IL122853A - שימוש באלילאמינים בהכנת תכשירי רוקחות - Google Patents
שימוש באלילאמינים בהכנת תכשירי רוקחותInfo
- Publication number
- IL122853A IL122853A IL12285396A IL12285396A IL122853A IL 122853 A IL122853 A IL 122853A IL 12285396 A IL12285396 A IL 12285396A IL 12285396 A IL12285396 A IL 12285396A IL 122853 A IL122853 A IL 122853A
- Authority
- IL
- Israel
- Prior art keywords
- compound
- pylori infection
- infection
- pharmaceutically acceptable
- formula
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 7
- 238000002360 preparation method Methods 0.000 title claims description 5
- 150000001875 compounds Chemical class 0.000 claims abstract description 37
- 150000003839 salts Chemical group 0.000 claims abstract description 18
- 208000015181 infectious disease Diseases 0.000 claims abstract description 17
- 239000012458 free base Substances 0.000 claims abstract description 16
- 201000010099 disease Diseases 0.000 claims abstract description 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 14
- 238000002560 therapeutic procedure Methods 0.000 claims description 12
- 206010019375 Helicobacter infections Diseases 0.000 claims description 11
- 239000013543 active substance Substances 0.000 claims description 11
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims description 7
- 208000007882 Gastritis Diseases 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 239000002775 capsule Substances 0.000 claims description 6
- 239000003085 diluting agent Substances 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 206010017758 gastric cancer Diseases 0.000 claims description 5
- 206010054949 Metaplasia Diseases 0.000 claims description 4
- 208000008469 Peptic Ulcer Diseases 0.000 claims description 4
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 208000011906 peptic ulcer disease Diseases 0.000 claims description 4
- 201000011549 stomach cancer Diseases 0.000 claims description 4
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 4
- 208000036170 B-Cell Marginal Zone Lymphoma Diseases 0.000 claims description 3
- 206010061850 Extranodal marginal zone B-cell lymphoma (MALT type) Diseases 0.000 claims description 3
- 201000003791 MALT lymphoma Diseases 0.000 claims description 3
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims description 3
- 208000025865 Ulcer Diseases 0.000 claims description 3
- 208000000718 duodenal ulcer Diseases 0.000 claims description 3
- 201000006549 dyspepsia Diseases 0.000 claims description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 3
- 208000004300 Atrophic Gastritis Diseases 0.000 claims description 2
- 208000016644 chronic atrophic gastritis Diseases 0.000 claims description 2
- 229960001380 cimetidine Drugs 0.000 claims description 2
- CCGSUNCLSOWKJO-UHFFFAOYSA-N cimetidine Chemical compound N#CNC(=N/C)\NCCSCC1=NC=N[C]1C CCGSUNCLSOWKJO-UHFFFAOYSA-N 0.000 claims description 2
- XUFQPHANEAPEMJ-UHFFFAOYSA-N famotidine Chemical compound NC(N)=NC1=NC(CSCCC(N)=NS(N)(=O)=O)=CS1 XUFQPHANEAPEMJ-UHFFFAOYSA-N 0.000 claims description 2
- 229960001596 famotidine Drugs 0.000 claims description 2
- 210000005095 gastrointestinal system Anatomy 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 125000001624 naphthyl group Chemical group 0.000 claims description 2
- 229960000620 ranitidine Drugs 0.000 claims description 2
- VMXUWOKSQNHOCA-LCYFTJDESA-N ranitidine Chemical compound [O-][N+](=O)/C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-LCYFTJDESA-N 0.000 claims description 2
- MNQYNQBOVCBZIQ-JQOFMKNESA-A sucralfate Chemical compound O[Al](O)OS(=O)(=O)O[C@@H]1[C@@H](OS(=O)(=O)O[Al](O)O)[C@H](OS(=O)(=O)O[Al](O)O)[C@@H](COS(=O)(=O)O[Al](O)O)O[C@H]1O[C@@]1(COS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)[C@H](OS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)O1 MNQYNQBOVCBZIQ-JQOFMKNESA-A 0.000 claims description 2
- 229960004291 sucralfate Drugs 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 abstract description 8
- 238000011282 treatment Methods 0.000 description 11
- 241000590002 Helicobacter pylori Species 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 230000001857 anti-mycotic effect Effects 0.000 description 3
- 229940037467 helicobacter pylori Drugs 0.000 description 3
- DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical compound C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 description 3
- VVJKKWFAADXIJK-UHFFFAOYSA-N Allylamine Chemical class NCC=C VVJKKWFAADXIJK-UHFFFAOYSA-N 0.000 description 2
- 206010003694 Atrophy Diseases 0.000 description 2
- 241000589562 Brucella Species 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- -1 N-[(E)-3-phenyl-2-propenyl]-2-piperidinyl Chemical group 0.000 description 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 description 2
- 108010046334 Urease Proteins 0.000 description 2
- 239000002543 antimycotic Substances 0.000 description 2
- 230000037444 atrophy Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000006161 blood agar Substances 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 230000008029 eradication Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 239000000902 placebo Substances 0.000 description 2
- 229940068196 placebo Drugs 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 229960002722 terbinafine Drugs 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 108010053835 Catalase Proteins 0.000 description 1
- 102000016938 Catalase Human genes 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 239000001828 Gelatine Substances 0.000 description 1
- 241000589989 Helicobacter Species 0.000 description 1
- 229940122957 Histamine H2 receptor antagonist Drugs 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102000005782 Squalene Monooxygenase Human genes 0.000 description 1
- 108020003891 Squalene monooxygenase Proteins 0.000 description 1
- 208000002474 Tinea Diseases 0.000 description 1
- 241000893966 Trichophyton verrucosum Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- 239000007478 blood agar base Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000001364 causal effect Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 208000023652 chronic gastritis Diseases 0.000 description 1
- 238000011443 conventional therapy Methods 0.000 description 1
- 238000009109 curative therapy Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 210000003495 flagella Anatomy 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000001156 gastric mucosa Anatomy 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 239000003485 histamine H2 receptor antagonist Substances 0.000 description 1
- 231100000003 human carcinogen Toxicity 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 229940089474 lamisil Drugs 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000003563 lymphoid tissue Anatomy 0.000 description 1
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
- 229960000282 metronidazole Drugs 0.000 description 1
- 239000004530 micro-emulsion Substances 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 238000012134 rapid urease test Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4458—Non condensed piperidines, e.g. piperocaine only substituted in position 2, e.g. methylphenidate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Hydrogenated Pyridines (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9513750.1A GB9513750D0 (en) | 1995-07-06 | 1995-07-06 | Use of allylamines |
| PCT/EP1996/002970 WO1997002026A1 (en) | 1995-07-06 | 1996-07-05 | Use of allylamine derivatives such as terbinafine, in the manufacture of a medicament for the treatment of helicobacter pylori infection of associated diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL122853A0 IL122853A0 (en) | 1998-08-16 |
| IL122853A true IL122853A (he) | 2001-04-30 |
Family
ID=10777201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12285396A IL122853A (he) | 1995-07-06 | 1996-07-05 | שימוש באלילאמינים בהכנת תכשירי רוקחות |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5935998A (he) |
| EP (1) | EP0863752B1 (he) |
| JP (1) | JP3680950B2 (he) |
| KR (1) | KR100425401B1 (he) |
| CN (1) | CN1204881C (he) |
| AT (1) | ATE232723T1 (he) |
| AU (1) | AU715270B2 (he) |
| CA (1) | CA2219678C (he) |
| CY (1) | CY2465B1 (he) |
| CZ (1) | CZ289440B6 (he) |
| DE (1) | DE69626301T2 (he) |
| DK (1) | DK0863752T3 (he) |
| ES (1) | ES2192608T3 (he) |
| GB (1) | GB9513750D0 (he) |
| HK (1) | HK1011527A1 (he) |
| HU (1) | HU224311B1 (he) |
| IL (1) | IL122853A (he) |
| MX (1) | MX9710093A (he) |
| MY (1) | MY132436A (he) |
| NO (1) | NO317496B1 (he) |
| PL (1) | PL187704B1 (he) |
| RU (1) | RU2193402C2 (he) |
| SI (1) | SI0863752T1 (he) |
| SK (1) | SK282874B6 (he) |
| TW (1) | TW522011B (he) |
| WO (1) | WO1997002026A1 (he) |
| ZA (1) | ZA965749B (he) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0001315D0 (en) * | 2000-01-20 | 2000-03-08 | Novartis Ag | Organic compounds |
| US7244703B2 (en) * | 2001-06-22 | 2007-07-17 | Bentley Pharmaceuticals, Inc. | Pharmaceutical compositions and methods for peptide treatment |
| KR20030066186A (ko) * | 2002-02-05 | 2003-08-09 | 한솔케미언스 주식회사 | (ｅ)-터비나핀 또는 이의 염산염의 제조방법 |
| CN101829319A (zh) | 2003-12-08 | 2010-09-15 | Cpex药品公司 | 用于胰岛素治疗的药用组合物及方法 |
| RU2449805C1 (ru) | 2011-01-27 | 2012-05-10 | Общество С Ограниченной Ответственностью "Гармония" | Пептидная фармацевтическая композиция, средство на ее основе для лечения гастродуоденальных заболеваний, вызываемых helicobacter pylori, и способ его использования |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2716943C2 (de) * | 1976-04-28 | 1986-08-14 | Sandoz-Patent-GmbH, 7850 Lörrach | N-(3-Phenyl-2-propenyl)-N-(1-naphthylmethyl)-amine, ihre Verwendung und Herstellung |
| DE2862103D1 (en) * | 1977-08-19 | 1982-11-18 | Sandoz Ag | Propenyl amines, processes for their production and pharmaceutical compositions containing them |
| DE3020113A1 (de) * | 1979-06-08 | 1980-12-18 | Sandoz Ag | 2-(1-naphthyl)piperidin-derivat, dessen herstellung sowie die verwendung als antimykotika |
| US5132459A (en) * | 1979-08-22 | 1992-07-21 | Sandoz Ltd. | Propenylamines, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals |
| DE3069633D1 (en) * | 1979-08-22 | 1984-12-20 | Sandoz Ag | Propenylamines, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals |
| US4894375A (en) * | 1986-09-29 | 1990-01-16 | Merck & Co., Inc. | Method of controlling mycotic infections and compositions therefor |
| CA2020888A1 (en) * | 1989-07-27 | 1991-01-28 | Philippe Guerry | Substituted aminoalkoxybenzene derivatives |
| US5200195A (en) * | 1991-12-06 | 1993-04-06 | Alza Corporation | Process for improving dosage form delivery kinetics |
| DE4317449A1 (de) * | 1993-05-19 | 1994-11-24 | Asche Ag | Arzneimittel zur Behandlung von Erkrankungen des Magen-Darm-Traktes |
-
1995
- 1995-07-06 GB GBGB9513750.1A patent/GB9513750D0/en active Pending
-
1996
- 1996-07-05 CA CA002219678A patent/CA2219678C/en not_active Expired - Fee Related
- 1996-07-05 KR KR10-1998-0700023A patent/KR100425401B1/ko not_active IP Right Cessation
- 1996-07-05 HU HU9802929A patent/HU224311B1/hu not_active IP Right Cessation
- 1996-07-05 JP JP50483397A patent/JP3680950B2/ja not_active Expired - Fee Related
- 1996-07-05 SI SI9630594T patent/SI0863752T1/xx unknown
- 1996-07-05 ES ES96924889T patent/ES2192608T3/es not_active Expired - Lifetime
- 1996-07-05 DK DK96924889T patent/DK0863752T3/da active
- 1996-07-05 PL PL96323305A patent/PL187704B1/pl not_active IP Right Cessation
- 1996-07-05 AU AU65195/96A patent/AU715270B2/en not_active Ceased
- 1996-07-05 WO PCT/EP1996/002970 patent/WO1997002026A1/en active IP Right Grant
- 1996-07-05 MY MYPI96002783A patent/MY132436A/en unknown
- 1996-07-05 DE DE69626301T patent/DE69626301T2/de not_active Expired - Lifetime
- 1996-07-05 ZA ZA9605749A patent/ZA965749B/xx unknown
- 1996-07-05 US US08/981,324 patent/US5935998A/en not_active Expired - Fee Related
- 1996-07-05 IL IL12285396A patent/IL122853A/he not_active IP Right Cessation
- 1996-07-05 SK SK6-98A patent/SK282874B6/sk not_active IP Right Cessation
- 1996-07-05 AT AT96924889T patent/ATE232723T1/de not_active IP Right Cessation
- 1996-07-05 CZ CZ199817A patent/CZ289440B6/cs not_active IP Right Cessation
- 1996-07-05 EP EP96924889A patent/EP0863752B1/en not_active Expired - Lifetime
- 1996-07-05 RU RU98102187/14A patent/RU2193402C2/ru not_active IP Right Cessation
- 1996-07-05 MX MX9710093A patent/MX9710093A/es not_active IP Right Cessation
- 1996-07-05 CN CNB96195289XA patent/CN1204881C/zh not_active Expired - Fee Related
- 1996-07-06 TW TW085108161A patent/TW522011B/zh not_active IP Right Cessation
-
1997
- 1997-12-09 NO NO19975790A patent/NO317496B1/no not_active IP Right Cessation
-
1998
- 1998-12-07 HK HK98112906A patent/HK1011527A1/xx not_active IP Right Cessation
-
2004
- 2004-07-02 CY CY0400055A patent/CY2465B1/xx unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6287597B1 (en) | Antihistaminic/decongestant compositions | |
| HU229292B1 (en) | New pharmaceutical composition | |
| JPH08512322A (ja) | Ｈ▲下２▼拮抗剤−胃腸運動性の薬剤組合せ物 | |
| JP2002525266A (ja) | 感染性潰瘍又は胃炎に対するタウロリジン及び／又はタウルルタム | |
| EP1791545B1 (en) | Prostaglandin derivatives for treating constipation | |
| CA2219678C (en) | Use of allylamine derivatives such as terbinafine, in the manufacture of a medicament for the treatment of helicobacter pylori infection or associated diseases | |
| FR2904774A1 (fr) | Composition pharmaceutique solide contenant une combinaison d'un agent regulateur de la motilite intestinale et d'un antiflatulent. | |
| JP2021535910A (ja) | ヘリコバクターピロリ菌を除菌するための組成物 | |
| JPH0930970A (ja) | 抗菌剤 | |
| WO1998013041A1 (en) | Prophylaxis and treatment of intestinal tract fluid and electrolyte loss using histidine compositions | |
| JP2005511721A (ja) | エポチロンを含む組成物およびカルチノイド症候群の治療のためのそれらの使用 | |
| JP3490146B2 (ja) | 抗ヘリコバクター・ピロリ剤 | |
| JPH11189529A (ja) | 抗ヘリコバクター・ピロリ剤 | |
| US6380217B1 (en) | Methods for controlling GGT-positive bacteria | |
| KR20010052895A (ko) | 치료 방법 | |
| LV13000B (en) | Venlafaxine and its analogues for inducing cognition enhancement | |
| AU690664B2 (en) | Low dosage ranitidine compositions for the treatment of minor gastrointestinal disorders associated with excess acid secretion | |
| JP2612417B2 (ja) | 消化器症状改善剤 | |
| JP2898930B2 (ja) | 消化器症状改善剤 | |
| FR2566664A1 (fr) | Composition utile au traitement de la diarrhee contenant du dextromethorphan | |
| Franco-Paredes | Mycobacterium leprae | |
| JP2000080031A (ja) | 抗菌剤 | |
| JPH01197443A (ja) | Ｈ↓１ブロッカー、ｈ↓２ブロッカー、ベーターアドレナリン作用剤又はそれらの組み合せ及びアルカリ化剤を含む非ステロイド抗炎症薬剤組成物及び投与方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |