TW321649B
(en)
*
|
1994-11-12 |
1997-12-01 |
Zeneca Ltd |
|
GB9424233D0
(en)
*
|
1994-11-30 |
1995-01-18 |
Zeneca Ltd |
Quinazoline derivatives
|
EP0824525B1
(en)
*
|
1995-04-27 |
2001-06-13 |
AstraZeneca AB |
Quinazoline derivatives
|
GB9508565D0
(en)
*
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quiazoline derivative
|
GB9508535D0
(en)
*
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quinazoline derivative
|
GB9508537D0
(en)
*
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quinazoline derivatives
|
GB9508538D0
(en)
*
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quinazoline derivatives
|
GB9624482D0
(en)
*
|
1995-12-18 |
1997-01-15 |
Zeneca Phaema S A |
Chemical compounds
|
TR199801530T2
(en)
|
1996-02-13 |
1998-11-23 |
Zeneca Limited |
Quinazoline derivatives as VEGF inhibitors.
|
GB9603097D0
(en)
*
|
1996-02-14 |
1996-04-10 |
Zeneca Ltd |
Quinazoline compounds
|
JP4464466B2
(en)
|
1996-03-05 |
2010-05-19 |
アストラゼネカ・ユーケイ・リミテッド |
4-anilinoquinazoline derivatives
|
PL190489B1
(en)
|
1996-04-12 |
2005-12-30 |
Warner Lambert Co |
Irreversible inhibitors of tyrosine kinases
|
GB9607729D0
(en)
*
|
1996-04-13 |
1996-06-19 |
Zeneca Ltd |
Quinazoline derivatives
|
AU6605200A
(en)
*
|
1999-06-30 |
2001-01-31 |
Merck & Co., Inc. |
Src kinase inhibitor compounds
|
UA72946C2
(en)
|
1999-11-05 |
2005-05-16 |
Астразенека Аб |
Quinasoline derivatives as inhibitors of vascular endothelial growth factor (vegf)
|
UA74803C2
(en)
|
1999-11-11 |
2006-02-15 |
Осі Фармасьютікалз, Інк. |
A stable polymorph of n-(3-ethynylphenyl)-6,7-bis(2-methoxyetoxy)-4-quinazolinamine hydrochloride, a method for producing thereof (variants) and pharmaceutical use
|
US6638929B2
(en)
|
1999-12-29 |
2003-10-28 |
Wyeth |
Tricyclic protein kinase inhibitors
|
AU2464601A
(en)
*
|
1999-12-29 |
2001-07-09 |
Wyeth |
Tricyclic protein kinase inhibitors
|
EP1324984A1
(en)
*
|
2000-10-11 |
2003-07-09 |
Morphochem AG |
Butenolide and pentenolide derivatives as kinase inhibitors
|
ES2318649T3
(en)
|
2000-10-20 |
2009-05-01 |
EISAI R&D MANAGEMENT CO., LTD. |
PROCEDURE FOR PREPARATION OF DERIVATIVES OF 4-FENOXI QUINOLINAS.
|
CN100457719C
(en)
|
2000-12-29 |
2009-02-04 |
惠氏公司 |
Method for the regioselective preparation of substituted benzo[g]quinoline-3-carbonitriles and benzo[g]quinazolines
|
AR032028A1
(en)
|
2001-01-05 |
2003-10-22 |
Pfizer |
ANTIBODIES AGAINST THE RECEIVER OF THE SIMILAR TO INSULIN GROWTH FACTOR
|
WO2003000194A2
(en)
|
2001-06-21 |
2003-01-03 |
Pfizer Inc. |
Thienopyridine and thienopyrimidine anticancer agents
|
AR039067A1
(en)
|
2001-11-09 |
2005-02-09 |
Pfizer Prod Inc |
ANTIBODIES FOR CD40
|
US7078409B2
(en)
|
2002-03-28 |
2006-07-18 |
Beta Pharma, Inc. |
Fused quinazoline derivatives useful as tyrosine kinase inhibitors
|
UA77303C2
(en)
|
2002-06-14 |
2006-11-15 |
Pfizer |
Derivatives of thienopyridines substituted by benzocondensed heteroarylamide useful as therapeutic agents, pharmaceutical compositions and methods for their use
|
AU2003250701A1
(en)
|
2002-07-31 |
2004-02-16 |
Wayne R. Danter |
Protein tyrosine kinase inhibitors
|
DE60318089T2
(en)
|
2002-10-09 |
2008-12-04 |
Critical Outcome Technologies, Inc. |
PROTEIN TYROSINE KINASE INHIBITORS
|
JP3814285B2
(en)
|
2002-12-19 |
2006-08-23 |
ファイザー・インク |
2- (1H-indazol-6-ylamino) -benzamide compounds as protein kinase inhibitors useful in the treatment of eye diseases
|
GEP20084341B
(en)
|
2003-02-26 |
2008-03-25 |
Sugen Inc |
Aminoheteroaryl compounds as protein kinase inhibitors
|
US20050026879A1
(en)
*
|
2003-07-31 |
2005-02-03 |
Robinson Cynthia B. |
Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or VCAM inhibitor for treatment of asthma or chronic obstructive pulmonary disease
|
HN2004000285A
(en)
|
2003-08-04 |
2006-04-27 |
Pfizer Prod Inc |
ANTIBODIES DIRECTED TO c-MET
|
DE602004017479D1
(en)
|
2003-08-29 |
2008-12-11 |
Pfizer |
THIENOPYRIDINPHENYLACETAMIDES SUITED AS NEW ANTIANGIOGENIC AGENTS AND DERIVATIVES THEREOF
|
AR045563A1
(en)
|
2003-09-10 |
2005-11-02 |
Warner Lambert Co |
ANTIBODIES DIRECTED TO M-CSF
|
CN101337930B
(en)
|
2003-11-11 |
2010-09-08 |
卫材R&D管理有限公司 |
Urea derivative preparation process
|
WO2005051919A1
(en)
|
2003-11-26 |
2005-06-09 |
Pfizer Products Inc. |
Aminopyrazole derivatives as gsk-3 inhibitors
|
CA2573821A1
(en)
|
2004-07-16 |
2006-01-26 |
Pfizer Products Inc. |
Combination treatment for non-hematologic malignancies using an anti-igf-1r antibody
|
CA2577664A1
(en)
*
|
2004-08-20 |
2006-03-02 |
Bayer Pharmaceuticals Corporation |
Novel heterocycles
|
ATE463486T1
(en)
|
2004-08-26 |
2010-04-15 |
Pfizer |
ENANTIOMER PURE AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS
|
US8969379B2
(en)
|
2004-09-17 |
2015-03-03 |
Eisai R&D Management Co., Ltd. |
Pharmaceutical compositions of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7=methoxy-6-quinolinecarboxide
|
UY29161A1
(en)
|
2004-10-15 |
2006-04-28 |
Bayer Pharmaceuticals Corp |
NEW HETEROCICLOS
|
EP1819711B1
(en)
|
2004-10-27 |
2010-04-21 |
Bayer Schering Pharma Aktiengesellschaft |
Pyrimidothienoindazoles capable of inhibiting tyrosine kinases of the epidermal growth factor
|
NZ562453A
(en)
|
2005-03-31 |
2010-04-30 |
Agensys Inc |
Antibodies and related molecules that bind to 161P2F10B proteins
|
BRPI0608096A2
(en)
|
2005-04-26 |
2009-11-10 |
Pfizer |
p-cadherin antibodies
|
WO2007015578A1
(en)
|
2005-08-02 |
2007-02-08 |
Eisai R & D Management Co., Ltd. |
Method for assay on the effect of vascularization inhibitor
|
UA94060C2
(en)
|
2005-09-07 |
2011-04-11 |
Эмджен Фримонт Инк. |
Monoclonal antibodies that specifically binds alk-1
|
WO2007035744A1
(en)
|
2005-09-20 |
2007-03-29 |
Osi Pharmaceuticals, Inc. |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
EA200802058A1
(en)
|
2006-05-09 |
2009-06-30 |
Пфайзер Продактс Инк. |
DERIVATIVES OF CYCLO-ALKYLAMINO ACIDS AND THEIR PHARMACEUTICAL COMPOSITIONS
|
NL2000613C2
(en)
|
2006-05-11 |
2007-11-20 |
Pfizer Prod Inc |
Triazole pyrazine derivatives.
|
CA2652442C
(en)
|
2006-05-18 |
2014-12-09 |
Eisai R & D Management Co., Ltd. |
Antitumor agent for thyroid cancer
|
KR101472600B1
(en)
|
2006-08-28 |
2014-12-15 |
에자이 알앤드디 매니지먼트 가부시키가이샤 |
Antitumor agent for undifferentiated gastric cancer
|
CA2676796C
(en)
|
2007-01-29 |
2016-02-23 |
Eisai R & D Management Co., Ltd. |
Composition for treatment of undifferentiated gastric cancer
|
JP5926487B2
(en)
|
2007-04-13 |
2016-05-25 |
デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド |
Method for treating cancer resistant to ErbB therapy
|
PT2185574E
(en)
|
2007-09-07 |
2013-08-26 |
Agensys Inc |
Antibodies and related molecules that bind to 24p4c12 proteins
|
WO2009060945A1
(en)
|
2007-11-09 |
2009-05-14 |
Eisai R & D Management Co., Ltd. |
Combination of anti-angiogenic substance and anti-tumor platinum complex
|
CA2710039C
(en)
|
2007-12-26 |
2018-07-03 |
Critical Outcome Technologies, Inc. |
Semicarbazones, thiosemicarbazones and related compounds and methods for treatment of cancer
|
WO2009104026A1
(en)
*
|
2008-02-19 |
2009-08-27 |
Vichem Chemie Kutató Kft |
Tricyclic benzo[4,5]thieno-[2,3-d]pyrimidine-4-yl-amin derivatives, their salts, process for producing the compounds and their pharmaceutical use
|
CA2730890C
(en)
|
2008-07-17 |
2018-05-15 |
Critical Outcome Technologies Inc. |
Thiosemicarbazone inhibitor compounds and cancer treatment methods
|
CA2737597C
(en)
|
2008-10-16 |
2017-03-14 |
University Of Pittsburgh-Of The Commonwealth System Of Higher Education |
Fully human antibodies to high molecular weight-melanoma associated antigen and uses thereof
|
SG172857A1
(en)
|
2009-02-09 |
2011-08-29 |
Supergen Inc |
Pyrrolopyrimidinyl axl kinase inhibitors
|
US20120189641A1
(en)
|
2009-02-25 |
2012-07-26 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
WO2010099137A2
(en)
|
2009-02-26 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
In situ methods for monitoring the emt status of tumor cells in vivo
|
WO2010099363A1
(en)
|
2009-02-27 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
|
JP2012519282A
(en)
|
2009-02-27 |
2012-08-23 |
オーエスアイ・ファーマシューティカルズ,エルエルシー |
Methods for identifying mesenchymal tumor cells or agents that inhibit their production
|
WO2010099138A2
(en)
|
2009-02-27 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
|
US20100222381A1
(en)
|
2009-02-27 |
2010-09-02 |
Hariprasad Vankayalapati |
Cyclopentathiophene/cyclohexathiophene DNA methyltransferase inhibitors
|
WO2011027249A2
(en)
|
2009-09-01 |
2011-03-10 |
Pfizer Inc. |
Benzimidazole derivatives
|
WO2011098971A1
(en)
|
2010-02-12 |
2011-08-18 |
Pfizer Inc. |
Salts and polymorphs of 8-fluoro-2-{4-[(methylamino}methyl]phenyl}-1,3,4,5-tetrahydro-6h-azepino[5,4,3-cd]indol-6-one
|
JP2013527748A
(en)
|
2010-03-03 |
2013-07-04 |
オーエスアイ・ファーマシューティカルズ,エルエルシー |
Biological markers useful for predicting anticancer responses to insulin-like growth factor 1 receptor kinase inhibitors
|
US20110217309A1
(en)
|
2010-03-03 |
2011-09-08 |
Buck Elizabeth A |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
US8987272B2
(en)
|
2010-04-01 |
2015-03-24 |
Critical Outcome Technologies Inc. |
Compounds and method for treatment of HIV
|
ES2611479T3
(en)
|
2010-06-16 |
2017-05-09 |
University Of Pittsburgh- Of The Commonwealth System Of Higher Education |
Endoplasmin antibodies and their use
|
EP2586443B1
(en)
|
2010-06-25 |
2016-03-16 |
Eisai R&D Management Co., Ltd. |
Antitumor agent using compounds having kinase inhibitory effect in combination
|
EP2630134B9
(en)
|
2010-10-20 |
2018-04-18 |
Pfizer Inc |
Pyridine-2- derivatives as smoothened receptor modulators
|
US20120214830A1
(en)
|
2011-02-22 |
2012-08-23 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors in hepatocellular carcinoma
|
KR20200003933A
(en)
|
2011-03-04 |
2020-01-10 |
뉴젠 세러퓨틱스 인코포레이티드 |
Alkyne substituted quinazoline compound and methods of use
|
BR112013023050A8
(en)
|
2011-03-09 |
2018-09-25 |
G Pestell Richard |
ccr5 antagonist, method for determining whether a human individual having prostate cancer is suffering from or at risk of metastasis, to identify a ccr5 antagonist, method for determining whether a human individual having prostate cancer is suffering from or under risk of developing metastasis, to identify a candidate compound, to produce in vitro primary epithelial cells, to diagnose prostate cancer, to select a treatment for an individual having a prostate cancer / tumor, cell line, and, animal model
|
US9150644B2
(en)
|
2011-04-12 |
2015-10-06 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Human monoclonal antibodies that bind insulin-like growth factor (IGF) I and II
|
CA2828946C
(en)
|
2011-04-18 |
2016-06-21 |
Eisai R&D Management Co., Ltd. |
Therapeutic agent for tumor
|
EP2699598B1
(en)
|
2011-04-19 |
2019-03-06 |
Pfizer Inc |
Combinations of anti-4-1bb antibodies and adcc-inducing antibodies for the treatment of cancer
|
WO2012149014A1
(en)
|
2011-04-25 |
2012-11-01 |
OSI Pharmaceuticals, LLC |
Use of emt gene signatures in cancer drug discovery, diagnostics, and treatment
|
ES2705950T3
(en)
|
2011-06-03 |
2019-03-27 |
Eisai R&D Man Co Ltd |
Biomarkers to predict and assess the responsiveness of subjects with thyroid and kidney cancer to lenvatinib compounds
|
ES2671748T3
(en)
|
2011-07-21 |
2018-06-08 |
Tolero Pharmaceuticals, Inc. |
Heterocyclic protein kinase inhibitors
|
WO2013042006A1
(en)
|
2011-09-22 |
2013-03-28 |
Pfizer Inc. |
Pyrrolopyrimidine and purine derivatives
|
EP3275902A1
(en)
|
2011-10-04 |
2018-01-31 |
IGEM Therapeutics Limited |
Ige anti-hmw-maa antibody
|
BR112014011115A2
(en)
|
2011-11-08 |
2017-06-13 |
Pfizer |
Methods for treating inflammatory disorders using anti-csf antibodies
|
WO2013152252A1
(en)
|
2012-04-06 |
2013-10-10 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
CA2873743C
(en)
|
2012-05-14 |
2022-12-06 |
Prostagene, Llc |
Using modulators of ccr5 for treating cancer
|
US9394257B2
(en)
|
2012-10-16 |
2016-07-19 |
Tolero Pharmaceuticals, Inc. |
PKM2 modulators and methods for their use
|
US9260426B2
(en)
|
2012-12-14 |
2016-02-16 |
Arrien Pharmaceuticals Llc |
Substituted 1H-pyrrolo [2, 3-b] pyridine and 1H-pyrazolo [3, 4-b] pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors
|
CN104755463A
(en)
|
2012-12-21 |
2015-07-01 |
卫材R&D管理有限公司 |
Amorphous form of quinoline derivative, and method for producing same
|
US10202356B2
(en)
|
2013-03-14 |
2019-02-12 |
Tolero Pharmaceuticals, Inc. |
JAK2 and ALK2 inhibitors and methods for their use
|
US9206188B2
(en)
|
2013-04-18 |
2015-12-08 |
Arrien Pharmaceuticals Llc |
Substituted pyrrolo[2,3-b]pyridines as ITK and JAK inhibitors
|
MX368099B
(en)
|
2013-05-14 |
2019-09-19 |
Eisai R&D Man Co Ltd |
Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds.
|
DK3052102T3
(en)
|
2013-10-04 |
2020-03-09 |
Aptose Biosciences Inc |
CANCER TREATMENT COMPOSITIONS
|
UA115388C2
(en)
|
2013-11-21 |
2017-10-25 |
Пфайзер Інк. |
2,6-substituted purine derivatives and their use in the treatment of proliferative disorders
|
WO2015155624A1
(en)
|
2014-04-10 |
2015-10-15 |
Pfizer Inc. |
Dihydropyrrolopyrimidine derivatives
|
PT3137460T
(en)
|
2014-04-30 |
2019-12-30 |
Pfizer |
Cycloalkyl-linked diheterocycle derivatives
|
WO2016001789A1
(en)
|
2014-06-30 |
2016-01-07 |
Pfizer Inc. |
Pyrimidine derivatives as pi3k inhibitors for use in the treatment of cancer
|
ES2848857T3
(en)
|
2014-07-31 |
2021-08-12 |
Us Gov Health & Human Services |
Human monoclonal antibodies against EphA4 and their use
|
JO3783B1
(en)
|
2014-08-28 |
2021-01-31 |
Eisai R&D Man Co Ltd |
Highly pure quinoline derivative and method for producing the same
|
ES2746839T3
(en)
|
2014-12-18 |
2020-03-09 |
Pfizer |
Pyrimidine and triazine derivatives and their use as AXL inhibitors
|
DK3263106T3
(en)
|
2015-02-25 |
2024-01-08 |
Eisai R&D Man Co Ltd |
PROCESS FOR SUPPRESSING BITTERNESS OF QUINOLINE DERIVATIVES
|
CA2978226A1
(en)
|
2015-03-04 |
2016-09-09 |
Merck Sharpe & Dohme Corp. |
Combination of a pd-1 antagonist and a vegfr/fgfr/ret tyrosine kinase inhibitor for treating cancer
|
MX2017013383A
(en)
|
2015-04-20 |
2017-12-07 |
Tolero Pharmaceuticals Inc |
Predicting response to alvocidib by mitochondrial profiling.
|
US10011629B2
(en)
|
2015-05-01 |
2018-07-03 |
Cocrystal Pharma, Inc. |
Nucleoside analogs for treatment of the flaviviridae family of viruses and cancer
|
KR102608921B1
(en)
|
2015-05-18 |
2023-12-01 |
스미토모 파마 온콜로지, 인크. |
Albocidip prodrug with increased bioavailability
|
CN107801379B
(en)
|
2015-06-16 |
2021-05-25 |
卫材R&D管理有限公司 |
Anticancer agent
|
WO2017009751A1
(en)
|
2015-07-15 |
2017-01-19 |
Pfizer Inc. |
Pyrimidine derivatives
|
MX2018001289A
(en)
|
2015-08-03 |
2018-04-30 |
Tolero Pharmaceuticals Inc |
Combination therapies for treatment of cancer.
|
JP6877429B2
(en)
|
2015-12-03 |
2021-05-26 |
アジオス ファーマシューティカルズ, インコーポレイテッド |
MAT2A inhibitor for treating MTAP null cancer
|
US11279694B2
(en)
|
2016-11-18 |
2022-03-22 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Alvocidib prodrugs and their use as protein kinase inhibitors
|
US10132797B2
(en)
|
2016-12-19 |
2018-11-20 |
Tolero Pharmaceuticals, Inc. |
Profiling peptides and methods for sensitivity profiling
|
WO2019055579A1
(en)
|
2017-09-12 |
2019-03-21 |
Tolero Pharmaceuticals, Inc. |
Treatment regimen for cancers that are insensitive to bcl-2 inhibitors using the mcl-1 inhibitor alvocidib
|
US20200237766A1
(en)
|
2017-10-13 |
2020-07-30 |
Tolero Pharmaceuticals, Inc. |
Pkm2 activators in combination with reactive oxygen species for treatment of cancer
|
CA3103995A1
(en)
|
2018-07-26 |
2020-01-30 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Methods for treating diseases associated with abnormal acvr1 expression and acvr1 inhibitors for use in the same
|
MX2021006544A
(en)
|
2018-12-04 |
2021-07-07 |
Sumitomo Pharma Oncology Inc |
Cdk9 inhibitors and polymorphs thereof for use as agents for treatment of cancer.
|
EP3924351A4
(en)
|
2019-02-12 |
2022-12-21 |
Sumitomo Pharma Oncology, Inc. |
Formulations comprising heterocyclic protein kinase inhibitors
|
WO2020191326A1
(en)
|
2019-03-20 |
2020-09-24 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Treatment of acute myeloid leukemia (aml) with venetoclax failure
|
AU2020245437A1
(en)
|
2019-03-22 |
2021-09-30 |
Sumitomo Pharma Oncology, Inc. |
Compositions comprising PKM2 modulators and methods of treatment using the same
|
WO2021155006A1
(en)
|
2020-01-31 |
2021-08-05 |
Les Laboratoires Servier Sas |
Inhibitors of cyclin-dependent kinases and uses thereof
|
WO2022143533A1
(en)
*
|
2020-12-30 |
2022-07-07 |
成都百裕制药股份有限公司 |
Quinazoline derivative and use thereof in medicine
|