ES2191256T3 - Preparacion de azitromicina. - Google Patents

Preparacion de azitromicina.

Info

Publication number
ES2191256T3
ES2191256T3 ES98303945T ES98303945T ES2191256T3 ES 2191256 T3 ES2191256 T3 ES 2191256T3 ES 98303945 T ES98303945 T ES 98303945T ES 98303945 T ES98303945 T ES 98303945T ES 2191256 T3 ES2191256 T3 ES 2191256T3
Authority
ES
Spain
Prior art keywords
azithromycin
preparation
carrying
same
methodation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98303945T
Other languages
English (en)
Inventor
William Dr Heggie
Mouro Vaz Azevedo Mendes Zi De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hovione Inter AG
Original Assignee
Hovione Inter AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hovione Inter AG filed Critical Hovione Inter AG
Application granted granted Critical
Publication of ES2191256T3 publication Critical patent/ES2191256T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Catalysts (AREA)

Abstract

LA AZITROMICINA SE PREPARA A PARTIR DE UN IMINOETER LLEVANDO A CABO UNA REDUCCION Y METILACION REDUCTIVA POSTERIOR CON UN CATALIZADOR DE METAL NOBLE E HIDROGENO EN PRESENCIA DE FORMALDEHIDO, O UNA FUENTE DEL MISMO, LLEVANDOSE A CABO LAS DOS REACCIONES EN EL MISMO RECIPIENTE DE REACCION.
ES98303945T 1997-05-19 1998-05-19 Preparacion de azitromicina. Expired - Lifetime ES2191256T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PT102006A PT102006B (pt) 1997-05-19 1997-05-19 Novo processo de preparacao de azitromicina

Publications (1)

Publication Number Publication Date
ES2191256T3 true ES2191256T3 (es) 2003-09-01

Family

ID=20085680

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98303945T Expired - Lifetime ES2191256T3 (es) 1997-05-19 1998-05-19 Preparacion de azitromicina.

Country Status (14)

Country Link
US (1) US6013778A (es)
EP (1) EP0879823B1 (es)
JP (1) JP3899181B2 (es)
CN (1) CN1125076C (es)
AT (1) ATE231516T1 (es)
AU (1) AU722688B2 (es)
CA (1) CA2237747C (es)
DE (1) DE69810842T2 (es)
ES (1) ES2191256T3 (es)
HU (1) HUP9801094A3 (es)
IL (1) IL124397A (es)
IN (1) IN189736B (es)
NZ (1) NZ330228A (es)
PT (1) PT102006B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6861411B1 (en) 1997-12-02 2005-03-01 Pfizer, Inc. Method of treating eye infections with azithromycin
TW546302B (en) * 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
FR2791680B1 (fr) * 1999-03-29 2001-06-29 Merial Sas Procede utile pour reduire les intermediaires imidates issus d'un rearrangement de beckmann d'un macrocycle 8a-azalide
US6239113B1 (en) 1999-03-31 2001-05-29 Insite Vision, Incorporated Topical treatment or prevention of ocular infections
US7056893B2 (en) 1999-03-31 2006-06-06 Insite Vision, Inc. Topical treatment for prevention of ocular infections
FR2806724B1 (fr) * 2000-03-24 2003-12-05 Merial Sas Procede pour la preparation de derives 9-deoxo-8a-aza- (8a-alkyl)-8a-homoerythromycine a a partir de la 9-deoxo-9 (z)-hydroxyiminoerythromycine a
US6528492B1 (en) 2000-07-25 2003-03-04 Instituto De Investigacion En Quimica Aplicada S.C. Single-step process for preparing 7, 16-deoxy-2-aza-10-0-cladinosil-12-0-desosaminil-4, 5-dihydroxy-6-ethyl-3,5,9,11,13,15-hexamethylbicycle (11.2.1) hexadeca-1(2)-en-ona and obtaining a new form of 9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin a
ATE306491T1 (de) 2000-08-23 2005-10-15 Wockhardt Ltd Verfahren zur herstellung von wasserfreiem azithromycin
JP2004519430A (ja) * 2000-11-27 2004-07-02 バイオケミ・エセ・ア マクロライドの溶媒和物
UA76967C2 (uk) * 2000-11-27 2006-10-16 Сандоз Аг Азитроміцин у формі моногідрату, фармацевтична композиція та спосіб його одержання
ES2179756B1 (es) * 2000-11-30 2004-10-01 Ercros Industrial, S.A. Procedimiento de obtencion de azaeritromicina.
KR100491183B1 (ko) * 2001-03-21 2005-05-25 한미약품 주식회사 아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물
ITMI20021209A1 (it) * 2002-06-04 2003-12-04 Chemi Spa Processo di preparazione di azitromicina ad elevata purezza
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7683162B2 (en) * 2004-08-30 2010-03-23 Taro Pharmaceutical Industries Limited Process of preparing a crystalline azithromycin monohydrate
CN1304407C (zh) * 2004-09-03 2007-03-14 南京圣和药业有限公司 一种阿奇霉素的精制方法
ES2407033T3 (es) 2007-05-04 2013-06-11 Mallinckrodt Llc Procedimientos mejorados para la preparación de opiáceos 6-alfa-hidroxi-n-alquilados
NZ582668A (en) 2007-07-17 2012-02-24 Mallinckrodt Llc Preparation of n-alkylated opiates by reductive amination
CA2738628C (en) 2008-09-30 2017-07-04 Mallinckrodt Inc. Processes for the selective amination of ketomorphinans
EP2358732B1 (en) * 2008-10-24 2013-06-19 Merial Ltd. Method of synthesizing macrolide compounds
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
WO2010144641A1 (en) 2009-06-11 2010-12-16 Mallinckrodt Inc. Preparation of 6-alpha-amino n-substituted morphinans by catalytic hydrogen transfer
EP2440561B1 (en) 2009-06-11 2014-04-30 Mallinckrodt LLC Reductive amination of 6-keto normorphinans by catalytic hydrogen transfer
MX2013013634A (es) 2011-06-09 2013-12-12 Mallinckrodt Llc Aminacion reductiva de 6-ceto-morfinanos por transfrencia catalitica de hidrogeno.
ES2566620T3 (es) 2011-09-08 2016-04-14 Mallinckrodt Llc Procesamiento de alcaloides sin el aislamiento de intermedios

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
PH19293A (en) * 1982-11-15 1986-03-04 Pfizer Epimeric azahomoerythromycin,pharmaceutical composition containing the same and method of use thereof
DK0699207T3 (da) * 1993-05-19 1997-12-08 Pfizer Mellemprodukt til azithromycin

Also Published As

Publication number Publication date
IN189736B (es) 2003-04-19
EP0879823A1 (en) 1998-11-25
DE69810842T2 (de) 2003-11-20
CN1125076C (zh) 2003-10-22
PT102006A (pt) 1998-12-31
HU9801094D0 (en) 1998-07-28
JPH10316699A (ja) 1998-12-02
JP3899181B2 (ja) 2007-03-28
HUP9801094A3 (en) 2000-03-28
AU6193898A (en) 1998-11-19
AU722688B2 (en) 2000-08-10
NZ330228A (en) 1999-06-29
PT102006B (pt) 2000-06-30
IL124397A (en) 2003-09-17
EP0879823B1 (en) 2003-01-22
CN1199736A (zh) 1998-11-25
DE69810842D1 (de) 2003-02-27
IL124397A0 (en) 1998-12-06
CA2237747C (en) 2007-04-10
HUP9801094A2 (hu) 1998-12-28
US6013778A (en) 2000-01-11
ATE231516T1 (de) 2003-02-15
CA2237747A1 (en) 1998-11-19

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