BG102790A - ПИРИМИДО/5,4-d/ПИРИМИДИНИ, ЛЕКАРСТВЕНИ СРЕДСТВА, СЪДЪРЖАЩИ ТЕЗИ СЪЕДИНЕНИЯ, ПРИЛОЖЕНИЕТО ИМ И МЕТОДЗА ТЯХНОТО ПОЛУЧАВАНЕ - Google Patents

ПИРИМИДО/5,4-d/ПИРИМИДИНИ, ЛЕКАРСТВЕНИ СРЕДСТВА, СЪДЪРЖАЩИ ТЕЗИ СЪЕДИНЕНИЯ, ПРИЛОЖЕНИЕТО ИМ И МЕТОДЗА ТЯХНОТО ПОЛУЧАВАНЕ Download PDF

Info

Publication number
BG102790A
BG102790A BG102790A BG10279098A BG102790A BG 102790 A BG102790 A BG 102790A BG 102790 A BG102790 A BG 102790A BG 10279098 A BG10279098 A BG 10279098A BG 102790 A BG102790 A BG 102790A
Authority
BG
Bulgaria
Prior art keywords
group
substituted
alkyl
piperidinyl
amino
Prior art date
Application number
BG102790A
Other languages
Bulgarian (bg)
English (en)
Inventor
Frank Himmelsbach
Georg Dahmann
Rueden Thomas Von
Thomas Metz
Original Assignee
Dr. Karl Thomae Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr. Karl Thomae Gmbh filed Critical Dr. Karl Thomae Gmbh
Publication of BG102790A publication Critical patent/BG102790A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
BG102790A 1996-03-06 1998-09-24 ПИРИМИДО/5,4-d/ПИРИМИДИНИ, ЛЕКАРСТВЕНИ СРЕДСТВА, СЪДЪРЖАЩИ ТЕЗИ СЪЕДИНЕНИЯ, ПРИЛОЖЕНИЕТО ИМ И МЕТОДЗА ТЯХНОТО ПОЛУЧАВАНЕ BG102790A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19608653A DE19608653A1 (de) 1996-03-06 1996-03-06 Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
PCT/EP1997/001058 WO1997032882A1 (de) 1996-03-06 1997-03-03 PYRIMIDO[5,4-d]PYRIMIDINE, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL, DEREN VERWENDUNG UND VERFAHREN ZU IHRER HERSTELLUNG

Publications (1)

Publication Number Publication Date
BG102790A true BG102790A (bg) 1999-09-30

Family

ID=7787391

Family Applications (1)

Application Number Title Priority Date Filing Date
BG102790A BG102790A (bg) 1996-03-06 1998-09-24 ПИРИМИДО/5,4-d/ПИРИМИДИНИ, ЛЕКАРСТВЕНИ СРЕДСТВА, СЪДЪРЖАЩИ ТЕЗИ СЪЕДИНЕНИЯ, ПРИЛОЖЕНИЕТО ИМ И МЕТОДЗА ТЯХНОТО ПОЛУЧАВАНЕ

Country Status (23)

Country Link
US (1) US5977102A (et)
EP (1) EP0885227A1 (et)
JP (1) JP2000506153A (et)
KR (1) KR19990087551A (et)
CN (1) CN1212696A (et)
AR (1) AR009937A1 (et)
AU (1) AU712072B2 (et)
BG (1) BG102790A (et)
BR (1) BR9708004A (et)
CA (1) CA2248316A1 (et)
CO (1) CO4650044A1 (et)
CZ (1) CZ281698A3 (et)
DE (1) DE19608653A1 (et)
EE (1) EE9800289A (et)
HU (1) HUP9901750A2 (et)
IL (1) IL125341A0 (et)
NO (1) NO984081L (et)
NZ (1) NZ331382A (et)
PL (1) PL328776A1 (et)
SK (1) SK120498A3 (et)
TR (1) TR199801753T2 (et)
WO (1) WO1997032882A1 (et)
ZA (1) ZA971886B (et)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997030035A1 (en) 1996-02-13 1997-08-21 Zeneca Limited Quinazoline derivatives as vegf inhibitors
DE69709319T2 (de) 1996-03-05 2002-08-14 Astrazeneca Ab 4-anilinochinazolin derivate
JP3270834B2 (ja) * 1999-01-27 2002-04-02 ファイザー・プロダクツ・インク 抗がん剤として有用なヘテロ芳香族二環式誘導体
UA71945C2 (en) * 1999-01-27 2005-01-17 Pfizer Prod Inc Substituted bicyclic derivatives being used as anticancer agents
DE19911510A1 (de) * 1999-03-15 2000-09-21 Boehringer Ingelheim Pharma Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
AU774526B2 (en) 1999-04-09 2004-07-01 Astrazeneca Ab Adamantane derivatives
WO2000069909A1 (en) 1999-05-14 2000-11-23 The United States Of America Through The Department Of Veterans Affairs Isolation and characterization of epidermal growth factor related protein
US7049410B2 (en) * 1999-05-14 2006-05-23 Majumdar Adhip P N Antibodies to a novel EGF-receptor related protein (ERRP)
PT1676845E (pt) 1999-11-05 2008-08-05 Astrazeneca Ab Novos derivados de quinazolina
SE9904505D0 (sv) 1999-12-09 1999-12-09 Astra Pharma Prod Novel compounds
TWI258462B (en) 1999-12-17 2006-07-21 Astrazeneca Ab Adamantane derivative compounds, process for preparing the same and pharmaceutical composition comprising the same
MXPA03002411A (es) * 2000-09-20 2003-06-19 Merck Patent Gmbh 4-amino-quinazolinas.
AU2001293817A1 (en) * 2000-09-20 2002-04-02 Merck Patent Gmbh 4-amino-quinazolines
PE20020958A1 (es) * 2001-03-23 2002-11-14 Bayer Corp Inhibidores de la rho-quinasa
AU2002250394A1 (en) * 2001-03-23 2002-10-08 Bayer Corporation Rho-kinase inhibitors
US7829566B2 (en) * 2001-09-17 2010-11-09 Werner Mederski 4-amino-quinazolines
ES2305435T3 (es) * 2002-01-10 2008-11-01 Bayer Healthcare Ag Inhibidores de la rho-quinasa.
US6943172B2 (en) * 2002-01-23 2005-09-13 Bayer Pharmaceuticals Corporation Rho-kinase inhibitors
CA2473510A1 (en) * 2002-01-23 2003-07-31 Bayer Pharmaceuticals Corporation Pyrimidine derivatives as rho-kinase inhibitors
KR101139038B1 (ko) * 2005-06-28 2012-05-02 삼성전자주식회사 피리미도피리미딘 유도체 및 이를 이용한 유기 박막 트랜지스터
TW201014860A (en) * 2008-09-08 2010-04-16 Boehringer Ingelheim Int New chemical compounds
CA2752265A1 (en) 2009-02-17 2010-08-26 Boehringer Ingelheim International Gmbh Pyrimido [5,4-d] pyrimidine derivatives for the inhibition of tyrosine kinases
EP2623491A3 (en) * 2009-04-02 2014-07-30 Merck Patent GmbH Piperidine and piperazine derivatives as autotaxin inhibitors
US20130023531A1 (en) 2011-01-27 2013-01-24 Boehringer Ingelheim International Gmbh Pyrimido[5,4-d]pyrimidylamino phenyl sulfonamides as serine/threonine kinase inhibitors
WO2014175370A1 (ja) * 2013-04-25 2014-10-30 塩野義製薬株式会社 ピロリジン誘導体およびそれらを含有する医薬組成物
TW201607923A (zh) 2014-07-15 2016-03-01 歌林達有限公司 被取代之氮螺環（４．５）癸烷衍生物
PL3169666T3 (pl) 2014-07-15 2019-03-29 Grünenthal GmbH Podstawione pochodne azaspiro(4,5)dekanu

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3031450A (en) * 1959-04-30 1962-04-24 Thomae Gmbh Dr K Substituted pyrimido-[5, 4-d]-pyrimidines
EP0023559B1 (de) * 1979-07-03 1984-09-19 Dr. Karl Thomae GmbH 2-(Perhydro-1,4-diazino)-pyrimido(5,4-d)pyrimidine, ihre Herstellung und diese Verbindungen enthaltenden Arzneimittel
DE3049207A1 (de) * 1980-12-27 1982-07-29 Dr. Karl Thomae Gmbh, 7950 Biberach Neue trisubstituierte pyrimido (5,4-d) pyrimidine, ihre herstellung und ihre verwendung als arzneimittel
DE3423092A1 (de) * 1984-06-22 1986-01-02 Dr. Karl Thomae Gmbh, 7950 Biberach Neue 8-alkylthio-2-piperazino-pyrimido(5,4-d) pyrimidine, ihre herstellung und diese verbindungen enthaltende arzneimittel
US5034393A (en) * 1989-07-27 1991-07-23 Dowelanco Fungicidal use of pyridopyrimidine, pteridine, pyrimidopyrimidine, pyrimidopyridazine, and pyrimido-1,2,4-triazine derivatives
DE4325900A1 (de) * 1993-08-02 1995-02-09 Thomae Gmbh Dr K Trisubstituierte Pyrimido [5,4-d] pyrimidine zur Modulation der Multidrugresistenz, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
IL112249A (en) * 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
TW414798B (en) * 1994-09-07 2000-12-11 Thomae Gmbh Dr K Pyrimido (5,4-d) pyrimidines, medicaments comprising these compounds, their use and processes for their preparation
DE4431867A1 (de) * 1994-09-07 1996-03-14 Thomae Gmbh Dr K Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
IL125341A0 (en) 1999-03-12
KR19990087551A (ko) 1999-12-27
WO1997032882A1 (de) 1997-09-12
PL328776A1 (en) 1999-02-15
SK120498A3 (en) 1999-04-13
NO984081D0 (no) 1998-09-04
DE19608653A1 (de) 1997-09-11
BR9708004A (pt) 1999-07-27
NZ331382A (en) 1999-08-30
EE9800289A (et) 1999-02-15
US5977102A (en) 1999-11-02
ZA971886B (en) 1998-09-07
CZ281698A3 (cs) 1999-02-17
AU712072B2 (en) 1999-10-28
AR009937A1 (es) 2000-05-17
HUP9901750A2 (hu) 1999-09-28
CA2248316A1 (en) 1997-09-12
JP2000506153A (ja) 2000-05-23
CO4650044A1 (es) 1998-09-03
CN1212696A (zh) 1999-03-31
AU1925297A (en) 1997-09-22
TR199801753T2 (xx) 1998-12-21
NO984081L (no) 1998-09-04
EP0885227A1 (de) 1998-12-23

Similar Documents

Publication Publication Date Title
BG102790A (bg) ПИРИМИДО/5,4-d/ПИРИМИДИНИ, ЛЕКАРСТВЕНИ СРЕДСТВА, СЪДЪРЖАЩИ ТЕЗИ СЪЕДИНЕНИЯ, ПРИЛОЖЕНИЕТО ИМ И МЕТОДЗА ТЯХНОТО ПОЛУЧАВАНЕ
AU710274B2 (en) 4-amino-pyrimidine derivates, medicaments containing these compounds, their use and process for their production
KR100597505B1 (ko) 4-아미노-6-페닐-피롤로[2,3-ｄ]피리미딘 유도체
CA2387013C (en) 6-position substituted indolinones, the preparation thereof and their use as pharmaceutical compositions
AU2013343550B2 (en) Substituted tricyclic benzimidazoles as kinase inhibitors
NZ292909A (en) Pyrimido[5,4-d]pyrimidines; medicaments
BG63163B1 (bg) Пиримидо/5,4-d/пиримидини, лекарствени средства, съдържащи тези съединения, приложението им и методза тяхното получаване
KR20070084191A (ko) 키나제 억제제로서의 １,４ 치환된 피라졸로피리미딘
ES2339174T3 (es) N-(aril- o heteroaril)-pirazo(1,5-a)pirimidinas 3-sustituidas como inhibidores de cinasa.
HUE035116T2 (hu) PI3K inhibitor pirimidinszármazékok és alkalmazásuk
SK12472002A3 (sk) 5-Alkylpyrido[2,3-d]pyrimidínové inhibítory tyrosínových kináz
TW200808325A (en) Novel compounds
KR20100015353A (ko) Ｊａｋ３ 억제제로서의 피롤로피리미딘 유도체
AU2007263017A1 (en) Pyridine and pyrazine derivatives as MNK kinase inhibitors
TW200831508A (en) Macrocyclic benzofused pyrimidine derivatives
CN107151249A (zh) 作为flt3抑制剂的蝶啶酮衍生物及应用
AU673814B2 (en) Imidazoquinazoline compounds and their preparation and use
NZ264133A (en) 2-[pyrrolidino, piperidino and hexamethyleneimino] substituted pyrimido pyrimidine derivatives and pharmaceutical compositions
KR20090007391A (ko) 키나제 억제제로서의 ３-비치환된 Ｎ-(아릴- 또는 헤테로아릴)-피라졸로[１,５-ａ]피리미딘
MXPA98007154A (en) Pirimido [5,4-d] pyrimidinas, medicines containing these compounds, its employment and procedures for its preparation
CA3233567A1 (en) Combination therapies of kras g12d inhibitors with pan erbb family inhibitors
KR100395271B1 (ko) 피리미도[5,4-d]피리미딘및이를포함하는약제