IL125440A - Vaccines against the IE-63 gene product of the chickenpox virus - Google Patents
Vaccines against the IE-63 gene product of the chickenpox virusInfo
- Publication number
- IL125440A IL125440A IL12544097A IL12544097A IL125440A IL 125440 A IL125440 A IL 125440A IL 12544097 A IL12544097 A IL 12544097A IL 12544097 A IL12544097 A IL 12544097A IL 125440 A IL125440 A IL 125440A
- Authority
- IL
- Israel
- Prior art keywords
- protein
- vzv
- varicella zoster
- zoster virus
- pharmaceutical composition
- Prior art date
Links
- 241000701085 Human alphaherpesvirus 3 Species 0.000 title claims abstract description 52
- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 39
- 229960005486 vaccine Drugs 0.000 title description 16
- 101710134694 Transcriptional regulator ICP22 homolog Proteins 0.000 claims abstract description 34
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 30
- 208000007514 Herpes zoster Diseases 0.000 claims abstract description 12
- 208000015181 infectious disease Diseases 0.000 claims abstract description 11
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 10
- 230000002265 prevention Effects 0.000 claims abstract description 7
- 150000007523 nucleic acids Chemical class 0.000 claims abstract 5
- 108020004707 nucleic acids Proteins 0.000 claims abstract 4
- 102000039446 nucleic acids Human genes 0.000 claims abstract 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract 4
- 239000000427 antigen Substances 0.000 claims description 22
- 102000036639 antigens Human genes 0.000 claims description 22
- 108091007433 antigens Proteins 0.000 claims description 22
- 230000004044 response Effects 0.000 claims description 13
- 101710176004 Major viral transcription factor ICP4 homolog Proteins 0.000 claims description 11
- 239000002671 adjuvant Substances 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 6
- 239000007764 o/w emulsion Substances 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 230000036737 immune function Effects 0.000 claims 1
- 210000000609 ganglia Anatomy 0.000 description 20
- 101900116756 Varicella-zoster virus Transcriptional regulator ICP22 homolog Proteins 0.000 description 18
- 230000000638 stimulation Effects 0.000 description 18
- 210000004027 cell Anatomy 0.000 description 17
- 210000001744 T-lymphocyte Anatomy 0.000 description 12
- 108020004414 DNA Proteins 0.000 description 11
- 241000700605 Viruses Species 0.000 description 11
- 108020001507 fusion proteins Proteins 0.000 description 11
- 102000037865 fusion proteins Human genes 0.000 description 11
- 239000000203 mixture Substances 0.000 description 9
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 8
- 238000003556 assay Methods 0.000 description 7
- 230000009089 cytolysis Effects 0.000 description 7
- 210000002569 neuron Anatomy 0.000 description 7
- 201000006082 Chickenpox Diseases 0.000 description 6
- 208000003098 Ganglion Cysts Diseases 0.000 description 6
- 208000005400 Synovial Cyst Diseases 0.000 description 6
- 206010046980 Varicella Diseases 0.000 description 6
- 210000002966 serum Anatomy 0.000 description 6
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 5
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 5
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 5
- 239000000839 emulsion Substances 0.000 description 5
- 229940035032 monophosphoryl lipid a Drugs 0.000 description 5
- 229940031439 squalene Drugs 0.000 description 5
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 5
- 210000000115 thoracic cavity Anatomy 0.000 description 5
- 210000001266 CD8-positive T-lymphocyte Anatomy 0.000 description 4
- 230000024932 T cell mediated immunity Effects 0.000 description 4
- 206010046865 Vaccinia virus infection Diseases 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000000805 cytoplasm Anatomy 0.000 description 4
- 230000034994 death Effects 0.000 description 4
- 239000012636 effector Substances 0.000 description 4
- 239000002953 phosphate buffered saline Substances 0.000 description 4
- 108091033319 polynucleotide Proteins 0.000 description 4
- 102000040430 polynucleotide Human genes 0.000 description 4
- 239000002157 polynucleotide Substances 0.000 description 4
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 4
- 229920000053 polysorbate 80 Polymers 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 206010037844 rash Diseases 0.000 description 4
- 229960000984 tocofersolan Drugs 0.000 description 4
- 208000007089 vaccinia Diseases 0.000 description 4
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 3
- 208000010201 Exanthema Diseases 0.000 description 3
- 108090000288 Glycoproteins Proteins 0.000 description 3
- 102000003886 Glycoproteins Human genes 0.000 description 3
- 230000006052 T cell proliferation Effects 0.000 description 3
- 229940087168 alpha tocopherol Drugs 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 201000005884 exanthem Diseases 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 238000002649 immunization Methods 0.000 description 3
- 239000002502 liposome Substances 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 238000002255 vaccination Methods 0.000 description 3
- 238000001262 western blot Methods 0.000 description 3
- 239000002076 α-tocopherol Substances 0.000 description 3
- 235000004835 α-tocopherol Nutrition 0.000 description 3
- 102000004127 Cytokines Human genes 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 2
- 206010061598 Immunodeficiency Diseases 0.000 description 2
- 241001092142 Molina Species 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 108010047620 Phytohemagglutinins Proteins 0.000 description 2
- 241001454523 Quillaja saponaria Species 0.000 description 2
- 235000009001 Quillaja saponaria Nutrition 0.000 description 2
- 101000999689 Saimiriine herpesvirus 2 (strain 11) Transcriptional regulator ICP22 homolog Proteins 0.000 description 2
- PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 description 2
- 230000005867 T cell response Effects 0.000 description 2
- UZQJVUCHXGYFLQ-AYDHOLPZSA-N [(2s,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-4-[(2r,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(hy Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)CC(O)[C@]1(CCC(CC14)(C)C)C(=O)O[C@H]1[C@@H]([C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O[C@H]4[C@@H]([C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)[C@H](O)[C@@H](CO)O4)O)[C@H](O)[C@@H](CO)O3)O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UZQJVUCHXGYFLQ-AYDHOLPZSA-N 0.000 description 2
- 125000003275 alpha amino acid group Chemical group 0.000 description 2
- 230000036755 cellular response Effects 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
- 238000005538 encapsulation Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000028996 humoral immune response Effects 0.000 description 2
- 230000001900 immune effect Effects 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- 201000001441 melanoma Diseases 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 239000013642 negative control Substances 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 210000000653 nervous system Anatomy 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 230000001885 phytohemagglutinin Effects 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 230000007420 reactivation Effects 0.000 description 2
- 230000000306 recurrent effect Effects 0.000 description 2
- 229930182490 saponin Natural products 0.000 description 2
- 150000007949 saponins Chemical class 0.000 description 2
- 235000017709 saponins Nutrition 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000010186 staining Methods 0.000 description 2
- 241001529453 unidentified herpesvirus Species 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- 108010042708 Acetylmuramyl-Alanyl-Isoglutamine Proteins 0.000 description 1
- 102000007469 Actins Human genes 0.000 description 1
- 108010085238 Actins Proteins 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 241000588807 Bordetella Species 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 101710094648 Coat protein Proteins 0.000 description 1
- 108020004705 Codon Proteins 0.000 description 1
- 235000001815 DL-alpha-tocopherol Nutrition 0.000 description 1
- 239000011627 DL-alpha-tocopherol Substances 0.000 description 1
- 102000005720 Glutathione transferase Human genes 0.000 description 1
- 108010070675 Glutathione transferase Proteins 0.000 description 1
- 102100027685 Hemoglobin subunit alpha Human genes 0.000 description 1
- 108091005902 Hemoglobin subunit alpha Proteins 0.000 description 1
- 208000029433 Herpesviridae infectious disease Diseases 0.000 description 1
- 108010007403 Immediate-Early Proteins Proteins 0.000 description 1
- 108010052285 Membrane Proteins Proteins 0.000 description 1
- 102000018697 Membrane Proteins Human genes 0.000 description 1
- 206010073333 Neuronophagia Diseases 0.000 description 1
- 108700001237 Nucleic Acid-Based Vaccines Proteins 0.000 description 1
- 108700026244 Open Reading Frames Proteins 0.000 description 1
- 238000012408 PCR amplification Methods 0.000 description 1
- 101100525628 Picea mariana SB62 gene Proteins 0.000 description 1
- 206010036376 Postherpetic Neuralgia Diseases 0.000 description 1
- 206010037407 Pulmonary hypoplasia Diseases 0.000 description 1
- -1 Quil A Chemical class 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 108091081024 Start codon Proteins 0.000 description 1
- 101710172711 Structural protein Proteins 0.000 description 1
- 108010022394 Threonine synthase Proteins 0.000 description 1
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 1
- 108700005077 Viral Genes Proteins 0.000 description 1
- 108010067390 Viral Proteins Proteins 0.000 description 1
- 208000008615 Zoster Sine Herpete Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 230000005875 antibody response Effects 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000011888 autopsy Methods 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 210000001736 capillary Anatomy 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000001516 cell proliferation assay Methods 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 230000016396 cytokine production Effects 0.000 description 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 238000002784 cytotoxicity assay Methods 0.000 description 1
- 231100000263 cytotoxicity test Toxicity 0.000 description 1
- 238000002716 delivery method Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 102000004419 dihydrofolate reductase Human genes 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000013020 final formulation Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000002962 histologic effect Effects 0.000 description 1
- 230000004727 humoral immunity Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 230000002480 immunoprotective effect Effects 0.000 description 1
- 230000003308 immunostimulating effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 210000003000 inclusion body Anatomy 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000002934 lysing effect Effects 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 210000003071 memory t lymphocyte Anatomy 0.000 description 1
- BSOQXXWZTUDTEL-ZUYCGGNHSA-N muramyl dipeptide Chemical compound OC(=O)CC[C@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](O)[C@@H]1NC(C)=O BSOQXXWZTUDTEL-ZUYCGGNHSA-N 0.000 description 1
- 208000004296 neuralgia Diseases 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 229940023146 nucleic acid vaccine Drugs 0.000 description 1
- 201000003508 omphalocele Diseases 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 210000001428 peripheral nervous system Anatomy 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000004224 protection Effects 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
- 230000010322 reactivation of latent virus Effects 0.000 description 1
- 230000001177 retroviral effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 229960000814 tetanus toxoid Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 210000000427 trigeminal ganglion Anatomy 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 230000007419 viral reactivation Effects 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/245—Herpetoviridae, e.g. herpes simplex virus
- A61K39/25—Varicella-zoster virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
- C12N2710/16722—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
- C12N2710/16734—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9602617.4A GB9602617D0 (en) | 1996-02-09 | 1996-02-09 | Vaccines |
| GBGB9626882.6A GB9626882D0 (en) | 1996-12-24 | 1996-12-24 | Vaccines |
| PCT/EP1997/000520 WO1997028820A1 (en) | 1996-02-09 | 1997-02-04 | Vaccines against varicella zoster virus gene 63 product |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL125440A0 IL125440A0 (en) | 1999-03-12 |
| IL125440A true IL125440A (en) | 2002-02-10 |
Family
ID=26308641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12544097A IL125440A (en) | 1996-02-09 | 1997-02-04 | Vaccines against the IE-63 gene product of the chickenpox virus |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0879060B1 (es) |
| JP (1) | JP2002504080A (es) |
| KR (1) | KR100365986B1 (es) |
| CN (1) | CN1210470A (es) |
| AR (1) | AR005750A1 (es) |
| AT (1) | ATE390146T1 (es) |
| AU (1) | AU723555B2 (es) |
| BR (1) | BR9707400A (es) |
| CA (1) | CA2245545C (es) |
| CZ (1) | CZ289971B6 (es) |
| DE (1) | DE69738597T2 (es) |
| ES (1) | ES2301175T3 (es) |
| HU (1) | HUP0001991A3 (es) |
| IL (1) | IL125440A (es) |
| NO (1) | NO983617L (es) |
| NZ (1) | NZ331164A (es) |
| PL (1) | PL188457B1 (es) |
| TR (1) | TR199801531T2 (es) |
| TW (1) | TW575427B (es) |
| WO (1) | WO1997028820A1 (es) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114891830B (zh) * | 2022-04-02 | 2024-03-01 | 武汉博沃生物科技有限公司 | 基于水痘-带状疱疹病毒的重组表达载体、重组病毒及用途 |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999011241A1 (en) * | 1997-09-05 | 1999-03-11 | Smithkline Beecham Biologicals S.A. | Oil in water emulsions containing saponins |
| ES2273482T3 (es) * | 1998-03-09 | 2007-05-01 | Glaxosmithkline Biologicals S.A. | Composiciones de vacunas combinadas. |
| GB9901254D0 (en) * | 1999-01-20 | 1999-03-10 | Smithkline Beecham Biolog | Vaccines |
| GB9921146D0 (en) * | 1999-09-07 | 1999-11-10 | Smithkline Beecham Biolog | Novel composition |
| EP1227840B1 (en) * | 1999-11-03 | 2007-10-03 | Powderject Vaccines, Inc. | Adjuvanted genetic vaccines |
| CA2400842C (en) | 2000-02-23 | 2013-01-15 | Smithkline Beecham Biologicals S.A. | Novel compounds |
| EA020617B1 (ru) | 2009-05-27 | 2014-12-30 | Глаксосмитклайн Байолоджикалс С.А. | Конструкции casb7439 |
| KR101723605B1 (ko) * | 2014-10-21 | 2017-04-07 | 진원생명과학 주식회사 | 대상포진 예방 및 치료용 dna 백신 조성물 및 이를 이용한 vzv 항원에 대한 t세포 활성화 방법 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4952674A (en) * | 1986-05-02 | 1990-08-28 | Merck & Co., Inc. | Vaccine against varicella-zoster virus |
| ATE119939T1 (de) * | 1989-06-27 | 1995-04-15 | Smithkline Beecham Biolog | Verbindungen. |
-
1997
- 1997-02-04 IL IL12544097A patent/IL125440A/en not_active IP Right Cessation
- 1997-02-04 ES ES97902334T patent/ES2301175T3/es not_active Expired - Lifetime
- 1997-02-04 JP JP52814197A patent/JP2002504080A/ja active Pending
- 1997-02-04 WO PCT/EP1997/000520 patent/WO1997028820A1/en active IP Right Grant
- 1997-02-04 CZ CZ19982486A patent/CZ289971B6/cs not_active IP Right Cessation
- 1997-02-04 BR BR9707400-4A patent/BR9707400A/pt not_active Application Discontinuation
- 1997-02-04 CA CA002245545A patent/CA2245545C/en not_active Expired - Fee Related
- 1997-02-04 HU HU0001991A patent/HUP0001991A3/hu not_active Application Discontinuation
- 1997-02-04 TR TR1998/01531T patent/TR199801531T2/xx unknown
- 1997-02-04 KR KR10-1998-0706090A patent/KR100365986B1/ko not_active IP Right Cessation
- 1997-02-04 AU AU16012/97A patent/AU723555B2/en not_active Ceased
- 1997-02-04 EP EP97902334A patent/EP0879060B1/en not_active Expired - Lifetime
- 1997-02-04 PL PL97328414A patent/PL188457B1/pl not_active IP Right Cessation
- 1997-02-04 CN CN97192099A patent/CN1210470A/zh active Pending
- 1997-02-04 NZ NZ331164A patent/NZ331164A/en unknown
- 1997-02-04 DE DE69738597T patent/DE69738597T2/de not_active Expired - Fee Related
- 1997-02-04 AT AT97902334T patent/ATE390146T1/de not_active IP Right Cessation
- 1997-02-07 AR ARP970100494A patent/AR005750A1/es not_active Application Discontinuation
- 1997-06-25 TW TW086102043A patent/TW575427B/zh not_active IP Right Cessation
-
1998
- 1998-08-06 NO NO983617A patent/NO983617L/no unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114891830B (zh) * | 2022-04-02 | 2024-03-01 | 武汉博沃生物科技有限公司 | 基于水痘-带状疱疹病毒的重组表达载体、重组病毒及用途 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2245545C (en) | 2008-12-30 |
| KR19990082360A (ko) | 1999-11-25 |
| NO983617L (no) | 1998-10-02 |
| TW575427B (en) | 2004-02-11 |
| DE69738597T2 (de) | 2008-07-24 |
| CN1210470A (zh) | 1999-03-10 |
| DE69738597D1 (de) | 2008-05-08 |
| ATE390146T1 (de) | 2008-04-15 |
| CA2245545A1 (en) | 1997-08-14 |
| NO983617D0 (no) | 1998-08-06 |
| WO1997028820A1 (en) | 1997-08-14 |
| NZ331164A (en) | 2000-02-28 |
| EP0879060B1 (en) | 2008-03-26 |
| PL188457B1 (pl) | 2005-02-28 |
| TR199801531T2 (xx) | 1998-10-21 |
| CZ289971B6 (cs) | 2002-05-15 |
| PL328414A1 (en) | 1999-01-18 |
| HUP0001991A2 (hu) | 2000-10-28 |
| BR9707400A (pt) | 2000-01-04 |
| AR005750A1 (es) | 1999-07-14 |
| ES2301175T3 (es) | 2008-06-16 |
| AU723555B2 (en) | 2000-08-31 |
| EP0879060A1 (en) | 1998-11-25 |
| JP2002504080A (ja) | 2002-02-05 |
| CZ248698A3 (cs) | 1998-12-16 |
| HUP0001991A3 (en) | 2003-08-28 |
| IL125440A0 (en) | 1999-03-12 |
| KR100365986B1 (ko) | 2003-02-20 |
| AU1601297A (en) | 1997-08-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6027730A (en) | Herpes simplex vaccine comprising HSV glycoprotein GD and 3 deacylated monophosphoryl lipid A | |
| JP5840167B2 (ja) | 水疱−帯状疱疹ウイルスワクチン | |
| CN110035772B (zh) | 水痘带状疱疹病毒疫苗 | |
| CZ296216B6 (cs) | Prostredek s vakcinacním úcinkem a jeho pouzití pro výrobu vakcíny | |
| AU723555B2 (en) | Vaccines against varicella zoster virus gene 63 product | |
| US7112331B2 (en) | Vaccines against varicella zoster virus gene 63 product | |
| MXPA98006411A (es) | Vacunas contra producto del gen 63 de virus zoster de varicela | |
| RU2750818C1 (ru) | Вирусный штамм для получения аттенуированной живой культуральной вакцины для профилактики и лечения опоясывающего герпеса для взрослого населения | |
| CN116212012A (zh) | 复合佐剂以及包含它的疫苗制剂 | |
| KR20230058101A (ko) | 토코페롤-함유 스쿠알렌 에멀젼 아쥬반트를 갖는 covid-19 백신 | |
| CN117122676A (zh) | Hsv免疫原性组合物及其应用 | |
| CN117618548A (zh) | 一种rsv疫苗组合物及其制备方法和应用 | |
| AU2012213948B2 (en) | Vaccine |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |