IL128084A0 - Conformationally constrained backbone cyclized somatostatin analogs - Google Patents
Conformationally constrained backbone cyclized somatostatin analogsInfo
- Publication number
- IL128084A0 IL128084A0 IL12808497A IL12808497A IL128084A0 IL 128084 A0 IL128084 A0 IL 128084A0 IL 12808497 A IL12808497 A IL 12808497A IL 12808497 A IL12808497 A IL 12808497A IL 128084 A0 IL128084 A0 IL 128084A0
- Authority
- IL
- Israel
- Prior art keywords
- somatostatin analogs
- conformationally constrained
- backbone cyclized
- analogs
- disclosed
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R31/00—Arrangements for testing electric properties; Arrangements for locating electric faults; Arrangements for electrical testing characterised by what is being tested not provided for elsewhere
- G01R31/28—Testing of electronic circuits, e.g. by signal tracer
- G01R31/317—Testing of digital circuits
- G01R31/3181—Functional testing
- G01R31/3185—Reconfiguring for testing, e.g. LSSD, partitioning
- G01R31/318533—Reconfiguring for testing, e.g. LSSD, partitioning using scanning techniques, e.g. LSSD, Boundary Scan, JTAG
- G01R31/318541—Scan latches or cell details
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- General Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/690,090 US5770687A (en) | 1995-06-07 | 1996-07-31 | Comformationally constrained backbone cyclized somatostatin analogs |
PCT/IL1997/000261 WO1998004583A1 (fr) | 1996-07-31 | 1997-07-30 | Analogues de la somatostatine cyclises par squelette a contrainte de conformation |
Publications (1)
Publication Number | Publication Date |
---|---|
IL128084A0 true IL128084A0 (en) | 1999-11-30 |
Family
ID=24771043
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL12808497A IL128084A0 (en) | 1996-07-31 | 1997-07-30 | Conformationally constrained backbone cyclized somatostatin analogs |
Country Status (13)
Country | Link |
---|---|
US (1) | US5770687A (fr) |
EP (1) | EP0920446B1 (fr) |
JP (1) | JP4018752B2 (fr) |
KR (1) | KR100477710B1 (fr) |
CN (1) | CN1124282C (fr) |
AT (1) | ATE363911T1 (fr) |
AU (1) | AU711100B2 (fr) |
BR (1) | BR9710636A (fr) |
CA (1) | CA2262778C (fr) |
DE (1) | DE69737787T2 (fr) |
IL (1) | IL128084A0 (fr) |
NZ (1) | NZ334046A (fr) |
WO (1) | WO1998004583A1 (fr) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6117974A (en) * | 1991-10-02 | 2000-09-12 | Peptor Limited | Libraries of backbone-cyclized peptidomimetics |
IL109943A (en) * | 1994-06-08 | 2006-08-01 | Develogen Israel Ltd | Conformationally constrained backbone cyclized peptide analogs |
US6051554A (en) * | 1995-06-07 | 2000-04-18 | Peptor Limited | Conformationally constrained backbone cyclized somatostatin analogs |
US6841533B1 (en) | 1995-12-07 | 2005-01-11 | Peptor Limited | Conformationally constrained backbone cyclized interleukin-6 antagonists |
WO1997023497A1 (fr) * | 1995-12-22 | 1997-07-03 | University Technologies International Inc. | Bras de liaison pour la synthese d'oligonucleotides sur un support solide et procede pour le former |
US6355613B1 (en) * | 1996-07-31 | 2002-03-12 | Peptor Limited | Conformationally constrained backbone cyclized somatostatin analogs |
AU745493B2 (en) * | 1998-06-16 | 2002-03-21 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Cyclic somatostatin analogs |
US6602849B1 (en) | 1998-06-16 | 2003-08-05 | Societe De Conseils De Recherche Et D'applications Scientifiques, S.A.S. | Cyclic somatostatin analogs |
US7135564B1 (en) * | 1998-07-02 | 2006-11-14 | University Technologies International Inc. | Reusable solid support for oligonucleotide synthesis |
AU6382999A (en) * | 1998-08-24 | 2000-03-14 | Jeffrey D. White | Somatostatin analogs |
US6465613B1 (en) | 1998-11-19 | 2002-10-15 | Tulane University | Hydrophilic somatostatin analogs |
US6358491B1 (en) | 1999-08-27 | 2002-03-19 | Berlex Laboratories, Inc. | Somatostatin analogs |
JP2004501061A (ja) * | 1999-12-15 | 2004-01-15 | ペプトル・リミテツド | 熱ショックタンパク質60のフラグメントおよびアンタゴニスト |
GB0018891D0 (en) | 2000-08-01 | 2000-09-20 | Novartis Ag | Organic compounds |
