IL121860A0 - Interleukin-18 binding proteins their preparation and use - Google Patents

Interleukin-18 binding proteins their preparation and use

Info

Publication number
IL121860A0
IL121860A0 IL12186097A IL12186097A IL121860A0 IL 121860 A0 IL121860 A0 IL 121860A0 IL 12186097 A IL12186097 A IL 12186097A IL 12186097 A IL12186097 A IL 12186097A IL 121860 A0 IL121860 A0 IL 121860A0
Authority
IL
Israel
Prior art keywords
interleukin
preparation
binding proteins
proteins
binding
Prior art date
Application number
IL12186097A
Other languages
English (en)
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL12155497A external-priority patent/IL121554A0/xx
Priority claimed from IL12163997A external-priority patent/IL121639A0/xx
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Priority to IL12186097A priority Critical patent/IL121860A0/xx
Priority to IL12213497A priority patent/IL122134A0/xx
Publication of IL121860A0 publication Critical patent/IL121860A0/xx
Priority to IL12546398A priority patent/IL125463A0/xx
Priority to PL338647A priority patent/PL206070B1/pl
Priority to DK98938877.2T priority patent/DK1003781T3/da
Priority to PT98938877T priority patent/PT1003781E/pt
Priority to ES98938877T priority patent/ES2149149T3/es
Priority to HU0003533A priority patent/HU226698B1/hu
Priority to PCT/IL1998/000379 priority patent/WO1999009063A1/en
Priority to EEP200000073A priority patent/EE05538B1/xx
Priority to CNB988081342A priority patent/CN1243021C/zh
Priority to IL13452398A priority patent/IL134523A0/xx
Priority to CZ20000490A priority patent/CZ300818B6/cs
Priority to SK176-2000A priority patent/SK287194B6/sk
Priority to JP2000509740A priority patent/JP4272348B2/ja
Priority to AU87460/98A priority patent/AU755794B2/en
Priority to EA200000216A priority patent/EA003675B1/ru
Priority to BRPI9811940-0 priority patent/BRPI9811940B8/pt
Priority to NZ502392A priority patent/NZ502392A/xx
Priority to AT98938877T priority patent/ATE443719T1/de
Priority to EP98938877A priority patent/EP1003781B1/en
Priority to KR1020007001504A priority patent/KR100687388B1/ko
Priority to CA2298855A priority patent/CA2298855C/en
Priority to UA2000031437A priority patent/UA75862C2/uk
Priority to DE69841175T priority patent/DE69841175D1/de
Priority to HK00108180.3A priority patent/HK1028773B/xx
Priority to US09/485,632 priority patent/US6605280B1/en
Priority to SI9830922T priority patent/SI1003781T1/sl
Priority to DE1003781T priority patent/DE1003781T1/de
Priority to ARP980104054A priority patent/AR013422A1/es
Priority to BG104149A priority patent/BG65519B1/bg
Priority to NO20000700A priority patent/NO327240B1/no
Priority to IL134523A priority patent/IL134523A/en
Priority to US09/790,338 priority patent/US7220717B2/en
Priority to US10/434,583 priority patent/US7101689B2/en
Priority to US11/376,794 priority patent/US7799541B2/en
Priority to US11/505,554 priority patent/US7704944B2/en
Priority to US11/724,737 priority patent/US7696154B2/en
Priority to ARP070104104A priority patent/AR062867A2/es
Priority to US12/511,756 priority patent/US8436148B2/en
Priority to CY20091101232T priority patent/CY1109664T1/el
Priority to US12/715,089 priority patent/US20100254941A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/826—Viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/834—Urine; urinary system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
IL12186097A 1997-08-14 1997-09-29 Interleukin-18 binding proteins their preparation and use IL121860A0 (en)

Priority Applications (42)

