IL130660A - History of benzothiophenecarboxamide and PGD2 antibodies containing them - Google Patents

History of benzothiophenecarboxamide and PGD2 antibodies containing them

Info

Publication number
IL130660A
IL130660A IL13066097A IL13066097A IL130660A IL 130660 A IL130660 A IL 130660A IL 13066097 A IL13066097 A IL 13066097A IL 13066097 A IL13066097 A IL 13066097A IL 130660 A IL130660 A IL 130660A
Authority
IL
Israel
Prior art keywords
compound
hydrate
acceptable salt
pharmaceutically acceptable
configuration
Prior art date
Application number
IL13066097A
Other languages
English (en)
Hebrew (he)
Other versions
IL130660A0 (en
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Priority to IL14586397A priority Critical patent/IL145863A/xx
Priority to IL14586497A priority patent/IL145864A/xx
Priority to IL14586597A priority patent/IL145865A/xx
Publication of IL130660A0 publication Critical patent/IL130660A0/xx
Publication of IL130660A publication Critical patent/IL130660A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
IL13066097A 1996-12-13 1997-12-10 History of benzothiophenecarboxamide and PGD2 antibodies containing them IL130660A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
IL14586397A IL145863A (en) 1996-12-13 1997-12-10 Benzothiophenecarboxamide derivatives
IL14586497A IL145864A (en) 1996-12-13 1997-12-10 Benzothiophenecarboxyamide derivatives
IL14586597A IL145865A (en) 1996-12-13 1997-12-10 Benzothiophene derivatives

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP33349596 1996-12-13
JP25400197 1997-09-19
PCT/JP1997/004527 WO1998025919A1 (en) 1996-12-13 1997-12-10 Benzothiophenecarboxamide derivatives and pgd2 antagonists comprising them

Publications (2)

Publication Number Publication Date
IL130660A0 IL130660A0 (en) 2000-06-01
IL130660A true IL130660A (en) 2002-03-10

Family

ID=26541496

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13066097A IL130660A (en) 1996-12-13 1997-12-10 History of benzothiophenecarboxamide and PGD2 antibodies containing them

Country Status (26)

Country Link
US (1) US6083974A (ru)
EP (1) EP0944614B1 (ru)
JP (1) JP3215441B2 (ru)
KR (1) KR100433568B1 (ru)
CN (2) CN1105112C (ru)
AR (1) AR008939A1 (ru)
AT (1) ATE223911T1 (ru)
AU (1) AU718958B2 (ru)
BR (1) BR9714016A (ru)
CA (1) CA2274591C (ru)
CZ (1) CZ297324B6 (ru)
DE (1) DE69715448T2 (ru)
DK (1) DK0944614T3 (ru)
ES (1) ES2181039T3 (ru)
HK (1) HK1020045A1 (ru)
HU (1) HU226458B1 (ru)
ID (1) ID22753A (ru)
IL (1) IL130660A (ru)
NO (1) NO992838L (ru)
NZ (1) NZ336143A (ru)
PL (1) PL191760B1 (ru)
PT (1) PT944614E (ru)
RU (1) RU2161617C1 (ru)
TR (1) TR199901280T2 (ru)
TW (1) TW438790B (ru)
WO (1) WO1998025919A1 (ru)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6399788B1 (en) 1998-03-31 2002-06-04 Shionogi & Co., Ltd. Process for producing benzothiophenecarboxylic acid amide derivatives
KR100596284B1 (ko) 1998-03-31 2006-07-03 시오노기 앤드 컴파니, 리미티드 5-히드록시벤조[비]티오펜-3-카복실산 유도체의 제조 방법
ATE295183T1 (de) * 1998-06-03 2005-05-15 Shionogi & Co Mittel zur linderung von juckreiz, enthaltend pgd2- antagonisten
EP1808427A3 (en) * 1999-07-02 2008-06-25 Shionogi & Co., Ltd. Novel processes for the preparation of bicyclic aminoalcohols
BR0109050A (pt) 2000-03-09 2004-04-27 Ono Pharmaceutical Co Derivados de indol, processo para prepapação e uso dos mesmos
WO2001078697A2 (en) * 2000-04-12 2001-10-25 Merck Frosst Canada & Co. Method and compositions for the treatment of allergic conditions using pgd2 receptor antagonists
US6410583B1 (en) * 2000-07-25 2002-06-25 Merck Frosst Canada & Co. Cyclopentanoindoles, compositions containing such compounds and methods of treatment
US7217725B2 (en) 2000-09-14 2007-05-15 Allergan, Inc. Prostaglandin D2 antagonist
US7273883B2 (en) 2000-09-14 2007-09-25 Allergan, Inc. Prostaglandin EP4 antagonist
DE60108515T2 (de) 2000-10-17 2006-01-12 Shionogi & Co., Ltd. Verfahren zur herstellung eines pgd2-antagonisten
JPWO2002036583A1 (ja) * 2000-11-01 2004-03-11 塩野義製薬株式会社 Ｐｇｄ２受容体拮抗性医薬組成物
AR038136A1 (es) 2002-01-24 2004-12-29 Merck Frosst Canada Inc Cicloalcanindoles con sustitucion con fluor composiciones que contienen estos compuestos y metodos de tratamiento
PL372466A1 (en) * 2002-03-19 2005-07-25 Ono Pharmaceutical Co, Ltd. Carboxylic acid compounds and drugs containing the compounds as the active ingredient
US20050222235A1 (en) * 2002-07-12 2005-10-06 Yoshihiro Urade Drugs for improving the prognosis of brain injury and a method of screening the same
EP1547598A1 (en) * 2002-09-30 2005-06-29 Shionogi & Co., Ltd. NOVEL USES OF PROSTAGLANDIN D sb 2 /sb , PROSTAGLANDIN D sb 2 /sb AGONIST AND PROSTAGLANDIN D sb 2 /sb ANTAGONIST
MXPA05004715A (es) 2002-10-30 2005-08-03 Merck Frosst Canada Inc Derivados de piridopirrolizina y piridoindolizina.
CN1930162B (zh) 2004-03-11 2010-06-16 埃科特莱茵药品有限公司 四氢吡啶并吲哚衍生物
JPWO2006068162A1 (ja) * 2004-12-24 2008-06-12 塩野義製薬株式会社 慢性閉塞性肺疾患の治療剤
TW200716093A (en) * 2005-04-28 2007-05-01 Shionogi & Co An antiasthmatic agent containing PGD2 receptor antagonist and leukotriene receptor antagonist
TWI410410B (zh) 2007-08-10 2013-10-01 Ono Pharmaceutical Co Phenylacetic acid compounds
EA201200855A1 (ru) 2009-12-23 2013-04-30 Айронвуд Фармасьютикелз, Инк. Модуляторы crth2
US20130178475A1 (en) 2010-03-17 2013-07-11 Ironwood Pharmaceuticals, Inc. sGC STIMULATORS
WO2012003405A1 (en) 2010-06-30 2012-01-05 Ironwood Pharmaceuticals, Inc. Sgc stimulators
US20130259830A1 (en) 2010-07-12 2013-10-03 Ironwood Pharmaceuticals, Inc. Crth2 modulators
US20130216552A1 (en) 2010-07-12 2013-08-22 Ironwood Pharmaceuticals, Inc. Crth2 modulators
AU2011326241B2 (en) 2010-11-09 2016-11-17 Ironwood Pharmaceuticals, Inc. sGC stimulators
CA2861804C (en) 2011-12-27 2021-10-26 Ironwood Pharmaceuticals, Inc. 2-benzyl,3(pyrimidin-2-yl)substituted pyrazoles useful as sgc stimulators
US9309235B2 (en) 2012-09-18 2016-04-12 Ironwood Pharmaceuticals, Inc. SGC stimulators
CA2885645A1 (en) 2012-09-19 2014-03-27 Ironwood Pharmaceuticals, Inc. Sgc stimulators
EA031746B1 (ru) 2013-03-15 2019-02-28 Айронвуд Фармасьютикалз, Инк. СТИМУЛЯТОРЫ sGC
WO2015089182A1 (en) 2013-12-11 2015-06-18 Ironwood Pharmaceuticals, Inc. Sgc stimulators
US20160324856A1 (en) 2014-01-13 2016-11-10 Ironwood Pharmaceuticals, Inc. Use of sgc stimulators for the treatment of neuromuscular disorders
MX2017003516A (es) 2014-09-17 2017-07-28 Ironwood Pharmaceuticals Inc Derivados de pirazol como estimuladores de guanilato ciclasa soluble (sgc).
WO2016044445A2 (en) 2014-09-17 2016-03-24 Ironwood Pharmaceuticals, Inc. sGC STIMULATORS
EP3194386A2 (en) 2014-09-17 2017-07-26 Ironwood Pharmaceuticals, Inc. Sgc stimulators
MA45592A (fr) 2016-07-07 2019-05-15 Ironwood Pharmaceuticals Inc Promédicaments à base de phosphore de stimulateurs de sgc
EP3481820B1 (en) 2016-07-07 2023-10-18 Cyclerion Therapeutics, Inc. Solid forms of an sgc stimulator

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4560343A (en) * 1984-06-11 1985-12-24 Honeywell Inc. Functional check for a hot surface ignitor element
JPS6149A (ja) * 1984-06-12 1986-01-06 Ono Pharmaceut Co Ltd 新規な１３―アザ―１４―オキソ―ＴｘＡ２類似化合物およびそれらを有効成分として含有するトロンボキサン起因疾患治療剤
NZ218115A (en) * 1985-11-18 1990-02-26 Shionogi & Co Bicyclic sulphonamides and pharmaceutical compositions
CA1294974C (en) * 1987-05-08 1992-01-28 Sanji Hagishita Bicyclic sulfonamide derivatives and process therefor
US5356926A (en) * 1992-02-24 1994-10-18 Warner-Lambert Company 3-alkyloxy-, aryloxy-, or arylalkyloxy-benzo [β]thiophene-2-carboxamides as inhibitors of cell adhesion
CA2113787A1 (en) * 1993-01-29 1994-07-30 Nobuyuki Hamanaka Carbocyclic sulfonamides
DE4317076A1 (de) * 1993-05-21 1994-11-24 Bayer Ag Benzthiophencarbonsäureamid-S-oxide
US5863936A (en) * 1995-04-18 1999-01-26 Geron Corporation Telomerase inhibitors
JP3195361B2 (ja) * 1995-06-21 2001-08-06 塩野義製薬株式会社 ビシクロ環系アミノ誘導体およびそれを含有するｐｇｄ２拮抗剤
JP2001501946A (ja) * 1996-10-08 2001-02-13 イーライ・リリー・アンド・カンパニー 新規セロトニン５―ｈｔ▲下１ｆ▼アゴニスト

Also Published As

Publication number Publication date
PL334072A1 (en) 2000-01-31
JP3215441B2 (ja) 2001-10-09
TR199901280T2 (xx) 1999-10-21
DK0944614T3 (da) 2003-01-13
JP2000514824A (ja) 2000-11-07
PT944614E (pt) 2003-01-31
HUP0002869A3 (en) 2003-01-28
HU226458B1 (en) 2008-12-29
ATE223911T1 (de) 2002-09-15
CN1240438A (zh) 2000-01-05
RU2161617C1 (ru) 2001-01-10
NO992838L (no) 1999-07-20
KR20000069402A (ko) 2000-11-25
DE69715448D1 (de) 2002-10-17
CN1105112C (zh) 2003-04-09
US6083974A (en) 2000-07-04
EP0944614A1 (en) 1999-09-29
CA2274591A1 (en) 1998-06-18
TW438790B (en) 2001-06-07
EP0944614B1 (en) 2002-09-11
ID22753A (id) 1999-12-09
BR9714016A (pt) 2000-02-29
CA2274591C (en) 2005-06-14
CN1185226C (zh) 2005-01-19
PL191760B1 (pl) 2006-06-30
AR008939A1 (es) 2000-02-23
AU5409798A (en) 1998-07-03
HK1020045A1 (en) 2000-03-10
WO1998025919A1 (en) 1998-06-18
ES2181039T3 (es) 2003-02-16
CZ206599A3 (cs) 1999-11-17
HUP0002869A2 (hu) 2001-06-28
AU718958B2 (en) 2000-05-04
NZ336143A (en) 2002-05-31
KR100433568B1 (ko) 2004-05-31
DE69715448T2 (de) 2003-08-07
NO992838D0 (no) 1999-06-10
CZ297324B6 (cs) 2006-11-15
IL130660A0 (en) 2000-06-01
CN1445225A (zh) 2003-10-01

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees