IL116775A - Tricyclic azolobenzodiazepines and similar compounds their preparation and pharmaceutical compositions containing them - Google Patents

Tricyclic azolobenzodiazepines and similar compounds their preparation and pharmaceutical compositions containing them

Info

Publication number
IL116775A
IL116775A IL11677596A IL11677596A IL116775A IL 116775 A IL116775 A IL 116775A IL 11677596 A IL11677596 A IL 11677596A IL 11677596 A IL11677596 A IL 11677596A IL 116775 A IL116775 A IL 116775A
Authority
IL
Israel
Prior art keywords
azolobenzodiazepines
tricyclic
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
IL11677596A
Other languages
English (en)
Other versions
IL116775A0 (en
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of IL116775A0 publication Critical patent/IL116775A0/xx
Publication of IL116775A publication Critical patent/IL116775A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL11677596A 1995-01-17 1996-01-16 Tricyclic azolobenzodiazepines and similar compounds their preparation and pharmaceutical compositions containing them IL116775A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/373,132 US5536718A (en) 1995-01-17 1995-01-17 Tricyclic benzazepine vasopressin antagonists

Publications (2)

Publication Number Publication Date
IL116775A0 IL116775A0 (en) 1996-05-14
IL116775A true IL116775A (en) 1999-08-17

Family

ID=23471110

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11677596A IL116775A (en) 1995-01-17 1996-01-16 Tricyclic azolobenzodiazepines and similar compounds their preparation and pharmaceutical compositions containing them

Country Status (24)

Country Link
US (3) US5536718A (zh)
EP (1) EP0804438B1 (zh)
JP (2) JP4163252B2 (zh)
KR (1) KR100443438B1 (zh)
CN (1) CN1065244C (zh)
AR (1) AR002022A1 (zh)
AT (1) ATE320429T1 (zh)
AU (1) AU707982B2 (zh)
BR (1) BR9607182A (zh)
CZ (1) CZ297797B6 (zh)
DE (1) DE69635922T2 (zh)
DK (1) DK0804438T3 (zh)
EA (1) EA001143B1 (zh)
ES (1) ES2258267T3 (zh)
HK (1) HK1004132A1 (zh)
HU (1) HUP9800646A3 (zh)
IL (1) IL116775A (zh)
MX (1) MX9705313A (zh)
NZ (1) NZ302111A (zh)
PT (1) PT804438E (zh)
TW (1) TW403752B (zh)
UA (1) UA54383C2 (zh)
WO (1) WO1996022293A1 (zh)
ZA (1) ZA96297B (zh)