Application Number Priority Date Filing Date Title
IL12186097A IL121860A0 (en) 1997-08-14 1997-09-29 Interleukin-18 binding proteins their preparation and use
IL12213497A IL122134A0 (en) 1997-08-14 1997-11-06 Interleukin-18 binding proteins their preparation and use
IL12546398A IL125463A0 (en) 1997-08-14 1998-07-22 Interleukin-18 binding proteins their preparation and use
US09/485,632 US6605280B1 (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use for blocking the activity of IL-18
SI9830922T SI1003781T1 (sl) 1997-08-14 1998-08-13 Interlevkin-18 vezavni proteini, njihova priprava in uporaba
DE1003781T DE1003781T1 (de) 1997-08-14 1998-08-13 Interleukin-18 bindende proteine, deren herstellung und verwendung
NZ502392A NZ502392A (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins (IL-18BP) their preparation and use in pharmaceuticals
CA2298855A CA2298855C (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use
PT98938877T PT1003781E (pt) 1997-08-14 1998-08-13 Proteínas de ligação a interleucina-18, sua preparação e utilização
ES98938877T ES2149149T3 (es) 1997-08-14 1998-08-13 Proteinas de union a interleuquina-18, su preparacion y uso.
HU0003533A HU226698B1 (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use
PCT/IL1998/000379 WO1999009063A1 (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use
EEP200000073A EE05538B1 (et) 1997-08-14 1998-08-13 Interleukiin-18 seostuvad valgud, nende valmistamine ja kasutamine
CNB988081342A CN1243021C (zh) 1997-08-14 1998-08-13 白细胞介素－18结合蛋白质及其制备和用途
IL13452398A IL134523A0 (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use
CZ20000490A CZ300818B6 (cs) 1997-08-14 1998-08-13 Interleukin-18-vazebné proteiny, príprava a použití
SK176-2000A SK287194B6 (sk) 1997-08-14 1998-08-13 Interleukínový-18 väzbový proteín - IL-18BP, DNA, replikovateľný vektor, transformovaná hostiteľská bunka, protilátka k IL-18BP, spôsob výroby IL-18BP, prostriedok s jeho obsahom a jeho použitie
JP2000509740A JP4272348B2 (ja) 1997-08-14 1998-08-13 インターロイキン−１８結合タンパク質、それらの調製および用途
AU87460/98A AU755794B2 (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use
EA200000216A EA003675B1 (ru) 1997-08-14 1998-08-13 Белки, связывающие интерлейкин-18, их получение и применение
BRPI9811940-0 BRPI9811940B8 (pt) 1997-08-14 1998-08-13 vetor de expressão para um polipeptídeo de ligação da interleucina-18 (il-18-bp), célula hospedeira procariótica transformada com o referido vetor, processo para produção de il-18-bp, proteína de fusão compreendendo o referido polipeptídeo, bem como il-18bp modificada.
PL338647A PL206070B1 (pl) 1997-08-14 1998-08-13 Izolowane białko wiążące IL-18, sposób jego wytwarzania i izolowania, izolowana cząsteczka DNA, zdolny do replikacji wektor, transformowana komórka gospodarza, przeciwciało, kompozycja farmaceutyczna oraz zastosowanie
AT98938877T ATE443719T1 (de) 1997-08-14 1998-08-13 Interleukin-18 bindende proteine, deren herstellung und verwendung
EP98938877A EP1003781B1 (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use
KR1020007001504A KR100687388B1 (ko) 1997-08-14 1998-08-13 인터루킨-18 결합 단백질, 이들의 제조방법 및 용도
DK98938877.2T DK1003781T3 (da) 1997-08-14 1998-08-13 Interleukin-18-bindende proteiner, fremstilling og anvendelse af disse
UA2000031437A UA75862C2 (uk) 1997-08-14 1998-08-13 Виділений поліпептид, що зв'язується з il-18 (il-18bp) (варіанти), виділена молекула нуклеїнової кислоти, що його кодує (варіанти), антитіло, що зв'язується з даним поліпептидом, спосіб очищення il-18bp та композиція, що його містить
DE69841175T DE69841175D1 (de) 1997-08-14 1998-08-13 Interleukin-18 bindende proteine, deren herstellung und verwendung
HK00108180.3A HK1028773B (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use
ARP980104054A AR013422A1 (es) 1997-08-14 1998-08-14 UN VECTOR DE EXPRESIoN REPLICABLE QUE COMPRENDE UN ÁCIDO NUCLEICO QUE CODIFICA PARA UN POLIPÉPTIDO, UNA CÉLULA HUÉSPED ANIMAL AISLADA INCAPAZ DE CONDUCIR A UN ORGANISMO COMPLETO, UN MICROORGANISMO, UN MÉTODO PARA PRODUCIR UN POLIPEPTIDO DE SEC IN N° 2, UNA PROTEíNA DE FUSIoN, UN ANTICUERPO MONOCLONA
BG104149A BG65519B1 (bg) 1997-08-14 2000-02-10 Белтъци, свързващи интерлевкин-18, тяхното получаване и приложение
NO20000700A NO327240B1 (no) 1997-08-14 2000-02-11 Interleukin-18-bindende protein, DNA som koder for dette, vektor og celle inneholdende slikt DNA, fremgangsmate for fremstilling av proteinet, antistoffer som reagerer mot proteinet samt anvendelse av proteinet for fremstilling av medikamenter.
IL134523A IL134523A (en) 1997-08-14 2000-02-13 Proteins that bind interleukin-18, their preparation and use
US09/790,338 US7220717B2 (en) 1997-08-14 2001-02-21 Interleukin-18 binding proteins, their preparation and use
US10/434,583 US7101689B2 (en) 1997-08-14 2003-05-08 Interleukin-18 binding proteins, their preparation and use
US11/376,794 US7799541B2 (en) 1997-08-14 2006-03-15 Interleukin-18 binding proteins, their preparation and use
US11/505,554 US7704944B2 (en) 1997-08-14 2006-08-16 Interleukin-18 binding proteins, their preparation and use for the treatment of sepsis
US11/724,737 US7696154B2 (en) 1997-08-14 2007-03-15 Methods for treating interleukin-18 mediated disorders with interleukin-18 binding proteins
ARP070104104A AR062867A2 (es) 1997-08-14 2007-09-17 Proteinas de enlace a interleuquina -18, (il- 18bp), secuencias de adn que codifican para la il -18 bp, secuencias de adnc, un vehiculo de expresion replicable, celula huesped, un proceso para su produccion y aislacion, anticuerpos, composiciones farmaceuticas, el uso de dichas composiciones para la
US12/511,756 US8436148B2 (en) 1997-08-14 2009-07-29 Antibodies against interleukin-18 binding protein, their preparation and use
CY20091101232T CY1109664T1 (el) 1997-08-14 2009-11-25 Πρωτεϊνες δεσμευσεως ιντερλευκινης-18, η παρασκευη και η χρηση τους
US12/715,089 US20100254941A1 (en) 1997-08-14 2010-03-01 Interleukin-18 binding proteins, their preparation and use for the treatment of sepsis

