IL134152A - Spectral biological imaging of the eye - Google Patents
Spectral biological imaging of the eyeInfo
- Publication number
- IL134152A IL134152A IL13415298A IL13415298A IL134152A IL 134152 A IL134152 A IL 134152A IL 13415298 A IL13415298 A IL 13415298A IL 13415298 A IL13415298 A IL 13415298A IL 134152 A IL134152 A IL 134152A
- Authority
- IL
- Israel
- Prior art keywords
- spectral
- eye
- light
- eye tissue
- image
- Prior art date
Links
- 230000003595 spectral effect Effects 0.000 title claims abstract description 424
- 238000003384 imaging method Methods 0.000 title claims abstract description 76
- 238000001228 spectrum Methods 0.000 claims abstract description 163
- 238000000034 method Methods 0.000 claims abstract description 152
- 230000003287 optical effect Effects 0.000 claims abstract description 83
- 230000002708 enhancing effect Effects 0.000 claims abstract description 46
- 238000007689 inspection Methods 0.000 claims abstract description 20
- 238000004422 calculation algorithm Methods 0.000 claims description 66
- 108010054147 Hemoglobins Proteins 0.000 claims description 41
- 102000001554 Hemoglobins Human genes 0.000 claims description 41
- 210000001525 retina Anatomy 0.000 claims description 37
- 230000033001 locomotion Effects 0.000 claims description 32
- 238000012937 correction Methods 0.000 claims description 30
- 238000005286 illumination Methods 0.000 claims description 22
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 21
- 229910052760 oxygen Inorganic materials 0.000 claims description 21
- 239000001301 oxygen Substances 0.000 claims description 21
- 210000001210 retinal vessel Anatomy 0.000 claims description 20
- 239000000523 sample Substances 0.000 claims description 20
- 230000001427 coherent effect Effects 0.000 claims description 17
- 210000000554 iris Anatomy 0.000 claims description 16
- 210000003733 optic disk Anatomy 0.000 claims description 16
- 210000004204 blood vessel Anatomy 0.000 claims description 15
- 210000003462 vein Anatomy 0.000 claims description 15
- 210000001367 artery Anatomy 0.000 claims description 14
- 208000028867 ischemia Diseases 0.000 claims description 14
- 206010025421 Macule Diseases 0.000 claims description 13
- 238000013507 mapping Methods 0.000 claims description 13
- 239000000126 substance Substances 0.000 claims description 13
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 claims description 12
- 108090000854 Oxidoreductases Proteins 0.000 claims description 12
- 102000004316 Oxidoreductases Human genes 0.000 claims description 12
- 208000002780 macular degeneration Diseases 0.000 claims description 12
- 206010012689 Diabetic retinopathy Diseases 0.000 claims description 11
- 238000006213 oxygenation reaction Methods 0.000 claims description 9
- 208000010412 Glaucoma Diseases 0.000 claims description 8
- 102000008186 Collagen Human genes 0.000 claims description 6
- 108010035532 Collagen Proteins 0.000 claims description 6
- 108010052832 Cytochromes Proteins 0.000 claims description 6
- 102000018832 Cytochromes Human genes 0.000 claims description 6
- 108010014258 Elastin Proteins 0.000 claims description 6
- 102000016942 Elastin Human genes 0.000 claims description 6
- 108091007187 Reductases Proteins 0.000 claims description 6
- 229920001436 collagen Polymers 0.000 claims description 6
- 229920002549 elastin Polymers 0.000 claims description 6
- 210000004126 nerve fiber Anatomy 0.000 claims description 6
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 claims description 6
- 208000001860 Eye Infections Diseases 0.000 claims description 5
- 208000010038 Ischemic Optic Neuropathy Diseases 0.000 claims description 5
- BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 claims description 5
- 206010030924 Optic ischaemic neuropathy Diseases 0.000 claims description 5
- 230000001154 acute effect Effects 0.000 claims description 5
- 201000007058 anterior ischemic optic neuropathy Diseases 0.000 claims description 5
- 208000011323 eye infectious disease Diseases 0.000 claims description 5
- 150000002211 flavins Chemical class 0.000 claims description 5
- 229950006238 nadide Drugs 0.000 claims description 5
- XJLXINKUBYWONI-NNYOXOHSSA-N NADP zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-NNYOXOHSSA-N 0.000 claims description 4
- 206010038910 Retinitis Diseases 0.000 claims description 4
- 210000004087 cornea Anatomy 0.000 claims description 3
- 210000001519 tissue Anatomy 0.000 description 128
- 230000006870 function Effects 0.000 description 60
- 238000005259 measurement Methods 0.000 description 46
- 238000000701 chemical imaging Methods 0.000 description 40
- 230000002207 retinal effect Effects 0.000 description 28
- 239000013598 vector Substances 0.000 description 25
- 238000004611 spectroscopical analysis Methods 0.000 description 21
- 210000004027 cell Anatomy 0.000 description 17
- 238000004458 analytical method Methods 0.000 description 14
- 238000001514 detection method Methods 0.000 description 14
- 230000008901 benefit Effects 0.000 description 13
- 238000012545 processing Methods 0.000 description 11
- 230000005540 biological transmission Effects 0.000 description 10
- 210000004369 blood Anatomy 0.000 description 10
- 239000008280 blood Substances 0.000 description 10
- 239000000470 constituent Substances 0.000 description 10
- 238000003745 diagnosis Methods 0.000 description 10
- 230000035945 sensitivity Effects 0.000 description 10
- 230000001629 suppression Effects 0.000 description 10
- 201000010099 disease Diseases 0.000 description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
- 239000011159 matrix material Substances 0.000 description 9
- 230000005855 radiation Effects 0.000 description 9
- 210000004556 brain Anatomy 0.000 description 8
- 230000008859 change Effects 0.000 description 8
- 230000009466 transformation Effects 0.000 description 8
- 208000017442 Retinal disease Diseases 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- MOFVSTNWEDAEEK-UHFFFAOYSA-M indocyanine green Chemical compound [Na+].[O-]S(=O)(=O)CCCCN1C2=CC=C3C=CC=CC3=C2C(C)(C)C1=CC=CC=CC=CC1=[N+](CCCCS([O-])(=O)=O)C2=CC=C(C=CC=C3)C3=C2C1(C)C MOFVSTNWEDAEEK-UHFFFAOYSA-M 0.000 description 7
- 229960004657 indocyanine green Drugs 0.000 description 7
- 238000012216 screening Methods 0.000 description 7
- 238000011282 treatment Methods 0.000 description 7
- 238000002583 angiography Methods 0.000 description 6
- 230000008033 biological extinction Effects 0.000 description 6
- 230000004087 circulation Effects 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 6
- 238000011156 evaluation Methods 0.000 description 6
- 230000005284 excitation Effects 0.000 description 6
- 230000004060 metabolic process Effects 0.000 description 6
- 230000008520 organization Effects 0.000 description 6
- 230000004044 response Effects 0.000 description 6
- 238000002560 therapeutic procedure Methods 0.000 description 6
- 241000557626 Corvus corax Species 0.000 description 5
- 206010028980 Neoplasm Diseases 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 5
- 238000004364 calculation method Methods 0.000 description 5
- 239000003086 colorant Substances 0.000 description 5
- 239000006185 dispersion Substances 0.000 description 5
- 238000009826 distribution Methods 0.000 description 5
- 238000013534 fluorescein angiography Methods 0.000 description 5
- 201000001441 melanoma Diseases 0.000 description 5
- 238000002310 reflectometry Methods 0.000 description 5
- 238000011160 research Methods 0.000 description 5
- 208000005590 Choroidal Neovascularization Diseases 0.000 description 4
- 206010060823 Choroidal neovascularisation Diseases 0.000 description 4
- 206010064930 age-related macular degeneration Diseases 0.000 description 4
- 238000013459 approach Methods 0.000 description 4
- 210000003161 choroid Anatomy 0.000 description 4
- 210000003917 human chromosome Anatomy 0.000 description 4
- 230000010354 integration Effects 0.000 description 4
- 210000000056 organ Anatomy 0.000 description 4
- 230000007170 pathology Effects 0.000 description 4
- 238000000513 principal component analysis Methods 0.000 description 4
- 238000011002 quantification Methods 0.000 description 4
- 210000003583 retinal pigment epithelium Anatomy 0.000 description 4
- 238000010183 spectrum analysis Methods 0.000 description 4
- 238000013519 translation Methods 0.000 description 4
- 210000005166 vasculature Anatomy 0.000 description 4
- 230000035899 viability Effects 0.000 description 4
- 208000032843 Hemorrhage Diseases 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 3
- 210000000349 chromosome Anatomy 0.000 description 3
- 230000002559 cytogenic effect Effects 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 239000000975 dye Substances 0.000 description 3
- 208000030533 eye disease Diseases 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 238000002189 fluorescence spectrum Methods 0.000 description 3
- 238000009615 fourier-transform spectroscopy Methods 0.000 description 3
- 238000003331 infrared imaging Methods 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 239000004973 liquid crystal related substance Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000002503 metabolic effect Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 210000003463 organelle Anatomy 0.000 description 3
- 238000002496 oximetry Methods 0.000 description 3
- 239000003973 paint Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 210000001957 retinal vein Anatomy 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 238000012935 Averaging Methods 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 208000003569 Central serous chorioretinopathy Diseases 0.000 description 2
- 241001442234 Cosa Species 0.000 description 2
- 208000037111 Retinal Hemorrhage Diseases 0.000 description 2
- 206010038923 Retinopathy Diseases 0.000 description 2
- 239000006096 absorbing agent Substances 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 230000001066 destructive effect Effects 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 230000004424 eye movement Effects 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 238000005305 interferometry Methods 0.000 description 2
- 238000013532 laser treatment Methods 0.000 description 2
- 201000002350 malignant ciliary body melanoma Diseases 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 2
- 238000010606 normalization Methods 0.000 description 2
- 210000001328 optic nerve Anatomy 0.000 description 2
- 238000005535 overpotential deposition Methods 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 238000002428 photodynamic therapy Methods 0.000 description 2
- 230000035479 physiological effects, processes and functions Effects 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 238000007781 pre-processing Methods 0.000 description 2
- 238000005316 response function Methods 0.000 description 2
- 210000001927 retinal artery Anatomy 0.000 description 2
- 208000032253 retinal ischemia Diseases 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000000411 transmission spectrum Methods 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 208000030507 AIDS Diseases 0.000 description 1
- 108010077544 Chromatin Proteins 0.000 description 1
- 208000031404 Chromosome Aberrations Diseases 0.000 description 1
- 241000701022 Cytomegalovirus Species 0.000 description 1
- 206010061818 Disease progression Diseases 0.000 description 1
- 208000012661 Dyskinesia Diseases 0.000 description 1
- 241001670157 Gymnura Species 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 208000015592 Involuntary movements Diseases 0.000 description 1
- 206010052098 Iodine allergy Diseases 0.000 description 1
- 208000035719 Maculopathy Diseases 0.000 description 1
- 241000428199 Mustelinae Species 0.000 description 1
- BAWFJGJZGIEFAR-NNYOXOHSSA-O NAD(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-O 0.000 description 1
- 108010064719 Oxyhemoglobins Proteins 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- 244000007853 Sarothamnus scoparius Species 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000003872 anastomosis Effects 0.000 description 1
- 210000002565 arteriole Anatomy 0.000 description 1
- 238000013528 artificial neural network Methods 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 210000001775 bruch membrane Anatomy 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 235000009120 camo Nutrition 0.000 description 1
- 244000213578 camo Species 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 210000003855 cell nucleus Anatomy 0.000 description 1
- 210000003986 cell retinal photoreceptor Anatomy 0.000 description 1
- 210000003483 chromatin Anatomy 0.000 description 1
- 231100000005 chromosome aberration Toxicity 0.000 description 1
- 238000010226 confocal imaging Methods 0.000 description 1
- 238000013480 data collection Methods 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 231100000517 death Toxicity 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000002059 diagnostic imaging Methods 0.000 description 1
- 238000011496 digital image analysis Methods 0.000 description 1
- 230000005750 disease progression Effects 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- KSCFJBIXMNOVSH-UHFFFAOYSA-N dyphylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1N(CC(O)CO)C=N2 KSCFJBIXMNOVSH-UHFFFAOYSA-N 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 230000005670 electromagnetic radiation Effects 0.000 description 1
- 238000000295 emission spectrum Methods 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 230000009760 functional impairment Effects 0.000 description 1
- 210000004220 fundus oculi Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
- 238000003703 image analysis method Methods 0.000 description 1
- 238000003709 image segmentation Methods 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 201000002742 malignant choroid melanoma Diseases 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 230000017311 musculoskeletal movement, spinal reflex action Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 238000002577 ophthalmoscopy Methods 0.000 description 1
- 238000012634 optical imaging Methods 0.000 description 1
- 238000003909 pattern recognition Methods 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000000886 photobiology Effects 0.000 description 1
- 108091008695 photoreceptors Proteins 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 238000001907 polarising light microscopy Methods 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000000985 reflectance spectrum Methods 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000004517 retinal physiology Effects 0.000 description 1
- 239000000790 retinal pigment Substances 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 230000001711 saccadic effect Effects 0.000 description 1
- 210000003786 sclera Anatomy 0.000 description 1
- 208000007056 sickle cell anemia Diseases 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 239000005315 stained glass Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000011272 standard treatment Methods 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 208000024444 uvea neoplasm Diseases 0.000 description 1
- 201000008073 uveal cancer Diseases 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000004393 visual impairment Effects 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14555—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted for the eye fundus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
- A61B5/411—Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6841—In situ hybridisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/12—Generating the spectrum; Monochromators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/12—Generating the spectrum; Monochromators
- G01J3/1256—Generating the spectrum; Monochromators using acousto-optic tunable filter
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/12—Generating the spectrum; Monochromators
- G01J3/26—Generating the spectrum; Monochromators using multiple reflection, e.g. Fabry-Perot interferometer, variable interference filters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J3/2823—Imaging spectrometer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
- G01J3/4406—Fluorescence spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J3/45—Interferometric spectrometry
- G01J3/453—Interferometric spectrometry by correlation of the amplitudes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J3/45—Interferometric spectrometry
- G01J3/453—Interferometric spectrometry by correlation of the amplitudes
- G01J3/4535—Devices with moving mirror
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
- G01N21/6458—Fluorescence microscopy
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
- G06V10/00—Arrangements for image or video recognition or understanding
- G06V10/88—Image or video recognition using optical means, e.g. reference filters, holographic masks, frequency domain filters or spatial domain filters
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
- G06V20/00—Scenes; Scene-specific elements
- G06V20/60—Type of objects
- G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7235—Details of waveform analysis
- A61B5/7253—Details of waveform analysis characterised by using transforms
- A61B5/7257—Details of waveform analysis characterised by using transforms using Fourier transforms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J2003/2866—Markers; Calibrating of scan
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/02—Details
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
- G01N2021/6423—Spectral mapping, video display
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
- G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Wood Science & Technology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medical Informatics (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Theoretical Computer Science (AREA)
- Multimedia (AREA)
- Ophthalmology & Optometry (AREA)
- Optics & Photonics (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/942,122 US6198532B1 (en) | 1991-02-22 | 1997-10-01 | Spectral bio-imaging of the eye |
PCT/US1998/020442 WO1999016353A1 (fr) | 1997-10-01 | 1998-09-29 | Bio-imagerie spectrale de l'oeil |
Publications (2)
Publication Number | Publication Date |
---|---|
IL134152A0 IL134152A0 (en) | 2001-04-30 |
IL134152A true IL134152A (en) | 2004-02-19 |
Family
ID=25477606
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL13415298A IL134152A (en) | 1997-10-01 | 1998-09-29 | Spectral biological imaging of the eye |
Country Status (6)
Country | Link |
---|---|
US (3) | US6198532B1 (fr) |
EP (1) | EP1026987A4 (fr) |
JP (1) | JP2001517521A (fr) |
AU (1) | AU9592098A (fr) |
IL (1) | IL134152A (fr) |
WO (1) | WO1999016353A1 (fr) |
Families Citing this family (331)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6198532B1 (en) * | 1991-02-22 | 2001-03-06 | Applied Spectral Imaging Ltd. | Spectral bio-imaging of the eye |
DE19648935B4 (de) * | 1996-11-26 | 2008-05-15 | IMEDOS Intelligente Optische Systeme der Medizin- und Messtechnik GmbH | Vorrichtung und Verfahren zur Untersuchung von Gefäßen |
US6453067B1 (en) * | 1997-10-20 | 2002-09-17 | Texas Instruments Incorporated | Brightness gain using white segment with hue and gain correction |
DE19758533B4 (de) * | 1997-12-04 | 2005-09-29 | Micronas Gmbh | Verfahren zum Strukturieren einer Oberflächenschicht |
US6637882B1 (en) * | 1998-11-24 | 2003-10-28 | Welch Allyn, Inc. | Eye viewing device for retinal viewing through undilated pupil |
US6549794B1 (en) | 1999-09-24 | 2003-04-15 | Cytometrics, Llc | Single use disposable protective cap |
JP4426032B2 (ja) * | 1999-10-28 | 2010-03-03 | 株式会社トプコン | 緑内障診断装置及び緑内障診断用記録媒体 |
DE19960586B4 (de) * | 1999-12-15 | 2008-04-24 | Siemens Ag | Verfahren und Einrichtung zur Messung von Kenngrössen einer Probe durch Spektralanalyse |
JP2001258853A (ja) * | 2000-03-23 | 2001-09-25 | Konan Medical Inc | 眼底組織撮影装置 |
US7297326B2 (en) * | 2000-08-21 | 2007-11-20 | The General Hospital Corporation | Ocular diagnosis of Alzheimer's disease |
WO2002016951A2 (fr) * | 2000-08-21 | 2002-02-28 | The General Hospital Corporation | Methodes permettant de diagnostiquer un etat neurodegeneratif |
WO2002015818A2 (fr) * | 2000-08-23 | 2002-02-28 | Philadelphia Ophthalmologic Imaging Systems, Inc. | Systemes et procedes de tele-ophtalmologie |
AU2001288425A1 (en) * | 2000-08-25 | 2002-03-04 | Cytometrics, Inc. | System, method and computer program product for measuring blood properties form a spectral image |
WO2002015788A1 (fr) * | 2000-08-25 | 2002-02-28 | Krotkov Eric P | Systeme, procede et programme informatique pour l'analyse d'une image spectrale |
US20040058311A1 (en) * | 2000-08-25 | 2004-03-25 | Gary Fletcher | Method and apparatus for measuring the hemoglobin concentration and/or hematocrit in whole blood using diffuse light |
US6735331B1 (en) * | 2000-09-05 | 2004-05-11 | Talia Technology Ltd. | Method and apparatus for early detection and classification of retinal pathologies |
US6678398B2 (en) * | 2000-09-18 | 2004-01-13 | Sti Medical Systems, Inc. | Dual mode real-time screening and rapid full-area, selective-spectral, remote imaging and analysis device and process |
JP4241038B2 (ja) | 2000-10-30 | 2009-03-18 | ザ ジェネラル ホスピタル コーポレーション | 組織分析のための光学的な方法及びシステム |
US9295391B1 (en) | 2000-11-10 | 2016-03-29 | The General Hospital Corporation | Spectrally encoded miniature endoscopic imaging probe |
FR2817986B1 (fr) * | 2000-12-07 | 2003-03-28 | Lyon Ecole Centrale | Procede de classification d'une image en couleur selon la prise de vue en exterieur ou en interieur |
AU2002233152A1 (en) * | 2001-01-03 | 2002-07-16 | Walthard Vilser | Device and method for imaging, stimulation, measurement and therapy, in particular for the eye |
US20020151774A1 (en) * | 2001-03-01 | 2002-10-17 | Umass/Worcester | Ocular spectrometer and probe method for non-invasive spectral measurement |
US7711403B2 (en) * | 2001-04-05 | 2010-05-04 | Rhode Island Hospital | Non-invasive determination of blood components |
GB2375679A (en) * | 2001-04-09 | 2002-11-20 | Patrick Kerr | Retinal function camera using plural light wavelengths to produce a retinal function image showing haemoglobin oxygenation. |
GB2378600A (en) * | 2001-08-06 | 2003-02-12 | Patrick Kerr | Retinal function camera to determine retinal blood oxygenation. |
EP2298361A3 (fr) * | 2001-04-27 | 2011-05-04 | The General Hospital Corporation | Diagnostic oculaire de la maladie d'Alzheimer |
EP2333523B1 (fr) | 2001-04-30 | 2020-04-08 | The General Hospital Corporation | Procédé et appareil permettant d'améliorer la clarté et la sensibilité de l'image en tomographie à cohérence optique au moyen d'une interaction permettant de contrôler les propriétés focales et la synchronisation de cohérence |
CA2473587C (fr) | 2001-05-01 | 2014-07-15 | The General Hospital Corporation | Procede et appareil pour determiner un type de plaque d'atherosclerose par mesure de proprietes optiques de tissu |
JP3731814B2 (ja) * | 2001-05-07 | 2006-01-05 | 富士写真フイルム株式会社 | 蛍光画像表示装置 |
CA2450656A1 (fr) * | 2001-06-15 | 2002-12-27 | The Cleveland Clinic Foundation | Quantification ratiometrique d'autofluorescence provoquee de l'oeil |
US7319755B2 (en) * | 2001-08-03 | 2008-01-15 | Waterstrike Incorporated | Image altering apparatus and method for providing confidential viewing of a fundamental display image |
US6980177B2 (en) * | 2001-08-03 | 2005-12-27 | Waterstrike Incorporated | Sequential inverse encoding apparatus and method for providing confidential viewing of a fundamental display image |
US6838074B2 (en) | 2001-08-08 | 2005-01-04 | Bristol-Myers Squibb Company | Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent |
JP2005508215A (ja) * | 2001-08-30 | 2005-03-31 | フィラデルフィア オフサルミック イメージング システムズ | 糖尿病性網膜症の患者をスクリーニングするためのシステムおよび方法 |
US7039452B2 (en) * | 2002-12-19 | 2006-05-02 | The University Of Utah Research Foundation | Method and apparatus for Raman imaging of macular pigments |
US7355716B2 (en) * | 2002-01-24 | 2008-04-08 | The General Hospital Corporation | Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands |
US6665426B1 (en) * | 2002-01-29 | 2003-12-16 | West Virginia University Research Corporation | Method of biometric identification of an individual and associated apparatus |
US20110201924A1 (en) * | 2002-04-30 | 2011-08-18 | The General Hospital Corporation | Method and Apparatus for Improving Image Clarity and Sensitivity in Optical Tomography Using Dynamic Feedback to Control Focal Properties and Coherence Gating |
DE60323625D1 (de) * | 2002-05-03 | 2008-10-30 | Vialogy Llc | Verfahren zur charakterisierung der ausgangssignale eines microarrays |
JP4059010B2 (ja) * | 2002-06-06 | 2008-03-12 | 株式会社日立製作所 | 投射型映像表示装置 |
US6926407B2 (en) | 2002-06-28 | 2005-08-09 | Trefford Simpson | Apparatus and method for measuring a hue of a predetermined primary color in reflected light |
US7222961B2 (en) * | 2002-08-05 | 2007-05-29 | Kestrel Corporation | Method for detecting a functional signal in retinal images |
US6992775B2 (en) * | 2002-08-29 | 2006-01-31 | Kestrel Corporation | Hyperspectral retinal imager |
US20040124366A1 (en) * | 2002-10-02 | 2004-07-01 | Haishan Zeng | Apparatus and methods relating to high speed spectroscopy and excitation-emission matrices |
US20040254438A1 (en) * | 2003-01-09 | 2004-12-16 | The Regents Of The University Of California | Implantable devices and methods for measuring intraocular, subconjunctival or subdermal pressure and/or analyte concentration |
WO2004064615A2 (fr) | 2003-01-23 | 2004-08-05 | Board Of Regents, The University Of Texas System | Procede et appareil pour diagnostiquer des tissus neovascularises |
US7643153B2 (en) * | 2003-01-24 | 2010-01-05 | The General Hospital Corporation | Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands |
JP2006516739A (ja) | 2003-01-24 | 2006-07-06 | ザ・ジェネラル・ホスピタル・コーポレイション | 低コヒーレンス干渉計を用いて組織を識別するためのシステムおよび方法 |
US6985232B2 (en) * | 2003-03-13 | 2006-01-10 | Tokyo Electron Limited | Scatterometry by phase sensitive reflectometer |
US20040193095A1 (en) * | 2003-03-29 | 2004-09-30 | Shadduck John H. | Implants for treating ocular hypertension, methods of use and methods of fabrication |
US7267648B2 (en) * | 2003-03-31 | 2007-09-11 | Olympus Corporation | Magnifying image pickup unit for an endoscope, an endoscope for in vivo cellular observation that uses it, and endoscopic, in vivo cellular observation methods |
EP2436307B1 (fr) | 2003-03-31 | 2015-10-21 | The General Hospital Corporation | Réduction des taches dans la tomographie de cohérence optique par combinaison angulaire codée pour la longueur de chemin |
DE10314944A1 (de) * | 2003-04-02 | 2004-10-14 | Carl Zeiss Meditec Ag | Beleuchtungs- und Bestrahlungseinheit für ophthalmologische Geräte |
US7545963B2 (en) * | 2003-04-04 | 2009-06-09 | Lumidigm, Inc. | Texture-biometrics sensor |
US7668350B2 (en) | 2003-04-04 | 2010-02-23 | Lumidigm, Inc. | Comparative texture analysis of tissue for biometric spoof detection |
US7539330B2 (en) * | 2004-06-01 | 2009-05-26 | Lumidigm, Inc. | Multispectral liveness determination |
US7751594B2 (en) | 2003-04-04 | 2010-07-06 | Lumidigm, Inc. | White-light spectral biometric sensors |
US7627151B2 (en) * | 2003-04-04 | 2009-12-01 | Lumidigm, Inc. | Systems and methods for improved biometric feature definition |
US7460696B2 (en) | 2004-06-01 | 2008-12-02 | Lumidigm, Inc. | Multispectral imaging biometrics |
US7394919B2 (en) * | 2004-06-01 | 2008-07-01 | Lumidigm, Inc. | Multispectral biometric imaging |
EP1611541B1 (fr) | 2003-04-04 | 2010-12-15 | Lumidigm, Inc. | Capteur biometrique multispectral |
US7400754B2 (en) * | 2003-04-08 | 2008-07-15 | The Regents Of The University Of California | Method and apparatus for characterization of chromophore content and distribution in skin using cross-polarized diffuse reflectance imaging |
JP2006525054A (ja) * | 2003-05-01 | 2006-11-09 | ミレニアム・ダイエット・アンド・ニュートリスーティカルズ・リミテッド | 黄斑色素の分布の測定 |
EP1639330B1 (fr) | 2003-06-06 | 2008-10-08 | The General Hospital Corporation | Source lumière accordable en longueur d'onde |
US20060268231A1 (en) * | 2003-07-03 | 2006-11-30 | Medibell Medicall Vision Technologies, Ltd. | Illumination method and system for obtaining color images by transcleral ophthalmic illumination |
US7356365B2 (en) * | 2003-07-09 | 2008-04-08 | Glucolight Corporation | Method and apparatus for tissue oximetry |
DE20313745U1 (de) * | 2003-09-02 | 2003-11-20 | Oculus Optikgeraete Gmbh | Ophthalmologisches Analysesystem |
US7321791B2 (en) | 2003-09-23 | 2008-01-22 | Cambridge Research And Instrumentation, Inc. | Spectral imaging of deep tissue |
US8634607B2 (en) | 2003-09-23 | 2014-01-21 | Cambridge Research & Instrumentation, Inc. | Spectral imaging of biological samples |
WO2005033678A1 (fr) | 2003-10-03 | 2005-04-14 | Olympus Corporation | Appareil et procede de traitement d'image |
WO2005036143A1 (fr) * | 2003-10-10 | 2005-04-21 | Hamamatsu Photonics K.K. | Procede et systeme de determination de la concentration d'un pigment fluorescent |
US7920908B2 (en) | 2003-10-16 | 2011-04-05 | David Hattery | Multispectral imaging for quantitative contrast of functional and structural features of layers inside optically dense media such as tissue |
CN1875242A (zh) | 2003-10-27 | 2006-12-06 | 通用医疗公司 | 用于使用频域干涉测量法进行光学成像的方法和设备 |
US7364297B2 (en) * | 2003-10-28 | 2008-04-29 | Welch Allyn, Inc. | Digital documenting ophthalmoscope |
US7708403B2 (en) * | 2003-10-30 | 2010-05-04 | Welch Allyn, Inc. | Apparatus and method for diagnosis of optically identifiable ophthalmic conditions |
US20090270717A1 (en) * | 2008-04-25 | 2009-10-29 | Welch Allyn, Inc. | Apparatus and method for diagnosis of optically identifiable ophthalmic conditions |
US7575321B2 (en) * | 2003-10-30 | 2009-08-18 | Welch Allyn, Inc. | Apparatus and method of diagnosis of optically identifiable ophthalmic conditions |
WO2005054780A1 (fr) * | 2003-11-28 | 2005-06-16 | The General Hospital Corporation | Procede et appareil d'imagerie codee de maniere spectrale tridimensionnelle |
US7263213B2 (en) * | 2003-12-11 | 2007-08-28 | Lumidigm, Inc. | Methods and systems for estimation of personal characteristics from biometric measurements |
US7510849B2 (en) * | 2004-01-29 | 2009-03-31 | Glucolight Corporation | OCT based method for diagnosis and therapy |
GB2427825B (en) * | 2004-01-30 | 2007-08-01 | Univ Brown | Non-Invasive Spectroscopy Of Mammalian Tissues |
US7512436B2 (en) * | 2004-02-12 | 2009-03-31 | The Regents Of The University Of Michigan | Method of evaluating metabolism of the eye |
DE102004008675B4 (de) * | 2004-02-20 | 2009-05-07 | Imedos Gmbh | Bildgebendes Verfahren zur Erfassung medizinisch relevanter Unterschiede von Strukturen und Eigenschaften eines Untersuchungsobjektes und dazu geeignete Vorrichtung |
US7524064B2 (en) * | 2004-03-09 | 2009-04-28 | Research Foundation Of The State University Of New York | Apparatus and method for assessing retinal damage |
DE102004011631B4 (de) * | 2004-03-10 | 2011-03-24 | Ott, Lutz, Dipl.-Ing. | Verfahren und Vorrichtung zur tiefenselektiven Detektion von Spontanaktivitäten und allgemeinen Muskelaktivitäten |
AU2005226667B2 (en) * | 2004-03-19 | 2010-04-01 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | A method for evaluating relative oxygen saturation in body tissues |
US20060155178A1 (en) * | 2004-03-26 | 2006-07-13 | Vadim Backman | Multi-dimensional elastic light scattering |
US20080144967A1 (en) * | 2004-03-30 | 2008-06-19 | Waterstrike Incorporated | Confidential Viewing System Utilizing Spatial Multiplexing |
DE102004016435B4 (de) * | 2004-03-31 | 2009-05-28 | Imedos Gmbh | Verfahren zur spektralphotometrischen Ermittlung der Sauerstoffsättigung des Blutes in optisch zugänglichen Blutgefäßen |
JP4750786B2 (ja) * | 2004-05-29 | 2011-08-17 | ザ ジェネラル ホスピタル コーポレイション | 光コヒーレンストモグラフィ(oct)イメージングにおける屈折層を用いた色分散補償プロセス、システム及びソフトウェア構成 |
CA2569440A1 (fr) * | 2004-06-01 | 2006-09-08 | Lumidigm, Inc. | Biometrie par imagerie spectrale |
US8229185B2 (en) | 2004-06-01 | 2012-07-24 | Lumidigm, Inc. | Hygienic biometric sensors |
JP4995720B2 (ja) | 2004-07-02 | 2012-08-08 | ザ ジェネラル ホスピタル コーポレイション | ダブルクラッドファイバを有する内視鏡撮像プローブ |
DE102004037479A1 (de) * | 2004-08-03 | 2006-03-16 | Carl Zeiss Meditec Ag | Fourier-Domain OCT Ray-Tracing am Auge |
US8081316B2 (en) | 2004-08-06 | 2011-12-20 | The General Hospital Corporation | Process, system and software arrangement for determining at least one location in a sample using an optical coherence tomography |
US8787630B2 (en) * | 2004-08-11 | 2014-07-22 | Lumidigm, Inc. | Multispectral barcode imaging |
US8036727B2 (en) * | 2004-08-11 | 2011-10-11 | Glt Acquisition Corp. | Methods for noninvasively measuring analyte levels in a subject |
US7254429B2 (en) | 2004-08-11 | 2007-08-07 | Glucolight Corporation | Method and apparatus for monitoring glucose levels in a biological tissue |
JP5334415B2 (ja) | 2004-08-24 | 2013-11-06 | ザ ジェネラル ホスピタル コーポレイション | 試料の機械的歪み及び弾性的性質を測定するプロセス、システム及びソフトウェア |
KR20070058523A (ko) | 2004-08-24 | 2007-06-08 | 더 제너럴 하스피탈 코포레이션 | 혈관절편 영상화 방법 및 장치 |
WO2006039091A2 (fr) | 2004-09-10 | 2006-04-13 | The General Hospital Corporation | Systeme et procede pour l'imagerie de coherence optique |
JP4997112B2 (ja) | 2004-09-29 | 2012-08-08 | ザ ジェネラル ホスピタル コーポレイション | 少なくとも1つの電磁放射を伝送させるための装置およびその製造方法 |
WO2006047408A2 (fr) * | 2004-10-22 | 2006-05-04 | Vanderbilt University | Polarimetrie sur puce utilisee pour le criblage a grande capacite de volumes d'echantillon de l'ordre du nanolitre ou d'une taille inferieure |
EP1807803A1 (fr) * | 2004-10-26 | 2007-07-18 | Koninklijke Philips Electronics N.V. | Amelioration de parties d'image floues |
US20080007734A1 (en) * | 2004-10-29 | 2008-01-10 | The General Hospital Corporation | System and method for providing Jones matrix-based analysis to determine non-depolarizing polarization parameters using polarization-sensitive optical coherence tomography |
WO2006058049A1 (fr) | 2004-11-24 | 2006-06-01 | The General Hospital Corporation | Interferometre a trajet commun pour oct endoscopique |
US8224425B2 (en) * | 2005-04-04 | 2012-07-17 | Hypermed Imaging, Inc. | Hyperspectral imaging in diabetes and peripheral vascular disease |
CA2631564A1 (fr) | 2004-11-29 | 2006-06-01 | Hypermed, Inc. | Imagerie medicale en hyperespace spectral destinee a l'evaluation de tissus et de tumeurs |
US8548570B2 (en) | 2004-11-29 | 2013-10-01 | Hypermed Imaging, Inc. | Hyperspectral imaging of angiogenesis |
US8922781B2 (en) | 2004-11-29 | 2014-12-30 | The General Hospital Corporation | Arrangements, devices, endoscopes, catheters and methods for performing optical imaging by simultaneously illuminating and detecting multiple points on a sample |
US7365856B2 (en) | 2005-01-21 | 2008-04-29 | Carl Zeiss Meditec, Inc. | Method of motion correction in optical coherence tomography imaging |
EP1846869B1 (fr) | 2005-01-27 | 2011-10-05 | Cambridge Research & Instrumentation, Inc. | Classification de caracteristiques d'images |
EP1698272B1 (fr) * | 2005-03-04 | 2012-12-05 | FUJIFILM Corporation | Endoscope et dispositif de traitement d'images |
JP4637620B2 (ja) * | 2005-03-18 | 2011-02-23 | 富士フイルム株式会社 | 内視鏡システム装置 |
WO2006100685A2 (fr) * | 2005-03-25 | 2006-09-28 | Cnoga Holdings Ltd | Dispositif a capteur optique et unite de traitement d'image permettant de mesurer des concentrations chimiques, des saturations chimiques et des parametres biophysiques |
US7474775B2 (en) * | 2005-03-31 | 2009-01-06 | University Of Iowa Research Foundation | Automatic detection of red lesions in digital color fundus photographs |
US8971984B2 (en) | 2005-04-04 | 2015-03-03 | Hypermed Imaging, Inc. | Hyperspectral technology for assessing and treating diabetic foot and tissue disease |
CA2604829C (fr) | 2005-04-04 | 2018-05-15 | Hypermed, Inc. | Imagerie hyperspectrale mise en oeuvre chez des patients souffrant de diabete ou d'une maladie vasculaire peripherique |
US7805009B2 (en) | 2005-04-06 | 2010-09-28 | Carl Zeiss Meditec, Inc. | Method and apparatus for measuring motion of a subject using a series of partial images from an imaging system |
EP1874178A4 (fr) | 2005-04-13 | 2009-12-09 | Glucolight Corp | Methode de diminution et d'etalonnage de donnees d'une reference croisee d'un glucometre sanguin base sur une tomographie de coherence optique et applications associees |
US7801338B2 (en) * | 2005-04-27 | 2010-09-21 | Lumidigm, Inc. | Multispectral biometric sensors |
JP5684452B2 (ja) | 2005-04-28 | 2015-03-11 | ザ ジェネラル ホスピタル コーポレイション | 光干渉測定法により解剖学的構造に関連する情報を評価するためのシステム、方法及びソフトウエア装置 |
EP1887926B1 (fr) * | 2005-05-31 | 2014-07-30 | The General Hospital Corporation | Systeme et procede qui utilisent des techniques d'interferometrie d'heterodyne a codage spectral pour l'imagerie |
US7774036B2 (en) * | 2005-06-07 | 2010-08-10 | Oxymap Ehf | Automatic registration of images |
US8255039B2 (en) * | 2006-09-29 | 2012-08-28 | Tearscience, Inc. | Meibomian gland illuminating and imaging |
ES2354287T3 (es) | 2005-08-09 | 2011-03-11 | The General Hospital Corporation | Aparato y método para realizar una desmodulación en cuadratura por polarización en tomografía de coherencia óptica. |
KR20080066705A (ko) | 2005-09-29 | 2008-07-16 | 더 제너럴 하스피탈 코포레이션 | 점진적으로 증가하는 분해능을 이용하여 하나 이상의 생물학적 샘플을 관찰 및 분석하기 위한 방법 및 장치 |
US7889348B2 (en) * | 2005-10-14 | 2011-02-15 | The General Hospital Corporation | Arrangements and methods for facilitating photoluminescence imaging |
US20070092115A1 (en) * | 2005-10-26 | 2007-04-26 | Usher David B | Method and system for detecting biometric liveness |
US20070179368A1 (en) * | 2005-10-27 | 2007-08-02 | Northwestern University | Method of recognizing abnormal tissue using the detection of early increase in microvascular blood content |
US20090203977A1 (en) * | 2005-10-27 | 2009-08-13 | Vadim Backman | Method of screening for cancer using parameters obtained by the detection of early increase in microvascular blood content |
US20070129615A1 (en) * | 2005-10-27 | 2007-06-07 | Northwestern University | Apparatus for recognizing abnormal tissue using the detection of early increase in microvascular blood content |
US9314164B2 (en) | 2005-10-27 | 2016-04-19 | Northwestern University | Method of using the detection of early increase in microvascular blood content to distinguish between adenomatous and hyperplastic polyps |
JP5680826B2 (ja) * | 2006-01-10 | 2015-03-04 | ザ ジェネラル ホスピタル コーポレイション | 1以上のスペクトルを符号化する内視鏡技術によるデータ生成システム |
US7876973B2 (en) * | 2006-01-12 | 2011-01-25 | Integrity Applications Incorporated | Edge ringing artifact suppression methods and apparatuses |
EP2289397A3 (fr) | 2006-01-19 | 2011-04-06 | The General Hospital Corporation | Procédés et systèmes pour visualiser de manière optique des organes intracavitaires épithéliaux lors d'un balayage au faisceau |
US20070223006A1 (en) * | 2006-01-19 | 2007-09-27 | The General Hospital Corporation | Systems and methods for performing rapid fluorescence lifetime, excitation and emission spectral measurements |
US8145018B2 (en) | 2006-01-19 | 2012-03-27 | The General Hospital Corporation | Apparatus for obtaining information for a structure using spectrally-encoded endoscopy techniques and methods for producing one or more optical arrangements |
WO2007084959A1 (fr) * | 2006-01-20 | 2007-07-26 | The General Hospital Corporation | Systemes et procedes utilises dans la microscopie a effet tunnel a miroirs |
EP2659851A3 (fr) | 2006-02-01 | 2014-01-15 | The General Hospital Corporation | Appareil pour appliquer une pluralité de rayonnements électromagnétiques à un échantillon |
US10426548B2 (en) * | 2006-02-01 | 2019-10-01 | The General Hosppital Corporation | Methods and systems for providing electromagnetic radiation to at least one portion of a sample using conformal laser therapy procedures |
EP1986562B1 (fr) * | 2006-02-01 | 2015-04-08 | The General Hospital Corporation | Appareil destiné à commander au moins l'une d'au moins deux sections d'au moins une fibre |
EP3143926B1 (fr) | 2006-02-08 | 2020-07-01 | The General Hospital Corporation | Procédés, agencements et systèmes pour obtenir des informations associées à un prélèvement anatomique utilisant la microscopie optique |
US20070224694A1 (en) * | 2006-02-10 | 2007-09-27 | Puchalski Daniel M | Method and system for hyperspectral detection of animal diseases |
EP1987318B1 (fr) | 2006-02-24 | 2015-08-12 | The General Hospital Corporation | Procédés et systèmes destinés à réaliser une tomographie par cohérence optique dans le domaine de fourier avec résolution angulaire |
US7734107B2 (en) * | 2006-02-24 | 2010-06-08 | Sony Corporation | System and method for performing wavelet-based texture feature extraction and classification |
JP2009533076A (ja) * | 2006-03-01 | 2009-09-17 | ザ ジェネラル ホスピタル コーポレイション | 光吸収体をマクロファージに標的化することによるアテローム班の細胞特異的レーザー治療を提供するシステム及び方法 |
WO2007109540A2 (fr) * | 2006-03-17 | 2007-09-27 | The General Hospital Corporation | Appareil, procédé et support accessible par ordinateur pour l'identification de caractéristiques d'au moins une partie d'un vaisseau sanguin compris à l'intérieur d'un tissu au moyen d'une interférométrie faible cohérence à domaine spectral |
US7742173B2 (en) * | 2006-04-05 | 2010-06-22 | The General Hospital Corporation | Methods, arrangements and systems for polarization-sensitive optical frequency domain imaging of a sample |
US8243999B2 (en) | 2006-05-03 | 2012-08-14 | Ut-Battelle, Llc | Method and system for the diagnosis of disease using retinal image content and an archive of diagnosed human patient data |
JP2009536740A (ja) | 2006-05-10 | 2009-10-15 | ザ ジェネラル ホスピタル コーポレイション | サンプルの周波数領域画像形成を提供するためのプロセス、構成およびシステム |
WO2007133964A2 (fr) * | 2006-05-12 | 2007-11-22 | The General Hospital Corporation | Processus, agencements et systèmes pour produire une carte d'épaisseur de couche de fibres sur la base d'images de tomographie à cohérence optique |
US8131348B2 (en) * | 2006-05-12 | 2012-03-06 | Northshore University Healthsystem | Systems, methods and apparatuses of elastic light scattering spectroscopy and low coherence enhanced backscattering spectroscopy |
AU2007254086B2 (en) * | 2006-05-19 | 2013-03-21 | Northshore University Health System | Method and apparatus for recognizing abnormal tissue using the detection of early increase in microvascular blood content |
US10010277B2 (en) * | 2006-06-22 | 2018-07-03 | The General Hospital Corporation | Cancer detection by optical measurement of compression-induced transients |
US7791686B2 (en) * | 2006-06-23 | 2010-09-07 | Waterstrike Incorporated | LCD-based confidential viewing apparatus utilizing auto-inversion masking |
US8644911B1 (en) | 2006-06-30 | 2014-02-04 | Hypermed Imaging, Inc. | OxyVu-1 hyperspectral tissue oxygenation (HTO) measurement system |
US7995808B2 (en) | 2006-07-19 | 2011-08-09 | Lumidigm, Inc. | Contactless multispectral biometric capture |
US8355545B2 (en) | 2007-04-10 | 2013-01-15 | Lumidigm, Inc. | Biometric detection using spatial, temporal, and/or spectral techniques |
CN103336941A (zh) | 2006-07-19 | 2013-10-02 | 光谱辨识公司 | 多重生物测定多谱成像器 |
US8175346B2 (en) | 2006-07-19 | 2012-05-08 | Lumidigm, Inc. | Whole-hand multispectral biometric imaging |
US7804984B2 (en) * | 2006-07-31 | 2010-09-28 | Lumidigm, Inc. | Spatial-spectral fingerprint spoof detection |
US7801339B2 (en) * | 2006-07-31 | 2010-09-21 | Lumidigm, Inc. | Biometrics with spatiospectral spoof detection |
US7538872B1 (en) * | 2006-08-02 | 2009-05-26 | Butler Eugene W | Diagnostic methods and apparatus for directed energy applications |
US7800746B2 (en) * | 2006-08-11 | 2010-09-21 | Northwestern University | Method for identifying refractive-index fluctuations of a target |
CN101589301B (zh) | 2006-08-25 | 2012-11-07 | 通用医疗公司 | 利用体积测定过滤技术来增强光学相干断层成像的装置和方法 |
US8249695B2 (en) | 2006-09-29 | 2012-08-21 | Tearscience, Inc. | Meibomian gland imaging |
WO2008049118A2 (fr) | 2006-10-19 | 2008-04-24 | The General Hospital Corporation | Dispositif et procédé d'obtention et de fourniture d'informations d'image associées à au moins une portion d' échantillon et permettant de réaliser une telle portion |
US8244021B2 (en) | 2006-12-20 | 2012-08-14 | Ventana Medical Systems, Inc. | Quantitative, multispectral image analysis of tissue specimens stained with quantum dots |
JP5019866B2 (ja) * | 2006-12-25 | 2012-09-05 | オリンパス株式会社 | 蛍光内視鏡及び蛍光内視鏡の作動方法 |
US7949019B2 (en) | 2007-01-19 | 2011-05-24 | The General Hospital | Wavelength tuning source based on a rotatable reflector |
US20080206804A1 (en) * | 2007-01-19 | 2008-08-28 | The General Hospital Corporation | Arrangements and methods for multidimensional multiplexed luminescence imaging and diagnosis |
EP2102583A2 (fr) | 2007-01-19 | 2009-09-23 | The General Hospital Corporation | Appareil et procédé pour contrôler la profondeur de télémétrie dans une imagerie de domaine de fréquence optique |
CN101589421B (zh) | 2007-01-26 | 2013-01-09 | 日本电气株式会社 | 图像处理设备、方法和显示器 |
US20080234586A1 (en) * | 2007-03-19 | 2008-09-25 | The General Hospital Corporation | System and method for providing noninvasive diagnosis of compartment syndrome using exemplary laser speckle imaging procedure |
CN101641049A (zh) | 2007-03-21 | 2010-02-03 | 光谱辨识公司 | 基于局部一致特征的生物测定 |
US9176319B2 (en) | 2007-03-23 | 2015-11-03 | The General Hospital Corporation | Methods, arrangements and apparatus for utilizing a wavelength-swept laser using angular scanning and dispersion procedures |
US10534129B2 (en) | 2007-03-30 | 2020-01-14 | The General Hospital Corporation | System and method providing intracoronary laser speckle imaging for the detection of vulnerable plaque |
US20080255545A1 (en) * | 2007-04-10 | 2008-10-16 | Mansfield John M | Apparatus and method for treating the inside of an eye |
WO2008131082A1 (fr) | 2007-04-17 | 2008-10-30 | The General Hospital Corporation | Appareil et procédés de mesure des vibrations à l'aide de techniques d'endoscopie spectralement codées |
WO2008137637A2 (fr) * | 2007-05-04 | 2008-11-13 | The General Hospital Corporation | Procédés, agencements et systèmes pour obtenir des informations associées à un échantillon à l'aide d'une microscopie optique |
WO2008144496A1 (fr) * | 2007-05-18 | 2008-11-27 | Vanderbilt University | Système et procédé de détection interférométrique amélioré |
US9326715B1 (en) * | 2007-07-02 | 2016-05-03 | Hypermed Imaging, Inc. | OxyVu-1 hyperspectral tissue oxygenation (HTO) measurement system |
CN101347334B (zh) * | 2007-07-19 | 2012-09-05 | 深圳迈瑞生物医疗电子股份有限公司 | 血氧饱和度测量方法和装置 |
US8132911B2 (en) * | 2007-07-26 | 2012-03-13 | The United States Of America As Represented By The Department Of Health And Human Services | Fundus photo-stimulation system and method |
EP2173254A2 (fr) * | 2007-07-31 | 2010-04-14 | The General Hospital Corporation | Systèmes et procédés pour fournir des motifs de balayage de faisceau pour une imagerie dans le domaine de la fréquence optique doppler de vitesse élevée |
US7828440B2 (en) * | 2007-08-17 | 2010-11-09 | Peyman Gholam A | Method of detecting glaucoma |
US7549752B2 (en) * | 2007-08-17 | 2009-06-23 | Peyman Gholam A | Method of detecting glaucoma |
EP2191254B1 (fr) | 2007-08-31 | 2017-07-19 | The General Hospital Corporation | Systeme et procede pour une microscopie par fluorescence a auto-interference, et support lisible par ordinateur associe à ceux-ci |
WO2009039466A1 (fr) | 2007-09-20 | 2009-03-26 | Vanderbilt University | Mesure de solution libre d'interactions moléculaires par interférométrie rétrodiffusée |
US20090099428A1 (en) * | 2007-10-03 | 2009-04-16 | Evasight Instruments Inc. | Method of blood oxygen saturation by ophthalmic measurement |
US7933021B2 (en) * | 2007-10-30 | 2011-04-26 | The General Hospital Corporation | System and method for cladding mode detection |
AU2008320965B2 (en) * | 2007-11-13 | 2014-10-23 | The Regents Of The University Of Michigan | Method and apparatus for detecting diseases associated with the eye |
US8124936B1 (en) * | 2007-12-13 | 2012-02-28 | The United States Of America As Represented By The Secretary Of The Army | Stand-off chemical detector |
DE102007055923A1 (de) * | 2007-12-21 | 2009-06-25 | Carl Zeiss Surgical Gmbh | Verfahren zur Ermittlung von Eigenschaften und/oder der Position charakteristischer Augenbestandteile |
US8662667B2 (en) | 2007-12-21 | 2014-03-04 | Carl Zeiss Meditec Ag | Ophthalmologic visualization system |
US9332942B2 (en) * | 2008-01-28 | 2016-05-10 | The General Hospital Corporation | Systems, processes and computer-accessible medium for providing hybrid flourescence and optical coherence tomography imaging |
US11123047B2 (en) | 2008-01-28 | 2021-09-21 | The General Hospital Corporation | Hybrid systems and methods for multi-modal acquisition of intravascular imaging data and counteracting the effects of signal absorption in blood |
WO2009105579A2 (fr) * | 2008-02-19 | 2009-08-27 | Garahan Patrick J | Support portatif pour contenants à boissons |
WO2009111542A2 (fr) | 2008-03-04 | 2009-09-11 | Glucolight Corporation | Procédés et systèmes pour l'estimation d'un niveau d'analyte en tomographie par cohérence optique |
US8109634B2 (en) * | 2008-03-05 | 2012-02-07 | Tamir Gil | Snapshot spectral imaging of the eye |
JP2011515189A (ja) * | 2008-03-27 | 2011-05-19 | ニューロプティックス コーポレイション | 眼の画像化 |
US8128227B2 (en) * | 2008-04-15 | 2012-03-06 | The United States Of America As Represented By The Secretary Of Agriculture | Method to detect transmissible spongiform encephalopathies via electroretinogram |
JP5607610B2 (ja) | 2008-05-07 | 2014-10-15 | ザ ジェネラル ホスピタル コーポレイション | 構造の特徴を決定する装置、装置の作動方法およびコンピュータアクセス可能な媒体 |
JP5795531B2 (ja) | 2008-06-20 | 2015-10-14 | ザ ジェネラル ホスピタル コーポレイション | フューズドファイバオプティックカプラ構造、及びその使用方法 |
US7585291B1 (en) * | 2008-07-03 | 2009-09-08 | Michael Campion | Eye coloring systems |
WO2010009136A2 (fr) | 2008-07-14 | 2010-01-21 | The General Hospital Corporation | Appareil et procédés d'endoscopie couleur |
US8406859B2 (en) | 2008-08-10 | 2013-03-26 | Board Of Regents, The University Of Texas System | Digital light processing hyperspectral imaging apparatus |
KR101679438B1 (ko) * | 2008-09-18 | 2016-11-24 | 세다르스-신나이 메디칼 센터 | 알츠하이머병의 검출을 위한 광학적 방법 |
US8218838B2 (en) * | 2008-11-03 | 2012-07-10 | Ut-Battelle, Llc | Method and system for assigning a confidence metric for automated determination of optic disc location |
CN102227747B (zh) * | 2008-11-27 | 2014-06-04 | 皇家飞利浦电子股份有限公司 | 产生未染色生物标本的多色图像 |
US8937724B2 (en) | 2008-12-10 | 2015-01-20 | The General Hospital Corporation | Systems and methods for extending imaging depth range of optical coherence tomography through optical sub-sampling |
US9885834B2 (en) | 2009-01-08 | 2018-02-06 | Northwestern University | Probe apparatus for measuring depth-limited properties with low-coherence enhanced backscattering |
EP2385786A4 (fr) * | 2009-01-08 | 2013-07-03 | American Biooptics Llc | Appareil à sonde permettant de reconnaître un tissu anormal |
WO2010085775A2 (fr) | 2009-01-26 | 2010-07-29 | The General Hospital Corporation | Système, procédé et support accessible par ordinateur permettant de fournir une microscopie de super-résolution à large champ |
EP2394336B1 (fr) | 2009-02-04 | 2023-05-24 | The General Hospital Corporation | Appareil et procédé d'utilisation d'une source d'ajustement de longueur d'onde optique à grande vitesse |
US9351642B2 (en) | 2009-03-12 | 2016-05-31 | The General Hospital Corporation | Non-contact optical system, computer-accessible medium and method for measurement at least one mechanical property of tissue using coherent speckle technique(s) |
JP5316161B2 (ja) * | 2009-03-27 | 2013-10-16 | ソニー株式会社 | 観察装置 |
CA3010578C (fr) | 2009-04-01 | 2021-03-09 | Tearscience, Inc. | Dispositifs, systemes et procedes d'interferometrie de surface oculaire (osi) pour imager, traiter et/ou afficher un film lacrymal oculaire et/ou mesurer une epaisseur de couche de film lacrymal oculaire (es) |
WO2010143208A2 (fr) * | 2009-06-12 | 2010-12-16 | Oxymap | Oxymètre temporal |
US8308298B2 (en) * | 2009-06-24 | 2012-11-13 | Carl Zeiss Meditec Ag | Microscopy system for eye surgery |
BR112012001042A2 (pt) | 2009-07-14 | 2016-11-22 | Gen Hospital Corp | equipamento e método de medição do fluxo de fluído dentro de estrutura anatômica. |
BR122013021647A2 (pt) | 2009-08-26 | 2016-04-05 | Lumidigm Inc | métodos de localização de objeto, de discriminação de objeto e de segundo plano, e, sistema |
US8668636B2 (en) * | 2009-09-30 | 2014-03-11 | Fujifilm Corporation | Electronic endoscope system, processor for electronic endoscope, and method of displaying vascular information |
WO2011097508A2 (fr) * | 2010-02-04 | 2011-08-11 | University Of Southern California | Imagerie spectrale et polarimétrique combinée et diagnostics |
EP2542145B1 (fr) | 2010-03-05 | 2020-08-12 | The General Hospital Corporation | Systèmes qui procurent des images microscopiques d'au moins une structure anatomique à une résolution particulière |
US8570149B2 (en) | 2010-03-16 | 2013-10-29 | Lumidigm, Inc. | Biometric imaging using an optical adaptive interface |
US9069130B2 (en) | 2010-05-03 | 2015-06-30 | The General Hospital Corporation | Apparatus, method and system for generating optical radiation from biological gain media |
US9557154B2 (en) | 2010-05-25 | 2017-01-31 | The General Hospital Corporation | Systems, devices, methods, apparatus and computer-accessible media for providing optical imaging of structures and compositions |
EP2575598A2 (fr) | 2010-05-25 | 2013-04-10 | The General Hospital Corporation | Appareil, systèmes, procédés et support accessible par ordinateur pour l'analyse spectrale d'images de tomographie par cohérence optique |
JP6066901B2 (ja) | 2010-06-03 | 2017-01-25 | ザ ジェネラル ホスピタル コーポレイション | 1つまたは複数の管腔器官内または管腔器官にある構造を撮像するための装置およびデバイスのための方法 |
JP2011257160A (ja) * | 2010-06-04 | 2011-12-22 | Canon Inc | 光干渉断層撮像装置、光干渉断層撮像方法、およびプログラム |
US9638632B2 (en) | 2010-06-11 | 2017-05-02 | Vanderbilt University | Multiplexed interferometric detection system and method |
SG188227A1 (en) | 2010-08-16 | 2013-04-30 | Cognoptix Inc | System and method for detecting amyloid proteins |
JP5384453B2 (ja) | 2010-09-09 | 2014-01-08 | シャープ株式会社 | 測定装置、測定システム、測定方法、制御プログラム、および、記録媒体 |
US9510758B2 (en) | 2010-10-27 | 2016-12-06 | The General Hospital Corporation | Apparatus, systems and methods for measuring blood pressure within at least one vessel |
WO2012078636A1 (fr) | 2010-12-07 | 2012-06-14 | University Of Iowa Research Foundation | Séparation optimale et conviviale d'arrière-plan d'objet |
US9063074B2 (en) * | 2010-12-30 | 2015-06-23 | Empire Technology Development Llc | Analyzing tissue morphology in three dimensions |
WO2012100221A1 (fr) | 2011-01-20 | 2012-07-26 | University Of Iowa Research Foundation | Détermination automatisée de rapport artérioveineux dans des images de vaisseaux sanguins |
GB2487940B (en) | 2011-02-09 | 2014-12-17 | Tel Hashomer Medical Res Infrastructure & Services Ltd | Methods and devices suitable for imaging blood-containing tissue |
US9562853B2 (en) | 2011-02-22 | 2017-02-07 | Vanderbilt University | Nonaqueous backscattering interferometric methods |
US9033510B2 (en) | 2011-03-30 | 2015-05-19 | Carl Zeiss Meditec, Inc. | Systems and methods for efficiently obtaining measurements of the human eye using tracking |
WO2012149175A1 (fr) | 2011-04-29 | 2012-11-01 | The General Hospital Corporation | Moyens pour déterminer des propriétés physiques et/ou optiques résolues en profondeur de milieux de diffusion |
WO2012170963A1 (fr) * | 2011-06-08 | 2012-12-13 | Digital Light Innovations | Système et procédé d'imagerie hyperspectrale |
JP5623348B2 (ja) * | 2011-07-06 | 2014-11-12 | 富士フイルム株式会社 | 内視鏡システム、内視鏡システムのプロセッサ装置、及び内視鏡システムの作動方法 |
WO2013004801A1 (fr) | 2011-07-07 | 2013-01-10 | Carl Zeiss Meditec Ag | Procédés améliorés d'acquisition de données pour réduire les artefacts de mouvement et applications en angiographie par oct |
JP2014523536A (ja) | 2011-07-19 | 2014-09-11 | ザ ジェネラル ホスピタル コーポレイション | 光コヒーレンストモグラフィーにおいて偏波モード分散補償を提供するためのシステム、方法、装置およびコンピュータアクセス可能な媒体 |
WO2013029047A1 (fr) | 2011-08-25 | 2013-02-28 | The General Hospital Corporation | Procédés, systèmes, configurations et support accessible par ordinateur permettant de mettre en œuvre des procédures de tomographie par cohérence micro-optique |
WO2013066631A1 (fr) | 2011-10-18 | 2013-05-10 | The General Hospital Corporation | Appareil et procédés de production et/ou d'utilisation de retard(s) optique(s) de recirculation |
US9101294B2 (en) | 2012-01-19 | 2015-08-11 | Carl Zeiss Meditec, Inc. | Systems and methods for enhanced accuracy in OCT imaging of the cornea |
WO2013142366A1 (fr) | 2012-03-19 | 2013-09-26 | Genetic Innovations, Inc. | Dispositifs, systèmes et procédés de coloration virtuelle |
EP2833776A4 (fr) | 2012-03-30 | 2015-12-09 | Gen Hospital Corp | Système d'imagerie, procédé et fixation distale permettant une endoscopie à champ de vision multidirectionnel |
WO2013165614A1 (fr) | 2012-05-04 | 2013-11-07 | University Of Iowa Research Foundation | Évaluation automatisée de la perte glaucomateuse par tomographie par cohérence optique |
US9273949B2 (en) | 2012-05-11 | 2016-03-01 | Vanderbilt University | Backscattering interferometric methods |
CA3088289A1 (fr) | 2012-05-18 | 2013-11-21 | Rebellion Photonics, Inc. | Systeme d'imagerie spectrale infrarouge a ouverture divisee pour detection chimique |
US9599508B2 (en) | 2012-05-18 | 2017-03-21 | Rebellion Photonics, Inc. | Divided-aperture infra-red spectral imaging system |
US11490797B2 (en) | 2012-05-21 | 2022-11-08 | The General Hospital Corporation | Apparatus, device and method for capsule microscopy |
JP5576993B2 (ja) | 2012-05-30 | 2014-08-20 | パナソニック株式会社 | 画像計測装置、画像計測方法及び画像計測システム |
JP6227652B2 (ja) | 2012-08-22 | 2017-11-08 | ザ ジェネラル ホスピタル コーポレイション | ソフトリソグラフィを用いてミニチュア内視鏡を製作するためのシステム、方法、およびコンピュータ・アクセス可能媒体 |
JP6124548B2 (ja) | 2012-10-17 | 2017-05-10 | キヤノン株式会社 | 眼科撮影方法および眼科装置 |
US9265458B2 (en) | 2012-12-04 | 2016-02-23 | Sync-Think, Inc. | Application of smooth pursuit cognitive testing paradigms to clinical drug development |
US9039179B2 (en) | 2012-12-11 | 2015-05-26 | Elwha Llc | Unobtrusive active eye interrogation |
US9039180B2 (en) | 2012-12-11 | 2015-05-26 | Elwah LLC | Self-aligning unobtrusive active eye interrogation |
US9101297B2 (en) | 2012-12-11 | 2015-08-11 | Elwha Llc | Time-based unobtrusive active eye interrogation |
FR3000346B1 (fr) * | 2012-12-21 | 2015-01-23 | Thales Sa | Procede et dispositif de correction de reponse spatiale pour spectrometres a transformee de fourier imageurs |
EP3000382A1 (fr) * | 2012-12-28 | 2016-03-30 | Canon Kabushiki Kaisha | Appareil et procédé de traitement des images |
WO2014120791A1 (fr) | 2013-01-29 | 2014-08-07 | The General Hospital Corporation | Appareil, systèmes et procédés pour donner des informations sur la valvule aortique |
WO2014121082A1 (fr) | 2013-02-01 | 2014-08-07 | The General Hospital Corporation | Agencement d'objectif pour endomicroscopie confocale |
US9380976B2 (en) | 2013-03-11 | 2016-07-05 | Sync-Think, Inc. | Optical neuroinformatics |
US10478072B2 (en) | 2013-03-15 | 2019-11-19 | The General Hospital Corporation | Methods and system for characterizing an object |
WO2014143891A1 (fr) | 2013-03-15 | 2014-09-18 | University Of Iowa Research Foundation | Séparation automatisée d'arbres binaires se chevauchant |
CA2911294C (fr) | 2013-05-03 | 2022-08-30 | Tearscience, Inc. | Systemes et procedes d'eclairage de paupiere pour imager des glandes de meibomius pour une analyse de glande de meibomius |
US9784681B2 (en) | 2013-05-13 | 2017-10-10 | The General Hospital Corporation | System and method for efficient detection of the phase and amplitude of a periodic modulation associated with self-interfering fluorescence |
EP3692887B1 (fr) | 2013-07-19 | 2024-03-06 | The General Hospital Corporation | Appareil d'imagerie faisant appel à l'endoscopie à champ de vision multidirectionnel |
EP3021735A4 (fr) | 2013-07-19 | 2017-04-19 | The General Hospital Corporation | Détermination de mouvement oculaire au moyen d'une imagerie de la rétine avec rétroaction d'un mouvement de l'oeil par imagerie de la rétine et fournir des informations en retour pour l'acquisition de signaux venant de la rétine |
WO2015013651A2 (fr) | 2013-07-26 | 2015-01-29 | The General Hospital Corporation | Système, appareil et procédé utilisant une dispersion optique pour réaliser une tomographie en cohérence optique dans le domaine de fourier |
US9562849B2 (en) | 2013-11-12 | 2017-02-07 | Rebellion Photonics, Inc. | Divided-aperture infra-red spectral imaging system |
US9733460B2 (en) | 2014-01-08 | 2017-08-15 | The General Hospital Corporation | Method and apparatus for microscopic imaging |
WO2015116986A2 (fr) | 2014-01-31 | 2015-08-06 | The General Hospital Corporation | Système et procédé pour faciliter une imagerie volumétrique manuelle et/ou automatique avec un retour de tension ou d'effort en temps réel au moyen d'un dispositif d'imagerie amarré |
US9211064B2 (en) | 2014-02-11 | 2015-12-15 | Welch Allyn, Inc. | Fundus imaging system |
US9237847B2 (en) | 2014-02-11 | 2016-01-19 | Welch Allyn, Inc. | Ophthalmoscope device |
WO2015143435A1 (fr) | 2014-03-21 | 2015-09-24 | University Of Iowa Research Foundation | Recherche par graphe au moyen d'un graphe déformé non euclidien |
US10228556B2 (en) | 2014-04-04 | 2019-03-12 | The General Hospital Corporation | Apparatus and method for controlling propagation and/or transmission of electromagnetic radiation in flexible waveguide(s) |
US11290662B2 (en) | 2014-05-01 | 2022-03-29 | Rebellion Photonics, Inc. | Mobile gas and chemical imaging camera |
US9756263B2 (en) | 2014-05-01 | 2017-09-05 | Rebellion Photonics, Inc. | Mobile gas and chemical imaging camera |
WO2015183994A1 (fr) * | 2014-05-28 | 2015-12-03 | Santec Corporation | Mesure optique non-invasive d'analyte sanguin |
US10458905B2 (en) | 2014-07-07 | 2019-10-29 | Rebellion Photonics, Inc. | Gas leak emission quantification with a gas cloud imager |
ES2907287T3 (es) | 2014-07-25 | 2022-04-22 | Massachusetts Gen Hospital | Aparato para imagenología y diagnóstico in vivo |
EP3000395B1 (fr) * | 2014-09-19 | 2018-05-23 | IMEC vzw | Système et procédé de surveillance de l'oeil d'un sujet |
JP2018506715A (ja) | 2015-01-23 | 2018-03-08 | ヴァンダービルト ユニバーシティー | 堅固なインターフェロメーター及びその使用方法 |
US10799115B2 (en) | 2015-02-27 | 2020-10-13 | Welch Allyn, Inc. | Through focus retinal image capturing |
US11045088B2 (en) | 2015-02-27 | 2021-06-29 | Welch Allyn, Inc. | Through focus retinal image capturing |
US10548520B2 (en) | 2015-04-01 | 2020-02-04 | Santec Corporation | Non-invasive optical measurement of blood analyte |
US10115194B2 (en) | 2015-04-06 | 2018-10-30 | IDx, LLC | Systems and methods for feature detection in retinal images |
EP4375631A2 (fr) | 2015-05-29 | 2024-05-29 | Rebellion Photonics, Inc. | Système d'imagerie à sulfure d'hydrogène |
JP6713149B2 (ja) | 2015-06-01 | 2020-06-24 | サンテック株式会社 | 2つの波長を合成する光コヒーレンストモグラフィーシステム |
US10136804B2 (en) | 2015-07-24 | 2018-11-27 | Welch Allyn, Inc. | Automatic fundus image capture system |
US10772495B2 (en) | 2015-11-02 | 2020-09-15 | Welch Allyn, Inc. | Retinal image capturing |
EP3190394A3 (fr) * | 2015-12-15 | 2017-11-15 | Applied Spectral Imaging Ltd. | Systèmes et procédés d'imagerie spectrale |
US10413179B2 (en) | 2016-01-07 | 2019-09-17 | Welch Allyn, Inc. | Infrared fundus imaging system |
WO2017132483A1 (fr) | 2016-01-29 | 2017-08-03 | Vanderbilt University | Interférométrie à fonction de réponse en solution libre |
GB201602068D0 (en) | 2016-02-05 | 2016-03-23 | Univ Bristol | Measuring sensitivity to polarized light |
EP3206061A1 (fr) * | 2016-02-15 | 2017-08-16 | Leica Instruments (Singapore) Pte. Ltd. | Système de filtre d'éclairage et système d'observation d'un microscope à fluorescence multispectrale |
US10677580B2 (en) | 2016-04-27 | 2020-06-09 | Santec Corporation | Optical coherence tomography system using polarization switching |
US10602926B2 (en) | 2016-09-29 | 2020-03-31 | Welch Allyn, Inc. | Through focus retinal image capturing |
US10285589B2 (en) | 2016-09-30 | 2019-05-14 | Welch Allyn, Inc. | Fundus image capture system |
EP4212851A1 (fr) | 2016-10-21 | 2023-07-19 | Rebellion Photonics, Inc. | Système d'imagerie à gaz |
CA3041105A1 (fr) | 2016-10-21 | 2018-04-26 | Rebellion Photonics, Inc. | Camera mobile d'imagerie de gaz et de produit chimique |
DE112018000393T5 (de) * | 2017-01-16 | 2019-09-26 | Hoya Corporation | Endoskopsystem und Bildanzeigevorrichtung |
WO2018144633A1 (fr) * | 2017-01-31 | 2018-08-09 | Theranos Ip Company, Llc | Procédés et dispositifs de détection améliorée de signaux à partir d'échantillons biologiques |
US10955355B2 (en) | 2017-02-22 | 2021-03-23 | Rebellion Photonics, Inc. | Systems and methods for monitoring remote installations |
WO2018200840A1 (fr) | 2017-04-27 | 2018-11-01 | Retinopathy Answer Limited | Système et procédé d'analyse d'image fondoscopique automatisée |
US10502546B2 (en) | 2017-11-07 | 2019-12-10 | Santec Corporation | Systems and methods for variable-range fourier domain imaging |
EP4379331A2 (fr) | 2017-11-09 | 2024-06-05 | Rebellion Photonics, Inc. | Capteurs d'obscurcissement de fenêtre pour caméras mobiles d'imagerie chimique et gazeuse |
EP3716838A4 (fr) | 2017-11-27 | 2021-08-11 | Retispec Inc. | Imageur oculaire raman guidé par image hyperspectrale pour des pathologies de la maladie d'alzheimer |
WO2019164455A1 (fr) * | 2018-02-21 | 2019-08-29 | Optotek D.O.O. | Appareil et procédé de traitement d'images pour la détection d'irrégularités dans un tissu |
US10582853B2 (en) | 2018-03-13 | 2020-03-10 | Welch Allyn, Inc. | Selective illumination fundus imaging |
US11213200B2 (en) | 2018-03-22 | 2022-01-04 | Santec Corporation | Topographical imaging using combined sensing inputs |
US11067671B2 (en) | 2018-04-17 | 2021-07-20 | Santec Corporation | LIDAR sensing arrangements |
US10838047B2 (en) | 2018-04-17 | 2020-11-17 | Santec Corporation | Systems and methods for LIDAR scanning of an environment over a sweep of wavelengths |
JP7484708B2 (ja) * | 2018-04-18 | 2024-05-16 | 株式会社ニコン | 画像処理方法、プログラム、及び画像処理装置 |
JP7279712B2 (ja) * | 2018-04-18 | 2023-05-23 | 株式会社ニコン | 画像処理方法、プログラム、及び画像処理装置 |
WO2019222616A1 (fr) | 2018-05-18 | 2019-11-21 | Northwestern University | Angiographie par tomographie par cohérence optique à contraste spectral |
US11096574B2 (en) | 2018-05-24 | 2021-08-24 | Welch Allyn, Inc. | Retinal image capturing |
JPWO2021020466A1 (fr) * | 2019-07-30 | 2021-02-04 | ||
US11161109B2 (en) | 2019-09-19 | 2021-11-02 | Invidx Corp. | Point-of-care testing cartridge with sliding cap |
US11327084B2 (en) * | 2019-09-19 | 2022-05-10 | Invidx Corp. | Joint hematology and biochemistry point-of-care testing system |
WO2021072408A1 (fr) * | 2019-10-10 | 2021-04-15 | Georgia Tech Research Corporation | Analyse d'hématologie et d'histopathologie sans étiquette à l'aide d'une microscopie à ultraviolets profonds |
JP2023507929A (ja) * | 2019-12-12 | 2023-02-28 | ケムイメージ コーポレーション | 組織ターゲットの区別のためのシステムおよび方法 |
CN112683899A (zh) * | 2020-04-29 | 2021-04-20 | 海南远生渔业有限公司 | 一种水产品品质检测方法 |
WO2024057149A1 (fr) * | 2022-09-14 | 2024-03-21 | Alcon Inc. | Génération d'informations d'imagerie multispectrale à l'aide d'une imagerie multispectrale analytique |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS598933A (ja) * | 1982-07-07 | 1984-01-18 | キヤノン株式会社 | 視標を具えた眼科機械 |
CH662261A5 (de) * | 1983-09-19 | 1987-09-30 | Yves Dr Med Robert | Ophthalmologisches geraet fuer die untersuchung des augenhintergrundes und messvorrichtung fuer das geraet. |
US4858124A (en) * | 1984-08-15 | 1989-08-15 | Riverside Research Institute | Method for enhancement of ultrasonic image data |
DD262797A1 (de) * | 1987-08-03 | 1988-12-14 | Zeiss Jena Veb Carl | Untersuchungsgeraet und verfahren fuer das auge, insbesondere den augenhintergrund |
US4922919A (en) | 1988-03-22 | 1990-05-08 | Duke University | Method for measuring ocular oxidative metabolism |
US5109276A (en) * | 1988-05-27 | 1992-04-28 | The University Of Connecticut | Multi-dimensional multi-spectral imaging system |
US4976542A (en) * | 1988-07-25 | 1990-12-11 | Washington University | Digital array scanned interferometer |
US5016173A (en) * | 1989-04-13 | 1991-05-14 | Vanguard Imaging Ltd. | Apparatus and method for monitoring visually accessible surfaces of the body |
GB8909491D0 (en) | 1989-04-26 | 1989-06-14 | Glynn Christopher J | Device for real-time monitoring of human or animal bodily functions |
FR2660182A1 (fr) | 1990-03-27 | 1991-10-04 | Ciposa Microtech | Papillometre. |
US5784162A (en) * | 1993-08-18 | 1998-07-21 | Applied Spectral Imaging Ltd. | Spectral bio-imaging methods for biological research, medical diagnostics and therapy |
US6198532B1 (en) * | 1991-02-22 | 2001-03-06 | Applied Spectral Imaging Ltd. | Spectral bio-imaging of the eye |
US5219400A (en) | 1991-06-11 | 1993-06-15 | The United States Of America As Represented By The Secretary Of The Army | Noninvasive method for quantitation of oxyhemoglobin saturation by near-infrared reflectance spectrophotometry |
US5400791A (en) | 1991-10-11 | 1995-03-28 | Candela Laser Corporation | Infrared fundus video angiography system |
US5303709A (en) * | 1991-12-16 | 1994-04-19 | Dreher Andreas W | Retinal eye disease diagnostic system |
US5377003A (en) * | 1992-03-06 | 1994-12-27 | The United States Of America As Represented By The Department Of Health And Human Services | Spectroscopic imaging device employing imaging quality spectral filters |
US5383467A (en) | 1992-11-18 | 1995-01-24 | Spectrascience, Inc. | Guidewire catheter and apparatus for diagnostic imaging |
EP0767361B1 (fr) * | 1993-07-22 | 2000-02-23 | Applied Spectral Imaging Ltd. | Procédé et dispositif d'analyse spectrale d'une image |
US5590660A (en) | 1994-03-28 | 1997-01-07 | Xillix Technologies Corp. | Apparatus and method for imaging diseased tissue using integrated autofluorescence |
HU215614B (hu) * | 1994-04-15 | 1999-09-28 | Coloryte Hungary Optikai Kutató, Fejlesztő és Gyártó RT. | Eljárás és berendezés szemben lévő színérzékelő receptorok spektrális érzékenységi paramétereinek meghatározására |
US5485229A (en) | 1994-05-24 | 1996-01-16 | Allergan, Inc. | Method and apparatus for determining electrical activity in the retinal nerve fiber layer using intrinsic birefringent properties of retinal ganglion cell axons |
US5493109A (en) | 1994-08-18 | 1996-02-20 | Carl Zeiss, Inc. | Optical coherence tomography assisted ophthalmologic surgical microscope |
-
1997
- 1997-10-01 US US08/942,122 patent/US6198532B1/en not_active Expired - Fee Related
-
1998
- 1998-09-29 EP EP98949638A patent/EP1026987A4/fr not_active Withdrawn
- 1998-09-29 JP JP2000513500A patent/JP2001517521A/ja active Pending
- 1998-09-29 IL IL13415298A patent/IL134152A/en active IP Right Grant
- 1998-09-29 US US09/194,196 patent/US6556853B1/en not_active Expired - Fee Related
- 1998-09-29 WO PCT/US1998/020442 patent/WO1999016353A1/fr not_active Application Discontinuation
- 1998-09-29 AU AU95920/98A patent/AU9592098A/en not_active Abandoned
-
2001
- 2001-01-03 US US09/752,833 patent/US6419361B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1026987A4 (fr) | 2004-03-24 |
JP2001517521A (ja) | 2001-10-09 |
EP1026987A1 (fr) | 2000-08-16 |
US6419361B2 (en) | 2002-07-16 |
US6556853B1 (en) | 2003-04-29 |
WO1999016353A1 (fr) | 1999-04-08 |
AU9592098A (en) | 1999-04-23 |
US20010033364A1 (en) | 2001-10-25 |
IL134152A0 (en) | 2001-04-30 |
US6198532B1 (en) | 2001-03-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6556853B1 (en) | Spectral bio-imaging of the eye | |
US6276798B1 (en) | Spectral bio-imaging of the eye | |
WO2000067635A1 (fr) | Imagerie biologique spectrale de l'oeil | |
US20020099295A1 (en) | System and method for functional brain mapping and an oxygen saturation difference map algorithm for effecting same | |
US5784162A (en) | Spectral bio-imaging methods for biological research, medical diagnostics and therapy | |
US8649008B2 (en) | Combined spectral and polarimetry imaging and diagnostics | |
Keane et al. | Retinal imaging in the twenty-first century: state of the art and future directions | |
US6088099A (en) | Method for interferometer based spectral imaging of moving objects | |
US11253151B2 (en) | Multispectral and hyperspectral ocular surface evaluator | |
Yoneya et al. | Retinal oxygen saturation levels in patients with central retinal vein occlusion | |
Lemmens et al. | Hyperspectral imaging and the retina: worth the wave? | |
Bittencourt et al. | Blue light versus green light fundus autofluorescence in normal subjects and in patients with retinochoroidopathy secondary to retinal and uveitic diseases | |
Alabboud et al. | New spectral imaging techniques for blood oximetry in the retina | |
JP3474883B2 (ja) | 可動物の、干渉形に基づくスペクトル結像装置 | |
Harvey et al. | Hyperspectral imaging for the detection of retinal diseases | |
US20220390369A1 (en) | Systems And Methods For Imaging And Characterizing Objects Including The Eye Using Non-Uniform Or Speckle Illumination Patterns | |
US20130225951A1 (en) | Determination of oxygen saturation in a tissue of visual system | |
Di Cecilia et al. | Hyperspectral imaging of the human iris | |
IL129842A (en) | Method and apparatus for spectral bio-imaging of the eye | |
Alterini | Hyperspectral imaging system for the fast recording of the ocular fundus | |
WO2002039873A2 (fr) | Systeme et technique de cartographie cerebrale fonctionnelle et algorithme associe de representation cartographique des differences de saturation en oxygene | |
Dwight | Snapshot Hyperspectral Imaging for Complete Fundus Oximetry | |
Atlan | Doppler holography for ophthalmology | |
Soliz et al. | Spectrally-based fundus imaging: implications for image enhancement and diagnosis of retinal diseases | |
Theelen | Scanning laser imaging of the retina. Basic concepts and clinical applications |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed |