IL115292A - Computer based system and method of automatically generating chemical compounds - Google Patents

Computer based system and method of automatically generating chemical compounds

Info

Publication number
IL115292A
IL115292A IL11529295A IL11529295A IL115292A IL 115292 A IL115292 A IL 115292A IL 11529295 A IL11529295 A IL 11529295A IL 11529295 A IL11529295 A IL 11529295A IL 115292 A IL115292 A IL 115292A
Authority
IL
Israel
Prior art keywords
computer based
based system
chemical compounds
automatically generating
generating chemical
Prior art date
Application number
IL11529295A
Other languages
English (en)
Other versions
IL115292A0 (en
Original Assignee
Dimensional Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dimensional Pharm Inc filed Critical Dimensional Pharm Inc
Priority to IL12501795A priority Critical patent/IL125017A/xx
Publication of IL115292A0 publication Critical patent/IL115292A0/xx
Publication of IL115292A publication Critical patent/IL115292A/xx

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G16B15/30—Drug targeting using structural data; Docking or binding prediction
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/10—Analysis or design of chemical reactions, syntheses or processes
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/60—In silico combinatorial chemistry
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/60—In silico combinatorial chemistry
    • G16C20/62—Design of libraries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00592—Split-and-pool, mix-and-divide processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00599—Solution-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00689—Automatic using computers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00691—Automatic using robots
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00695—Synthesis control routines, e.g. using computer programs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00698—Measurement and control of process parameters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/007—Simulation or vitual synthesis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/08—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/30—Prediction of properties of chemical compounds, compositions or mixtures
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/70—Machine learning, data mining or chemometrics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Computing Systems (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Evolutionary Biology (AREA)
  • Library & Information Science (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
IL11529295A 1994-09-16 1995-09-14 Computer based system and method of automatically generating chemical compounds IL115292A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL12501795A IL125017A (en) 1994-09-16 1995-09-14 Computer based system and method of automatically generating chemical compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/306,915 US5463564A (en) 1994-09-16 1994-09-16 System and method of automatically generating chemical compounds with desired properties

Publications (2)

Publication Number Publication Date
IL115292A0 IL115292A0 (en) 1995-12-31
IL115292A true IL115292A (en) 1999-06-20

Family

ID=23187448

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11529295A IL115292A (en) 1994-09-16 1995-09-14 Computer based system and method of automatically generating chemical compounds

Country Status (9)

Country Link
US (6) US5463564A (xx)
EP (1) EP0781436A4 (xx)
JP (1) JPH10505832A (xx)
AU (1) AU688598B2 (xx)
CA (1) CA2199264A1 (xx)
HU (1) HUT77914A (xx)
IL (1) IL115292A (xx)
TW (1) TW420779B (xx)
WO (1) WO1996008781A1 (xx)

Families Citing this family (337)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2012139C (en) * 1990-03-08 2004-01-13 Michael P. Teter Apparatus and method for predicting physical and chemical properties of materials
US5703792A (en) * 1993-05-21 1997-12-30 Arris Pharmaceutical Corporation Three dimensional measurement of molecular diversity
AU686186B2 (en) * 1993-05-27 1998-02-05 Aventisub Ii Inc. Topologically segregated, encoded solid phase libraries
US6087186A (en) 1993-07-16 2000-07-11 Irori Methods and apparatus for synthesizing labeled combinatorial chemistry libraries
US7047171B1 (en) * 1995-12-08 2006-05-16 Sproch Norman K Method for the characterization of the three-dimensional structure of proteins employing mass spectrometric analysis and computational feedback modeling
US20060277017A1 (en) * 1993-11-04 2006-12-07 Sproch Norman K Method for the characterization of the three-dimensional structure of proteins employing mass spectrometric analysis and computational feedback modeling
US5577239A (en) * 1994-08-10 1996-11-19 Moore; Jeffrey Chemical structure storage, searching and retrieval system
US5463564A (en) * 1994-09-16 1995-10-31 3-Dimensional Pharmaceuticals, Inc. System and method of automatically generating chemical compounds with desired properties
US5585069A (en) * 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5985119A (en) * 1994-11-10 1999-11-16 Sarnoff Corporation Electrokinetic pumping
US5603351A (en) * 1995-06-07 1997-02-18 David Sarnoff Research Center, Inc. Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
JP3398749B2 (ja) * 1994-11-10 2003-04-21 オーキッド バイオ サイエンシズ， インコーポレイテッド 液体分配システム
US5712171A (en) 1995-01-20 1998-01-27 Arqule, Inc. Method of generating a plurality of chemical compounds in a spatially arranged array
US5612894A (en) * 1995-02-08 1997-03-18 Wertz; David H. System and method for molecular modeling utilizing a sensitivity factor
CA2215193C (en) * 1995-03-17 2004-05-11 Kureha Kagaku Kogyo Kabushiki Kaisha Biochemical information processing apparatus, biochemical information processing method, and biochemical information recording medium
US5657255C1 (en) * 1995-04-14 2002-06-11 Interleukin Genetics Inc Hierarchic biological modelling system and method
US5751629A (en) 1995-04-25 1998-05-12 Irori Remotely programmable matrices with memories
US6416714B1 (en) 1995-04-25 2002-07-09 Discovery Partners International, Inc. Remotely programmable matrices with memories
US5961923A (en) * 1995-04-25 1999-10-05 Irori Matrices with memories and uses thereof
US6017496A (en) 1995-06-07 2000-01-25 Irori Matrices with memories and uses thereof
US6329139B1 (en) 1995-04-25 2001-12-11 Discovery Partners International Automated sorting system for matrices with memory
US6331273B1 (en) 1995-04-25 2001-12-18 Discovery Partners International Remotely programmable matrices with memories
US6284459B1 (en) 1995-04-25 2001-09-04 Discovery Partners International Solid support matrices with memories and combinatorial libraries therefrom
US5925562A (en) * 1995-04-25 1999-07-20 Irori Remotely programmable matrices with memories
US6100026A (en) * 1995-04-25 2000-08-08 Irori Matrices with memories and uses thereof
US5874214A (en) 1995-04-25 1999-02-23 Irori Remotely programmable matrices with memories
US6025129A (en) * 1995-04-25 2000-02-15 Irori Remotely programmable matrices with memories and uses thereof
US6120665A (en) * 1995-06-07 2000-09-19 Chiang; William Yat Chung Electrokinetic pumping
CA2203832A1 (en) * 1995-09-08 1997-03-13 Jaime E. Arenas Screen for compounds with affinity for rna
US6266622B1 (en) * 1995-12-13 2001-07-24 Regents Of The University Of California Nuclear receptor ligands and ligand binding domains
US6185506B1 (en) 1996-01-26 2001-02-06 Tripos, Inc. Method for selecting an optimally diverse library of small molecules based on validated molecular structural descriptors
WO1997027559A1 (en) * 1996-01-26 1997-07-31 Patterson David E Method of creating and searching a molecular virtual library using validated molecular structure descriptors
US5880972A (en) * 1996-02-26 1999-03-09 Pharmacopeia, Inc. Method and apparatus for generating and representing combinatorial chemistry libraries
CA2251781A1 (en) 1996-03-20 1997-09-25 Charles Nicolette A method for identifying cytotoxic t-cell epitopes
CA2198433A1 (en) * 1996-03-22 1997-09-23 Sheila Helen Hobbs Dewitt Information management system for automated multiple simultaneous synthesis
US6220743B1 (en) * 1996-04-05 2001-04-24 The Dow Chemical Co. Processes and materials selection knowledge-based system
ES2213823T3 (es) * 1996-04-08 2004-09-01 Glaxo Group Limited Codificacion y analisis cualitativo de bibliotecas combinatorias basadas en masa.
