IL118171A - Stable liquid composition containing urate oxidase and its preparation - Google Patents
Stable liquid composition containing urate oxidase and its preparationInfo
- Publication number
- IL118171A IL118171A IL11817196A IL11817196A IL118171A IL 118171 A IL118171 A IL 118171A IL 11817196 A IL11817196 A IL 11817196A IL 11817196 A IL11817196 A IL 11817196A IL 118171 A IL118171 A IL 118171A
- Authority
- IL
- Israel
- Prior art keywords
- urate oxidase
- preparation
- composition containing
- liquid composition
- stable liquid
- Prior art date
Links
- 108010092464 Urate Oxidase Proteins 0.000 title abstract 3
- 229940005267 urate oxidase Drugs 0.000 title abstract 3
- 239000007788 liquid Substances 0.000 title 1
- CTKXFMQHOOWWEB-UHFFFAOYSA-N Ethylene oxide/propylene oxide copolymer Chemical compound CCCOC(C)COCCO CTKXFMQHOOWWEB-UHFFFAOYSA-N 0.000 abstract 2
- 229920001993 poloxamer 188 Polymers 0.000 abstract 2
- 229940044519 poloxamer 188 Drugs 0.000 abstract 2
- -1 polyoxyethylene Polymers 0.000 abstract 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 abstract 1
- 229920001451 polypropylene glycol Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
- A61K38/443—Oxidoreductases (1) acting on CH-OH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9505606A FR2733914B1 (fr) | 1995-05-11 | 1995-05-11 | Composition de liquide stable contenant de l'urate oxydase et composition lyophilisee pour sa preparation |
| US08/644,163 US5811096A (en) | 1995-05-11 | 1996-05-10 | Stable liquid composition containing urate oxidase and lyophilized composition for its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL118171A0 IL118171A0 (en) | 1996-09-12 |
| IL118171A true IL118171A (en) | 2000-08-31 |
Family
ID=26231954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11817196A IL118171A (en) | 1995-05-11 | 1996-05-07 | Stable liquid composition containing urate oxidase and its preparation |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US5811096A (es) |
| EP (1) | EP0742013B1 (es) |
| JP (1) | JP2950775B2 (es) |
| CN (1) | CN1090972C (es) |
| AT (1) | ATE183925T1 (es) |
| AU (1) | AU710288B2 (es) |
| BR (1) | BR1100337A (es) |
| CA (1) | CA2175971C (es) |
| CZ (1) | CZ290799B6 (es) |
| DE (1) | DE69604009T2 (es) |
| DK (1) | DK0742013T3 (es) |
| EA (1) | EA000024B1 (es) |
| ES (1) | ES2137635T3 (es) |
| FR (1) | FR2733914B1 (es) |
| GR (1) | GR3031896T3 (es) |
| HU (1) | HU225147B1 (es) |
| IL (1) | IL118171A (es) |
| NO (1) | NO315261B1 (es) |
| NZ (1) | NZ286554A (es) |
| PL (1) | PL184135B1 (es) |
| SG (1) | SG42355A1 (es) |
| SI (1) | SI0742013T1 (es) |
| TW (1) | TW420614B (es) |
| ZA (1) | ZA963683B (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030166525A1 (en) * | 1998-07-23 | 2003-09-04 | Hoffmann James Arthur | FSH Formulation |
| ES2245114T3 (es) | 1998-08-06 | 2005-12-16 | Mountain View Pharmaceuticals, Inc. | Conjugados de peg-oxidasa de urato y su uso. |
| US6783965B1 (en) * | 2000-02-10 | 2004-08-31 | Mountain View Pharmaceuticals, Inc. | Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates |
| FR2782455B3 (fr) * | 1998-08-20 | 2000-09-15 | Sanofi Sa | Composition pharmaceutique injectable a base d'un sel pharmaceutiquement acceptable du clopidogrel ou de ticlopidine |
| KR101235507B1 (ko) * | 2003-02-28 | 2013-02-20 | 추가이 세이야쿠 가부시키가이샤 | 단백질을 함유하는 안정화 제제 |
| CA2518903C (en) * | 2003-04-02 | 2013-02-05 | Ares Trading S.A. | Liquid pharmaceutical formulations of fsh and lh together with a non-ionic surfactant |
| WO2004112826A1 (en) * | 2003-06-20 | 2004-12-29 | Ares Trading Sa | Freeze-dried fsh / lh formulations |
| HUE052976T2 (hu) | 2005-04-11 | 2021-06-28 | Horizon Pharma Rheumatology Llc | Urát-oxidáz variáns formái és azok alkalmazása |
| US20080159976A1 (en) * | 2005-04-11 | 2008-07-03 | Jacob Hartman | Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase |
| US8148123B2 (en) * | 2005-04-11 | 2012-04-03 | Savient Pharmaceuticals, Inc. | Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase |
| WO2006110761A2 (en) | 2005-04-11 | 2006-10-19 | Savient Pharmaceuticals, Inc. | A variant form of urate oxidase and use thereof |
| CN1864744B (zh) * | 2005-05-18 | 2010-09-29 | 杭州北斗生物技术有限公司 | 含有尿酸氧化酶的药用制剂 |
| WO2006125452A1 (en) * | 2005-05-23 | 2006-11-30 | Universite De Geneve | Injectable superparamagnetic nanoparticles for treatment by hyperthermia and use for forming an hyperthermic implant |
| CN101622270B (zh) | 2006-04-12 | 2014-01-01 | 萨文特医药公司 | 用阳离子表面活性剂纯化蛋白质的方法 |
| HUP1200205A3 (en) | 2009-06-25 | 2012-09-28 | Savient Pharmaceuticals | Method and kits for perdicting infusion reaction risk and antibody-mediated low of response by monitoring serum uric acid during pegylated uricare therapy |
| CN105412942B (zh) * | 2015-12-23 | 2019-02-26 | 沈阳三生制药有限责任公司 | 聚乙二醇化的重组产朊假丝酵母尿酸氧化酶冻干注射剂 |
| US20190060241A1 (en) * | 2016-04-13 | 2019-02-28 | Medimmune, Llc | Use of amino acids as stabilizing compounds in pharmaceutical compositions containing high concentrations of protein-based therapeutic agents |
| CN110234340A (zh) | 2016-11-11 | 2019-09-13 | 好利恩风湿病制药有限责任公司 | 泼尼松和尿酸酶分子的组合疗法及其用途 |
| US20200237881A1 (en) | 2019-01-30 | 2020-07-30 | Horizon Pharma Rheumatology Llc | Reducing immunogenicity to pegloticase |
| KR101744900B1 (ko) * | 2017-01-20 | 2017-06-08 | 주식회사 대웅 | 보툴리눔 독소를 포함하는 안정한 액상 조성물 |
| US12121566B2 (en) | 2019-01-30 | 2024-10-22 | Horizon Therapeutics Usa, Inc. | Methods for treating gout |
| US12269875B2 (en) | 2023-08-03 | 2025-04-08 | Jeff R. Peterson | Gout flare prevention methods using IL-1BETA blockers |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3997470A (en) * | 1971-10-20 | 1976-12-14 | Mallinckrodt, Inc. | Surfactant containing reagent formulations for assaying biological specimens and methods of preparing same |
| US3928137A (en) * | 1971-10-20 | 1975-12-23 | Mallinckrodt Inc | Reagent formulation for uric acid assay |
| JPS51104807A (en) * | 1975-03-12 | 1976-09-17 | Hitachi Ltd | Teepurekoodano ootoribaasuseigyokairo |
| JPS5417027A (en) * | 1977-07-07 | 1979-02-08 | Canon Inc | Image forming system |
| DE3126759A1 (de) * | 1981-07-07 | 1983-01-27 | Boehringer Mannheim Gmbh, 6800 Mannheim | Loesliche leber-uricase, verfahren zu ihrer herstellung und verwendung |
| JPS60224499A (ja) * | 1984-04-23 | 1985-11-08 | Toyobo Co Ltd | 安定なウリカ−ゼ製剤 |
| DE3743405A1 (de) * | 1987-05-14 | 1988-11-24 | Boehringer Mannheim Gmbh | Verfahren zur bestimmung von fructosamin |
| JPH0243471A (ja) * | 1988-08-03 | 1990-02-14 | Iwataro Moriyama | 立体駐車装置 |
| WO1992016555A1 (en) | 1991-03-18 | 1992-10-01 | Enzon, Inc. | Hydrazine containing conjugates of polypeptides and glycopolypeptides with polymers |
| CA2130357A1 (en) | 1992-02-18 | 1993-08-19 | Doron Friedman | Dry compositions for preparing submicron emulsions |
-
1995
- 1995-05-11 FR FR9505606A patent/FR2733914B1/fr not_active Expired - Lifetime
-
1996
- 1996-05-07 CA CA002175971A patent/CA2175971C/en not_active Expired - Lifetime
- 1996-05-07 EA EA199600024A patent/EA000024B1/ru not_active IP Right Cessation
- 1996-05-07 IL IL11817196A patent/IL118171A/xx not_active IP Right Cessation
- 1996-05-07 AU AU52139/96A patent/AU710288B2/en not_active Expired
- 1996-05-08 TW TW085105457A patent/TW420614B/zh not_active IP Right Cessation
- 1996-05-09 DE DE69604009T patent/DE69604009T2/de not_active Expired - Lifetime
- 1996-05-09 EP EP96400995A patent/EP0742013B1/fr not_active Expired - Lifetime
- 1996-05-09 ES ES96400995T patent/ES2137635T3/es not_active Expired - Lifetime
- 1996-05-09 DK DK96400995T patent/DK0742013T3/da active
- 1996-05-09 ZA ZA9603683A patent/ZA963683B/xx unknown
- 1996-05-09 CZ CZ19961350A patent/CZ290799B6/cs not_active IP Right Cessation
- 1996-05-09 AT AT96400995T patent/ATE183925T1/de active
- 1996-05-09 HU HU9601241A patent/HU225147B1/hu unknown
- 1996-05-09 SI SI9630093T patent/SI0742013T1/xx unknown
- 1996-05-09 PL PL96314147A patent/PL184135B1/pl unknown
- 1996-05-10 US US08/644,163 patent/US5811096A/en not_active Expired - Lifetime
- 1996-05-10 CN CN96110721A patent/CN1090972C/zh not_active Expired - Lifetime
- 1996-05-10 SG SG1996006306A patent/SG42355A1/en unknown
- 1996-05-10 JP JP8152802A patent/JP2950775B2/ja not_active Expired - Lifetime
- 1996-05-10 NZ NZ286554A patent/NZ286554A/en not_active IP Right Cessation
- 1996-05-10 NO NO19961915A patent/NO315261B1/no not_active IP Right Cessation
-
1997
- 1997-04-24 BR BR1100337-5A patent/BR1100337A/pt active IP Right Grant
-
1999
- 1999-11-18 GR GR990402988T patent/GR3031896T3/el unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| EXP | Patent expired |