IL126544A - Test for component detection using detectable particles in diffused light - Google Patents

Test for component detection using detectable particles in diffused light

Info

Publication number
IL126544A
IL126544A IL12654497A IL12654497A IL126544A IL 126544 A IL126544 A IL 126544A IL 12654497 A IL12654497 A IL 12654497A IL 12654497 A IL12654497 A IL 12654497A IL 126544 A IL126544 A IL 126544A
Authority
IL
Israel
Prior art keywords
particles
light
particle
scattered
analytes
Prior art date
Application number
IL12654497A
Other languages
English (en)
Hebrew (he)
Other versions
IL126544A0 (en
Original Assignee
Genicon Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genicon Sciences Inc filed Critical Genicon Sciences Inc
Publication of IL126544A0 publication Critical patent/IL126544A0/xx
Publication of IL126544A publication Critical patent/IL126544A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1456—Electro-optical investigation, e.g. flow cytometers without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Electro-optical investigation, e.g. flow cytometers without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N2015/0038—Investigating nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N2015/1493—Particle size
IL12654497A 1996-04-25 1997-04-17 Test for component detection using detectable particles in diffused light IL126544A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1638396P 1996-04-25 1996-04-25
PCT/US1997/006584 WO1997040181A1 (en) 1996-04-25 1997-04-17 Analyte assay using particulate labels

Publications (2)

Publication Number Publication Date
IL126544A0 IL126544A0 (en) 1999-08-17
IL126544A true IL126544A (en) 2004-08-31

Family

ID=21776844

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12654497A IL126544A (en) 1996-04-25 1997-04-17 Test for component detection using detectable particles in diffused light

Country Status (12)

Country Link
US (1) US6214560B1 (xx)
EP (1) EP1021554B1 (xx)
JP (3) JP2000510582A (xx)
CN (1) CN1262667C (xx)
AT (1) ATE357663T1 (xx)
AU (1) AU736340B2 (xx)
BR (1) BR9710836A (xx)
CA (1) CA2253710A1 (xx)
DE (1) DE69737513T2 (xx)
IL (1) IL126544A (xx)
RU (1) RU2251572C2 (xx)
WO (1) WO1997040181A1 (xx)

Families Citing this family (309)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US6586193B2 (en) * 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
US7169556B2 (en) 1996-07-29 2007-01-30 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US7098320B1 (en) 1996-07-29 2006-08-29 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6506564B1 (en) 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6361944B1 (en) 1996-07-29 2002-03-26 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US20020172953A1 (en) * 1996-07-29 2002-11-21 Mirkin Chad A. Movement of biomolecule-coated nanoparticles in an electric field
US6984491B2 (en) * 1996-07-29 2006-01-10 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6582921B2 (en) 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
CA2262018C (en) * 1996-07-29 2007-10-02 Nanosphere Llc Nanoparticles having oligonucleotides attached thereto and uses therefor
US6750016B2 (en) 1996-07-29 2004-06-15 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
GB9618897D0 (en) 1996-09-10 1996-10-23 Bio Rad Micromeasurements Ltd Micro defects in silicon wafers
CA2279574C (en) 1997-01-31 2007-07-24 The Horticulture & Food Research Institute Of New Zealand Ltd. Optical apparatus
JP4209471B2 (ja) 1997-02-20 2009-01-14 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア プラズモン共鳴粒子、方法、および装置
US6852252B2 (en) 1997-03-12 2005-02-08 William Marsh Rice University Use of metalnanoshells to impede the photo-oxidation of conjugated polymer
US6344272B1 (en) 1997-03-12 2002-02-05 Wm. Marsh Rice University Metal nanoshells
CA2291180A1 (en) * 1997-05-23 1998-11-26 Lynx Therapeutics, Inc. System and apparatus for sequential processing of analytes
US6974669B2 (en) 2000-03-28 2005-12-13 Nanosphere, Inc. Bio-barcodes based on oligonucleotide-modified nanoparticles
US20050037397A1 (en) * 2001-03-28 2005-02-17 Nanosphere, Inc. Bio-barcode based detection of target analytes
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US6699724B1 (en) 1998-03-11 2004-03-02 Wm. Marsh Rice University Metal nanoshells for biosensing applications
US6428811B1 (en) 1998-03-11 2002-08-06 Wm. Marsh Rice University Temperature-sensitive polymer/nanoshell composites for photothermally modulated drug delivery
US20030153023A1 (en) * 1999-05-13 2003-08-14 Starzl Timothy W. Enumeration method of analyte detection
EP1135682B1 (en) 1998-11-30 2007-07-11 Nanosphere, Inc. Nanoparticles with polymer shells
EP1141762A1 (de) * 1998-12-17 2001-10-10 Leica Microsystems Heidelberg GmbH Verfahren zur differenzierten untersuchung unterschiedlicher strukturen in vorzugsweise biologischen präparaten
EP1039291A1 (en) * 1999-03-26 2000-09-27 Sony International (Europe) GmbH Optochemical sensor and method for its construction
US20050100943A1 (en) * 2000-04-11 2005-05-12 Hideki Kambara Method of producing probe arrays for biological materials using fine particles
EP1175505A4 (en) * 1999-04-15 2005-04-20 Vitra Bioscience Inc COMBINATORY CHEMICAL BANK HOLDERS HAVING BRANDS AT CODING POSITIONS, AND METHODS OF USE
US6908737B2 (en) * 1999-04-15 2005-06-21 Vitra Bioscience, Inc. Systems and methods of conducting multiplexed experiments
US20030166015A1 (en) * 1999-04-15 2003-09-04 Zarowitz Michael A. Multiplexed analysis of cell-substrate interactions
US7253435B2 (en) * 1999-04-15 2007-08-07 Millipore Corporation Particles with light-polarizing codes
US20030207249A1 (en) * 1999-04-15 2003-11-06 Beske Oren E. Connection of cells to substrates using association pairs
US20030129654A1 (en) * 1999-04-15 2003-07-10 Ilya Ravkin Coded particles for multiplexed analysis of biological samples
US20030134330A1 (en) * 1999-04-15 2003-07-17 Ilya Ravkin Chemical-library composition and method
US6868371B1 (en) * 1999-05-03 2005-03-15 General Electric Company System and method to quantify appearance defects in molded plastic parts
US6608716B1 (en) 1999-05-17 2003-08-19 New Mexico State University Technology Transfer Corporation Optical enhancement with nanoparticles and microcavities
US20030096321A1 (en) * 1999-05-19 2003-05-22 Jose Remacle Method for the identification and/or the quantification of a target compound obtained from a biological sample upon chips
US6606566B1 (en) * 1999-11-01 2003-08-12 Steven A. Sunshine Computer code for portable sensing
US7033840B1 (en) 1999-11-09 2006-04-25 Sri International Reaction calorimeter and differential scanning calorimeter for the high-throughput synthesis, screening and characterization of combinatorial libraries
WO2001034291A2 (en) 1999-11-09 2001-05-17 Sri International High-throughput synthesis, screening and characterization of combinatorial libraries
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
AU774593C (en) 2000-01-13 2005-06-23 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
AU2001275475A1 (en) * 2000-06-12 2001-12-24 Genicon Sciences Corporation Assay for genetic polymorphisms using scattered light detectable labels
AU7687001A (en) 2000-07-11 2002-01-21 Nanospherre Inc Method of detection by enhancement of silver staining
JP2004537712A (ja) 2000-10-18 2004-12-16 バーチャル・アレイズ・インコーポレーテッド 多重細胞分析システム
US7713687B2 (en) * 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
WO2002043486A1 (en) 2000-11-29 2002-06-06 Xy, Inc. System for in-vitro fertilization with spermatozoa separated into x-chromosome and y-chromosome bearing populations
WO2002046483A2 (en) 2000-12-06 2002-06-13 Northwestern University Silver stain removal from dna detection chips by cyanide etching or sonication
US7015047B2 (en) * 2001-01-26 2006-03-21 Aviva Biosciences Corporation Microdevices having a preferential axis of magnetization and uses thereof
US7811768B2 (en) * 2001-01-26 2010-10-12 Aviva Biosciences Corporation Microdevice containing photorecognizable coding patterns and methods of using and producing the same
CA2439307A1 (en) 2001-02-23 2002-09-06 Genicon Sciences Corporation Methods for providing extended dynamic range in analyte assays
US20040166502A1 (en) * 2001-03-13 2004-08-26 Yaming Lai Microelectromagnetic dispenser heads and uses thereof
WO2002079490A2 (en) * 2001-03-28 2002-10-10 Nanosphere, Inc. Bio-barcodes based on oligonucleotide-modified particles
US20060040286A1 (en) * 2001-03-28 2006-02-23 Nanosphere, Inc. Bio-barcode based detection of target analytes
US7354733B2 (en) * 2001-03-29 2008-04-08 Cellect Technologies Corp. Method for sorting and separating living cells
US20040253637A1 (en) * 2001-04-13 2004-12-16 Biosite Incorporated Markers for differential diagnosis and methods of use thereof
US7713705B2 (en) * 2002-12-24 2010-05-11 Biosite, Inc. Markers for differential diagnosis and methods of use thereof
US20040126767A1 (en) * 2002-12-27 2004-07-01 Biosite Incorporated Method and system for disease detection using marker combinations
US20040121350A1 (en) * 2002-12-24 2004-06-24 Biosite Incorporated System and method for identifying a panel of indicators
US20040203083A1 (en) * 2001-04-13 2004-10-14 Biosite, Inc. Use of thrombus precursor protein and monocyte chemoattractant protein as diagnostic and prognostic indicators in vascular diseases
US20030113740A1 (en) * 2001-04-26 2003-06-19 Mirkin Chad A. Oligonucleotide-modified ROMP polymers and co-polymers
US7147687B2 (en) * 2001-05-25 2006-12-12 Nanosphere, Inc. Non-alloying core shell nanoparticles
US7238472B2 (en) * 2001-05-25 2007-07-03 Nanosphere, Inc. Non-alloying core shell nanoparticles
AU2002320058A1 (en) 2001-06-06 2002-12-16 The General Hspital Corporation Magnetic-nanoparticle conjugates and methods of use
AU2002310343A1 (en) * 2001-06-07 2002-12-16 University Of Pennsylvania-Center For Technology Transfer Multiplexing method
US6714299B2 (en) 2001-07-13 2004-03-30 Genicon Sciences Corporation Use of light scattering particles in design, manufacture, and quality control of small volume instruments, devices, and processes
WO2003053535A2 (en) * 2001-08-03 2003-07-03 Nanosphere, Inc. Nanoparticle imaging system and method
US20040146917A1 (en) * 2001-08-03 2004-07-29 Nanosphere, Inc. Nanoparticle imaging system and method
US20030049866A1 (en) * 2001-09-05 2003-03-13 Genicon Sciences Corporation Sample device preservation
WO2003021853A2 (en) * 2001-09-05 2003-03-13 Genicon Sciences Corporation Apparatus for reading signals generated from resonance light scattered particle labels
EP1432786B1 (en) * 2001-09-06 2009-07-22 Genomic Profiling Systems, Inc. Rapid detection of replicating cells
CN100420739C (zh) 2001-09-20 2008-09-24 抗癌公司 表达巢蛋白的毛囊干细胞
US6754414B2 (en) * 2001-09-27 2004-06-22 Bio-Rad Laboratories, Inc. Imaging of microarrays using fiber optic exciter
US8148171B2 (en) * 2001-10-09 2012-04-03 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
WO2003035829A2 (en) * 2001-10-09 2003-05-01 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US20030219800A1 (en) * 2001-10-18 2003-11-27 Beske Oren E. Multiplexed cell transfection using coded carriers
DE60228128D1 (de) * 2001-11-09 2008-09-18 Nanosphere Inc Biokonjugat-nanopartikelsonden
US7083975B2 (en) * 2002-02-01 2006-08-01 Roland Green Microarray synthesis instrument and method
US7214427B2 (en) * 2002-03-21 2007-05-08 Aviva Biosciences Corporation Composite beads comprising magnetizable substance and electro-conductive substance
US7029631B2 (en) * 2002-04-19 2006-04-18 Agilent Technologies, Inc. Apparatus for improved light collection
US20030211488A1 (en) * 2002-05-07 2003-11-13 Northwestern University Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection
WO2003096015A1 (fr) * 2002-05-08 2003-11-20 Matsushita Electric Industrial Co., Ltd. Substrat biomoleculaire, masse moleculaire d'essai ou de diagnostic utilisant ce substrat, et appareil s'y rapportant
US20040126773A1 (en) * 2002-05-23 2004-07-01 Beske Oren E. Assays with coded sensor particles to sense assay conditions
GB2389230A (en) 2002-05-28 2003-12-03 Univ Nat Taiwan Nanoparticle light emitting device (LED)
JP2005532456A (ja) * 2002-07-02 2005-10-27 ナノスフェアー　インコーポレイテッド ナノ粒子ポリアニオン複合物ならびに分析物の検出における同複合物の用途
MXPA05000865A (es) * 2002-07-22 2005-04-28 Xy Inc Sistema para el proceso de celulas espermaticas.
US20040018495A1 (en) * 2002-07-24 2004-01-29 Xing-Xiang Li Microparticle based signal amplification for the detection of analytes
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
MXPA05001100A (es) * 2002-08-01 2005-04-28 Xy Inc Sistema de separacion de baja presion para celulas de esperma.
MXPA05001654A (es) 2002-08-15 2005-10-18 Xy Inc Citometro de flujo de alta resolucion.
US7901630B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Diffraction grating-based encoded microparticle assay stick
WO2004019277A1 (en) * 2002-08-20 2004-03-04 Cyvera Corporation Diffraction grating-based encoded micro-particles for multiplexed experiments
US7508608B2 (en) 2004-11-17 2009-03-24 Illumina, Inc. Lithographically fabricated holographic optical identification element
US7164533B2 (en) 2003-01-22 2007-01-16 Cyvera Corporation Hybrid random bead/chip based microarray
US7399643B2 (en) * 2002-09-12 2008-07-15 Cyvera Corporation Method and apparatus for aligning microbeads in order to interrogate the same
US7900836B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Optical reader system for substrates having an optically readable code
US7872804B2 (en) 2002-08-20 2011-01-18 Illumina, Inc. Encoded particle having a grating with variations in the refractive index
US7923260B2 (en) 2002-08-20 2011-04-12 Illumina, Inc. Method of reading encoded particles
AU2003265583C1 (en) * 2002-08-20 2009-05-21 Cyvera Corporation Diffraction grating-based optical identification element
US20040043385A1 (en) * 2002-09-03 2004-03-04 Yo-Hsin Su Microarray biochip
US7092160B2 (en) 2002-09-12 2006-08-15 Illumina, Inc. Method of manufacturing of diffraction grating-based optical identification element
AU2003270726A1 (en) * 2002-09-12 2004-04-30 Cidra Corporation Diffraction grating-based encoded micro-particles for multiplexed experiments
US20100255603A9 (en) * 2002-09-12 2010-10-07 Putnam Martin A Method and apparatus for aligning microbeads in order to interrogate the same
CA2498916A1 (en) * 2002-09-12 2004-03-25 Cyvera Corporation Chemical synthesis using diffraction grating-based encoded optical elements
EP1540592A1 (en) * 2002-09-12 2005-06-15 Cyvera Corporation Method and apparatus for labeling using diffraction grating-based encoded optical identification elements
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
US20060183106A1 (en) * 2002-10-18 2006-08-17 Adam Siddiqui-Jain Processes for identifying quadruplex-targeted antiviral molecules
WO2004042403A2 (en) * 2002-11-04 2004-05-21 Ludwig-Maximilian-Uni Versität München Methods, device and instrument for detection of analytes
US7122384B2 (en) * 2002-11-06 2006-10-17 E. I. Du Pont De Nemours And Company Resonant light scattering microparticle methods
AU2003302340B8 (en) * 2002-12-24 2008-09-11 Biosite Incorporated Markers for differential diagnosis and methods of use thereof
WO2004064751A2 (en) * 2003-01-16 2004-08-05 St. Johns University New York Nanoparticle based stabilization of ir fluorescent dyes
EP1597399A2 (en) * 2003-02-27 2005-11-23 Nanosphere, Inc. Label-free gene expression profiling with universal nanoparticle probes in microarray assay format
ES2546658T3 (es) * 2003-03-27 2015-09-25 The General Hospital Corporation Método para tratamiento dermatológico cosmético y renovación fraccionada de la piel
MX347048B (es) 2003-03-28 2017-04-07 Inguran Llc * Aparato de muestreo digital y métodos para separar partículas.
EP1610759A4 (en) * 2003-04-07 2007-04-25 Cylene Pharmaceuticals Inc SUBSTITUTED QUINOBENZOXAZINE ANALOGUES
US7354916B2 (en) * 2003-04-07 2008-04-08 Cylene Pharmaceuticals Substituted quinobenzoxazine analogs
WO2004091627A2 (en) * 2003-04-07 2004-10-28 Cylene Pharmaceuticals, Inc. Heterocyclic substituted 1,4-dihydro-4-oxo-1,8-naphthpyridine analogs
US7507727B2 (en) * 2003-04-07 2009-03-24 Cylene Pharmaceuticals, Inc. Substituted quinobenzoxazine analogs and methods of using thereof
GB0308182D0 (en) * 2003-04-09 2003-05-14 Aoti Operating Co Inc Detection method and apparatus
US7177487B2 (en) * 2003-04-21 2007-02-13 Baxter International Inc. Determination of particle size by image analysis
ES2541121T3 (es) * 2003-05-15 2015-07-16 Xy, Llc Clasificación eficiente de células haploides por sistemas de citometría de flujo
US20050250094A1 (en) * 2003-05-30 2005-11-10 Nanosphere, Inc. Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes
US7341841B2 (en) * 2003-07-12 2008-03-11 Accelr8 Technology Corporation Rapid microbial detection and antimicrobial susceptibility testing
US20120077206A1 (en) 2003-07-12 2012-03-29 Accelr8 Technology Corporation Rapid Microbial Detection and Antimicrobial Susceptibility Testing
CA2956645A1 (en) 2003-07-12 2005-03-31 David A. Goldberg Sensitive and rapid biodetection
US7641971B2 (en) * 2003-08-13 2010-01-05 Crane Company Metal-treated particles for remediation
WO2005074417A2 (en) * 2003-09-03 2005-08-18 Salk Institute For Biological Studies Multiple antigen detection assays and reagents
US20050208468A1 (en) * 2003-09-15 2005-09-22 Beske Oren E Assays with primary cells
US7488451B2 (en) * 2003-09-15 2009-02-10 Millipore Corporation Systems for particle manipulation
US7413868B2 (en) * 2003-11-05 2008-08-19 Trellis Bioscience, Inc. Use of particulate labels in bioanalyte detection methods
WO2005062940A2 (en) 2003-12-22 2005-07-14 John Wayne Cancer Institute Method and apparatus for in vivo collection and surveillance of circulating biological components
US20050153309A1 (en) 2003-12-22 2005-07-14 David Hoon Method and apparatus for in vivo surveillance of circulating biological components
US7553625B2 (en) * 2003-12-22 2009-06-30 John Wayne Cancer Institute Method and apparatus for in vivo collection of circulating biological components
WO2005066613A1 (en) 2003-12-31 2005-07-21 President And Fellows Of Harvard College Assay device and method
US20050141843A1 (en) * 2003-12-31 2005-06-30 Invitrogen Corporation Waveguide comprising scattered light detectable particles
WO2005072858A1 (en) 2004-01-26 2005-08-11 President And Fellows Of Harvard College Fluid delivery system and method
US8030057B2 (en) * 2004-01-26 2011-10-04 President And Fellows Of Harvard College Fluid delivery system and method
DE102004006470B4 (de) * 2004-02-06 2006-06-01 Senova Gesellschaft für Biowissenschaft und Technik mbH Absorptionsphotometrisches Verfahren zur quantitativen Stoffanalyse
US7433123B2 (en) * 2004-02-19 2008-10-07 Illumina, Inc. Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein
US20060023310A1 (en) * 2004-02-19 2006-02-02 Putnam Martin A Optical identification element using separate or partially overlapped diffraction gratings
WO2005079545A2 (en) * 2004-02-19 2005-09-01 Illumina, Inc. Optical identification element using separate or partially overlapped diffraction gratings
US20050270603A1 (en) * 2004-02-19 2005-12-08 Cyuera Corporation Optical identification element using separate or partially overlapped diffraction gratings
CA2561661C (en) 2004-03-29 2015-11-24 Monsanto Technology Llc Sperm suspensions for sorting into x or y chromosome-bearing enriched populations
US7407816B2 (en) * 2004-05-07 2008-08-05 Gentius, Inc Isoelectric particles and uses thereof
US20090054255A1 (en) * 2004-07-01 2009-02-26 The Regents Of The University Of California Microfluidic devices and methods
DE102004034486B4 (de) * 2004-07-16 2007-08-23 Infineon Technologies Ag Verfahren zum Nachweis von Lumineszenzlicht aus einer porösen Trägerstruktur
WO2006020363A2 (en) 2004-07-21 2006-02-23 Illumina, Inc. Method and apparatus for drug product tracking using encoded optical identification elements
AR049732A1 (es) 2004-07-22 2006-08-30 Monsanto Co Proceso para enriquecer una poblacion de celulas de esperma
CA2572178A1 (en) * 2004-07-26 2006-03-16 Nanosphere, Inc. Method for distinguishing methicillin resistant s. aureus from methicillin sensitive s. aureus in a mixed culture
US20060024815A1 (en) * 2004-07-30 2006-02-02 Allman Steve L High sensitivity array-based detection system
US9494581B2 (en) 2004-08-24 2016-11-15 University Of Wyoming System and method for Raman spectroscopy assay using paramagnetic particles
US7288134B2 (en) * 2004-09-10 2007-10-30 International Business Machines Corporation Dumbbell-like nanoparticles and a process of forming the same
EP2339342B1 (en) * 2004-09-14 2014-11-12 LSI Medience Corporation Biomaterial structure, method of producing the same and uses thereof
US7612769B2 (en) * 2004-09-14 2009-11-03 E.I. Du Pont De Nemours And Company Computer-implemented methods for organizing image data produced by resonant Mie scattering of light from microparticles and resulting data structures
RU2464320C2 (ru) * 2004-09-24 2012-10-20 Инджиниес Инк. Геномный анализ
DE602005019791D1 (de) 2004-11-16 2010-04-15 Illumina Inc Verfahren und vorrichtung zum lesen von kodierten mikrokugeln
WO2006055735A2 (en) * 2004-11-16 2006-05-26 Illumina, Inc Scanner having spatial light modulator
AU2006236410B2 (en) 2005-04-19 2012-11-01 President And Fellows Of Harvard College Fluidic structures including meandering and wide channels
CA2606924C (en) 2005-05-09 2013-04-16 The General Hospital Corporation Water relaxation-based sensors
WO2007002567A2 (en) * 2005-06-23 2007-01-04 Nanosphere, Inc. Selective isolation and concentration of nucleic acids from complex samples
US8597576B2 (en) * 2005-06-23 2013-12-03 National Institute Of Advanced Industrial Science And Technology Analyzer for glycan or complex carbohydrate
TWI391645B (zh) * 2005-07-06 2013-04-01 Nanometrics Inc 晶圓或其他工作表面下污染物及缺陷非接觸測量之差分波長光致發光
TWI439684B (zh) * 2005-07-06 2014-06-01 Nanometrics Inc 具自晶圓或其他工件特定材料層所發射光致發光信號優先偵測之光致發光成像
CA2659640C (en) 2005-08-02 2011-11-15 University Of Maryland Biotechnology Institute Nanostructures for polarized imaging and receptor/ligand quantization: breaking the diffraction limit for imaging
ATE489482T1 (de) * 2005-08-19 2010-12-15 Nanosphere Inc Verfahren zur herstellung von hybridsubstraten mit dna und antikörpern sowie verwendungen davon
JP5295769B2 (ja) 2005-08-31 2013-09-18 ティツー・バイオシステムズ・インコーポレーテッド 分析物を検出するためのｎｍｒ装置
WO2007030521A1 (en) * 2005-09-06 2007-03-15 Invitrogen Corporation Control of chemical modification
US9057046B2 (en) 2005-09-26 2015-06-16 Rapid Micro Biosystems, Inc. Cassette containing growth medium
US7723120B2 (en) 2005-10-26 2010-05-25 General Electric Company Optical sensor array system and method for parallel processing of chemical and biochemical information
US8133741B2 (en) 2005-10-26 2012-03-13 General Electric Company Methods and systems for delivery of fluidic samples to sensor arrays
US20090291437A1 (en) * 2005-11-02 2009-11-26 O'brien Sean Methods for targeting quadruplex sequences
US7623624B2 (en) * 2005-11-22 2009-11-24 Illumina, Inc. Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction
WO2007087582A1 (en) 2006-01-24 2007-08-02 Invitrogen Corporation Device and methods for quantifying analytes
US7830575B2 (en) 2006-04-10 2010-11-09 Illumina, Inc. Optical scanner with improved scan time
US10488408B2 (en) * 2006-05-09 2019-11-26 Koninklijke Philips N.V. Detection of target molecules in a sample by using a magnetic field
EP2021766A2 (en) * 2006-05-17 2009-02-11 Luminex Corporation Chip-based flow cytometer type systems for analyzing fluorescently tagged particles
EP2602321B1 (en) 2006-05-31 2017-08-23 Sequenom, Inc. Methods and compositions for the extraction and amplification of nucleic acid from a sample
US8207509B2 (en) 2006-09-01 2012-06-26 Pacific Biosciences Of California, Inc. Substrates, systems and methods for analyzing materials
JP5151097B2 (ja) * 2006-09-01 2013-02-27 株式会社リコー 複合金属ナノ粒子、複合金属ナノ粒子を含む多光子吸収反応材料と反応生成物、複合金属ナノ粒子を含む多光子吸収反応助剤
US8124598B2 (en) 2006-09-14 2012-02-28 Sharon Sageman 7-keto DHEA for psychiatric use
US7902345B2 (en) 2006-12-05 2011-03-08 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
US20120321759A1 (en) * 2007-01-05 2012-12-20 Myskin, Inc. Characterization of food materials by optomagnetic fingerprinting
CN101583863A (zh) * 2007-01-19 2009-11-18 图德·阿尔温特 用于检测和登记样品性质的方法和设备
DK2152417T3 (en) 2007-05-04 2018-08-06 Opko Diagnostics Llc APPARATUS AND PROCEDURE FOR ANALYSIS IN MICROFLUID SYSTEMS
US7883898B2 (en) 2007-05-07 2011-02-08 General Electric Company Method and apparatus for measuring pH of low alkalinity solutions
US8097422B2 (en) 2007-06-20 2012-01-17 Salk Institute For Biological Studies Kir channel modulators
US9097644B2 (en) 2007-08-17 2015-08-04 Massachusetts Institute Of Technology Magnetic resonance-based viscometers and methods
US9404150B2 (en) 2007-08-29 2016-08-02 Sequenom, Inc. Methods and compositions for universal size-specific PCR
US20100160274A1 (en) * 2007-09-07 2010-06-24 Sharon Sageman 7-KETO DHEA for Psychiatric Use
US8278057B2 (en) * 2007-09-14 2012-10-02 Nestec S.A. Addressable antibody arrays and methods of use
JP4597175B2 (ja) * 2007-09-21 2010-12-15 株式会社日立ハイテクノロジーズ 標的物質を検出するための分析装置、又は分析方法、若しくはこれら分析装置及び分析方法に用いるデバイス
CN101836102B (zh) * 2007-10-25 2012-02-29 皇家飞利浦电子股份有限公司 用于样品中靶粒子的传感器装置
JP4975599B2 (ja) * 2007-12-17 2012-07-11 シスメックス株式会社 標本作製装置および標本作製方法
JP2009150799A (ja) * 2007-12-21 2009-07-09 Sysmex Corp 分析装置、コンピュータプログラムおよび分析方法
US20090181361A1 (en) * 2008-01-14 2009-07-16 Weidong Xu Rapid test for detecting infection
US8852864B2 (en) 2008-01-17 2014-10-07 Sequenom Inc. Methods and compositions for the analysis of nucleic acids
EP2271772B1 (en) 2008-03-11 2014-07-16 Sequenom, Inc. Nucleic acid-based tests for prenatal gender determination
JP2009229103A (ja) * 2008-03-19 2009-10-08 Toshiba Corp 金属コロイドの定量方法
RU2472221C2 (ru) * 2008-03-21 2013-01-10 Закрытое акционерное общество "СЕЛЬМАШПРОЕКТ" Система для моделирования генетической и лингвистической информации
EP2285491A1 (en) 2008-04-25 2011-02-23 Claros Diagnostics, Inc. Flow control in microfluidic systems
KR101947004B1 (ko) * 2008-06-10 2019-02-12 엑스트랄리스 테크놀로지 리미티드 입자 검출
TW201017149A (en) * 2008-08-06 2010-05-01 Invitrox Inc Use of focused light scattering techniques in biological applications
WO2010033193A2 (en) 2008-09-16 2010-03-25 Pacific Biosciences Of California, Inc. Substrates and optical systems and methods of use thereof
US8962247B2 (en) * 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
CA2738317C (en) 2008-09-24 2020-01-14 Straus Holdings Inc. Imaging analyzer for testing analytes
EP2331941B1 (en) * 2008-09-25 2014-11-12 Koninklijke Philips N.V. Detection system and method
US9157974B2 (en) 2008-10-29 2015-10-13 T2 Biosystems, Inc. NMR detection of coagulation time
US10533215B2 (en) 2008-11-24 2020-01-14 Sequenom, Inc. Nucleic acid quantification products and processes
US8591829B2 (en) 2008-12-18 2013-11-26 Opko Diagnostics, Llc Reagent storage in microfluidic systems and related articles and methods
CN102365543A (zh) 2009-01-16 2012-02-29 纽约大学 用全息视频显微术的自动实时粒子表征和三维速度计量
EP3278877B1 (en) 2009-02-02 2020-06-03 Opko Diagnostics, LLC Structures for controlling light interaction with microfluidic devices
WO2010099137A2 (en) 2009-02-26 2010-09-02 Osi Pharmaceuticals, Inc. In situ methods for monitoring the emt status of tumor cells in vivo
CA2755615A1 (en) * 2009-03-18 2010-09-23 Sequenom, Inc. Use of thermostable endonucleases for generating reporter molecules
EP2414545B1 (en) 2009-04-03 2017-01-11 Sequenom, Inc. Nucleic acid preparation compositions and methods
US8697435B2 (en) * 2009-08-31 2014-04-15 Mbio Diagnostics, Inc. Integrated sample preparation and analyte detection
US20110143378A1 (en) * 2009-11-12 2011-06-16 CyVek LLC. Microfluidic method and apparatus for high performance biological assays
US9700889B2 (en) 2009-11-23 2017-07-11 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
US9651568B2 (en) 2009-11-23 2017-05-16 Cyvek, Inc. Methods and systems for epi-fluorescent monitoring and scanning for microfluidic assays
JP5701894B2 (ja) 2009-11-23 2015-04-15 サイヴェク・インコーポレイテッド アッセイを行う方法及び装置
US9759718B2 (en) 2009-11-23 2017-09-12 Cyvek, Inc. PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use
US10065403B2 (en) 2009-11-23 2018-09-04 Cyvek, Inc. Microfluidic assay assemblies and methods of manufacture
US9500645B2 (en) 2009-11-23 2016-11-22 Cyvek, Inc. Micro-tube particles for microfluidic assays and methods of manufacture
US9855735B2 (en) 2009-11-23 2018-01-02 Cyvek, Inc. Portable microfluidic assay devices and methods of manufacture and use
HUE053571T2 (hu) 2009-11-24 2021-07-28 Opko Diagnostics Llc Folyadékkeverés és szállítás mikrofluid rendszerekben
CN102667452B (zh) * 2009-12-18 2014-12-24 皇家飞利浦电子股份有限公司 物质确定设备
WO2011087760A2 (en) 2009-12-22 2011-07-21 Sequenom, Inc. Processes and kits for identifying aneuploidy
EP2558203A1 (en) 2010-04-16 2013-02-20 Opko Diagnostics, LLC Systems and devices for analysis of samples
USD645971S1 (en) 2010-05-11 2011-09-27 Claros Diagnostics, Inc. Sample cassette
CA2812208C (en) * 2010-09-24 2019-10-22 The Governing Council Of The University Of Toronto Synthesis of fluorescent noble metal nanoparticles
US8409807B2 (en) 2010-10-22 2013-04-02 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
CN103384724B (zh) 2010-10-22 2017-11-17 T2生物系统公司 用于检测分析物的核磁共振系统和方法
DK2673373T6 (da) 2011-02-08 2021-08-23 Medimmune Llc Antistoffer, der binder specifikt til staphylococcus aureus alfa-toksin, og fremgangsmåder til anvendelse
JP5681517B2 (ja) * 2011-02-15 2015-03-11 新日本空調株式会社 粒子導電性判別装置及び粒子導電性判別方法
WO2012122314A2 (en) 2011-03-07 2012-09-13 Accelr8 Technology Corporation Rapid cell purification systems
US10254204B2 (en) 2011-03-07 2019-04-09 Accelerate Diagnostics, Inc. Membrane-assisted purification
CN106552682B (zh) 2011-03-22 2020-06-19 西维克公司 微流体装置以及制造方法和用途
EP3378954B1 (en) 2011-04-29 2021-02-17 Sequenom, Inc. Quantification of a minority nucleic acid species
WO2012177792A2 (en) 2011-06-24 2012-12-27 Sequenom, Inc. Methods and processes for non-invasive assessment of a genetic variation
EP2732046B1 (en) 2011-07-13 2017-09-06 T2 Biosystems, Inc. Nmr methods for monitoring blood clot formation
JP5762225B2 (ja) * 2011-09-08 2015-08-12 新留　康郎 銀シェル金ナノロッドを用いる分析方法
US10620205B2 (en) 2011-09-21 2020-04-14 T2 Biosystems, Inc. NMR methods for endotoxin analysis
US9367663B2 (en) 2011-10-06 2016-06-14 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9984198B2 (en) 2011-10-06 2018-05-29 Sequenom, Inc. Reducing sequence read count error in assessment of complex genetic variations
US10196681B2 (en) 2011-10-06 2019-02-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10424394B2 (en) 2011-10-06 2019-09-24 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2013052907A2 (en) 2011-10-06 2013-04-11 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US8688388B2 (en) 2011-10-11 2014-04-01 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
PL3327110T3 (pl) 2011-11-07 2020-07-27 Rapid Micro Biosystems, Inc. Kaseta do badania sterylności
DE102011087679B3 (de) * 2011-12-02 2013-04-18 Schildtec GmbH Meßkammer für einen optisch arbeitenden Sensor zum Bestimmen einer Konzentration eines Stoffes
ES2929923T3 (es) 2012-01-20 2022-12-02 Sequenom Inc Procesos de diagnóstico que condicionan las condiciones experimentales
EP4155401A1 (en) 2012-03-02 2023-03-29 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EA030682B1 (ru) 2012-03-05 2018-09-28 Ой Арктик Партнерс Аб Способы и аппараты для прогнозирования риска рака предстательной железы и объема предстательной железы
JP2013181935A (ja) * 2012-03-05 2013-09-12 Fujifilm Corp クロマトグラフ方法
KR102114734B1 (ko) 2012-03-08 2020-05-25 싸이벡, 아이엔씨 미세유체 분석 장치용 마이크로튜브 입자 및 제조방법
CN107841461A (zh) 2012-04-16 2018-03-27 快速微型生物系统公司 细胞培养装置
US9562271B2 (en) 2012-04-20 2017-02-07 T2 Biosystems, Inc. Compositions and methods for detection of Candida species
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
US10504613B2 (en) 2012-12-20 2019-12-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10497461B2 (en) 2012-06-22 2019-12-03 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20140004105A1 (en) 2012-06-29 2014-01-02 Sequenom, Inc. Age-related macular degeneration diagnostics
CA2878979C (en) 2012-07-13 2021-09-14 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US10482994B2 (en) 2012-10-04 2019-11-19 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20140146157A1 (en) * 2012-11-29 2014-05-29 Fluid Imaging Technologies, Inc. System and method for sample dilution and particle imaging
CA2893591A1 (en) 2012-12-07 2014-06-12 T2 Biosystems, Inc. Methods for monitoring tight clot formation
US20130309666A1 (en) 2013-01-25 2013-11-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2014168711A1 (en) 2013-03-13 2014-10-16 Sequenom, Inc. Primers for dna methylation analysis
US9588027B2 (en) 2013-03-13 2017-03-07 UPKO Diagnostics, LLC Mixing of fluids in fluidic systems
US9677109B2 (en) 2013-03-15 2017-06-13 Accelerate Diagnostics, Inc. Rapid determination of microbial growth and antimicrobial susceptibility
ES2939547T3 (es) 2013-04-03 2023-04-24 Sequenom Inc Métodos y procedimientos para la evaluación no invasiva de variaciones genéticas
WO2014190286A2 (en) 2013-05-24 2014-11-27 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
ES2721051T3 (es) 2013-06-21 2019-07-26 Sequenom Inc Método para la evaluación no invasiva de variaciones genéticas
EP2827130A1 (en) * 2013-07-15 2015-01-21 F. Hoffmann-La Roche AG Device for use in the detection of binding affinities
BR112016007401B1 (pt) 2013-10-04 2023-04-11 Sequenom, Inc. Método para determinar a presença ou ausência de uma aneuploidia cromossômica em uma amostra
US10438691B2 (en) 2013-10-07 2019-10-08 Sequenom, Inc. Non-invasive assessment of chromosome alterations using change in subsequence mappability
ES2812611T3 (es) 2014-02-12 2021-03-17 Univ New York Identificación rápida de características para el seguimiento holográfico y la caracterización de partículas coloidales
EP3117011B1 (en) 2014-03-13 2020-05-06 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US11783911B2 (en) 2014-07-30 2023-10-10 Sequenom, Inc Methods and processes for non-invasive assessment of genetic variations
WO2016077472A1 (en) 2014-11-12 2016-05-19 New York University Colloidal fingerprints for soft materials using total holographic characterization
MX2017007576A (es) 2014-12-12 2018-03-09 Opko Diagnostics Llc Sistemas fluídicos que comprenden un canal de incubación, que incluye sistemas fluídicos formados por moldeo.
US10253355B2 (en) 2015-03-30 2019-04-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
US10023895B2 (en) 2015-03-30 2018-07-17 Accelerate Diagnostics, Inc. Instrument and system for rapid microogranism identification and antimicrobial agent susceptibility testing
EP3091347A1 (en) * 2015-05-04 2016-11-09 The European Union, represented by the European Commission Screening of nanoparticle properties
USD804682S1 (en) 2015-08-10 2017-12-05 Opko Diagnostics, Llc Multi-layered sample cassette
JP6929560B2 (ja) 2015-09-18 2021-09-01 ニュー・ヨーク・ユニヴァーシティー 精密スラリ内の大きい不純物粒子のホログラフィック検出及び特徴付け
US9983115B2 (en) 2015-09-21 2018-05-29 Fluid Imaging Technologies, Inc. System and method for monitoring particles in a fluid using ratiometric cytometry
US10228367B2 (en) 2015-12-01 2019-03-12 ProteinSimple Segmented multi-use automated assay cartridge
US20170160187A1 (en) * 2015-12-08 2017-06-08 Tdk Corporation Laser Scanner Particle Counter and Imager
EP3387447A4 (en) 2015-12-11 2019-08-28 Opko Diagnostics, LLC FLUID SYSTEMS WITH INCUBATION SAMPLES AND / OR REAGENTS
CA3011901A1 (en) 2016-01-21 2017-07-27 T2 Biosystems, Inc. Nmr methods and systems for the rapid detection of bacteria
WO2017139279A2 (en) 2016-02-08 2017-08-17 New York University Holographic characterization of protein aggregates
RU2631237C2 (ru) * 2016-02-26 2017-09-19 Государственное Научное Учреждение "Институт Физики Имени Б.И. Степанова Национальной Академии Наук Беларуси" Способ контроля структурного качества тонких плёнок для светопоглощающих слоёв солнечных элементов и устройство для его реализации
US10670677B2 (en) 2016-04-22 2020-06-02 New York University Multi-slice acceleration for magnetic resonance fingerprinting
SG10202012275PA (en) 2016-06-09 2021-01-28 Haimachek Inc Collector for detection and reversible capturing of cells from body fluids in vivo
RU169521U1 (ru) * 2016-06-28 2017-03-21 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт глазных болезней" Устройство для оценки интенсивности светорассеивающей способности биологической ткани
WO2018022890A1 (en) 2016-07-27 2018-02-01 Sequenom, Inc. Genetic copy number alteration classifications
CA3207879A1 (en) 2017-01-24 2018-08-02 Sequenom, Inc. Methods and processes for assessment of genetic variations
WO2020014296A1 (en) 2018-07-12 2020-01-16 Luminex Corporation Systems and methods for performing variable sample preparation and analysis processes
CN109254022B (zh) * 2018-10-24 2021-07-20 首钢智新迁安电磁材料有限公司 一种测量晶粒尺寸的方法
CN109540855B (zh) * 2018-11-07 2021-03-23 沈阳化工大学 一种荧光金壳磁性椭球的制备方法
FI129722B (en) * 2018-12-28 2022-07-29 Kemira Oyj Monitoring and regulation of hydrophobic components in a pulping process
EA202191931A1 (ru) * 2019-01-30 2022-02-14 Ридженерон Фармасьютикалз, Инк. Способ характеризации видимых и/или невидимых частиц в биологических препаратах
IL265914B (en) * 2019-04-08 2020-11-30 Convergent R N R Ltd System and method for optimization of radiotherapy treatments
US11543338B2 (en) 2019-10-25 2023-01-03 New York University Holographic characterization of irregular particles
US11948302B2 (en) 2020-03-09 2024-04-02 New York University Automated holographic video microscopy assay
CN112014369B (zh) * 2020-08-25 2024-02-09 上海市皮肤病医院 超灵敏数字层析快速检测分析物的系统及方法
CN112229769B (zh) * 2020-10-22 2023-03-14 山东长信化学科技股份有限公司 一种n-甲基吡咯烷酮颗粒度的检测系统及检测方法
CN113340894B (zh) * 2021-05-28 2023-04-07 上海睿钰生物科技有限公司 一种非透明微粒的检测方法
CN115482643B (zh) * 2022-08-24 2024-02-02 清华大学 火灾烟雾探测器及其探测方法

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3975084A (en) 1973-09-27 1976-08-17 Block Engineering, Inc. Particle detecting system
US3939350A (en) * 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US4157498A (en) * 1977-08-01 1979-06-05 Miles Laboratories, Inc. Flow-through type particle analyzing apparatus
NL7807532A (nl) 1978-07-13 1980-01-15 Akzo Nv Metaal-immunotest.
US4420558A (en) 1981-02-12 1983-12-13 Janssen Pharmaceutica N.V. Bright field light microscopic method of enumerating and characterizing subtypes of white blood cells and their precursors
GB2095258B (en) 1981-03-19 1984-09-05 Janssen Pharmaceutica Nv A bright field light microscopic method of localizing tissue antigens
US4480042A (en) 1981-10-28 1984-10-30 E. I. Du Pont De Nemours And Company Covalently bonded high refractive index particle reagents and their use in light scattering immunoassays
US4597944A (en) * 1983-10-18 1986-07-01 Cottingham Hugh V Agglutination reagent detection system
US4752567A (en) 1984-06-21 1988-06-21 Janssen Pharmaceutica N.V. Method of visualizing individual submicroscopic metal particles
US4647544A (en) * 1984-06-25 1987-03-03 Nicoli David F Immunoassay using optical interference detection
US4983834A (en) * 1985-10-10 1991-01-08 Quantex Corporation Large area particle detector system
US5501949A (en) * 1985-12-10 1996-03-26 Murex Diagnostics Corporation Particle bound binding component immunoassay
CA1291031C (en) 1985-12-23 1991-10-22 Nikolaas C.J. De Jaeger Method for the detection of specific binding agents and their correspondingbindable substances
US4851329A (en) 1986-06-06 1989-07-25 Massachusetts Institute Of Technology Immunoassay employing optical pulse particle size analysis
US5514602A (en) 1986-06-09 1996-05-07 Ortho Diagnostic Systems, Inc. Method of producing a metal sol reagent containing colloidal metal particles
AU7385387A (en) * 1986-06-09 1987-12-10 Ortho Diagnostic Systems Inc. Immunoassay using detection of colloidal gold
US5017009A (en) * 1986-06-26 1991-05-21 Ortho Diagnostic Systems, Inc. Scattered total internal reflectance immunoassay system
GB8623072D0 (en) * 1986-09-25 1986-10-29 Amersham Int Plc Particle analysis
US5015580A (en) * 1987-07-29 1991-05-14 Agracetus Particle-mediated transformation of soybean plants and lines
US5202231A (en) * 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US5110727A (en) * 1987-04-03 1992-05-05 Cardiovascular Diagnostics, Inc. Method for performing coagulation assays accurately, rapidly and simply, using dry chemical reagents and paramagnetic particles
GB8803000D0 (en) 1988-02-10 1988-03-09 Ekins Roger Philip Determination of ambient concentrations of several analytes
US5079172A (en) 1988-11-04 1992-01-07 Board Of Trustees Operating Michigan State University Method for detecting the presence of antibodies using gold-labeled antibodies and test kit
US5100805A (en) * 1989-01-26 1992-03-31 Seradyn, Inc. Quantitative immunoassay system and method for agglutination assays
US5338353A (en) * 1989-04-07 1994-08-16 Nippon Shokubai Kagaku Kogyo Method for production of powder of fine inorganic particles
US5120135A (en) * 1989-12-13 1992-06-09 Syntex (U.S.A.) Inc. Method and apparatus for keeping particles in suspension
JP2899360B2 (ja) 1990-05-21 1999-06-02 興和株式会社 流体中の粒子計測方法及びその装置
US5350697A (en) * 1990-08-28 1994-09-27 Akzo N.V. Scattered light detection apparatus
US5294369A (en) 1990-12-05 1994-03-15 Akzo N.V. Ligand gold bonding
JP3115641B2 (ja) 1991-04-24 2000-12-11 シスメックス株式会社 粒子計数方法
US5286452A (en) 1991-05-20 1994-02-15 Sienna Biotech, Inc. Simultaneous multiple assays
JP2523227Y2 (ja) 1991-07-30 1997-01-22 株式会社堀場製作所 異物検査装置
US5516670A (en) * 1991-09-30 1996-05-14 Kuehnle; Adelheid R. Magnetophoretic particle delivery method and apparatus for the treatment of cells
US5151956A (en) 1991-12-20 1992-09-29 The United Staes Of America As Represented By The Secretary Of The Army Waveguide polarizer using localized surface plasmons
US5248772A (en) * 1992-01-29 1993-09-28 Coulter Corporation Formation of colloidal metal dispersions using aminodextrans as reductants and protective agents
US5305073A (en) 1992-02-12 1994-04-19 Precision Detectors, Inc. Methods and apparatus for molecular characterization
US5451525A (en) * 1992-02-14 1995-09-19 Coulter Corporation Method and materials for determining particle count in a flow cytometer
US5357320A (en) * 1992-09-04 1994-10-18 Canon Kabushiki Kaisha Electrophotographic apparatus
DE69331570T2 (de) * 1992-10-21 2002-10-02 Dade Behring Inc Agglutinationstest unter Anwendung eines multivalenten Liganden
JP3410777B2 (ja) * 1993-09-13 2003-05-26 株式会社東芝 超微粒子無機蛍光体標識特異的結合物質およびこれを用いた検出方法
DE4414166C1 (de) * 1994-04-22 1995-12-07 Lorenz Mesgeraetebau Verfahren und Vorrichtung zur Messung der Lichtstreuung an Partikeln
US5734498A (en) * 1994-05-09 1998-03-31 The Regents Of The University Of California Illuminator elements for conventional light microscopes
JPH0881678A (ja) * 1994-09-14 1996-03-26 Toshiba Corp 無機蛍光体および特異的結合物質
US5599668A (en) * 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events
US5851777A (en) * 1996-02-05 1998-12-22 Dade Behring Inc. Homogeneous sol-sol assay
JP4209471B2 (ja) * 1997-02-20 2009-01-14 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア プラズモン共鳴粒子、方法、および装置

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CN1262667C (zh) 2006-07-05
EP1021554A4 (en) 2004-06-30
US6214560B1 (en) 2001-04-10
EP1021554A1 (en) 2000-07-26
BR9710836A (pt) 2000-10-24
ATE357663T1 (de) 2007-04-15
IL126544A0 (en) 1999-08-17
JP2009236921A (ja) 2009-10-15
JP2007263974A (ja) 2007-10-11
AU2805697A (en) 1997-11-12
RU2251572C2 (ru) 2005-05-10
DE69737513D1 (de) 2007-05-03
DE69737513T2 (de) 2007-12-13
AU736340B2 (en) 2001-07-26
CA2253710A1 (en) 1997-10-30
EP1021554B1 (en) 2007-03-21
JP2000510582A (ja) 2000-08-15
WO1997040181A1 (en) 1997-10-30
CN1223692A (zh) 1999-07-21

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