US5840256A (en) * 1996-04-09 1998-11-24 David Sarnoff Research Center Inc. Plate for reaction system
AU741049B2 (en) 1996-05-09 2001-11-22 Life Technologies Corporation Microplate thermal shift assay and apparatus for ligand development and multi-variable protein chemistry optimization
US20030004653A1 (en) * 1996-05-24 2003-01-02 Michael Flavin Automated technology of screening of stationary phases
US6175816B1 (en) * 1997-05-23 2001-01-16 Advanced Life Sciences, Inc. Use of automated technology in chemical process research and development
US6044212A (en) * 1996-05-24 2000-03-28 Advanced Life Sciences, Inc. Use of automated technology in chemical process research and development
US5989835A (en) 1997-02-27 1999-11-23 Cellomics, Inc. System for cell-based screening
EP0818744A3 (en) * 1996-07-08 1998-07-08 Proteus Molecular Design Limited Process for selecting candidate drug compounds
US6558916B2 (en) 1996-08-02 2003-05-06 Axiom Biotechnologies, Inc. Cell flow apparatus and method for real-time measurements of patient cellular responses
US5804436A (en) * 1996-08-02 1998-09-08 Axiom Biotechnologies, Inc. Apparatus and method for real-time measurement of cellular response
US6280967B1 (en) 1996-08-02 2001-08-28 Axiom Biotechnologies, Inc. Cell flow apparatus and method for real-time of cellular responses
US5751605A (en) * 1996-08-15 1998-05-12 Tripos, Inc. Molecular hologram QSAR
CA2301230A1 (en) 1996-09-20 1998-03-26 Digital Drives, Inc. Spatially addressable combinatorial chemical arrays in cd-rom format
US6025371A (en) * 1996-10-28 2000-02-15 Versicor, Inc. Solid phase and combinatorial library syntheses of fused 2,4-pyrimidinediones
US6413724B1 (en) 1996-10-28 2002-07-02 Versicor, Inc. Solid phase and combinatorial library syntheses of fused 2,4-pyrimidinediones
EP0882500A1 (en) 1996-10-30 1998-12-09 Sumitomo Chemical Company Limited Synthesis experiment automating system, liquid separating treating apparatus and reaction vessel
CA2269669A1 (en) * 1996-11-04 1998-05-14 3-Dimensional Pharmaceuticals, Inc. System, method and computer program product for identifying chemical compounds having desired properties
US6453246B1 (en) 1996-11-04 2002-09-17 3-Dimensional Pharmaceuticals, Inc. System, method, and computer program product for representing proximity data in a multi-dimensional space
US6571227B1 (en) * 1996-11-04 2003-05-27 3-Dimensional Pharmaceuticals, Inc. Method, system and computer program product for non-linear mapping of multi-dimensional data
US6127191A (en) * 1996-12-03 2000-10-03 3-Dimensional Pharmaceuticals, Inc. Aminobenzenedicarboxylic acid-based combinatorial libraries
WO1998024464A1 (en) * 1996-12-03 1998-06-11 Trustees Of Boston University Specific antagonists for glucose-dependent insulinotropic polypeptide (gip)
US5859191A (en) * 1996-12-05 1999-01-12 The Regents Of The University Of California Method for the site-specific modification of peptide alpha amines
US5862514A (en) * 1996-12-06 1999-01-19 Ixsys, Inc. Method and means for synthesis-based simulation of chemicals having biological functions
US6274094B1 (en) 1997-01-13 2001-08-14 Weller, Iii Harold Norris Nestable, modular apparatus for synthesis of multiple organic compounds
US5798526A (en) * 1997-01-24 1998-08-25 Infrasoft International Llc Calibration system for spectrographic analyzing instruments
WO1998046551A1 (en) * 1997-04-16 1998-10-22 Arqule, Inc. Synthesis and use of biased arrays
US5891646A (en) * 1997-06-05 1999-04-06 Duke University Methods of assaying receptor activity and constructs useful in such methods
US7541151B2 (en) 1997-06-05 2009-06-02 Duke University Single-cell biosensor for the measurement of GPCR ligands in a test sample
US6528271B1 (en) * 1997-06-05 2003-03-04 Duke University Inhibition of βarrestin mediated effects prolongs and potentiates opioid receptor-mediated analgesia
US6182016B1 (en) * 1997-08-22 2001-01-30 Jie Liang Molecular classification for property prediction
US5961925A (en) 1997-09-22 1999-10-05 Bristol-Myers Squibb Company Apparatus for synthesis of multiple organic compounds with pinch valve block
US6051029A (en) * 1997-10-31 2000-04-18 Entelos, Inc. Method of generating a display for a dynamic simulation model utilizing node and link representations
EP0918296A1 (en) * 1997-11-04 1999-05-26 Cerep Method of virtual retrieval of analogs of lead compounds by constituting potential libraries
US6068393A (en) * 1997-11-05 2000-05-30 Zymark Corporation Robotic system for processing chemical products
US6073055A (en) * 1997-11-10 2000-06-06 Basf Corporation Computerized virtual paint manufacturing and application system
IL136046A0 (en) 1997-11-12 2001-05-20 Dimensional Pharm Inc Methods for classifying proteins
GB9724784D0 (en) * 1997-11-24 1998-01-21 Biofocus Plc Method of designing chemical substances
US6069629A (en) * 1997-11-25 2000-05-30 Entelos, Inc. Method of providing access to object parameters within a simulation model
US6078739A (en) * 1997-11-25 2000-06-20 Entelos, Inc. Method of managing objects and parameter values associated with the objects within a simulation model
JP3571201B2 (ja) * 1997-12-12 2004-09-29 富士通株式会社 データベース検索装置及びデータベース検索プログラムを記録したコンピュータ読み取り可能な記録媒体
DE19755516A1 (de) * 1997-12-13 1999-06-17 Conducta Endress & Hauser Messeinrichtung für die Flüssigkeits- und/oder Gasanalyse und/oder für die Messung von Feuchte in Flüssigkeiten und/oder Gasen
FR2773240B1 (fr) * 1997-12-30 2002-11-29 Synt Em Procede pour prevoir, identifier et decrire des molecules susceptibles de presenter un comportement recherche, notamment dans le domaine de la pharmacie et molecules obtenues par ce procede
CN1288462A (zh) 1998-01-23 2001-03-21 法玛西雅厄普约翰美国公司 噁唑烷酮组合库、组合物和制备方法
GB9803466D0 (en) 1998-02-19 1998-04-15 Chemical Computing Group Inc Discrete QSAR:a machine to determine structure activity and relationships for high throughput screening
DE19812210C1 (de) 1998-03-19 1999-05-06 Siemens Ag Vorrichtung und Verfahren zum Sichern eines Kraftfahrzeugs gegen unberechtigte Benutzung
US6537504B1 (en) 1998-04-06 2003-03-25 Li Young Method and apparatus for concurrent and sequential multi-step reactions for producing a plurality of different chemical compounds
US7321828B2 (en) * 1998-04-13 2008-01-22 Isis Pharmaceuticals, Inc. System of components for preparing oligonucleotides
US20030228597A1 (en) * 1998-04-13 2003-12-11 Cowsert Lex M. Identification of genetic targets for modulation by oligonucleotides and generation of oligonucleotides for gene modulation
US20040186071A1 (en) * 1998-04-13 2004-09-23 Bennett C. Frank Antisense modulation of CD40 expression
US6253168B1 (en) * 1998-05-12 2001-06-26 Isis Pharmaceuticals, Inc. Generation of virtual combinatorial libraries of compounds
CA2331726C (en) * 1998-05-12 2010-03-09 Isis Pharmaceuticals Inc. Modulation of molecular interaction sites on rna and other biomolecules
EP1077993A4 (en) * 1998-05-12 2004-09-08 Isis Pharmaceuticals Inc GENERATION OF COMBINATORIAL LIBRARIES OF COMPOUNDS CORRESPONDING TO VIRTUAL LIBRARIES OF COMPOUNDS
US6872535B2 (en) 1998-05-20 2005-03-29 Aventis Pharmaceuticals Inc. Three-dimensional array of supports for solid-phase parallel synthesis and method of use
US6541211B1 (en) * 1998-05-20 2003-04-01 Selectide Corporation Apparatus and method for synthesizing combinational libraries
CA2319495A1 (en) * 1998-06-08 1999-12-16 Advanced Medicine, Inc. Multibinding inhibitors of microsomal triglyceride transferase protein
US6713651B1 (en) 1999-06-07 2004-03-30 Theravance, Inc. β2-adrenergic receptor agonists
AU4672699A (en) * 1998-06-08 1999-12-30 Theravance, Inc. Novel sodium channel drugs and uses
EP1079845A1 (en) * 1998-06-08 2001-03-07 Advanced Medicine, Inc. Novel therapeutic agents for macromolecular structures
WO1999063939A2 (en) 1998-06-08 1999-12-16 Advanced Medicine, Inc. Multibinding inhibitors of cyclooxygenase-2
US6541669B1 (en) 1998-06-08 2003-04-01 Theravance, Inc. β2-adrenergic receptor agonists
AU4543699A (en) 1998-06-08 1999-12-30 Advanced Medicine, Inc. Multibinding inhibitors of hmg-coa reductase
US6897305B2 (en) 1998-06-08 2005-05-24 Theravance, Inc. Calcium channel drugs and uses
US6349160B2 (en) 1998-07-24 2002-02-19 Aurora Biosciences Corporation Detector and screening device for ion channels
US6608671B2 (en) * 1998-07-17 2003-08-19 Vertex Pharmaceuticals (San Diego) Llc Detector and screening device for ion channels
CA2339639C (en) * 1998-08-10 2010-09-28 The Scripps Research Institute Programmable one-pot oligosaccharide synthesis
US5993662A (en) * 1998-08-28 1999-11-30 Thetagen, Inc. Method of purifying and identifying a large multiplicity of chemical reaction products simultaneously
DE19843242A1 (de) * 1998-09-11 2000-03-23 Inst Angewandte Chemie Berlin Verfahren zur Herstellung aktiver und/oder selektiver Feststoff-Katalysatoren aus anorganischen oder metallorganischen Feststoffen oder Gemischen davon
AU6244099A (en) * 1998-09-11 2000-04-03 Gene Logic, Inc. Genomic knowledge discovery
BR9803848A (pt) * 1998-10-08 2000-10-31 Opp Petroquimica S A Sistema para inferência em linha de propriedades fìsicas e quìmicas, sistema para inferência em linha de variáveis de processo, e, sistema de controle em linha
US7101909B2 (en) * 1998-10-12 2006-09-05 Theravance, Inc. Calcium channel drugs and uses
US7199809B1 (en) 1998-10-19 2007-04-03 Symyx Technologies, Inc. Graphic design of combinatorial material libraries
EP1153358A2 (en) * 1998-10-28 2001-11-14 Glaxo Group Limited Pharmacophore fingerprinting in qsar and primary library design
US6569631B1 (en) * 1998-11-12 2003-05-27 3-Dimensional Pharmaceuticals, Inc. Microplate thermal shift assay for ligand development using 5-(4″dimethylaminophenyl)-2-(4′-phenyl)oxazole derivative fluorescent dyes
AU1615600A (en) * 1998-11-13 2000-06-05 Cellomics, Inc. Methods and system for efficient collection and storage of experimental data
NZ568033A (en) 1998-11-27 2011-04-29 Darwin Discovery Ltd Compositions and methods for increasing bone mineralization
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
AU2368900A (en) * 1998-12-18 2000-07-03 Symyx Technologies, Inc. Apparatus and method for characterizing libraries of different materials using x-ray scattering
DE19902378A1 (de) * 1999-01-21 2000-08-03 Morphochem Gmbh Verfahren zur Auffindung und Herstellung von biologisch wirksamen chemischen Verbindungen
US6720139B1 (en) 1999-01-27 2004-04-13 Elitra Pharmaceuticals, Inc. Genes identified as required for proliferation in Escherichia coli
US6500609B1 (en) 1999-02-11 2002-12-31 Scynexis Chemistry & Automation, Inc. Method and apparatus for synthesizing characterizing and assaying combinatorial libraries
US6693202B1 (en) 1999-02-16 2004-02-17 Theravance, Inc. Muscarinic receptor antagonists
US6904423B1 (en) 1999-02-19 2005-06-07 Bioreason, Inc. Method and system for artificial intelligence directed lead discovery through multi-domain clustering
US6864235B1 (en) * 1999-04-01 2005-03-08 Eva A. Turley Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans
US6911429B2 (en) * 1999-04-01 2005-06-28 Transition Therapeutics Inc. Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans
US7219020B1 (en) 1999-04-09 2007-05-15 Axontologic, Inc. Chemical structure similarity ranking system and computer-implemented method for same
AU4216400A (en) * 1999-04-09 2000-11-14 Merck & Co., Inc. Chemical structure similarity ranking system and computer-implemented method forsame
WO2000063793A2 (en) 1999-04-16 2000-10-26 Entelos, Inc. Method and apparatus for conducting linked simulation operations utilizing a computer-based system model
US20040117125A1 (en) * 1999-04-26 2004-06-17 Hao Chen Drug discovery method and apparatus
CA2371093A1 (en) * 1999-04-26 2000-11-02 David M. Manyak Receptor selectivity mapping
US20030138372A1 (en) * 1999-04-28 2003-07-24 The Research Foundation Of State University Of New York Method for identifying and synthesizing high dielectric constant perovskites
US20030083483A1 (en) * 1999-05-12 2003-05-01 Ecker David J. Molecular interaction sites of vimentin RNA and methods of modulating the same
US6969763B1 (en) 1999-05-12 2005-11-29 Isis Pharmaceuticals, Inc. Molecular interaction sites of interleukin-2 RNA and methods of modulating the same
US6485690B1 (en) 1999-05-27 2002-11-26 Orchid Biosciences, Inc. Multiple fluid sample processor and system
US6683115B2 (en) 1999-06-02 2004-01-27 Theravance, Inc. β2-adrenergic receptor agonists
US6593497B1 (en) 1999-06-02 2003-07-15 Theravance, Inc. β2-adrenergic receptor agonists
US6479498B1 (en) 1999-06-04 2002-11-12 Theravance, Inc. Sodium channel drugs and uses
US6420560B1 (en) 1999-06-07 2002-07-16 Theravance, Inc. H1—histamine receptor antagonists
US6524863B1 (en) 1999-08-04 2003-02-25 Scynexis Chemistry & Automation, Inc. High throughput HPLC method for determining Log P values
US6413431B1 (en) 1999-08-10 2002-07-02 Scynexis Chemistry & Automation, Inc. HPLC method for purifying organic compounds
EP1212128A1 (en) 1999-08-27 2002-06-12 Scynexis Chemistry and Automation, Inc. Sample preparation for high throughput purification
EP1222459A4 (en) * 1999-10-14 2003-01-22 Bristol Myers Squibb Co CRYSTALLOGRAPHIC STRUCTURE OF THE ANDROGEN RECEPTOR LIGAND BINDING DOMAIN
US7033840B1 (en) 1999-11-09 2006-04-25 Sri International Reaction calorimeter and differential scanning calorimeter for the high-throughput synthesis, screening and characterization of combinatorial libraries
US6589738B1 (en) 1999-11-09 2003-07-08 Elitra Pharmaceuticals, Inc. Genes essential for microbial proliferation and antisense thereto
WO2001034291A2 (en) 1999-11-09 2001-05-17 Sri International High-throughput synthesis, screening and characterization of combinatorial libraries
UA73965C2 (en) 1999-12-08 2005-10-17 Theravance Inc b2 ADRENERGIC RECEPTOR ANTAGONISTS
CA2395335A1 (en) * 1999-12-23 2001-07-05 Elitra Pharmaceuticals, Inc. Genes identified as required for proliferation of e. coli
US20050089923A9 (en) * 2000-01-07 2005-04-28 Levinson Douglas A. Method and system for planning, performing, and assessing high-throughput screening of multicomponent chemical compositions and solid forms of compounds
US20050095696A9 (en) * 2000-01-07 2005-05-05 Lemmo Anthony V. Apparatus and method for high-throughput preparation and characterization of compositions
US20050118637A9 (en) * 2000-01-07 2005-06-02 Levinson Douglas A. Method and system for planning, performing, and assessing high-throughput screening of multicomponent chemical compositions and solid forms of compounds
US20020048610A1 (en) * 2000-01-07 2002-04-25 Cima Michael J. High-throughput formation, identification, and analysis of diverse solid-forms
US20070021929A1 (en) * 2000-01-07 2007-01-25 Transform Pharmaceuticals, Inc. Computing methods for control of high-throughput experimental processing, digital analysis, and re-arraying comparative samples in computer-designed arrays
US20070020662A1 (en) * 2000-01-07 2007-01-25 Transform Pharmaceuticals, Inc. Computerized control of high-throughput experimental processing and digital analysis of comparative samples for a compound of interest
US7108970B2 (en) * 2000-01-07 2006-09-19 Transform Pharmaceuticals, Inc. Rapid identification of conditions, compounds, or compositions that inhibit, prevent, induce, modify, or reverse transitions of physical state
US6977723B2 (en) * 2000-01-07 2005-12-20 Transform Pharmaceuticals, Inc. Apparatus and method for high-throughput preparation and spectroscopic classification and characterization of compositions
US6728641B1 (en) 2000-01-21 2004-04-27 General Electric Company Method and system for selecting a best case set of factors for a chemical reaction
EP1252598A2 (en) 2000-01-25 2002-10-30 Cellomics, Inc. Method and system for automated inference of physico-chemical interaction knowledge