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US5736540A (en) * 1993-07-29 1998-04-07 American Cyanamid Company Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
US7071133B2 (en) * 1993-11-16 2006-07-04 Ppg Industries Ohio, Inc. Colored glass compositions and-automotive vision panels with-reduced transmitted-color shift
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JPH10513435A (ja) * 1994-09-30 1998-12-22 ビーエーエスエフ アクチェンゲゼルシャフト 複素環で置換された新規イミダゾロキノキサリノン、その製造および使用
US5700796A (en) * 1995-01-17 1997-12-23 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5753648A (en) * 1995-01-17 1998-05-19 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
US5880122A (en) * 1996-11-01 1999-03-09 American Home Products Corporation 3-Carboxamide derivatives of 5H-pyrrolo 2,1-c! 1,4!-benzodiazepines
US20030039843A1 (en) * 1997-03-14 2003-02-27 Christopher Johnson Photoactive coating, coated article, and method of making same
US7096692B2 (en) * 1997-03-14 2006-08-29 Ppg Industries Ohio, Inc. Visible-light-responsive photoactive coating, coated article, and method of making same
US20020155299A1 (en) 1997-03-14 2002-10-24 Harris Caroline S. Photo-induced hydrophilic article and method of making same
WO1998043976A1 (fr) * 1997-03-31 1998-10-08 Wakamoto Pharmaceutical Co., Ltd. Derives de biphenyle et compositions medicinales
WO1998046596A1 (en) * 1997-04-15 1998-10-22 Eli Lilly And Company Method for providing neuro-protective effects
US20030022889A1 (en) * 1997-04-15 2003-01-30 Bymaster Franklin P. Method for providing neuro-protective effects
US6194407B1 (en) 1997-07-30 2001-02-27 American Home Products Corporation Tricyclic pyrido vasopressin agonists
US6511974B1 (en) 1997-07-30 2003-01-28 Wyeth Tricyclic vasopressin agonists
US7138393B2 (en) * 1998-07-24 2006-11-21 Wyeth Biologically active vasopressin agonist metabolites
US6090803A (en) * 1998-07-24 2000-07-18 American Home Products Corporation Tricyclic vasopressin agonists
US6235900B1 (en) 1999-02-04 2001-05-22 American Home Products Corporation Tricyclic pyridine N-oxides vasopressin agonists
US6297234B1 (en) 1999-02-04 2001-10-02 American Home Products Corporation Arylthiophene vasopressin agonists
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CA2418912A1 (en) * 2000-08-08 2002-02-14 Ortho-Mcneil Pharmaceutical, Inc. Neuroprotective 2-pyridinamine compositions and related methods
US20050203092A1 (en) * 2000-08-08 2005-09-15 Benjamin Elfrida R. 4-Pyrimidinamine derivatives, pharmaceutical compositions and related methods
US7323249B2 (en) * 2000-08-31 2008-01-29 Ppg Industries Ohio, Inc. Methods of obtaining photoactive coatings and/or anatase crystalline phase of titanium oxides and articles made thereby
US6677063B2 (en) 2000-08-31 2004-01-13 Ppg Industries Ohio, Inc. Methods of obtaining photoactive coatings and/or anatase crystalline phase of titanium oxides and articles made thereby
US7326700B2 (en) * 2001-04-12 2008-02-05 Wyeth Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
US7022699B2 (en) 2001-04-12 2006-04-04 Wyeth Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators
CA2444455A1 (en) * 2001-04-12 2002-10-24 Amedeo Arturo Failli N-biphenylcarbonyl- and n-phenylpyridylcarbonyl substituted bi- and tricyclic azepines and diazepines as vasopressing agonists
US7064120B2 (en) * 2001-04-12 2006-06-20 Wyeth Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
US6977254B2 (en) * 2001-04-12 2005-12-20 Wyeth Hydroxy cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
US6900200B2 (en) 2001-04-12 2005-05-31 Wyeth Tricyclic hydroxy carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
EP1381608B1 (en) * 2001-04-12 2007-10-10 Wyeth Cyclohexylphenyl vasopressin agonists
US7109193B2 (en) 2001-04-12 2006-09-19 Wyeth Tricyclic diazepines tocolytic oxytocin receptor antagonists
US7202239B2 (en) * 2001-04-12 2007-04-10 Wyeth Cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists
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US20040010010A1 (en) * 2002-04-30 2004-01-15 Ebetino Frank Hallock Melanocortin receptor ligands
US7741352B2 (en) * 2003-03-11 2010-06-22 Neurosearch A/S KCNQ channel modulating compounds and their pharmaceutical use
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US20100124642A1 (en) * 2008-11-19 2010-05-20 Ppg Industries Ohio, Inc. Undercoating layers providing improved conductive topcoat functionality
DE112009003493T5 (de) 2008-11-19 2012-09-06 Ppg Industries Ohio, Inc. Grundierungsschichten, die eine verbesserte Deckschichtfunktionalität verleihen
US7998586B2 (en) 2008-11-19 2011-08-16 Ppg Industries Ohio, Inc. Undercoating layers providing improved topcoat functionality
US8133599B2 (en) * 2008-11-19 2012-03-13 Ppg Industries Ohio, Inc Undercoating layers providing improved photoactive topcoat functionality
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US9224892B2 (en) 2009-12-21 2015-12-29 Ppg Industries Ohio, Inc. Silicon thin film solar cell having improved haze and methods of making the same
US20110146768A1 (en) 2009-12-21 2011-06-23 Ppg Industries Ohio, Inc. Silicon thin film solar cell having improved underlayer coating
RU2518102C1 (ru) * 2012-11-01 2014-06-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кубанский государственный технологический университет" (ФГБОУ ВПО "КубГТУ") Способ получения производных 2-диалкиламинопирроло[1,2-альфа][1,4]бензодиазепина
AU2017377653B2 (en) * 2016-12-12 2022-04-21 Kinoxis Therapeutics Pty Ltd Non-peptide oxytocin receptor agonists
KR101798840B1 (ko) 2017-05-17 2017-11-17 주식회사 레고켐 바이오사이언스 신규 오토탁신 저해 화합물 및 이를 함유하는 약제학적 조성물
US10961242B2 (en) 2017-05-17 2021-03-30 Legochem Biosciences, Inc. Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same
JOP20200001A1 (ar) 2017-07-11 2022-10-30 Vertex Pharma كاربوكسأميدات بوصفها معدلات لقنوات الصوديوم

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Also Published As

Publication number Publication date
JPH11500106A (ja) 1999-01-06
AU707982B2 (en) 1999-07-22
HUP9800646A2 (hu) 1998-08-28
DE69635922T2 (de) 2006-08-17
HK1004132A1 (en) 1998-11-20
IL116775A0 (en) 1996-05-14
NZ302111A (en) 1999-04-29
EP0804438A1 (en) 1997-11-05
US5612334A (en) 1997-03-18
CN1198746A (zh) 1998-11-11
MX9705313A (es) 1998-07-31
ATE320429T1 (de) 2006-04-15
ES2258267T3 (es) 2006-08-16
DE69635922D1 (de) 2006-05-11
US5610156A (en) 1997-03-11
EA199700117A1 (ru) 1997-12-30
ZA96297B (en) 1997-07-15
CZ297797B6 (cs) 2007-04-04
JP2008101012A (ja) 2008-05-01
KR100443438B1 (ko) 2004-10-14
PT804438E (pt) 2006-07-31
JP4163252B2 (ja) 2008-10-08
AU4769896A (en) 1996-08-07
AR002022A1 (es) 1998-01-07
DK0804438T3 (da) 2006-06-12
US5536718A (en) 1996-07-16
UA54383C2 (uk) 2003-03-17
HUP9800646A3 (en) 1998-12-28
TW403752B (en) 2000-09-01
CZ224997A3 (en) 1997-12-17
EA001143B1 (ru) 2000-10-30
EP0804438B1 (en) 2006-03-15
WO1996022293A1 (en) 1996-07-25
CN1065244C (zh) 2001-05-02
BR9607182A (pt) 1997-11-11

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