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
IL12155497A IL121554A0 (en) 1997-08-14 1997-08-14 Interleukin-18 binding proteins their preparation and use
IL12163997A IL121639A0 (en) 1997-08-14 1997-08-27 Interleukin-18 binding proteins their preparation and use
IL12186097A IL121860A0 (en) 1997-08-14 1997-09-29 Interleukin-18 binding proteins their preparation and use
IL12213497A IL122134A0 (en) 1997-08-14 1997-11-06 Interleukin-18 binding proteins their preparation and use
IL12546398A IL125463A0 (en) 1997-08-14 1998-07-22 Interleukin-18 binding proteins their preparation and use
PCT/IL1998/000379 WO1999009063A1 (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use

Publications (1)

Publication Number Publication Date
IL121860A0 true IL121860A0 (en) 1998-02-22

Family

ID=27517687

Family Applications (5)

Application Number Title Priority Date Filing Date
IL12186097A IL121860A0 (en) 1997-08-14 1997-09-29 Interleukin-18 binding proteins their preparation and use
IL12213497A IL122134A0 (en) 1997-08-14 1997-11-06 Interleukin-18 binding proteins their preparation and use
IL12546398A IL125463A0 (en) 1997-08-14 1998-07-22 Interleukin-18 binding proteins their preparation and use
IL13452398A IL134523A0 (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use
IL134523A IL134523A (en) 1997-08-14 2000-02-13 Proteins that bind interleukin-18, their preparation and use

Family Applications After (4)

Application Number Title Priority Date Filing Date
IL12213497A IL122134A0 (en) 1997-08-14 1997-11-06 Interleukin-18 binding proteins their preparation and use
IL12546398A IL125463A0 (en) 1997-08-14 1998-07-22 Interleukin-18 binding proteins their preparation and use
IL13452398A IL134523A0 (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use
IL134523A IL134523A (en) 1997-08-14 2000-02-13 Proteins that bind interleukin-18, their preparation and use

Country Status (28)

Country Link
US (4) US6605280B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP1003781B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JP4272348B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR100687388B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (1) CN1243021C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AR (2) AR013422A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE443719T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU755794B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BG (1) BG65519B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BR (1) BRPI9811940B8 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2298855C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CY (1) CY1109664T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CZ (1) CZ300818B6 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (2) DE69841175D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK1003781T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EA (1) EA003675B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EE (1) EE05538B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2149149T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU226698B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (5) IL121860A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO327240B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ502392A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PL (1) PL206070B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT1003781E (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SI (1) SI1003781T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SK (1) SK287194B6 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
UA (1) UA75862C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO1999009063A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7393663B2 (en) * 1997-08-01 2008-07-01 Serono Genetics Institute S.A. Expressed sequence tags and encoded human proteins
IL121860A0 (en) * 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
CA2276216A1 (en) * 1998-06-24 1999-12-24 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo An artificial peptide capable of neutralizing the biological activity of interleukin-18
EP1110969A4 (en) * 1998-09-01 2002-01-09 Hayashibara Biochem Lab INTERLEUKIN 18-BINDING PROTEINS
AR022952A1 (es) 1999-03-19 2002-09-04 Smithkline Beecham Corp ANTICUERPO MONOCLONAL DE ROEDOR ESPECIFICAMENTE NEUTRALIZANTE PARA LA INTERLEUQUINA-18 HUMANA , UN FRAGMENTO FAB NEUTRALIZANTE o FRAGMENTO F(AB')2, UNA REGION DE COMPLEMENTARIEDAD DE CADENA LIGERA DE INMONOGLOBULINA(CDR), UNA MOLECULA DE ACIDO NUCLEICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE, EL
IL131047A0 (en) * 1999-07-22 2001-01-28 Yeda Res & Dev Use of il-18 inhibitors
DE60041432D1 (de) * 1999-11-16 2009-03-12 Hayashibara Biochem Lab Antikörper spezifisch für den Interleukin-18 Vorläufer
TW201305214A (zh) * 2000-02-10 2013-02-01 Abbott Gmbh & Co Kg 與人類間白素－１８結合之抗體，及其製法及用途
JP4744763B2 (ja) * 2000-02-21 2011-08-10 イエダ リサーチ アンド デベロップメント カンパニー リミテッド Ｉｌ−１８阻害剤の用途
MXPA02010895A (es) * 2000-05-05 2003-03-27 Applied Research Systems Uso de inhibidores de interleucina 18 para el tratamiento y/o prevencion de aterosclerosis.
AU2005211606B2 (en) * 2000-05-05 2007-02-22 Inserm - Institut National De La Sante Et De La Recherche Medicale Use of IL-18 inhibitors for the treatment and/or prevention of atherosclerosis
WO2002031115A2 (en) * 2000-10-11 2002-04-18 Viron Therapeutics, Inc. Nucleic acid molecules and polypeptides for immune modulation