US7172759B2 (en) * 2000-02-01 2007-02-06 Pangenetics Bv Induction of cytotoxic T lymphocyte responses using anti-CD40 antibodies
WO2001057523A1 (en) * 2000-02-03 2001-08-09 Nanoscale Combinatorial Synthesis, Inc. Structure identification methods using mass measurements
US7435392B2 (en) * 2000-02-03 2008-10-14 Acclavis, Llc Scalable continuous production system
US7056477B1 (en) * 2000-02-03 2006-06-06 Cellular Process Chemistry, Inc. Modular chemical production system incorporating a microreactor
US7416524B1 (en) 2000-02-18 2008-08-26 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. System, method and computer program product for fast and efficient searching of large chemical libraries
US6625585B1 (en) 2000-02-18 2003-09-23 Bioreason, Inc. Method and system for artificial intelligence directed lead discovery though multi-domain agglomerative clustering
AU2001241800A1 (en) 2000-02-29 2001-09-12 3-Dimensional Pharmaceuticals, Inc. Method and computer program product for designing combinatorial arrays
US6907350B2 (en) * 2000-03-13 2005-06-14 Chugai Seiyaku Kabushiki Kaisha Method, system and apparatus for handling information on chemical substances
AU2001247627A1 (en) 2000-03-22 2001-10-03 3-Dimensional Pharmaceuticals, Inc. System, method, and computer program product for representing object relationships in a multidimensional space
US7216113B1 (en) * 2000-03-24 2007-05-08 Symyx Technologies, Inc. Remote Execution of Materials Library Designs
AU2001249805A1 (en) 2000-04-03 2001-10-15 3-Dimensional Pharmaceuticals, Inc. Method, system, and computer program product for representing object relationships in a multidimensional space
GB0008563D0 (en) * 2000-04-07 2000-05-24 Cambridge Discovery Chemistry Investigating different physical and/or chemical forms of materials
DE10028875A1 (de) * 2000-06-10 2001-12-20 Hte Gmbh Rechnergestützte Optimierung von Substanzbibliotheken
US7065453B1 (en) * 2000-06-15 2006-06-20 Accelrys Software, Inc. Molecular docking technique for screening of combinatorial libraries
EP1297175A4 (en) * 2000-06-30 2005-02-02 Univ California METHODS AND COMPOUNDS FOR MODULATING THE FIXATION OF COACTIVATORS TO NUCLEAR RECEPTORS
US7413714B1 (en) 2000-07-16 2008-08-19 Ymc Co. Ltd. Sequential reaction system
US6576472B1 (en) 2000-07-26 2003-06-10 Smithkline Beecham Corporation Chemical constructs for solution phase chemistry
US6584411B1 (en) 2000-07-26 2003-06-24 Smithkline Beecham Corporation Methods to facilitate the calculation of yields of reaction products
DE10036602A1 (de) * 2000-07-27 2002-02-14 Cpc Cellular Process Chemistry Mikroreaktor für Reaktionen zwischen Gasen und Flüssigkeiten
EP1350193A2 (en) * 2000-08-22 2003-10-08 3-Dimensional Pharmaceuticals, Inc. Method, system, and computer program product for determining properties of combinatorial library products from features of library building blocks
US6813615B1 (en) 2000-09-06 2004-11-02 Cellomics, Inc. Method and system for interpreting and validating experimental data with automated reasoning
US20030027286A1 (en) * 2000-09-06 2003-02-06 Robert Haselbeck Bacterial promoters and methods of use
DE10043853A1 (de) * 2000-09-06 2002-03-14 Merck Patent Gmbh Verfahren zur Erstellung von Synthesepfaden
WO2002025504A2 (en) * 2000-09-20 2002-03-28 Lobanov Victor S Method, system, and computer program product for encoding and building products of a virtual combinatorial library
EP1191312A3 (en) * 2000-09-21 2004-12-22 Tecan Trading AG System and method for optimization of parameters of liquid-handling instruments
ES2483991T3 (es) 2000-10-10 2014-08-08 Genentech, Inc. Anticuerpos contra C5 que inhibe la activación de las células endoteliales de tipo II
SK4682003A3 (en) * 2000-10-17 2003-12-02 Applied Research Systems Method of operating a computer system to perform a discrete substructural analysis
US6826487B1 (en) * 2000-10-25 2004-11-30 General Electric Company Method for defining an experimental space and method and system for conducting combinatorial high throughput screening of mixtures
US7319945B1 (en) * 2000-11-10 2008-01-15 California Institute Of Technology Automated methods for simulating a biological network
US6973148B2 (en) * 2000-11-30 2005-12-06 Adc Telecommunications, Inc. Clock recovery mechanism
AU2002230981A1 (en) * 2000-12-15 2002-06-24 Symyx Technologies, Inc. Methods and apparatus for designing high-dimensional combinatorial experiments
EP1363736B1 (en) * 2000-12-18 2011-03-02 Protedyne Corporation Extruding gel material for gel electrophoresis
US7085773B2 (en) * 2001-01-05 2006-08-01 Symyx Technologies, Inc. Laboratory database system and methods for combinatorial materials research
US6658429B2 (en) 2001-01-05 2003-12-02 Symyx Technologies, Inc. Laboratory database system and methods for combinatorial materials research
US20020127597A1 (en) * 2001-01-10 2002-09-12 General Electric Company Method and apparatus for exploring an experimental space
US7250950B2 (en) * 2001-01-29 2007-07-31 Symyx Technologies, Inc. Systems, methods and computer program products for determining parameters for chemical synthesis
US20020143725A1 (en) * 2001-01-29 2002-10-03 Smith Robin Young Systems, methods and computer program products for determining parameters for chemical synthesis and for supplying the reagents, equipment and/or chemicals synthesized thereby
US7054757B2 (en) * 2001-01-29 2006-05-30 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Method, system, and computer program product for analyzing combinatorial libraries
US20030004612A1 (en) * 2001-02-22 2003-01-02 Domanico Paul L. Methods and computer program products for automated experimental design
DE10108590A1 (de) * 2001-02-22 2002-09-05 Merck Patent Gmbh Verfahren zum Ermitteln pharmazeutisch wirksamer Substanzen
JP2004537338A (ja) * 2001-03-02 2004-12-16 ユーロ−セルティーク，エス．エイ． 個別の投与剤形を調合するための方法と装置
US20030013137A1 (en) * 2001-03-13 2003-01-16 Barak Larry S. Automated methods of detecting receptor activity
WO2002075608A1 (en) * 2001-03-16 2002-09-26 General Electric Company Method and system for selecting a best case set of factors for a chemical reaction
JP4071476B2 (ja) * 2001-03-21 2008-04-02 株式会社東芝 半導体ウェーハ及び半導体ウェーハの製造方法
US7514263B2 (en) 2001-04-02 2009-04-07 3M Innovative Properties Company Continuous process for the production of combinatorial libraries of materials
US20060129329A1 (en) * 2001-04-09 2006-06-15 Kobylecki Ryszard J Investigating different physical and/or chemical forms of materials
WO2003084997A1 (en) * 2001-04-10 2003-10-16 Transtech Pharma, Inc. Probes, systems and methods for drug discovery
ATE405586T1 (de) 2001-05-08 2008-09-15 Darwin Molecular Corp Verfahren zur regulierung der immunfunktion in primaten unter verwendung des foxp3-proteins
WO2002093439A1 (en) * 2001-05-15 2002-11-21 Akzo Nobel N.V. Method of product specification for a processing chemical
EP1393253A4 (en) 2001-05-17 2009-12-16 Entelos Inc DEVICE AND METHOD FOR VALIDATING A COMPUTER MODEL
JP2005508295A (ja) * 2001-06-07 2005-03-31 エフ．ホフマン−ラ　ロシュ　アーゲー Ｉｇｆ結合タンパク質の変異体、およびそれらのアゴニストの作製法
EP1409982A4 (en) * 2001-06-14 2006-05-24 Anadys Pharmaceuticals Inc PROCESS FOR SCREENING ON LIGANDS OF TARGET MOLECULES
DK2461156T3 (da) 2001-06-29 2020-08-03 Meso Scale Technologies Llc Indretning til luminescenstestmålinger
US20040073380A1 (en) * 2001-07-10 2004-04-15 Puglisi Joseph D. Structural targets in hepatittis c virus ires element
US20030036619A1 (en) * 2001-07-26 2003-02-20 Chrisman Ray W. Method for optimizing material transformation
EP3021106B8 (en) 2001-07-30 2019-03-27 Meso Scale Technologies, LLC Methods of using assay electrode having immobilized lipid/protein layers for luminescence test measurements
US20030216871A1 (en) * 2001-07-31 2003-11-20 Artem Tcherkassov Calculating a characteristic property of a molecule by correlation analysis
EP1878441B1 (en) 2001-08-17 2018-01-24 Genentech, Inc. Complement pathway inhibitors binding to C5 and C5a without preventing the formation of C5b
US20030083824A1 (en) * 2001-08-31 2003-05-01 General Electric Company Method and system for selecting a best case set of factors for a chemical reaction
AU2002336457A1 (en) * 2001-09-07 2003-03-24 Transform Pharmaceuticals, Inc. Apparatus and method for high-throughput preparation and characterization of compositions
JP4768224B2 (ja) * 2001-09-10 2011-09-07 メソ スケイル テクノロジーズ，エルエルシー １つの試料について複数の測定を実施する方法及び装置
MXPA04003451A (es) * 2001-10-09 2005-02-17 Dimensional Pharm Inc Difeniloxazoles substituidos, la sintesis de los mismos y el uso de los mismo como detectores fluorescencia.
US20040029129A1 (en) * 2001-10-25 2004-02-12 Liangsu Wang Identification of essential genes in microorganisms
DE10156245A1 (de) * 2001-11-15 2003-06-05 Bayer Ag Verfahren zur Identifikation von Pharmakophoren
US20030170694A1 (en) * 2001-12-21 2003-09-11 Daniel Wall Stabilized nucleic acids in gene and drug discovery and methods of use
US20040137518A1 (en) * 2002-01-31 2004-07-15 Lambert Millard Hurst CRYSTALLIZED PPARa LIGAND BINDING DOMAIN POLYPEPTIDE AND SCREENING METHODS EMPLOYING SAME
US20030149933A1 (en) * 2002-02-01 2003-08-07 Marco Falcioni Graphical design of chemical discovery processes
FI20020197A0 (fi) * 2002-02-01 2002-02-01 Orion Corp Yhdistelmä akuutin myokardiilisen infarktin hoitoon
US20030182669A1 (en) * 2002-03-19 2003-09-25 Rockman Howard A. Phosphoinositide 3-kinase mediated inhibition of GPCRs
WO2003083609A2 (en) * 2002-03-25 2003-10-09 Synthematix, Inc. Systems, methods and computer program products for determining parameters for chemical synthesis
AU2003226043A1 (en) * 2002-04-10 2003-10-27 Transtech Pharma, Inc. System and method for integrated computer-aided molecular discovery
US20030232369A1 (en) * 2002-04-17 2003-12-18 Bushnell David A. Molecular structure of RNA polymerase II
US20030222905A1 (en) * 2002-06-04 2003-12-04 Argonaut Technologies, Inc. Recipe recorder for automated chemistry
HUP0202551A2 (hu) * 2002-08-01 2004-03-29 Comgenex, Inc. Kémiai, biokémiai és biológiai folyamatok miniatürizálására szolgáló hibrid lapka (chip) és eljárás annak alkalmazására
US7632916B2 (en) 2002-08-02 2009-12-15 3M Innovative Properties Company Process to modify polymeric materials and resulting compositions
US20040082783A1 (en) * 2002-08-06 2004-04-29 Schafmeister Christian E. Bis (amino acid) molecular scaffolds
US20030125548A1 (en) * 2002-09-13 2003-07-03 Dorit Arad Molecules derived from mechanism based drug design
