IL122748A0 - Naphthyl and dihydronaphthyl intermediates compounds compositions and methods - Google Patents
Naphthyl and dihydronaphthyl intermediates compounds compositions and methodsInfo
- Publication number
- IL122748A0 IL122748A0 IL12274896A IL12274896A IL122748A0 IL 122748 A0 IL122748 A0 IL 122748A0 IL 12274896 A IL12274896 A IL 12274896A IL 12274896 A IL12274896 A IL 12274896A IL 122748 A0 IL122748 A0 IL 122748A0
- Authority
- IL
- Israel
- Prior art keywords
- alkyl
- compounds
- pyrrolidinyl
- present
- methods
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL13460000A IL134600A0 (en) | 1995-07-31 | 2000-02-17 | Intermediates for naphthyl and dihydronaphthyl compounds, pharmaceutical compositions containing them and uses thereof as medicaments in the treatment of post-menopausal syndrome |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US168295P | 1995-07-31 | 1995-07-31 | |
PCT/US1996/012387 WO1997004763A1 (fr) | 1995-07-31 | 1996-07-26 | Composes naphtyle et dihydronaphtyle, intermediaires, compositions et procedes correspondants |
Publications (1)
Publication Number | Publication Date |
---|---|
IL122748A0 true IL122748A0 (en) | 1998-08-16 |
Family
ID=21697295
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL12274896A IL122748A0 (en) | 1995-07-31 | 1996-07-26 | Naphthyl and dihydronaphthyl intermediates compounds compositions and methods |
Country Status (21)
Country | Link |
---|---|
US (1) | US5811421A (fr) |
EP (1) | EP0761659B1 (fr) |
JP (1) | JPH11510798A (fr) |
KR (1) | KR19990036006A (fr) |
CN (1) | CN1198668A (fr) |
AT (1) | ATE240948T1 (fr) |
AU (1) | AU703317B2 (fr) |
BR (1) | BR9609844A (fr) |
CA (1) | CA2228178A1 (fr) |
CZ (1) | CZ289605B6 (fr) |
DE (1) | DE69628246T2 (fr) |
ES (1) | ES2198462T3 (fr) |
HU (1) | HUP9802408A3 (fr) |
IL (1) | IL122748A0 (fr) |
MX (1) | MX9800800A (fr) |
NO (1) | NO310186B1 (fr) |
NZ (1) | NZ315174A (fr) |
PL (1) | PL324816A1 (fr) |
RU (1) | RU2167158C2 (fr) |
TR (1) | TR199800132T1 (fr) |
WO (1) | WO1997004763A1 (fr) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2214070C (fr) * | 1996-08-29 | 2006-03-14 | Eli Lilly And Company | Dihydronaphtalenes et naphtalenes, intermediaires, formulations et methodes |
CA2213814A1 (fr) * | 1996-08-29 | 1998-02-28 | Henry Uhlman Bryant | Composes naphtaleniques, intermediaires, formulations et methodes |
CA2214929A1 (fr) * | 1996-09-26 | 1998-03-26 | Charles Willis Lugar, Iii | Naphtofluorenes, intermediaires, compositions et methodes |
CA2214931A1 (fr) * | 1996-09-26 | 1998-03-26 | Henry Uhlman Bryant | Tetrahydrobenzo-a-fluorenes et methode d'utilisation |
CA2214935A1 (fr) * | 1996-09-26 | 1998-03-26 | Henry Uhlman Bryant | Benzofluorenes, intermediaires, compositions et methodes |
US5916916A (en) * | 1996-10-10 | 1999-06-29 | Eli Lilly And Company | 1-aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods |
CA2217810A1 (fr) * | 1996-10-10 | 1998-04-10 | Eli Lilly And Company | Composes 2-aryl-3-aminoaryloxynaphtyliques, intermediaires, compositions et methodes |
JP2002510289A (ja) * | 1997-04-25 | 2002-04-02 | イーライ・リリー・アンド・カンパニー | Sermとしての活性を持つインデン化合物 |
JP2001513501A (ja) * | 1997-08-07 | 2001-09-04 | イーライ・リリー・アンド・カンパニー | エストロゲン阻害活性を有する1−[4−(置換アルコキシ)ベンジル]ナフタレン化合物 |
US5929090A (en) * | 1997-09-12 | 1999-07-27 | Eli Lilly And Company | 2-aryl-3-aminoaryloxynaphthy1 compounds, intermediates, compositions and methods |
US6249683B1 (en) | 1999-04-08 | 2001-06-19 | Qualcomm Incorporated | Forward link power control of multiple data streams transmitted to a mobile station using a common power control channel |
US6610705B1 (en) * | 2000-03-31 | 2003-08-26 | Council Of Scientific And Industrial Research | Process for the preparation of diaryl naphthyl methanes |
WO2002094268A1 (fr) * | 2001-05-22 | 2002-11-28 | Eli Lilly And Company | Derives de tetrahydroquinoline pour l'inhibition de maladies associees a l'isolement d'oestrogenes ou a une reponse physiologique aberrante a un oestrogene endogene |
DE60210283T2 (de) * | 2001-05-22 | 2006-11-09 | Eli Lilly And Co., Indianapolis | 2-substituierte 1,2,3,4-tetrahydrochinoline und derivate davon, zusammensetzungen und verfahren |
EP1709023B1 (fr) * | 2004-01-22 | 2009-11-11 | Eli Lilly And Company | Modulateurs selectifs du recepteur des oestrogenes |
EP1709022A1 (fr) * | 2004-01-22 | 2006-10-11 | Eli Lilly And Company | Modulateurs selectifs du recepteur des oestrogenes |
US7429681B2 (en) | 2005-06-14 | 2008-09-30 | Baylor University | Combretastatin analogs with tubulin binding activity |
WO2011156908A1 (fr) | 2010-06-16 | 2011-12-22 | Endorecherche, Inc. | Méthodes de traitement prophylactique ou thérapeutique de maladies liées aux œstrogènes |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3274213A (en) * | 1961-09-05 | 1966-09-20 | Upjohn Co | Alkoxy-substituted 2-phenyl-1-(tertiary-aminoalkoxy)phenyl-3, 4-dihydronaphthalenes |
US3396169A (en) * | 1966-10-26 | 1968-08-06 | Upjohn Co | Substituted 2-phenyl-1-(tertiary-aminoalkoxy) phenyl-3, 4-dihydronaphthalenes |
US3862232A (en) * | 1963-07-03 | 1975-01-21 | Upjohn Co | 1-(p-hydroxyphenyl)-2-phenyl-6-(2-diethylaminoethoxy)-3,4-dihydronaphthalene and the salts thereof |
US3313853A (en) * | 1963-10-16 | 1967-04-11 | Upjohn Co | 2-(tertiaryaminoalkoxyphenyl)-3, 4-dihydronaphthalenes and 2-(tertiaryaminoalkoxyphenyl) -3, 4- dihydro -1(2h)-naphthalenones |
US3293263A (en) * | 1963-12-09 | 1966-12-20 | Upjohn Co | Diphenylbenzocycloalkenes |
US3320271A (en) * | 1964-06-01 | 1967-05-16 | Upjohn Co | 1, 2-diphenyl-3, 4-dihydronaphthalenes and 2, 3-diphenylindenes |
DE1300575B (de) * | 1965-05-21 | 1969-08-07 | Bristol Myers Co | Benzo[b]thiophene |
US3394125A (en) * | 1965-10-23 | 1968-07-23 | Bristol Myers Co | 2-phenyl-3-tertiary-aminoalkoxy phenyl-and corresponding tertiaryaminoalkyl thio benzfurans substituted in the benzo nucleus with an alkoxy or tertiaryamino alkoxy or alkylthio group |
US3483293A (en) * | 1967-12-15 | 1969-12-09 | Upjohn Co | Method for controlling birds and rodents |
US3567737A (en) * | 1968-01-02 | 1971-03-02 | Upjohn Co | Derivatives of (2-cycloalkyl-1-phenyl-3,4-dihydronaphthalenes and) 2 - cycloalkyl - 1 - phenyl - 1,2,3,4 - tetrahydro-naphthalenes |
US4133814A (en) * | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
US4230862A (en) * | 1975-10-28 | 1980-10-28 | Eli Lilly And Company | Antifertility compounds |
US4380635A (en) * | 1981-04-03 | 1983-04-19 | Eli Lilly And Company | Synthesis of acylated benzothiophenes |
US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
GB8311678D0 (en) * | 1983-04-28 | 1983-06-02 | Ici Plc | Phenol derivatives |
US4859695A (en) * | 1986-06-10 | 1989-08-22 | Merck & Co., Inc. | Antiestrogen agents having anabolic activity in animals |
GB8705174D0 (en) * | 1987-03-05 | 1987-04-08 | Ici Plc | Heterocyclic compounds |
US5013761A (en) * | 1988-06-03 | 1991-05-07 | Eli Lilly And Company | Serotonin antagonists |
US5395842A (en) * | 1988-10-31 | 1995-03-07 | Endorecherche Inc. | Anti-estrogenic compounds and compositions |
US5254568A (en) * | 1990-08-09 | 1993-10-19 | Council Of Scientific & Industrial Research | Benzopyrans as antiestrogenic agents |
DE4117512A1 (de) * | 1991-05-25 | 1992-11-26 | Schering Ag | 2-phenylbenzo(b)furane und -thiophene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
JP3157882B2 (ja) * | 1991-11-15 | 2001-04-16 | 帝国臓器製薬株式会社 | 新規なベンゾチオフエン誘導体 |
US6756388B1 (en) * | 1993-10-12 | 2004-06-29 | Pfizer Inc. | Benzothiophenes and related compounds as estrogen agonists |
US5554628A (en) * | 1994-09-20 | 1996-09-10 | Eli Lilly And Company | Method for minimizing the uterothrophic effect of tamoxifen and tamoxifen analogs |
US7501441B1 (en) * | 1994-09-20 | 2009-03-10 | Eli Lilly And Company | Naphthyl compounds, intermediates, processes, compositions, and methods |
US6391892B1 (en) * | 1995-03-10 | 2002-05-21 | Eli Lilly And Company | Naphthyl pharmaceutical compounds |
-
1996
- 1996-07-16 US US08/679,593 patent/US5811421A/en not_active Expired - Fee Related
- 1996-07-22 ES ES96305344T patent/ES2198462T3/es not_active Expired - Lifetime
- 1996-07-22 DE DE69628246T patent/DE69628246T2/de not_active Expired - Fee Related
- 1996-07-22 EP EP96305344A patent/EP0761659B1/fr not_active Expired - Lifetime
- 1996-07-22 AT AT96305344T patent/ATE240948T1/de not_active IP Right Cessation
- 1996-07-26 MX MX9800800A patent/MX9800800A/es unknown
- 1996-07-26 CZ CZ1998276A patent/CZ289605B6/cs not_active IP Right Cessation
- 1996-07-26 WO PCT/US1996/012387 patent/WO1997004763A1/fr not_active Application Discontinuation
- 1996-07-26 HU HU9802408A patent/HUP9802408A3/hu unknown
- 1996-07-26 KR KR1019980700670A patent/KR19990036006A/ko not_active Application Discontinuation
- 1996-07-26 JP JP9507821A patent/JPH11510798A/ja not_active Withdrawn
- 1996-07-26 TR TR1998/00132T patent/TR199800132T1/xx unknown
- 1996-07-26 PL PL96324816A patent/PL324816A1/xx unknown
- 1996-07-26 AU AU66821/96A patent/AU703317B2/en not_active Ceased
- 1996-07-26 RU RU98103465/04A patent/RU2167158C2/ru active
- 1996-07-26 IL IL12274896A patent/IL122748A0/xx unknown
- 1996-07-26 NZ NZ315174A patent/NZ315174A/xx unknown
- 1996-07-26 CN CN96197331A patent/CN1198668A/zh active Pending
- 1996-07-26 BR BR9609844A patent/BR9609844A/pt not_active Application Discontinuation
- 1996-07-26 CA CA002228178A patent/CA2228178A1/fr not_active Abandoned
-
1998
- 1998-01-29 NO NO19980395A patent/NO310186B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR19990036006A (ko) | 1999-05-25 |
BR9609844A (pt) | 1999-03-09 |
NO310186B1 (no) | 2001-06-05 |
CA2228178A1 (fr) | 1997-02-13 |
PL324816A1 (en) | 1998-06-22 |
NO980395L (no) | 1998-03-26 |
TR199800132T1 (xx) | 1998-05-21 |
CZ27698A3 (cs) | 1998-07-15 |
JPH11510798A (ja) | 1999-09-21 |
CZ289605B6 (cs) | 2002-03-13 |
MX9800800A (es) | 1998-04-30 |
RU2167158C2 (ru) | 2001-05-20 |
NZ315174A (en) | 1999-07-29 |
HUP9802408A3 (en) | 1999-06-28 |
DE69628246T2 (de) | 2004-03-25 |
CN1198668A (zh) | 1998-11-11 |
ATE240948T1 (de) | 2003-06-15 |
DE69628246D1 (de) | 2003-06-26 |
EP0761659B1 (fr) | 2003-05-21 |
AU703317B2 (en) | 1999-03-25 |
US5811421A (en) | 1998-09-22 |
WO1997004763A1 (fr) | 1997-02-13 |
AU6682196A (en) | 1997-02-26 |
ES2198462T3 (es) | 2004-02-01 |
EP0761659A1 (fr) | 1997-03-12 |
HUP9802408A2 (hu) | 1999-01-28 |
NO980395D0 (no) | 1998-01-29 |
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