NZ532204A (en) | 2001-09-21 | 2006-04-28 | Univ Tulane | Diagnostic or therapeutic somatostatin or bombesin analog conjugates and uses thereof |
DK1487493T3 (da) * | 2002-03-01 | 2010-05-25 | Univ Tulane | Konjugater af cytotoksiske midler og biologisk aktive peptider |
IL148921A0 (en) | 2002-03-26 | 2002-09-12 | Peptor Ltd | Photo active backbone cyclized somatostatin analogs for optical imaging and photodynamic therapy |
US7304128B2 (en) | 2002-06-04 | 2007-12-04 | E.I. Du Pont De Nemours And Company | Carbon nanotube binding peptides |
IL150384A0 (en) * | 2002-06-24 | 2002-12-01 | Peptor Ltd | Radiolabelled somatostatin analogs backbone cyclized through metal complexation |
US20040121407A1 (en) * | 2002-09-06 | 2004-06-24 | Elixir Pharmaceuticals, Inc. | Regulation of the growth hormone/IGF-1 axis |
WO2004081031A2 (fr) * | 2003-03-10 | 2004-09-23 | Biogen Idec Inc. | Fixation de medicament a mediation de thiol a des peptides de ciblage |
US20070185031A1 (en) * | 2003-07-14 | 2007-08-09 | Northwestern University | Reducing polyglutamine-based aggregation |
EP1648923B1 (fr) * | 2003-07-31 | 2008-12-31 | Tranzyme Pharma Inc. | Composes macrocycliques definis spatialement incorporant des substituts de liaison peptidique |
GB0318682D0 (en) | 2003-08-08 | 2003-09-10 | Novartis Ag | Organic compounds |
WO2005018682A2 (fr) * | 2003-08-20 | 2005-03-03 | The Regents Of The University Of California | Analogues de somatostatine a activite inhibitrice de liberation d'hormone de croissance |
WO2005041901A2 (fr) * | 2003-11-03 | 2005-05-12 | Elixir Pharmaceuticals, Inc. | Agents therapeutiques utilisant les agonistes de somatostatine |
WO2006045483A2 (fr) * | 2004-10-19 | 2006-05-04 | Lonza Ag | Cyclisation de peptides sur resine |
AU2006253733A1 (en) * | 2005-05-31 | 2006-12-07 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Backbone cyclized melanocortin stimulating hormone (alpha S ) analogs |
US20120270774A1 (en) | 2009-08-28 | 2012-10-25 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd | Macrocyclic compounds, compositions comprising them and methods for preventing or treating hiv infection |
FR2956115B1 (fr) | 2010-02-05 | 2012-04-06 | Isp Investments Inc | Nouveaux peptides activateurs de la caspase-14 et compositions les comprenant |
EP2604281B1 (fr) | 2011-12-14 | 2014-07-30 | Centre National de la Recherche Scientifique (CNRS) | Analogues conjugués de somatostatine coupés pour des applications biologiques |
EP2807182A1 (fr) | 2012-01-23 | 2014-12-03 | Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd. | Hélices peptidiques stabilisées pour l'inhibition de la dimérisation du récepteur 2 de chimiokine de motif c (ccr2) |
WO2015087334A1 (fr) | 2013-12-15 | 2015-06-18 | Yissum Research Develoment Company Of The Hebrew University Of Jerusalem Ltd. | Peptides dérivés de vipéristatine et leurs utilisations |
CN109415413A (zh) | 2016-06-07 | 2019-03-01 | 耶路撒冷希伯来大学伊森姆研究发展有限公司 | 髓样分化因子88(myd88)的主链环化抑制肽 |
US11261215B2 (en) | 2017-09-19 | 2022-03-01 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Somatostatin prodrugs |
WO2020170249A1 (fr) | 2019-02-21 | 2020-08-27 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Peptides dérivés de par4, analogues et leurs utilisations |
WO2022003673A1 (fr) | 2020-06-30 | 2022-01-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Analogues de l'humanine et leurs utilisations |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4011182A (en) * | 1975-03-21 | 1977-03-08 | American Home Products Corporation | Cyclic undecapeptide analogs of somatostatin and intermediates |
US3988304A (en) * | 1975-08-25 | 1976-10-26 | American Home Products Corporation | Cyclic dodecapeptide derivatives of somatostatin and intermediates thereof |
US4054558A (en) * | 1976-05-24 | 1977-10-18 | American Home Products Corporation | Cyclic dodecapeptide and intermediates therefor |
SU798098A1 (ru) * | 1977-12-14 | 1981-01-23 | Ордена Трудового Красного Знамениинститут Органического Синтезаан Латвийской Ccp | Циклический аналог брадикинина,обла-дАющий СпОСОбНОСТью СОздАВАТь пРОлОНги-РОВАННый дЕпРЕССОРНый эффЕКТ B эКСпЕРиМЕН-TE ,A ТАКжЕ ВАСКул РНую пРОНи-цАЕМОСТь B эКСпЕРиМЕНТЕ |
US4310518A (en) * | 1979-10-31 | 1982-01-12 | Merck & Co., Inc. | Cyclic hexapeptide somatostatin analogs |
US4235886A (en) * | 1979-10-31 | 1980-11-25 | Merck & Co., Inc. | Cyclic hexapeptide somatostatin analogs |
US4360516A (en) * | 1981-04-13 | 1982-11-23 | Merck & Co., Inc. | Modified D-retro cyclic hexapeptide somatostatin analogs |
JPS5852259A (ja) * | 1981-09-22 | 1983-03-28 | Shiraimatsu Shinyaku Kk | アミノ酸9個で構成された新規ソマトスタチン類似体 |
DE3264693D1 (en) * | 1981-12-24 | 1985-08-14 | Ciba Geigy Ag | Cyclic octapeptides and pharmaceutical compositions thereof, and processes for their production and use |
US4725577A (en) * | 1985-04-25 | 1988-02-16 | Administrators Of The Tulane Educational Fund | Biologically active lysine containing octapeptides |
US4923963A (en) * | 1987-09-02 | 1990-05-08 | Nova Technology Limited Partnership | Bradykinin antagonist peptides |
EP0334244A3 (fr) * | 1988-03-25 | 1991-05-29 | The Procter & Gamble Company | Peptides antagonistes de Bradykinine |
JPH03504496A (ja) * | 1988-04-08 | 1991-10-03 | スクリプス クリニック アンド リサーチ ファウンデーション | 水素結合の共有結合置換により安定化されたポリペプチド |
IE63490B1 (en) * | 1988-11-24 | 1995-05-03 | Hoechst Ag | Peptides having bradykinin antagonist action |
JP2882679B2 (ja) * | 1989-04-26 | 1999-04-12 | ジ・アドミニストレーターズ・オブ・ザ・ツーレイン・エデュケイショナル・ファンド | 線状ソマトスタチン類似体 |
US5650489A (en) * | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
DE4119544C1 (fr) * | 1991-06-13 | 1992-10-15 | Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf), 3300 Braunschweig, De | |
US5364851A (en) * | 1991-06-14 | 1994-11-15 | International Synthecon, Llc | Conformationally restricted biologically active peptides, methods for their production and uses thereof |
US6117974A (en) * | 1991-10-02 | 2000-09-12 | Peptor Limited | Libraries of backbone-cyclized peptidomimetics |
IL99628A (en) * | 1991-10-02 | 2004-07-25 | Yissum Res Dev Co | Processes for the preparation of cyclic peptides, and pharmaceutical compositions containing them |
US5371070A (en) * | 1992-11-09 | 1994-12-06 | The Salk Institute For Biological Studies | Bicyclic GnRH antagonists and a method for regulating the secretion of gonadotropins |
JPH09500625A (ja) * | 1993-07-09 | 1997-01-21 | スミスクライン・ビーチャム・コーポレイション | 環状セミランダムペプチドライブラリー |
IL109943A (en) * | 1994-06-08 | 2006-08-01 | Develogen Israel Ltd | Conformationally constrained backbone cyclized peptide analogs |
-
1996
- 1996-07-31 US US08/690,090 patent/US5770687A/en not_active Expired - Lifetime
-
1997
- 1997-07-30 NZ NZ334046A patent/NZ334046A/en unknown
- 1997-07-30 EP EP97932978A patent/EP0920446B1/fr not_active Expired - Lifetime
- 1997-07-30 JP JP50866698A patent/JP4018752B2/ja not_active Expired - Fee Related
- 1997-07-30 AT AT97932978T patent/ATE363911T1/de not_active IP Right Cessation
- 1997-07-30 DE DE69737787T patent/DE69737787T2/de not_active Expired - Fee Related
- 1997-07-30 KR KR10-1999-7000727A patent/KR100477710B1/ko not_active IP Right Cessation
- 1997-07-30 CA CA002262778A patent/CA2262778C/fr not_active Expired - Fee Related
- 1997-07-30 WO PCT/IL1997/000261 patent/WO1998004583A1/fr active IP Right Grant
- 1997-07-30 AU AU36331/97A patent/AU711100B2/en not_active Ceased
- 1997-07-30 IL IL12808497A patent/IL128084A0/xx unknown
- 1997-07-30 CN CN97198197A patent/CN1124282C/zh not_active Expired - Fee Related
- 1997-07-30 BR BR9710636-4A patent/BR9710636A/pt not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2262778A1 (fr) | 1998-02-05 |
KR20000029654A (ko) | 2000-05-25 |
JP2000516592A (ja) | 2000-12-12 |
ATE363911T1 (de) | 2007-06-15 |
BR9710636A (pt) | 2000-01-11 |
AU3633197A (en) | 1998-02-20 |
CA2262778C (fr) | 2006-10-10 |
EP0920446A1 (fr) | 1999-06-09 |
DE69737787T2 (de) | 2008-03-06 |
WO1998004583A1 (fr) | 1998-02-05 |
US5770687A (en) | 1998-06-23 |
CN1124282C (zh) | 2003-10-15 |
EP0920446B1 (fr) | 2007-06-06 |
NZ334046A (en) | 1999-10-28 |
DE69737787D1 (de) | 2007-07-19 |
CN1231672A (zh) | 1999-10-13 |
KR100477710B1 (ko) | 2005-03-18 |
AU711100B2 (en) | 1999-10-07 |
EP0920446A4 (fr) | 2004-06-02 |
JP4018752B2 (ja) | 2007-12-05 |
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