IL132468A - Kit for inducing immune response against a tumor or a disease caused by an infectious agent - Google Patents
Kit for inducing immune response against a tumor or a disease caused by an infectious agentInfo
- Publication number
- IL132468A IL132468A IL13246895A IL13246895A IL132468A IL 132468 A IL132468 A IL 132468A IL 13246895 A IL13246895 A IL 13246895A IL 13246895 A IL13246895 A IL 13246895A IL 132468 A IL132468 A IL 132468A
- Authority
- IL
- Israel
- Prior art keywords
- agent
- cells
- immunoglobulin
- kit
- tumor
- Prior art date
Links
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
- C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US08/268,129 US5798100A (en) | 1994-07-06 | 1994-07-06 | Multi-stage cascade boosting vaccine |
| IL11444495A IL114444A (en) | 1994-07-06 | 1995-07-04 | Kit for inducing immune response against a tumor or a disease caused by an infectious agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL132468A true IL132468A (en) | 2004-12-15 |
Family
ID=23021598
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13246895A IL132468A (en) | 1994-07-06 | 1995-07-04 | Kit for inducing immune response against a tumor or a disease caused by an infectious agent |
| IL11444495A IL114444A (en) | 1994-07-06 | 1995-07-04 | Kit for inducing immune response against a tumor or a disease caused by an infectious agent |
| IL13246899A IL132468A0 (en) | 1994-07-06 | 1999-10-20 | A kit for inducing immune response against a tumor or a disease caused by an infection agent |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11444495A IL114444A (en) | 1994-07-06 | 1995-07-04 | Kit for inducing immune response against a tumor or a disease caused by an infectious agent |
| IL13246899A IL132468A0 (en) | 1994-07-06 | 1999-10-20 | A kit for inducing immune response against a tumor or a disease caused by an infection agent |
Country Status (9)
| Country | Link |
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| US (3) | US5798100A (xx) |
| EP (1) | EP0768894B1 (xx) |
| JP (2) | JP3769014B2 (xx) |
| AT (1) | ATE306939T1 (xx) |
| AU (1) | AU2953895A (xx) |
| CA (2) | CA2194166C (xx) |
| DE (1) | DE69534528T2 (xx) |
| IL (3) | IL132468A (xx) |
| WO (1) | WO1996001126A1 (xx) |
Families Citing this family (93)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5798100A (en) * | 1994-07-06 | 1998-08-25 | Immunomedics, Inc. | Multi-stage cascade boosting vaccine |
| US7354587B1 (en) * | 1994-07-06 | 2008-04-08 | Immunomedics, Inc. | Use of immunoconjugates to enhance the efficacy of multi-stage cascade boosting vaccines |
| US5874540A (en) * | 1994-10-05 | 1999-02-23 | Immunomedics, Inc. | CDR-grafted type III anti-CEA humanized mouse monoclonal antibodies |
| JP2000511403A (ja) | 1996-03-20 | 2000-09-05 | イムノメディクス，インコーポレイテッド | 抗癌胎児抗原抗イディオタイプ抗体のヒト化と腫瘍ワクチンとしての使用及びターゲッティング用途のための使用 |
| IL121041A0 (en) * | 1997-06-09 | 1997-11-20 | Yeda Res & Dev | Immunogenic compositions for induction of anti-tumor immunity |
| KR20080009171A (ko) * | 1997-08-13 | 2008-01-24 | 더 유에이비 리서치 파운데이션 | 유전자 벡터의 국소 적용에 의한 백신접종 |
| US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| NZ512722A (en) | 1999-01-13 | 2003-07-25 | Igeneon Krebs Immuntherapie | Use of Ep-CAM antibodies for anticancer vaccination |
| US7737258B2 (en) * | 2000-10-18 | 2010-06-15 | Sloan-Kettering Institute For Cancer Research | Uses of monoclonal antibody 8H9 |
| US7666424B2 (en) * | 2001-10-17 | 2010-02-23 | Sloan-Kettering Institute For Cancer Research | Methods of preparing and using single chain anti-tumor antibodies |
| US8501471B2 (en) | 2000-10-18 | 2013-08-06 | Sloan-Kettering Institute For Cancer Research | Uses of monoclonal antibody 8H9 |
| US8414892B2 (en) | 2000-10-18 | 2013-04-09 | Sloan-Kettering Institute For Cancer Research | Uses of monoclonal antibody 8H9 |
| US7740845B2 (en) | 2000-10-18 | 2010-06-22 | Sloan-Kettering Institute For Cancer Research | Uses of monoclonal antibody 8H9 |
| US7244814B2 (en) * | 2002-02-21 | 2007-07-17 | University Of Medicine & Dentistry Of New Jersey | Variant Tat proteins and methods for use thereof |
| US7591994B2 (en) | 2002-12-13 | 2009-09-22 | Immunomedics, Inc. | Camptothecin-binding moiety conjugates |
| MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
| JP4212921B2 (ja) * | 2002-03-29 | 2009-01-21 | 独立行政法人科学技術振興機構 | 抗体を提示するタンパク質中空ナノ粒子を用いる治療薬剤およびタンパク質中空ナノ粒子 |
| US7803372B2 (en) | 2002-10-08 | 2010-09-28 | Immunomedics, Inc. | Antibody therapy |
| GB0224442D0 (en) * | 2002-10-21 | 2002-11-27 | Molmed Spa | A delivery system |
| JP5354835B2 (ja) * | 2002-11-07 | 2013-11-27 | イミュノジェン・インコーポレーテッド | 抗ｃｄ３３抗体、及びそれを用いた急性骨髄性白血病の治療方法 |
| US7696322B2 (en) * | 2003-07-28 | 2010-04-13 | Catalent Pharma Solutions, Inc. | Fusion antibodies |
| US20070269414A1 (en) | 2003-11-04 | 2007-11-22 | Shinji Okano | Method for Producing Gene Transferred Denritic Cells |
| AU2005206410A1 (en) | 2004-01-22 | 2005-08-04 | Dnavec Research Inc. | Method of producing minus strand RNA virus vector with the use of hybrid promoter containing cytomegalovirus enhancer and avian beta-actin promoter |
| US20110064754A1 (en) * | 2005-03-03 | 2011-03-17 | Center For Molecular Medicine And Immunology | Immunoconjugates Comprising Poxvirus-Derived Peptides and Antibodies Against Antigen-Presenting Cells for Subunit-Based Poxvirus Vaccines |
| US8562988B2 (en) * | 2005-10-19 | 2013-10-22 | Ibc Pharmaceuticals, Inc. | Strategies for improved cancer vaccines |
| US8652484B2 (en) | 2004-02-13 | 2014-02-18 | Immunomedics, Inc. | Delivery system for cytotoxic drugs by bispecific antibody pretargeting |
| US8435539B2 (en) * | 2004-02-13 | 2013-05-07 | Immunomedics, Inc. | Delivery system for cytotoxic drugs by bispecific antibody pretargeting |
| US9481878B2 (en) | 2004-02-13 | 2016-11-01 | Immunomedics, Inc. | Compositions and methods of use of immunotoxins comprising ranpirnase (Rap) show potent cytotoxic activity |
| US8551480B2 (en) | 2004-02-13 | 2013-10-08 | Immunomedics, Inc. | Compositions and methods of use of immunotoxins comprising ranpirnase (Rap) show potent cytotoxic activity |
| US20110020273A1 (en) * | 2005-04-06 | 2011-01-27 | Ibc Pharmaceuticals, Inc. | Bispecific Immunocytokine Dock-and-Lock (DNL) Complexes and Therapeutic Use Thereof |
| US8491914B2 (en) * | 2004-02-13 | 2013-07-23 | Ibc Pharmaceuticals, Inc. | Dock-and-lock (DNL) complexes for delivery of interference RNA |
| DE102004054326B4 (de) * | 2004-11-10 | 2007-01-11 | FICO CABLES S.A. Technological Centre Pujol & Tarragó | Vorrichtung zur Einstellung der Vorspannung eine Zugelements |
| US8916165B2 (en) | 2004-12-15 | 2014-12-23 | Janssen Alzheimer Immunotherapy | Humanized Aβ antibodies for use in improving cognition |
| WO2006116423A2 (en) | 2005-04-26 | 2006-11-02 | Eisai Co., Ltd | Compositions and methods for cancer immunotherapy |
| EP2674440B1 (en) | 2005-12-16 | 2019-07-03 | IBC Pharmaceuticals, Inc. | Multivalent immunoglobulin-based bioactive assemblies |
| US20100167341A1 (en) | 2006-01-17 | 2010-07-01 | Dnavec Corporation | Novel protein expression system |
| US8575319B2 (en) * | 2006-03-10 | 2013-11-05 | The Regents Of The University Of California | Cleavable vaccine compositions and uses thereof and methods of making and using the same |
| US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
| WO2008007581A1 (fr) | 2006-07-13 | 2008-01-17 | Dnavec Corporation | Vecteur de virus paramyxoviridae non répliquant |
| JP2010523478A (ja) * | 2007-03-22 | 2010-07-15 | スローン − ケタリング・インスティテュート・フォー・キャンサー・リサーチ | モノクローナル抗体８ｈ９の使用 |
| US8003097B2 (en) | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
| JPWO2008136438A1 (ja) | 2007-04-27 | 2010-07-29 | 国立大学法人九州大学 | 遺伝子治療用ウイルスベクター |
| PL2182983T3 (pl) | 2007-07-27 | 2014-10-31 | Janssen Alzheimer Immunotherap | Leczenie chorób amyloidowych z wykorzystaniem humanizowanych przeciwciał specyficznych względem Abeta |
| JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
| CN102186499B (zh) * | 2008-08-20 | 2015-05-20 | Ibc医药公司 | 用于癌症治疗的对接和锁定(dnl)疫苗 |
| US9186128B2 (en) | 2008-10-01 | 2015-11-17 | Covidien Lp | Needle biopsy device |
| US8968210B2 (en) | 2008-10-01 | 2015-03-03 | Covidien LLP | Device for needle biopsy with integrated needle protection |
| US9332973B2 (en) | 2008-10-01 | 2016-05-10 | Covidien Lp | Needle biopsy device with exchangeable needle and integrated needle protection |
| US9782565B2 (en) | 2008-10-01 | 2017-10-10 | Covidien Lp | Endoscopic ultrasound-guided biliary access system |
| US11298113B2 (en) | 2008-10-01 | 2022-04-12 | Covidien Lp | Device for needle biopsy with integrated needle protection |
| US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
| PT3912643T (pt) | 2009-02-13 | 2023-01-12 | Immunomedics Inc | Imunoconjugados com uma ligação intracelular clivável |
| US9493578B2 (en) * | 2009-09-02 | 2016-11-15 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
| IN2012DN03354A (xx) | 2009-12-02 | 2015-10-23 | Immunomedics Inc | |
| AU2012250924B2 (en) | 2011-05-02 | 2017-05-25 | Immunomedics, Inc. | Ultrafiltration concentration of allotype selected antibodies for small-volume administration |
| KR101870555B1 (ko) | 2011-08-23 | 2018-06-22 | 로슈 글리카트 아게 | T 세포 활성화 항원 및 종양 항원에 대해 특이적인 이중특이적 항체 및 이의 사용 방법 |
| CN104379169A (zh) | 2012-08-14 | 2015-02-25 | Ibc药品公司 | 用于治疗疾病的t-细胞重定向双特异性抗体 |
| RU2015117393A (ru) | 2012-10-08 | 2016-12-10 | Роше Гликарт Аг | Лишенные fc антитела, содержащие два Fab-фрагмента, и способы их применения |
| KR102356017B1 (ko) | 2012-12-13 | 2022-01-27 | 이뮤노메딕스, 인코오포레이티드 | 개선된 효능 및 감소된 독성을 위한 항체 및 sn-38의 면역컨쥬게이트의 투약 |
| CN105143270B (zh) | 2013-02-26 | 2019-11-12 | 罗切格利卡特公司 | 双特异性t细胞活化抗原结合分子 |
| KR20210094673A (ko) | 2013-02-26 | 2021-07-29 | 로슈 글리카트 아게 | 이중특이적 t 세포 활성화 항원 결합 분자 |
| LT3736292T (lt) | 2013-12-17 | 2024-07-25 | Genentech, Inc. | Antikūnai prieš cd3 ir jų naudojimo būdai |
| WO2015126548A1 (en) | 2014-02-21 | 2015-08-27 | Ibc Pharmaceuticals, Inc. | Disease therapy by inducing immune response to trop-2 expressing cells |
| EP3110445A4 (en) | 2014-02-25 | 2017-09-27 | Immunomedics, Inc. | Humanized rfb4 anti-cd22 antibody |
| EP3160504B1 (en) | 2014-06-24 | 2020-09-16 | Immunomedics, Inc. | Anti-histone therapy for vascular necrosis in severe glomerulonephritis |
| HUE044814T2 (hu) | 2014-08-04 | 2019-11-28 | Hoffmann La Roche | Bispecifikus, T-sejt-aktiváló antigénkötõ molekulák |
| PE20170670A1 (es) | 2014-09-12 | 2017-06-06 | Genentech Inc | Anticuerpos anti-cll-1 e inmunoconjugados |
| WO2016057398A1 (en) | 2014-10-07 | 2016-04-14 | Immunomedics, Inc. | Neoadjuvant use of antibody-drug conjugates |
| PL3789402T3 (pl) | 2014-11-20 | 2022-10-17 | F. Hoffmann-La Roche Ag | Terapia skojarzona składająca się z dwuswoistych cząsteczek wiążących antygen aktywujących limfocyty T oraz antagonistów wiązania osi PD-1 |
| CA2981543A1 (en) | 2015-04-22 | 2016-10-27 | Immunomedics, Inc. | Isolation, detection, diagnosis and/or characterization of circulating trop-2-positive cancer cells |
| US10501545B2 (en) | 2015-06-16 | 2019-12-10 | Genentech, Inc. | Anti-CLL-1 antibodies and methods of use |
| PT3310814T (pt) | 2015-06-16 | 2023-10-02 | H Hoffnabb La Roche Ag | Anticorpos humanizados e de afinidade amadurecida para fcrh5 e métodos de utilização |
| ES2953441T3 (es) | 2015-06-25 | 2023-11-13 | Immunomedics Inc | Combinación de anticuerpos anti-hla-dr o anti-Trop-2 con inhibidores de microtúbulos, inhibidores de parp, inhibidores de la cinasa de bruton o inhibidores de la fosfoinositida 3-cinasa mejora significativamente el resultado terapéutico en el cáncer |
| EP3316885B1 (en) | 2015-07-01 | 2021-06-23 | Immunomedics, Inc. | Antibody-sn-38 immunoconjugates with a cl2a linker |
| AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
| CA2990755A1 (en) | 2015-10-02 | 2017-04-06 | F. Hoffman-La Roche Ag | Bispecific anti-ceaxcd3 t cell activating antigen binding molecules |
| CA2997406C (en) | 2015-12-09 | 2024-05-28 | F. Hoffmann-La Roche Ag | Type ii anti-cd20 antibody for reducing formation of anti-drug antibodies or cytokine release |
| WO2017118675A1 (en) | 2016-01-08 | 2017-07-13 | F. Hoffmann-La Roche Ag | Methods of treating cea-positive cancers using pd-1 axis binding antagonists and anti-cea/anti-cd3 bispecific antibodies |
| HRP20230528T1 (hr) | 2016-03-22 | 2023-08-04 | F. Hoffmann - La Roche Ag | Bispecifične molekule t stanica aktivirane proteazom |
| US10188749B2 (en) | 2016-04-14 | 2019-01-29 | Fred Hutchinson Cancer Research Center | Compositions and methods to program therapeutic cells using targeted nucleic acid nanocarriers |
| EP3519437B1 (en) | 2016-09-30 | 2021-09-08 | F. Hoffmann-La Roche AG | Bispecific antibodies against p95her2 |
| KR20190074300A (ko) | 2016-11-15 | 2019-06-27 | 제넨테크, 인크. | 항-cd20/항-cd3 이중특이적 항체에 의한 치료를 위한 투약 |
| CN110121336A (zh) * | 2017-01-05 | 2019-08-13 | 弗莱德哈钦森癌症研究中心 | 改善疫苗功效的系统和方法 |
| US11649288B2 (en) | 2017-02-07 | 2023-05-16 | Seattle Children's Hospital | Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents |
| JP7178355B2 (ja) | 2017-02-28 | 2022-11-25 | エンドサイト・インコーポレイテッド | Ｃａｒ ｔ細胞療法のための組成物および方法 |
| TW201940182A (zh) | 2018-01-22 | 2019-10-16 | 美商安德賽特公司 | Car t 細胞之使用方法 |
| CA3089287A1 (en) | 2018-02-08 | 2019-08-15 | Genentech, Inc. | Bispecific antigen-binding molecules and methods of use |
| PE20221511A1 (es) | 2019-12-13 | 2022-10-04 | Genentech Inc | Anticuerpos anti-ly6g6d y metodos de uso |
| US11780920B2 (en) | 2020-06-19 | 2023-10-10 | Hoffmann-La Roche Inc. | Antibodies binding to CD3 and CD19 |
| US20230256114A1 (en) | 2020-07-07 | 2023-08-17 | Bionecure Therapeutics, Inc. | Novel maytansinoids as adc payloads and their use for the treatment of cancer |
| WO2022239720A1 (ja) | 2021-05-10 | 2022-11-17 | 公益財団法人川崎市産業振興財団 | 抗原への結合親和性を低減させた抗体 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4818709A (en) * | 1983-01-21 | 1989-04-04 | Primus Frederick J | CEA-family antigens, Anti-CEA antibodies and CEA immunoassay |
| US5614610A (en) * | 1984-12-21 | 1997-03-25 | Oncogen | Tumor immunotherapy using anti-idiotypic antibodies |
| US5525338A (en) * | 1992-08-21 | 1996-06-11 | Immunomedics, Inc. | Detection and therapy of lesions with biotin/avidin conjugates |
| IL86278A (en) * | 1988-05-04 | 2003-06-24 | Yeda Res & Dev | Endowing cells with antibody specificity using chimeric t cell receptor |
| ATE149841T1 (de) * | 1990-01-26 | 1997-03-15 | Immunomedics Inc | Impfstoffe gegen krebs und infektionskrankheiten |
| IE920716A1 (en) * | 1991-03-07 | 1992-09-09 | Gen Hospital Corp | Redirection of cellular immunity by receptor chimeras |
| US5932448A (en) * | 1991-11-29 | 1999-08-03 | Protein Design Labs., Inc. | Bispecific antibody heterodimers |
| WO1993019163A1 (en) * | 1992-03-18 | 1993-09-30 | Yeda Research And Development Co, Ltd. | Chimeric receptor genes and cells transformed therewith |
| WO1994005329A1 (en) * | 1992-08-31 | 1994-03-17 | Jenner Technologies | Stimulation of an antitumor t-cell response using anti-idiotypic antibodies |
| US5798100A (en) * | 1994-07-06 | 1998-08-25 | Immunomedics, Inc. | Multi-stage cascade boosting vaccine |
| US5874540A (en) | 1994-10-05 | 1999-02-23 | Immunomedics, Inc. | CDR-grafted type III anti-CEA humanized mouse monoclonal antibodies |
-
1994
- 1994-07-06 US US08/268,129 patent/US5798100A/en not_active Expired - Lifetime
-
1995
- 1995-07-04 IL IL13246895A patent/IL132468A/en not_active IP Right Cessation
- 1995-07-04 IL IL11444495A patent/IL114444A/xx not_active IP Right Cessation
- 1995-07-06 EP EP95925387A patent/EP0768894B1/en not_active Expired - Lifetime
- 1995-07-06 CA CA002194166A patent/CA2194166C/en not_active Expired - Fee Related
- 1995-07-06 DE DE69534528T patent/DE69534528T2/de not_active Expired - Lifetime
- 1995-07-06 WO PCT/US1995/008222 patent/WO1996001126A1/en active IP Right Grant
- 1995-07-06 AT AT95925387T patent/ATE306939T1/de not_active IP Right Cessation
- 1995-07-06 JP JP50392696A patent/JP3769014B2/ja not_active Expired - Fee Related
- 1995-07-06 AU AU29538/95A patent/AU2953895A/en not_active Abandoned
-
1998
- 1998-08-21 US US09/138,287 patent/US6132718A/en not_active Expired - Lifetime
-
1999
- 1999-10-20 IL IL13246899A patent/IL132468A0/xx unknown
- 1999-12-15 JP JP11355893A patent/JP2000154153A/ja active Pending
-
2000
- 2000-10-16 US US09/688,089 patent/US6926893B1/en not_active Expired - Fee Related
-
2003
- 2003-11-25 CA CA002448831A patent/CA2448831A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JPH10503758A (ja) | 1998-04-07 |
| US6132718A (en) | 2000-10-17 |
| WO1996001126A1 (en) | 1996-01-18 |
| IL132468A0 (en) | 2001-03-19 |
| CA2448831A1 (en) | 2005-05-25 |
| ATE306939T1 (de) | 2005-11-15 |
| US6926893B1 (en) | 2005-08-09 |
| DE69534528T2 (de) | 2006-07-13 |
| JP3769014B2 (ja) | 2006-04-19 |
| CA2194166A1 (en) | 1996-01-18 |
| EP0768894A1 (en) | 1997-04-23 |
| CA2194166C (en) | 2003-11-25 |
| EP0768894B1 (en) | 2005-10-19 |
| US5798100A (en) | 1998-08-25 |
| JP2000154153A (ja) | 2000-06-06 |
| DE69534528D1 (de) | 2006-03-02 |
| AU2953895A (en) | 1996-01-25 |
| IL114444A (en) | 2000-02-17 |
| IL114444A0 (en) | 1995-11-27 |
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| MM9K | Patent not in force due to non-payment of renewal fees |