IL124397A - One-pot process for the preparation of azithromycin - Google Patents
One-pot process for the preparation of azithromycinInfo
- Publication number
- IL124397A IL124397A IL12439798A IL12439798A IL124397A IL 124397 A IL124397 A IL 124397A IL 12439798 A IL12439798 A IL 12439798A IL 12439798 A IL12439798 A IL 12439798A IL 124397 A IL124397 A IL 124397A
- Authority
- IL
- Israel
- Prior art keywords
- azithromycin
- preparation
- pot process
- formaldehyde
- reactions
- Prior art date
Links
- MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 title abstract 2
- 229960004099 azithromycin Drugs 0.000 title abstract 2
- 238000005580 one pot reaction Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 abstract 1
- ODUCDPQEXGNKDN-UHFFFAOYSA-N nitroxyl Chemical compound O=N ODUCDPQEXGNKDN-UHFFFAOYSA-N 0.000 abstract 1
- 229910000510 noble metal Inorganic materials 0.000 abstract 1
- 238000006722 reduction reaction Methods 0.000 abstract 1
- 238000006485 reductive methylation reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Indole Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PT102006A PT102006B (pt) | 1997-05-19 | 1997-05-19 | Novo processo de preparacao de azitromicina |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL124397A0 IL124397A0 (en) | 1998-12-06 |
| IL124397A true IL124397A (en) | 2003-09-17 |
Family
ID=20085680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12439798A IL124397A (en) | 1997-05-19 | 1998-05-10 | One-pot process for the preparation of azithromycin |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6013778A (forum.php) |
| EP (1) | EP0879823B1 (forum.php) |
| JP (1) | JP3899181B2 (forum.php) |
| CN (1) | CN1125076C (forum.php) |
| AT (1) | ATE231516T1 (forum.php) |
| AU (1) | AU722688B2 (forum.php) |
| CA (1) | CA2237747C (forum.php) |
| DE (1) | DE69810842T2 (forum.php) |
| ES (1) | ES2191256T3 (forum.php) |
| HU (1) | HUP9801094A3 (forum.php) |
| IL (1) | IL124397A (forum.php) |
| IN (1) | IN189736B (forum.php) |
| NZ (1) | NZ330228A (forum.php) |
| PT (1) | PT102006B (forum.php) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6861411B1 (en) | 1997-12-02 | 2005-03-01 | Pfizer, Inc. | Method of treating eye infections with azithromycin |
| TW546302B (en) | 1998-05-08 | 2003-08-11 | Biochemie Sa | Improvements in macrolide production |
| FR2791680B1 (fr) * | 1999-03-29 | 2001-06-29 | Merial Sas | Procede utile pour reduire les intermediaires imidates issus d'un rearrangement de beckmann d'un macrocycle 8a-azalide |
| US6239113B1 (en) | 1999-03-31 | 2001-05-29 | Insite Vision, Incorporated | Topical treatment or prevention of ocular infections |
| US7056893B2 (en) | 1999-03-31 | 2006-06-06 | Insite Vision, Inc. | Topical treatment for prevention of ocular infections |
| FR2806724B1 (fr) * | 2000-03-24 | 2003-12-05 | Merial Sas | Procede pour la preparation de derives 9-deoxo-8a-aza- (8a-alkyl)-8a-homoerythromycine a a partir de la 9-deoxo-9 (z)-hydroxyiminoerythromycine a |
| WO2002010144A1 (es) | 2000-07-25 | 2002-02-07 | Laboratorio Silanes, S.A. De C.V. | PROCESO PARA LA PREPARACION EN UN SOLO PASO DE 7,16-DIOXA-2-AZA-10-O-CLADINOSIL-12-O-DESOSAMINIL-4,5-DIHIDROXI-6-ETIL-3,5,9,11,13,15-HEXAMETILBICICLO[11.2.1]HEXADECA-1(2)-EN-8-ONA Y OBTENCION DE UNA FORMA NUEVA DE 9-DESOXO-9a-AZA-9a-METIL-9a-HOMOERITROMICINA A |
| CA2419873A1 (en) * | 2000-08-23 | 2002-02-28 | Wockhardt Limited | Process for preparation of anhydrous azithromycin |
| CN100341886C (zh) * | 2000-11-27 | 2007-10-10 | 桑多斯股份公司 | 大环内酯类化合物的溶剂化物 |
| EE05200B1 (et) * | 2000-11-27 | 2009-08-17 | Biochemie S.A. | Asitromtsiin monohdraadina, selle valmistamismeetod ja selle kasutamine ravimkoostises |
| ES2179756B1 (es) * | 2000-11-30 | 2004-10-01 | Ercros Industrial, S.A. | Procedimiento de obtencion de azaeritromicina. |
| KR100491183B1 (ko) | 2001-03-21 | 2005-05-25 | 한미약품 주식회사 | 아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물 |
| ITMI20021209A1 (it) * | 2002-06-04 | 2003-12-04 | Chemi Spa | Processo di preparazione di azitromicina ad elevata purezza |
| US7468428B2 (en) | 2004-03-17 | 2008-12-23 | App Pharmaceuticals, Llc | Lyophilized azithromycin formulation |
| US20060116336A1 (en) * | 2004-03-17 | 2006-06-01 | American Pharmaceutical Partners, Inc. | Lyophilized azithromycin formulation |
| US7683162B2 (en) * | 2004-08-30 | 2010-03-23 | Taro Pharmaceutical Industries Limited | Process of preparing a crystalline azithromycin monohydrate |
| CN1304407C (zh) * | 2004-09-03 | 2007-03-14 | 南京圣和药业有限公司 | 一种阿奇霉素的精制方法 |
| EP2189460B1 (en) | 2007-05-04 | 2014-04-23 | Mallinckrodt LLC | Improved process for the preparation of 6-alpha-hydroxy-n-alkylated opiates |
| NZ582668A (en) | 2007-07-17 | 2012-02-24 | Mallinckrodt Llc | Preparation of n-alkylated opiates by reductive amination |
| ES2439015T3 (es) | 2008-09-30 | 2014-01-21 | Mallinckrodt Llc | Procedimientos de aminación selectiva de cetomorfinanos |
| US8314218B2 (en) * | 2008-10-24 | 2012-11-20 | Merial Limited | Method of synthesizing macrolide compounds |
| US8946419B2 (en) | 2009-02-23 | 2015-02-03 | Mallinckrodt Llc | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
| EP2440561B1 (en) | 2009-06-11 | 2014-04-30 | Mallinckrodt LLC | Reductive amination of 6-keto normorphinans by catalytic hydrogen transfer |
| US8519133B2 (en) | 2009-06-11 | 2013-08-27 | Mallinckrodt Llc | Preparation of 6-alpha-amino N-substituted morphinans by catalytic hydrogen transfer |
| KR20140036215A (ko) | 2011-06-09 | 2014-03-25 | 말린크로트 엘엘씨 | 촉매 수소 전달에 의한 6-케토 모르피난의 환원 아미노화 |
| CN103917543A (zh) | 2011-09-08 | 2014-07-09 | 马林克罗特有限公司 | 在不分离中间体的情况下制备生物碱 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI8110592A8 (en) * | 1981-03-06 | 1996-06-30 | Pliva Pharm & Chem Works | Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof |
| US4474768A (en) * | 1982-07-19 | 1984-10-02 | Pfizer Inc. | N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor |
| PH19293A (en) * | 1982-11-15 | 1986-03-04 | Pfizer | Epimeric azahomoerythromycin,pharmaceutical composition containing the same and method of use thereof |
| ATE154806T1 (de) * | 1993-05-19 | 1997-07-15 | Pfizer | Zwischenprodukt für azithromycin |
-
1997
- 1997-05-19 PT PT102006A patent/PT102006B/pt not_active IP Right Cessation
-
1998
- 1998-04-17 AU AU61938/98A patent/AU722688B2/en not_active Ceased
- 1998-04-20 NZ NZ330228A patent/NZ330228A/xx unknown
- 1998-04-21 JP JP11041098A patent/JP3899181B2/ja not_active Expired - Fee Related
- 1998-04-27 IN IN1094DE1998 patent/IN189736B/en unknown
- 1998-05-10 IL IL12439798A patent/IL124397A/xx not_active IP Right Cessation
- 1998-05-15 CA CA002237747A patent/CA2237747C/en not_active Expired - Fee Related
- 1998-05-15 HU HU9801094A patent/HUP9801094A3/hu active IP Right Revival
- 1998-05-18 US US09/080,856 patent/US6013778A/en not_active Expired - Fee Related
- 1998-05-18 CN CN98108489A patent/CN1125076C/zh not_active Expired - Fee Related
- 1998-05-19 ES ES98303945T patent/ES2191256T3/es not_active Expired - Lifetime
- 1998-05-19 AT AT98303945T patent/ATE231516T1/de active
- 1998-05-19 EP EP98303945A patent/EP0879823B1/en not_active Expired - Lifetime
- 1998-05-19 DE DE69810842T patent/DE69810842T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69810842D1 (de) | 2003-02-27 |
| DE69810842T2 (de) | 2003-11-20 |
| IN189736B (forum.php) | 2003-04-19 |
| NZ330228A (en) | 1999-06-29 |
| CN1125076C (zh) | 2003-10-22 |
| PT102006B (pt) | 2000-06-30 |
| IL124397A0 (en) | 1998-12-06 |
| AU722688B2 (en) | 2000-08-10 |
| AU6193898A (en) | 1998-11-19 |
| EP0879823B1 (en) | 2003-01-22 |
| EP0879823A1 (en) | 1998-11-25 |
| JPH10316699A (ja) | 1998-12-02 |
| HU9801094D0 (en) | 1998-07-28 |
| HUP9801094A3 (en) | 2000-03-28 |
| ES2191256T3 (es) | 2003-09-01 |
| HUP9801094A2 (hu) | 1998-12-28 |
| CN1199736A (zh) | 1998-11-25 |
| ATE231516T1 (de) | 2003-02-15 |
| US6013778A (en) | 2000-01-11 |
| PT102006A (pt) | 1998-12-31 |
| CA2237747A1 (en) | 1998-11-19 |
| CA2237747C (en) | 2007-04-10 |
| JP3899181B2 (ja) | 2007-03-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |