ATE231516T1 - Herstellung von azithromycin - Google Patents

Herstellung von azithromycin

Info

Publication number
ATE231516T1
ATE231516T1 AT98303945T AT98303945T ATE231516T1 AT E231516 T1 ATE231516 T1 AT E231516T1 AT 98303945 T AT98303945 T AT 98303945T AT 98303945 T AT98303945 T AT 98303945T AT E231516 T1 ATE231516 T1 AT E231516T1
Authority
AT
Austria
Prior art keywords
azithromycin
preparation
formaldehyde
reactions
conducted
Prior art date
Application number
AT98303945T
Other languages
English (en)
Inventor
William Dr Heggie
Mouro Vaz Azevedo Mendes Zi De
Original Assignee
Hovione Int Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hovione Int Ltd filed Critical Hovione Int Ltd
Application granted granted Critical
Publication of ATE231516T1 publication Critical patent/ATE231516T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Catalysts (AREA)
AT98303945T 1997-05-19 1998-05-19 Herstellung von azithromycin ATE231516T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PT102006A PT102006B (pt) 1997-05-19 1997-05-19 Novo processo de preparacao de azitromicina

Publications (1)

Publication Number Publication Date
ATE231516T1 true ATE231516T1 (de) 2003-02-15

Family

ID=20085680

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98303945T ATE231516T1 (de) 1997-05-19 1998-05-19 Herstellung von azithromycin

Country Status (14)

Country Link
US (1) US6013778A (de)
EP (1) EP0879823B1 (de)
JP (1) JP3899181B2 (de)
CN (1) CN1125076C (de)
AT (1) ATE231516T1 (de)
AU (1) AU722688B2 (de)
CA (1) CA2237747C (de)
DE (1) DE69810842T2 (de)
ES (1) ES2191256T3 (de)
HU (1) HUP9801094A3 (de)
IL (1) IL124397A (de)
IN (1) IN189736B (de)
NZ (1) NZ330228A (de)
PT (1) PT102006B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6861411B1 (en) 1997-12-02 2005-03-01 Pfizer, Inc. Method of treating eye infections with azithromycin
TW546302B (en) 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
FR2791680B1 (fr) * 1999-03-29 2001-06-29 Merial Sas Procede utile pour reduire les intermediaires imidates issus d'un rearrangement de beckmann d'un macrocycle 8a-azalide
US6239113B1 (en) 1999-03-31 2001-05-29 Insite Vision, Incorporated Topical treatment or prevention of ocular infections
US7056893B2 (en) 1999-03-31 2006-06-06 Insite Vision, Inc. Topical treatment for prevention of ocular infections
FR2806724B1 (fr) * 2000-03-24 2003-12-05 Merial Sas Procede pour la preparation de derives 9-deoxo-8a-aza- (8a-alkyl)-8a-homoerythromycine a a partir de la 9-deoxo-9 (z)-hydroxyiminoerythromycine a
ES2260047T3 (es) 2000-07-25 2006-11-01 Laboratorio Silanes, S.A. De C.V. Proceso de etapa unica para la preparacion de 7,16-deoxi-2-aza-10-o-cladinosil-12-o-desosaminil-4,5-dihidroxi-6-etil-3,5,9,11,13,15-hexametilbiciclo(11.2.1)hexadeca-1(2)-en-ona y obtencion de una forma nueva de 9-deoxo-9a-metil-9a-homoeritromicina a.
JP2004506664A (ja) 2000-08-23 2004-03-04 ウォックハート・リミテッド 無水アジトロマイシンの製造法
EE05200B1 (et) * 2000-11-27 2009-08-17 Biochemie S.A. Asitromtsiin monohdraadina, selle valmistamismeetod ja selle kasutamine ravimkoostises
UA76967C2 (uk) * 2000-11-27 2006-10-16 Сандоз Аг Азитроміцин у формі моногідрату, фармацевтична композиція та спосіб його одержання
ES2179756B1 (es) * 2000-11-30 2004-10-01 Ercros Industrial, S.A. Procedimiento de obtencion de azaeritromicina.
KR100491183B1 (ko) * 2001-03-21 2005-05-25 한미약품 주식회사 아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물
ITMI20021209A1 (it) * 2002-06-04 2003-12-04 Chemi Spa Processo di preparazione di azitromicina ad elevata purezza
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7683162B2 (en) * 2004-08-30 2010-03-23 Taro Pharmaceutical Industries Limited Process of preparing a crystalline azithromycin monohydrate
CN1304407C (zh) * 2004-09-03 2007-03-14 南京圣和药业有限公司 一种阿奇霉素的精制方法
EP2152715B1 (de) 2007-05-04 2010-12-29 Mallinckrodt Inc. Verbessertes verfahren zur herstellung von 6-alpha-hydroxy-n-alkylierten opiaten
JP2010533719A (ja) 2007-07-17 2010-10-28 マリンクロッド・インコーポレイテッド 還元的アミノ化によるｎ−アルキル化オピエートの調製
NZ607842A (en) 2008-09-30 2013-12-20 Mallinckrodt Llc Processes for the selective amination of ketomorphinans
CA2741599C (en) * 2008-10-24 2016-09-13 Merial Limited Method of synthesizing macrolide compounds
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
PL2440562T3 (pl) 2009-06-11 2017-07-31 Mallinckrodt Llc Otrzymywanie 6-alfa-amino-N-podstawionych morfinanów w wyniku katalitycznego przeniesienia wodoru
WO2010144640A2 (en) 2009-06-11 2010-12-16 Mallinckrodt Inc. Reductive amination of 6-keto normorphinans by catalytic hydrogen transfer
AU2012267780B2 (en) 2011-06-09 2016-09-08 SpecGx LLC Reductive amination of 6-keto morphinans by catalytic hydrogen transfer
KR20140063763A (ko) 2011-09-08 2014-05-27 말린크로트 엘엘씨 중간체를 단리하지 않는 알칼로이드의 제조 방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
PH19293A (en) * 1982-11-15 1986-03-04 Pfizer Epimeric azahomoerythromycin,pharmaceutical composition containing the same and method of use thereof
EP0699207B1 (de) * 1993-05-19 1997-06-25 Pfizer Inc. Zwischenprodukt für azithromycin

Also Published As

Publication number Publication date
IL124397A0 (en) 1998-12-06
DE69810842T2 (de) 2003-11-20
JPH10316699A (ja) 1998-12-02
PT102006A (pt) 1998-12-31
AU722688B2 (en) 2000-08-10
CN1199736A (zh) 1998-11-25
AU6193898A (en) 1998-11-19
IL124397A (en) 2003-09-17
PT102006B (pt) 2000-06-30
EP0879823B1 (de) 2003-01-22
CA2237747C (en) 2007-04-10
NZ330228A (en) 1999-06-29
EP0879823A1 (de) 1998-11-25
HUP9801094A2 (hu) 1998-12-28
JP3899181B2 (ja) 2007-03-28
CA2237747A1 (en) 1998-11-19
ES2191256T3 (es) 2003-09-01
CN1125076C (zh) 2003-10-22
US6013778A (en) 2000-01-11
HUP9801094A3 (en) 2000-03-28
HU9801094D0 (en) 1998-07-28
IN189736B (de) 2003-04-19
DE69810842D1 (de) 2003-02-27

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