IL125341A0 - Pyrimido [5,4-d] pyrimidines their preparation and pharmaceutical compositions containing them - Google Patents

Pyrimido [5,4-d] pyrimidines their preparation and pharmaceutical compositions containing them

Info

Publication number
IL125341A0
IL125341A0 IL12534197A IL12534197A IL125341A0 IL 125341 A0 IL125341 A0 IL 125341A0 IL 12534197 A IL12534197 A IL 12534197A IL 12534197 A IL12534197 A IL 12534197A IL 125341 A0 IL125341 A0 IL 125341A0
Authority
IL
Israel
Prior art keywords
pyrimido
pyrimidines
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
IL12534197A
Other languages
English (en)
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of IL125341A0 publication Critical patent/IL125341A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL12534197A 1996-03-06 1997-03-03 Pyrimido [5,4-d] pyrimidines their preparation and pharmaceutical compositions containing them IL125341A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19608653A DE19608653A1 (de) 1996-03-06 1996-03-06 Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
PCT/EP1997/001058 WO1997032882A1 (de) 1996-03-06 1997-03-03 PYRIMIDO[5,4-d]PYRIMIDINE, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL, DEREN VERWENDUNG UND VERFAHREN ZU IHRER HERSTELLUNG

Publications (1)

Publication Number Publication Date
IL125341A0 true IL125341A0 (en) 1999-03-12

Family

ID=7787391

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12534197A IL125341A0 (en) 1996-03-06 1997-03-03 Pyrimido [5,4-d] pyrimidines their preparation and pharmaceutical compositions containing them

Country Status (23)

Country Link
US (1) US5977102A (et)
EP (1) EP0885227A1 (et)
JP (1) JP2000506153A (et)
KR (1) KR19990087551A (et)
CN (1) CN1212696A (et)
AR (1) AR009937A1 (et)
AU (1) AU712072B2 (et)
BG (1) BG102790A (et)
BR (1) BR9708004A (et)
CA (1) CA2248316A1 (et)
CO (1) CO4650044A1 (et)
CZ (1) CZ281698A3 (et)
DE (1) DE19608653A1 (et)
EE (1) EE9800289A (et)
HU (1) HUP9901750A2 (et)
IL (1) IL125341A0 (et)
NO (1) NO984081D0 (et)
NZ (1) NZ331382A (et)
PL (1) PL328776A1 (et)
SK (1) SK120498A3 (et)
TR (1) TR199801753T2 (et)
WO (1) WO1997032882A1 (et)
ZA (1) ZA971886B (et)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL194689B1 (pl) 1996-02-13 2007-06-29 Astrazeneca Uk Ltd Pochodne chinazoliny, ich kompozycje farmaceutyczne oraz ich zastosowania
NZ331191A (en) 1996-03-05 2000-03-27 Zeneca Ltd 4-anilinoquinazoline derivatives and pharmaceutical compositions thereof
UA71945C2 (en) * 1999-01-27 2005-01-17 Pfizer Prod Inc Substituted bicyclic derivatives being used as anticancer agents
JP3270834B2 (ja) * 1999-01-27 2002-04-02 ファイザー・プロダクツ・インク 抗がん剤として有用なヘテロ芳香族二環式誘導体
DE19911510A1 (de) * 1999-03-15 2000-09-21 Boehringer Ingelheim Pharma Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
BR0009651A (pt) 1999-04-09 2002-01-08 Astrazeneca Ab Composto, processo para a preparação de um composto, composição farmacêutica, uso de um composto, e, método para tratar artrite reumatóide e uma doença obstrutiva das vias aéreas
US7049410B2 (en) * 1999-05-14 2006-05-23 Majumdar Adhip P N Antibodies to a novel EGF-receptor related protein (ERRP)
US6399743B1 (en) 1999-05-14 2002-06-04 Dept. Of Veterans Affairs Isolation and characterization of a rat epidermal growth factor related protein
UA72946C2 (uk) 1999-11-05 2005-05-16 Астразенека Аб Похідні хіназоліну як інгібітори васкулярного ендотеліального фактора росту (vegf)
SE9904505D0 (sv) 1999-12-09 1999-12-09 Astra Pharma Prod Novel compounds
TWI258462B (en) 1999-12-17 2006-07-21 Astrazeneca Ab Adamantane derivative compounds, process for preparing the same and pharmaceutical composition comprising the same
CA2422488A1 (en) * 2000-09-20 2002-03-28 Merck Patent Gesellschaft Mit Beschraenkter Haftung 4-amino-quinazolines
EP1318985A2 (en) * 2000-09-20 2003-06-18 MERCK PATENT GmbH 4-amino-quinazolines
DK1370552T3 (da) * 2001-03-23 2007-05-07 Bayer Pharmaceuticals Corp Rho-kinase-inhibitorer
CA2441492C (en) * 2001-03-23 2011-08-09 Bayer Corporation Rho-kinase inhibitors
US7829566B2 (en) * 2001-09-17 2010-11-09 Werner Mederski 4-amino-quinazolines
ES2305435T3 (es) * 2002-01-10 2008-11-01 Bayer Healthcare Ag Inhibidores de la rho-quinasa.
CA2473910C (en) * 2002-01-23 2011-03-15 Bayer Pharmaceuticals Corporation Pyrimidine derivatives as rho-kinase inhibitors
MXPA04007191A (es) * 2002-01-23 2005-03-31 Bayer Pharmaceuticals Corp Derivados de pirimidina como inhibidores de rho-quinasa.
KR101139038B1 (ko) * 2005-06-28 2012-05-02 삼성전자주식회사 피리미도피리미딘 유도체 및 이를 이용한 유기 박막 트랜지스터
AR073501A1 (es) * 2008-09-08 2010-11-10 Boehringer Ingelheim Int Derivados de pirimido[5,4-d]pirimidina inhibidores de la tirosinoquinasa
CA2752265A1 (en) 2009-02-17 2010-08-26 Boehringer Ingelheim International Gmbh Pyrimido [5,4-d] pyrimidine derivatives for the inhibition of tyrosine kinases
ES2880623T3 (es) * 2009-04-02 2021-11-25 Merck Patent Gmbh Derivados de piperidina y piperazina como inhibidores de autotaxina
US20130023531A1 (en) 2011-01-27 2013-01-24 Boehringer Ingelheim International Gmbh Pyrimido[5,4-d]pyrimidylamino phenyl sulfonamides as serine/threonine kinase inhibitors
WO2014175370A1 (ja) * 2013-04-25 2014-10-30 塩野義製薬株式会社 ピロリジン誘導体およびそれらを含有する医薬組成物
CA2955071A1 (en) 2014-07-15 2016-01-21 Grunenthal Gmbh Substituted azaspiro(4.5)decane derivatives
TW201607923A (zh) 2014-07-15 2016-03-01 歌林達有限公司 被取代之氮螺環（４．５）癸烷衍生物
WO2022221227A1 (en) 2021-04-13 2022-10-20 Nuvalent, Inc. Amino-substituted heterocycles for treating cancers with egfr mutations

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3031450A (en) * 1959-04-30 1962-04-24 Thomae Gmbh Dr K Substituted pyrimido-[5, 4-d]-pyrimidines
EP0023559B1 (de) * 1979-07-03 1984-09-19 Dr. Karl Thomae GmbH 2-(Perhydro-1,4-diazino)-pyrimido(5,4-d)pyrimidine, ihre Herstellung und diese Verbindungen enthaltenden Arzneimittel
DE3049207A1 (de) * 1980-12-27 1982-07-29 Dr. Karl Thomae Gmbh, 7950 Biberach Neue trisubstituierte pyrimido (5,4-d) pyrimidine, ihre herstellung und ihre verwendung als arzneimittel
DE3423092A1 (de) * 1984-06-22 1986-01-02 Dr. Karl Thomae Gmbh, 7950 Biberach Neue 8-alkylthio-2-piperazino-pyrimido(5,4-d) pyrimidine, ihre herstellung und diese verbindungen enthaltende arzneimittel
US5034393A (en) * 1989-07-27 1991-07-23 Dowelanco Fungicidal use of pyridopyrimidine, pteridine, pyrimidopyrimidine, pyrimidopyridazine, and pyrimido-1,2,4-triazine derivatives
DE4325900A1 (de) * 1993-08-02 1995-02-09 Thomae Gmbh Dr K Trisubstituierte Pyrimido [5,4-d] pyrimidine zur Modulation der Multidrugresistenz, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
IL112249A (en) * 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
TW414798B (en) * 1994-09-07 2000-12-11 Thomae Gmbh Dr K Pyrimido (5,4-d) pyrimidines, medicaments comprising these compounds, their use and processes for their preparation
DE4431867A1 (de) * 1994-09-07 1996-03-14 Thomae Gmbh Dr K Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
CN1212696A (zh) 1999-03-31
WO1997032882A1 (de) 1997-09-12
PL328776A1 (en) 1999-02-15
CO4650044A1 (es) 1998-09-03
CA2248316A1 (en) 1997-09-12
KR19990087551A (ko) 1999-12-27
NO984081L (no) 1998-09-04
AU712072B2 (en) 1999-10-28
BG102790A (bg) 1999-09-30
TR199801753T2 (xx) 1998-12-21
CZ281698A3 (cs) 1999-02-17
EP0885227A1 (de) 1998-12-23
NZ331382A (en) 1999-08-30
ZA971886B (en) 1998-09-07
HUP9901750A2 (hu) 1999-09-28
JP2000506153A (ja) 2000-05-23
DE19608653A1 (de) 1997-09-11
SK120498A3 (en) 1999-04-13
BR9708004A (pt) 1999-07-27
EE9800289A (et) 1999-02-15
AU1925297A (en) 1997-09-22
US5977102A (en) 1999-11-02
AR009937A1 (es) 2000-05-17
NO984081D0 (no) 1998-09-04

Similar Documents

Publication Publication Date Title
IL125342A0 (en) Pyrimido [5,4-d] pyrimidines their preparation and pharmaceutical compositions containing them
IL125341A0 (en) Pyrimido [5,4-d] pyrimidines their preparation and pharmaceutical compositions containing them
HUP9801336A3 (en) 6-substituted pyrazolo[3,4-d]pyrimidin-4-ones and pharmaceutical compositions containing them
HUP0002104A3 (en) Pyrazolo[3,4-d]pyrimidinedione derivatives, process for their preparation and pharmaceutical compositions containing them
HUP0100202A3 (en) Novel triazolo[4,5-d]pyrimidine derivatives, process for their preparation, their use and pharmaceutical compositions containing them
HUP0004333A3 (en) Novel triazolo [4,5-d] pyrimidine derivatives, process for their preparation and pharmaceutical compositions containing thereof
IL128869A (en) ARYSULFONYL-SUBSTITUTED-PYRAZOLO [1,5-a]-PYRIMIDINE AND PYRAZOLO [1,5-a] [1, 3, 5]-TRIAZINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
HUP0105081A3 (en) Triazolo[4,5-d]pyrimidine derivatives, process for their preparation, their use and pharmaceutical compositions containing them
HUP0103472A3 (en) Pyrrolo[2,3-d]pyrimidine derivatives and pharmaceutical compositions containing the same
HUP0001507A3 (en) Pyrrolo [2,3-d] pyrimidine derivatives, process for their preparation, their use and pharmaceutical compositions containing them
ZA931637B (en) Pyrrolobenzodiazepine derivatives, their preparation and compositions containing them
IL134688A (en) CYCLOOXYGENASE 2 INHIBITING 2, 3-DIARYL-PYRAZOLO [1, 5-b] PYRIDAZINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
HK1024914A1 (en) 1,2,4-triazolo 4,3-b]pyrido 3,2-d]pyridazine derivatives and pharmaceutical compositions containing them
IL127056A (en) Aryl pyrimidine derivatives, their preparation and pharmaceutical compositions comprising them
IL121236A0 (en) Cycloalkano-pyridines their preparation and pharmaceutical compositions containing them
IL116770A (en) 2,8-disubstituted quinazolinones their preparation and pharmaceutical compositions containing them
IL139787A0 (en) PYRROLO [2, 3d] PYRIMIDINE COMPOSITIONS AND THEIR USE
HUP0001805A3 (en) 6-benzyl-1,5-dihydro-pyrazolo[3,4-d]-pyrimidin-4-one derivatives, process for their preparation and pharmaceutical compositions containing them
HUP0002839A3 (en) Pyrrolo[3,4-d]pyrimidinone derivatives, their use, pharmaceutical compositions containing them, process for their preparation
HUP0103921A3 (en) [1,2,4]triazolo[1,5-c]pyrimidine derivatives and pharmaceutical compositions thereof
HUP0003826A3 (en) Novel triazolo [4,5-b] pyrimidine derivatives, process for their preparation and pharmaceutical compositions thereof
HUP9801394A3 (en) 6-phenyl-pyrazolo[3,4-d]pyrimidin-4-one derivatives and pharmaceutical compositions containing them
NZ322197A (en) Pyrido[2,3-d] pyrimidine derivatives and pharmaceutical compositions thereof
IL109073A0 (en) Amidine derivatives, their preparation and pharmaceutical compositions containing them
HUP0102981A3 (en) Pyrrolo[1,2-a]pyrazine derivatives and pharmaceutical compositions thereof