liposomes |
US5091187A (en) * | 1990-04-26 | 1992-02-25 | Haynes Duncan H | Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs |
US5169934A (en) * | 1990-05-14 | 1992-12-08 | Anergen, Inc. | Intracellularly cleavable compounds |
USRE35192E (en) * | 1990-11-13 | 1996-03-26 | Phoenix Surgical Products, Inc. | Post-surgical anesthesia at a continuous and progressively decreasing administration rate |
IS1685B (is) | 1990-12-11 | 1998-02-24 | Bracco International B.V. | Aðferð við að búa til fitukúlur (liposomes) sem eru gæddar auknum hæfileika til að draga í sig og halda í sér aðskotaefnum |
SE506930C2 (sv) | 1991-03-25 | 1998-03-02 | Svedala Pumps & Process Ab | Förfarande och anordning för förtjockning av finpartikulära suspensioner |
US5885260A (en) * | 1991-05-30 | 1999-03-23 | Mehl, Sr.; Thomas L. | Freeze-dried liposome delivery system for application of skin treatment agents |
AU654835B2 (en) | 1991-07-03 | 1994-11-24 | Nexstar Pharmaceuticals, Inc. | Loading technique for preparing drug containing liposomes |
US5977326A (en) | 1991-08-06 | 1999-11-02 | Salford Ultrafine Chemicals And Research Limited | Process for making morphine-6-glucuronide or substituted morphine-6-glucuronide |
SE9200952D0 (sv) | 1992-03-27 | 1992-03-27 | Kabi Pharmacia Ab | Pharmaceutical carrier system containing defined lipids |
US5922340A (en) | 1992-09-10 | 1999-07-13 | Children's Medical Center Corporation | High load formulations and methods for providing prolonged local anesthesia |
CA2146963A1 (en) * | 1992-10-16 | 1994-04-28 | Andreas Sachse | Process and device for producing liquid, dispersed systems |
US5321012A (en) * | 1993-01-28 | 1994-06-14 | Virginia Commonwealth University Medical College | Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance |
JPH06247842A (ja) | 1993-02-23 | 1994-09-06 | Green Cross Corp:The | リポソーム組成物の製造方法 |
EP0616801B1 (de) * | 1993-03-24 | 1998-05-27 | Novartis AG | Verfahren zur Herstellung einer Liposomendispersion im Hochdruckbereich |
WO1994022430A1 (en) | 1993-04-02 | 1994-10-13 | The Liposome Company, Inc. | Method of producing liposomes |
US5891842A (en) | 1993-04-09 | 1999-04-06 | Trustees Of Tufts College | Methodology for eliciting an analgesic response in a living subject |
CA2161225C (en) | 1993-04-22 | 2003-07-01 | Sinil Kim | Cyclodextrin liposomes encapsulating pharmacologic compounds and methods for their use |
US5455044A (en) | 1993-05-14 | 1995-10-03 | Depotech Corporation | Method for treating neurological disorders |
JPH09503743A (ja) | 1993-05-14 | 1997-04-15 | デポテック コーポレーション | 神経学的疾患の治療方法 |
US5554382A (en) | 1993-05-28 | 1996-09-10 | Aphios Corporation | Methods and apparatus for making liposomes |
US5776486A (en) * | 1993-05-28 | 1998-07-07 | Aphios Corporation | Methods and apparatus for making liposomes containing hydrophobic drugs |
EP0706374B1 (de) | 1993-06-30 | 1997-12-10 | Genentech, Inc. | Verfahren zur herstellung von liposomen |
SE503277C2 (sv) * | 1993-07-20 | 1996-05-13 | Alfa Laval Brewery Syst Ab | Filter avsett för tvärströmsfiltrering |
US5543158A (en) * | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
US5853755A (en) | 1993-07-28 | 1998-12-29 | Pharmaderm Laboratories Ltd. | Biphasic multilamellar lipid vesicles |
US5387387A (en) * | 1993-09-30 | 1995-02-07 | Alex James & Associates, Inc. | Method and apparatus for dry spinning spandex |
GB9320668D0 (en) | 1993-10-07 | 1993-11-24 | Secr Defence | Liposomes containing particulare materials |
US5849763A (en) | 1993-10-13 | 1998-12-15 | Darwin Discovery Limited | Use of levobupivacaine as an anesthetic agent |
GB9321061D0 (en) | 1993-10-13 | 1993-12-01 | Chiroscience Ltd | Analgestic agent and its use |
JPH09503778A (ja) * | 1993-10-13 | 1997-04-15 | カイロサイエンス・リミテッド | 鎮痛剤およびその使用 |
AU683957B2 (en) * | 1993-11-05 | 1997-11-27 | Amgen, Inc. | Liposome preparation and material encapsulation method |
ES2149955T3 (es) * | 1993-11-16 | 2000-11-16 | Skyepharma Inc | Vesiculas con liberacion controlada de sustancias activas. |
US5766627A (en) | 1993-11-16 | 1998-06-16 | Depotech | Multivescular liposomes with controlled release of encapsulated biologically active substances |
US5879672A (en) * | 1994-10-07 | 1999-03-09 | Regeneron Pharmaceuticals, Inc. | Tie-2 ligand 1 |
US5451408A (en) | 1994-03-23 | 1995-09-19 | Liposome Pain Management, Ltd. | Pain management with liposome-encapsulated analgesic drugs |
SE518578C2 (sv) | 1994-06-15 | 2002-10-29 | Gs Dev Ab | Lipidbaserad komposition |
US5741516A (en) | 1994-06-20 | 1998-04-21 | Inex Pharmaceuticals Corporation | Sphingosomes for enhanced drug delivery |
US6048545A (en) | 1994-06-24 | 2000-04-11 | Biozone Laboratories, Inc. | Liposomal delivery by iontophoresis |
US6066331A (en) | 1994-07-08 | 2000-05-23 | Barenholz; Yechezkel | Method for preparation of vesicles loaded with biological structures, biopolymers and/or oligomers |
SE9402453D0 (sv) | 1994-07-12 | 1994-07-12 | Astra Ab | New pharmaceutical preparation |
DE4430592A1 (de) | 1994-08-20 | 1996-02-22 | Max Delbrueck Centrum | Liposomale Zubereitung, ihre Herstellung und ihre Verwendung |
US5993850A (en) * | 1994-09-13 | 1999-11-30 | Skyepharma Inc. | Preparation of multivesicular liposomes for controlled release of encapsulated biologically active substances |
US5589189A (en) * | 1994-09-14 | 1996-12-31 | Nexstar Pharmaceuticals, Inc. | Liposome dispersion |
US5702722A (en) * | 1994-09-30 | 1997-12-30 | Bracco Research S.A. | Liposomes with enhanced entrapment capacity, method and use |
IL115849A0 (en) * | 1994-11-03 | 1996-01-31 | Merz & Co Gmbh & Co | Tangential filtration preparation of liposomal drugs and liposome product thereof |
EP0711557A1 (de) * | 1994-11-09 | 1996-05-15 | Ciba-Geigy Ag | Pharmazeutische Formulierungsgrundlage |
WO1996024330A1 (en) | 1995-02-10 | 1996-08-15 | Medtronic, Inc. | Method and device for administering analgesics |
CA2211995A1 (en) * | 1995-02-24 | 1996-08-29 | Cantab Pharmaceuticals Research Limited | Polypeptides useful as immunotherapeutic agents and methods of polypeptide preparation |
US6007838A (en) * | 1995-06-07 | 1999-12-28 | The United States Of America As Represented By The Secretary Of The Army | Process for making liposome preparation |
ATE217792T1 (de) | 1995-07-05 | 2002-06-15 | Europ Economic Community | Biokompatibele und biodegradierbare nanokapseln zur absorption und verabreichung von proteinischen arzneimitteln |
US5931809A (en) | 1995-07-14 | 1999-08-03 | Depotech Corporation | Epidural administration of therapeutic compounds with sustained rate of release |
AU6698196A (en) * | 1995-08-15 | 1997-03-12 | Universite Libre De Bruxelles | Liposomes preparation method and plant |
US5942253A (en) * | 1995-10-12 | 1999-08-24 | Immunex Corporation | Prolonged release of GM-CSF |
GB9605915D0 (en) | 1996-03-21 | 1996-05-22 | Univ Bruxelles | Liposome encapsulated amphiphilic drug compositions |
US6197333B1 (en) | 1996-03-28 | 2001-03-06 | The Board Of Trustees Of The University Of Illinois | Materials and methods for making improved liposome compositions |
GB9614902D0 (en) * | 1996-07-16 | 1996-09-04 | Rhodes John | Sustained release composition |
US6046187A (en) | 1996-09-16 | 2000-04-04 | Children's Medical Center Corporation | Formulations and methods for providing prolonged local anesthesia |
US5997899A (en) * | 1996-10-01 | 1999-12-07 | Skyepharma Inc. | Method for producing liposomes with increased percent of compound encapsulated |
NZ514133A (en) | 1996-10-15 | 2001-09-28 | Liposome Co Inc | N-acyl phosphatidylethanolamine-mediated liposomal drug delivery |
US5837282A (en) * | 1996-10-30 | 1998-11-17 | University Of British Columbia | Ionophore-mediated liposome loading |
WO1998024415A1 (en) | 1996-12-02 | 1998-06-11 | The Regents Of The University Of California | A bilayer structure which encapsulates multiple containment units and uses thereof |
US5865184A (en) | 1997-01-13 | 1999-02-02 | Takiguchi; Tetsuo | Combined spinal and epidural anesthesia |
US5891467A (en) * | 1997-01-31 | 1999-04-06 | Depotech Corporation | Method for utilizing neutral lipids to modify in vivo release from multivesicular liposomes |
US5827533A (en) | 1997-02-06 | 1998-10-27 | Duke University | Liposomes containing active agents aggregated with lipid surfactants |
US5945126A (en) * | 1997-02-13 | 1999-08-31 | Oakwood Laboratories L.L.C. | Continuous microsphere process |
GB9704352D0 (en) | 1997-03-03 | 1997-04-23 | Chiroscience Ltd | Levobupivacaine and its use |
GB9704351D0 (en) | 1997-03-03 | 1997-04-23 | Chiroscience Ltd | Levobupivacaine and its use |
EP1201241B8 (de) | 1997-03-13 | 2010-10-27 | James N. Campbell | Zusammensetzungen enthaltend Capsaicin oder Capsaicin Analoge und ein Anästhetikum |
US5947689A (en) * | 1997-05-07 | 1999-09-07 | Scilog, Inc. | Automated, quantitative, system for filtration of liquids having a pump controller |
US6264988B1 (en) * | 1997-06-05 | 2001-07-24 | Hemosphere, Inc. | Fibrinogen-coated microspheres |
US6287587B2 (en) | 1997-07-15 | 2001-09-11 | Takeda Chemical Industries, Ltd. | Process for producing sustained-release preparation by in-water drying |
BR9802536A (pt) | 1997-07-21 | 1999-07-20 | Darwin Discovery Ltd | Método para anestesiar um paciente humano antes de cirurgias |
CA2294921C (en) | 1997-07-22 | 2009-04-07 | Darwin Discovery Limited | Levobupivacaine and its use |
US5776915A (en) * | 1997-08-12 | 1998-07-07 | Clarion Pharmaceuticals Inc. | Phosphocholines of retinoids |
US6106858A (en) * | 1997-09-08 | 2000-08-22 | Skyepharma, Inc. | Modulation of drug loading in multivescular liposomes |
US6306432B1 (en) * | 1997-09-08 | 2001-10-23 | Chiron Corporation | High and low load formulations of IGF-I in multivesicular liposomes |
ATE535232T1 (de) * | 1997-09-18 | 2011-12-15 | Pacira Pharmaceuticals Inc | Retardierte freisetzung liposomaler anesthetischer zusammensetzungen |
US6033708A (en) * | 1997-09-30 | 2000-03-07 | The United States Of America As Represented By The Secretary Of The Navy | Method for producing sterile filterable liposome dispersion |
DE69940735D1 (de) | 1998-07-17 | 2009-05-28 | Pacira Pharmaceuticals Inc | Biologisch abbaubare anordnungen zur kontrollierten freigabe eingeschlossener substanzen |
US6358060B2 (en) * | 1998-09-03 | 2002-03-19 | Jsr Llc | Two-stage transmucosal medicine delivery system for symptom relief |
US6270802B1 (en) * | 1998-10-28 | 2001-08-07 | Oakwood Laboratories L.L.C. | Method and apparatus for formulating microspheres and microcapsules |
US6248760B1 (en) * | 1999-04-14 | 2001-06-19 | Paul C Wilhelmsen | Tablet giving rapid release of nicotine for transmucosal administration |
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1998
- 1998-11-13 AU AU14075/99A patent/AU752802C/en not_active Expired
- 1998-11-13 JP JP2000520753A patent/JP4575592B2/ja not_active Expired - Lifetime
- 1998-11-13 ES ES98957937T patent/ES2384094T3/es not_active Expired - Lifetime
- 1998-11-13 US US09/192,064 patent/US20020039596A1/en not_active Abandoned
- 1998-11-13 NZ NZ504188A patent/NZ504188A/en not_active IP Right Cessation
- 1998-11-13 WO PCT/US1998/024261 patent/WO1999025319A1/en active Application Filing
- 1998-11-13 AT AT98957937T patent/ATE554748T1/de active
- 1998-11-13 EP EP98957937A patent/EP1030652B1/de not_active Expired - Lifetime
- 1998-11-13 IL IL13598998A patent/IL135989A0/xx active IP Right Grant
- 1998-11-13 CA CA002309548A patent/CA2309548A1/en not_active Abandoned
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2000
- 2000-05-05 IL IL135989A patent/IL135989A/en not_active IP Right Cessation
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2002
- 2002-10-01 AU AU2002301268A patent/AU2002301268B2/en not_active Expired
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2006
- 2006-01-06 AU AU2006200044A patent/AU2006200044A1/en not_active Abandoned
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2007
- 2007-02-25 US US11/678,615 patent/US9585838B2/en not_active Expired - Lifetime
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2008
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- 2008-08-31 IL IL193778A patent/IL193778A0/en unknown
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- 2010-07-20 JP JP2010162514A patent/JP2010285438A/ja active Pending
- 2010-08-13 AU AU2010212347A patent/AU2010212347B2/en not_active Expired
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Also Published As
Publication number | Publication date |
---|---|
EP1030652A1 (de) | 2000-08-30 |
AU2006200044A1 (en) | 2006-02-02 |
AU2002301268B2 (en) | 2005-10-06 |
ES2384094T3 (es) | 2012-06-29 |
WO1999025319A1 (en) | 1999-05-27 |
AU752802C (en) | 2006-04-13 |
IL193778A0 (en) | 2009-05-04 |
AU2008203032A1 (en) | 2008-07-31 |
IL135989A (en) | 2009-02-11 |
CA2309548A1 (en) | 1999-05-27 |
JP4575592B2 (ja) | 2010-11-04 |
JP2001522870A (ja) | 2001-11-20 |
EP1030652B1 (de) | 2012-04-25 |
NZ504188A (en) | 2001-10-26 |
US20020039596A1 (en) | 2002-04-04 |
AU752802B2 (en) | 2002-10-03 |
AU1407599A (en) | 1999-06-07 |
AU2010212347A1 (en) | 2010-09-09 |
US9585838B2 (en) | 2017-03-07 |
US20070235889A1 (en) | 2007-10-11 |
US20140004173A1 (en) | 2014-01-02 |
ATE554748T1 (de) | 2012-05-15 |
AU2008203032B2 (en) | 2010-05-13 |
EP1030652A4 (de) | 2006-05-24 |
JP2010285438A (ja) | 2010-12-24 |
AU2010212347B2 (en) | 2012-03-22 |
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