US7718368B2 (en) * 2000-12-04 2010-05-18 Viron Therapeutics Inc. Immunomodulatory protein and useful embodiments thereof
KR100857376B1 (ko) * 2001-01-29 2008-09-05 라보라토리스 세로노 에스.에이. 심장 질환의 치료 및/또는 예방에 사용되는 ｉｌ-18저해물질
EP1425028B1 (en) * 2001-05-16 2009-12-16 Yeda Research And Development Co. Ltd. Use of il-18 inhibitors for the treatement or prevention of sepsis
ES2617084T3 (es) * 2001-05-25 2017-06-15 Ares Trading S.A. Uso de inhibidores de IL-18 para tratar o prevenir lesiones en el SNC
BRPI0210579B8 (pt) 2001-06-26 2021-05-25 Amgen Fremont Inc anticorpo e composição farmacêutica
UA78516C2 (en) * 2001-08-10 2007-04-10 Applied Research Systems Use of inhibitors of il-18 for treatment and/or prevention of hypersensitivity disorders, and in particular of delayed-type hypersensitivity
IL164211A0 (en) * 2002-03-22 2005-12-18 Applied Research Systems Il-18 inhibitors and peripheral vascular diseases
JP2006508056A (ja) 2002-08-28 2006-03-09 イミュネックス・コーポレーション 心臓血管疾患を治療するための組成物および方法
JP4563813B2 (ja) * 2002-10-08 2010-10-13 アレス トレーディング ソシエテ アノニム Ｉｌ−１８ｂｐに結合でき、第２サイトカインの活性を阻害するサイトカインの使用
IL152232A0 (en) * 2002-10-10 2003-05-29 Yeda Res & Dev Promoter to il-18bp, its preparation and use
KR100988129B1 (ko) * 2003-04-30 2010-10-18 쥬리디컬 파운데이션 더 케모-세로-쎄라퓨틱 리서치 인스티튜트 인간 항인간 인터루킨-18 항체와 그 단편, 및 이들의이용방법
ES2384241T3 (es) 2003-05-13 2012-07-02 Merck Serono Sa Variantes activas de la proteína que fija IL-18 y usos médicos de las mismas
CA2544146C (en) * 2003-11-05 2012-10-02 Ares Trading S.A. Process for the purification of il-18 binding protein
US20050100965A1 (en) 2003-11-12 2005-05-12 Tariq Ghayur IL-18 binding proteins
CA2545359C (en) * 2003-11-12 2012-11-06 The Regents Of The University Of Colorado, A Body Corporate Compositions and methods for regulation of tumor necrosis factor-alpha
US7968684B2 (en) 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
IL159670A0 (en) * 2003-12-31 2004-06-01 Yeda Res & Dev Use of il-18 binding protein in inflammations
ATE375385T1 (de) * 2004-03-01 2007-10-15 Ares Trading Sa Verwendung eines serumfreien zellkulturmediums zur produktion von il-18bp in säugerzellen
WO2005097998A2 (en) * 2004-03-31 2005-10-20 Regeneron Pharmaceuticals, Inc. Il-18 specific polypeptides and therapeutic uses thereof
AU2005259269B2 (en) * 2004-06-29 2010-12-09 Ares Trading S.A. Process for the purification of IL-18 binding protein
PL1888100T3 (pl) 2005-06-03 2012-03-30 Merck Serono Sa Zastosowanie lizoform IL-18BP do leczenia i/lub zapobiegania neurologicznym chorobom zapalnym
SI2267024T1 (sl) * 2005-06-03 2012-09-28 Ares Trading Sa Proizvodnja rekombinantnega IL-18 vezavnega proteina
AU2006256763B2 (en) * 2005-06-10 2012-08-02 Ares Trading S.A. Process for the purification of IL-18 binding protein
CN101003812B (zh) * 2006-01-17 2011-01-05 温州医学院 一种用于制备重组人egf-il18融合蛋白的方法
US8133978B2 (en) 2006-05-25 2012-03-13 Glaxo Group Limited Humanised anti-interleukin-18 antibody
WO2010040736A2 (en) * 2008-10-07 2010-04-15 Ablynx Nv Amino acid sequences directed against il18 and/or the il-18 receptor and polypeptides comprising the same for the treatment of diseases and/or disorders associated with il-18 mediated signaling
CA2897067A1 (en) * 2013-01-02 2014-07-10 Wilsa, Inc. Method and apparatus for conditioning fluids
PH12016500425B1 (en) * 2013-09-05 2022-07-29 Ab2 Bio Sa Il-18 binding protein (il-18bp) in inflammatory diseases
UA128752C2 (uk) * 2015-03-05 2024-10-16 Аб2 Біо Са Фармацевтична композиція для лікування асоційованого з il-18 захворювання або порушення
EP3943097A1 (en) 2020-07-24 2022-01-26 AB2 Bio SA Car-t cell therapy
WO2023143535A1 (zh) * 2022-01-28 2023-08-03 和径医药科技（上海）有限公司 一种靶向il-18bp的抗体及其应用
MX2024011278A (es) * 2022-03-15 2024-09-25 Compugen Ltd Anticuerpos antagonistas de il-18bp y su uso en monoterapia y terapia de combinacion en el tratamiento del cancer.
CN114605521A (zh) * 2022-04-06 2022-06-10 内蒙古农业大学 一种细胞免疫调节蛋白及其应用
CN114891125B (zh) * 2022-06-16 2023-04-11 广东医科大学 一种长效重组白细胞介素-18结合蛋白及其生产方法与应用
AU2024206448A1 (en) 2023-01-06 2025-08-21 Lassen Therapeutics, Inc. Anti-il-18bp antibodies
TW202515608A (zh) 2023-06-26 2025-04-16 以色列商坎布根有限公司 Ｉｌ—１８ｂｐ拮抗抗體及其於癌症治療之單一療法及組合療法的用途

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985863A (en) * 1996-09-12 1999-11-16 Vertex Pharmaceuticals, Inc. Compositions and methods for decreasing IGIF and IFN-γ production by administering an ICE inhibitor
GB9214857D0 (en) * 1992-07-13 1992-08-26 Medical Res Council Human nucleic acid fragments and their use
US5744451A (en) 1995-09-12 1998-04-28 Warner-Lambert Company N-substituted glutamic acid derivatives with interleukin-1 β converting enzyme inhibitory activity
US5776731A (en) 1996-02-21 1998-07-07 Immunex Corporation DNA encoding type-I interleukin-I receptor-like protein designated 2F1
PT936923E (pt) 1996-11-15 2004-04-30 Kennedy Inst Of Rheumatology Supressao de tnfalfa e il-12 em terapia
ATE346085T1 (de) 1996-12-06 2006-12-15 Vertex Pharma Inhibitoren des interleukin-1-beta konvertierenden enzyms
US7141393B2 (en) 1996-12-26 2006-11-28 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Interleukin-18-receptor proteins
US6087116A (en) 1997-03-12 2000-07-11 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Interleukin-18 (IL-18) receptor polypeptides and their uses
PL336464A1 (en) 1997-03-18 2000-06-19 Basf Ag Method of and compositions for modulating reactivity in respect to corticosteroids i
JP2001512012A (ja) 1997-08-01 2001-08-21 ジェンセット 精巣およびその他の組織で発現する分泌タンパク質の５’ｅｓｔ
CA2296844A1 (en) 1997-08-01 1999-02-11 Genset 5' ests for secreted proteins expressed in various tissues
IL121860A0 (en) * 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
AU762621B2 (en) 1998-04-28 2003-07-03 Merck Serono Sa Polyol-IFN-beta conjugates
CA2276216A1 (en) 1998-06-24 1999-12-24 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo An artificial peptide capable of neutralizing the biological activity of interleukin-18
EP1110969A4 (en) 1998-09-01 2002-01-09 Hayashibara Biochem Lab INTERLEUKIN 18-BINDING PROTEINS
AR022952A1 (es) 1999-03-19 2002-09-04 Smithkline Beecham Corp ANTICUERPO MONOCLONAL DE ROEDOR ESPECIFICAMENTE NEUTRALIZANTE PARA LA INTERLEUQUINA-18 HUMANA , UN FRAGMENTO FAB NEUTRALIZANTE o FRAGMENTO F(AB')2, UNA REGION DE COMPLEMENTARIEDAD DE CADENA LIGERA DE INMONOGLOBULINA(CDR), UNA MOLECULA DE ACIDO NUCLEICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE, EL
AU6078500A (en) 1999-07-09 2001-01-30 Amgen, Inc. Combination therapy for conditions leading to bone loss
WO2001019373A2 (en) 1999-09-17 2001-03-22 Basf Aktiengesellschaft Methods and compositions for modulating responsiveness to corticosteroids

Also Published As

Publication number Publication date
CZ300818B6 (cs) 2009-08-19
IL125463A0 (en) 1999-03-12
CN1243021C (zh) 2006-02-22
DK1003781T3 (da) 2010-01-25
ES2149149T1 (es) 2000-11-01
HK1028773A1 (en) 2001-03-02
AR013422A1 (es) 2000-12-27
US20060154294A1 (en) 2006-07-13
KR100687388B1 (ko) 2007-02-26
AU8746098A (en) 1999-03-08
US7101689B2 (en) 2006-09-05
BRPI9811940A (pt) 2000-09-05
US8436148B2 (en) 2013-05-07
AR062867A2 (es) 2008-12-10
US6605280B1 (en) 2003-08-12
NO20000700D0 (no) 2000-02-11
US20100010200A1 (en) 2010-01-14
SK1762000A3 (en) 2000-09-12
EE05538B1 (et) 2012-04-16
EA003675B1 (ru) 2003-08-28
SI1003781T1 (sl) 2009-12-31
PL206070B1 (pl) 2010-06-30
PT1003781E (pt) 2009-10-26
IL134523A (en) 2011-09-27
US7799541B2 (en) 2010-09-21
CZ2000490A3 (cs) 2000-08-16
EA200000216A1 (ru) 2000-08-28
NZ502392A (en) 2002-12-20
CN1267307A (zh) 2000-09-20
HUP0003533A3 (en) 2003-08-28
KR20010022900A (ko) 2001-03-26
JP4272348B2 (ja) 2009-06-03
NO327240B1 (no) 2009-05-18
PL338647A1 (en) 2000-11-06
NO20000700L (no) 2000-04-14
IL134523A0 (en) 2001-04-30
CA2298855A1 (en) 1999-02-25
CY1109664T1 (el) 2014-08-13
BG65519B1 (bg) 2008-10-31
ATE443719T1 (de) 2009-10-15
JP2001514876A (ja) 2001-09-18
US20040037829A1 (en) 2004-02-26
EP1003781B1 (en) 2009-09-23
EE200000073A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2000-10-16
BRPI9811940B1 (pt) 2011-10-04
UA75862C2 (uk) 2006-06-15
BG104149A (bg) 2000-08-31
HU226698B1 (en) 2009-07-28
DE69841175D1 (de) 2009-11-05
BRPI9811940B8 (pt) 2021-07-06
HUP0003533A2 (hu) 2001-01-29
IL122134A0 (en) 1998-04-05
WO1999009063A1 (en) 1999-02-25
AU755794B2 (en) 2002-12-19
DE1003781T1 (de) 2001-01-11
ES2149149T3 (es) 2009-12-01
EP1003781A1 (en) 2000-05-31
SK287194B6 (sk) 2010-03-08
CA2298855C (en) 2014-05-27

Similar Documents

Publication Publication Date Title
IL121860A0 (en) Interleukin-18 binding proteins their preparation and use
HUP0001400A3 (en) Osteoprotegerin binding proteins and receptors
ZA983189B (en) Osteoprotegerin binding proteins and receptors
EP1007562A4 (en) TANGO-63d AND TANGO-63e PROTEINS RELATED TO THE TUMOR NECROSIS FACTOR RECEPTOR
HU9602311D0 (en) Binding protein function modulator
IL123647A0 (en) Substituted amino compounds their preparation and use
GB9705903D0 (en) VP22 Proteins and uses thereof
IL131929A0 (en) Rap protein its preparation and use
AU8596498A (en) Annexin binding protein
EP1012262A4 (en) HFLP PROTEIN HFLP
AU7410598A (en) Novel human RNA binding protein
IL131247A0 (en) Cash protein its preparation and use
GB9423372D0 (en) Proteins and their uses
ZA984322B (en) Sucrose-binding proteins
AU6035298A (en) Human zinc binding proteins
ZA978220B (en) PTX-sensitive G proteins their preparation and use
IL121639A0 (en) Interleukin-18 binding proteins their preparation and use
IL121554A0 (en) Interleukin-18 binding proteins their preparation and use
AU1320600A (en) Human rna binding proteins
GB9726956D0 (en) Protein binding polypeptides
AU6894398A (en) Human gtp binding protein
AU2003200442A1 (en) Interleukin-18 binding proteins, their preparation and use
IL123477A0 (en) Nik binding proteins their preparation and use
AUPP004197A0 (en) Novel hbv binding protein and portions thereof
GB9424797D0 (en) Binding proteins