US7491312B2 (en) * 2002-10-30 2009-02-17 Edison Pharmaceuticals, Inc. Identifying therapeutic compounds based on their physical-chemical properties
DE60334246D1 (de) 2002-11-21 2010-10-28 Celltech R & D Inc Modulieren von immunantworten
US20040122641A1 (en) * 2002-12-20 2004-06-24 Lab2Plant, Inc. (An Indiana Corporation) System and method for chemical process scale-up and preliminary design and analysis
US7213034B2 (en) * 2003-01-24 2007-05-01 Symyx Technologies, Inc. User-configurable generic experiment class for combinatorial materials research
US20070026397A1 (en) * 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
WO2004097408A1 (en) * 2003-03-24 2004-11-11 Novascreen Biosciences Corporation Drug discovery method and apparatus
US7101515B2 (en) * 2003-04-14 2006-09-05 Cellular Process Chemistry, Inc. System and method for determining optimal reaction parameters using continuously running process
US20050010462A1 (en) * 2003-07-07 2005-01-13 Mark Dausch Knowledge management system and methods for crude oil refining
US7966331B2 (en) * 2003-08-18 2011-06-21 General Electric Company Method and system for assessing and optimizing crude selection
US7396940B2 (en) * 2003-10-23 2008-07-08 Hoffmann-La Roche Inc. Combinatorial library of 3-aryl-1H-indole-2-carboxylic acid
US20050089936A1 (en) * 2003-10-23 2005-04-28 Jianping Cai Combinatorial library of 3-aryl-1H-indole-2-carboxylic acid amides
US20050130229A1 (en) * 2003-12-16 2005-06-16 Symyx Technologies, Inc. Indexing scheme for formulation workflows
CA2563413A1 (en) * 2004-04-15 2005-10-27 Thermo Crs Ltd. Method and system for drug screening
US20050278308A1 (en) * 2004-06-01 2005-12-15 Barstow James F Methods and systems for data integration
NL1029182C2 (nl) * 2004-06-03 2009-08-11 John Bernard Olson Werkwijzen en toestellen voor het ontwerp van visuele applicaties.
WO2005121864A2 (en) 2004-06-07 2005-12-22 Fluidigm Corporation Optical lens system and method for microfluidic devices
US7702467B2 (en) * 2004-06-29 2010-04-20 Numerate, Inc. Molecular property modeling using ranking
EP1810008A4 (en) * 2004-10-15 2008-09-10 Signal Pharm Llc P27 UBIQUITINATION TEST AND USE PROCESS
US7977119B2 (en) * 2004-12-08 2011-07-12 Agilent Technologies, Inc. Chemical arrays and methods of using the same
WO2006081428A2 (en) * 2005-01-27 2006-08-03 Symyx Technologies, Inc. Parser for generating structure data
US20060218107A1 (en) * 2005-03-24 2006-09-28 The University Of Tennessee Research Foundation Method for controlling a product production process
CN101287411B (zh) 2005-04-28 2013-03-06 普罗秋斯生物医学公司 药物信息系统及其用途
US7475050B2 (en) * 2005-06-02 2009-01-06 Agilent Technologies, Inc. Systems for developing analytical device methods
US20070050092A1 (en) * 2005-08-12 2007-03-01 Symyx Technologies, Inc. Event-based library process design
WO2007020658A2 (en) * 2005-08-17 2007-02-22 Jubilant Biosys Ltd 'a novel homology model of the glycogen synthase kinase 3 alpha and its uses thereof'
US9550162B2 (en) * 2005-09-19 2017-01-24 Intematix Corporation Printing liquid solution arrays for inorganic combinatorial libraries
US7711674B2 (en) * 2005-11-01 2010-05-04 Fuji Xerox Co., Ltd. System and method for automatic design of components in libraries
US7966095B2 (en) * 2005-11-15 2011-06-21 Chen-Te Huang Computer-aided color paint formula adjusting system and method thereof
GB0605584D0 (en) * 2006-03-20 2006-04-26 Olink Ab Method for analyte detection using proximity probes
GB0612114D0 (en) * 2006-06-19 2006-07-26 Cresset Biomolecular Discovery Method and system for automated iterative drug discovery
WO2008077070A2 (en) * 2006-12-18 2008-06-26 University Of Massachusetts Crystal structures of hiv-1 protease inhibitors bound to hiv-1 protease
WO2008101184A2 (en) * 2007-02-16 2008-08-21 The Board Of Trustees Of Southern Illinois University Arl-1 specific antibodies
US8685666B2 (en) * 2007-02-16 2014-04-01 The Board Of Trustees Of Southern Illinois University ARL-1 specific antibodies and uses thereof
US20090171592A1 (en) * 2007-06-12 2009-07-02 Brookhaven Science Associates, Llc Homology Models of Mammalian Zinc Transporters and Methods of Using Same
US20100168114A1 (en) * 2007-06-18 2010-07-01 Yuan-Ping Pang Invertebrate acetylcholinesterase inhibitors
US8961412B2 (en) 2007-09-25 2015-02-24 Proteus Digital Health, Inc. In-body device with virtual dipole signal amplification
EP2222851B1 (en) 2007-11-20 2017-06-28 Ionis Pharmaceuticals, Inc. Modulation of cd40 expression
US9449150B2 (en) 2008-04-24 2016-09-20 The Invention Science Fund I, Llc Combination treatment selection methods and systems
US9662391B2 (en) * 2008-04-24 2017-05-30 The Invention Science Fund I Llc Side effect ameliorating combination therapeutic products and systems
US9026369B2 (en) 2008-04-24 2015-05-05 The Invention Science Fund I, Llc Methods and systems for presenting a combination treatment
US20100063368A1 (en) * 2008-04-24 2010-03-11 Searete Llc, A Limited Liability Corporation Computational system and method for memory modification
US20100069724A1 (en) * 2008-04-24 2010-03-18 Searete Llc Computational system and method for memory modification
US8615407B2 (en) * 2008-04-24 2013-12-24 The Invention Science Fund I, Llc Methods and systems for detecting a bioactive agent effect
US9282927B2 (en) 2008-04-24 2016-03-15 Invention Science Fund I, Llc Methods and systems for modifying bioactive agent use
US9649469B2 (en) 2008-04-24 2017-05-16 The Invention Science Fund I Llc Methods and systems for presenting a combination treatment
US8606592B2 (en) 2008-04-24 2013-12-10 The Invention Science Fund I, Llc Methods and systems for monitoring bioactive agent use
US9064036B2 (en) 2008-04-24 2015-06-23 The Invention Science Fund I, Llc Methods and systems for monitoring bioactive agent use
US8930208B2 (en) 2008-04-24 2015-01-06 The Invention Science Fund I, Llc Methods and systems for detecting a bioactive agent effect
US8876688B2 (en) 2008-04-24 2014-11-04 The Invention Science Fund I, Llc Combination treatment modification methods and systems
US9560967B2 (en) 2008-04-24 2017-02-07 The Invention Science Fund I Llc Systems and apparatus for measuring a bioactive agent effect
US8682687B2 (en) 2008-04-24 2014-03-25 The Invention Science Fund I, Llc Methods and systems for presenting a combination treatment
US9239906B2 (en) 2008-04-24 2016-01-19 The Invention Science Fund I, Llc Combination treatment selection methods and systems
US20100280332A1 (en) * 2008-04-24 2010-11-04 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for monitoring bioactive agent use
US20100130811A1 (en) * 2008-04-24 2010-05-27 Searete Llc Computational system and method for memory modification
GB0900425D0 (en) * 2009-01-12 2009-02-11 Ucb Pharma Sa Biological products
NZ596292A (en) 2009-04-28 2014-04-30 Proteus Digital Health Inc Highly reliable ingestible event markers and methods for using the same
WO2011083147A1 (en) 2010-01-08 2011-07-14 Cemm-Forschungsinstitut Für Molekulare Medizin Gmbh Wave1 inhibition in the medical intervention of inflammatory diseases and/or infections caused by a pathogen
GB201004292D0 (en) * 2010-03-15 2010-04-28 Olink Ab Assay for localised detection of analytes
US20130116304A1 (en) 2010-04-19 2013-05-09 Ernst R. Werner Tmem195 encodes for tetrahydrobiopterin-dependent alkylglycerol monooxygenase activity
US8639486B2 (en) * 2010-06-07 2014-01-28 Indian Institute Of Science Method for identifying inhibitors of Staphylococcus aureus
US8538983B2 (en) * 2010-09-21 2013-09-17 Cambridgesoft Corporation Systems, methods, and apparatus for facilitating chemical analyses
CA2816763A1 (en) 2010-11-05 2012-05-10 Transbio Ltd Markers of endothelial progenitor cells and uses thereof
GB201101621D0 (en) 2011-01-31 2011-03-16 Olink Ab Method and product
CA2826894A1 (en) * 2011-02-14 2012-08-23 Carnegie Mellon University Learning to predict effects of compounds on targets
US9447156B2 (en) 2011-05-17 2016-09-20 St. Jude Children's Research Hospital Methods and compositions for inhibiting neddylation of proteins
GB201116092D0 (en) 2011-09-16 2011-11-02 Bioceros B V Antibodies and uses thereof
AU2012327878A1 (en) 2011-10-28 2014-05-29 Patrys Limited PAT-LM1 epitopes and methods for using same
GB201201547D0 (en) 2012-01-30 2012-03-14 Olink Ab Method and product
US9977876B2 (en) 2012-02-24 2018-05-22 Perkinelmer Informatics, Inc. Systems, methods, and apparatus for drawing chemical structures using touch and gestures
US9603897B2 (en) 2012-03-12 2017-03-28 Massachusetts Institute Of Technology Methods for treating tissue damage associated with ischemia with apolipoprotein D
GB201209239D0 (en) * 2012-05-25 2012-07-04 Univ Glasgow Methods of evolutionary synthesis including embodied chemical synthesis
WO2014033136A1 (en) 2012-08-27 2014-03-06 Cemm - Research Center For Molecular Medicine Of The Austrian Academy Of Sciences Aminoheteroaryl compounds as mth1 inhibitors
US9535583B2 (en) 2012-12-13 2017-01-03 Perkinelmer Informatics, Inc. Draw-ahead feature for chemical structure drawing applications
US8854361B1 (en) 2013-03-13 2014-10-07 Cambridgesoft Corporation Visually augmenting a graphical rendering of a chemical structure representation or biological sequence representation with multi-dimensional information
EP2973005A1 (en) 2013-03-13 2016-01-20 Perkinelmer Informatics, Inc. Systems and methods for gesture-based sharing of data between separate electronic devices
EP2976361B1 (en) 2013-03-18 2018-07-18 BiocerOX Products B.V. Humanized anti-cd134 (ox40) antibodies and uses thereof
US9430127B2 (en) * 2013-05-08 2016-08-30 Cambridgesoft Corporation Systems and methods for providing feedback cues for touch screen interface interaction with chemical and biological structure drawing applications
US9751294B2 (en) 2013-05-09 2017-09-05 Perkinelmer Informatics, Inc. Systems and methods for translating three dimensional graphic molecular models to computer aided design format
WO2015020523A1 (en) 2013-08-07 2015-02-12 Stichting Vu-Vumc Biomarkers for early diagnosis of alzheimer's disease
WO2015152724A2 (en) 2014-04-02 2015-10-08 Stichting Vu-Vumc Biomarkers for the detection of frontotemporal dementia
CN104504152B (zh) * 2015-01-09 2017-08-29 常州三泰科技有限公司 提高化学工艺效率和促进化学信息分享的装置和方法
US20160279878A1 (en) * 2015-03-27 2016-09-29 John AMBIELLI Rapid synthetic material prototyping process
US10776712B2 (en) 2015-12-02 2020-09-15 Preferred Networks, Inc. Generative machine learning systems for drug design
KR102523472B1 (ko) 2016-08-01 2023-04-18 삼성전자주식회사 신규 물질의 구조 생성 방법 및 장치
US10998087B2 (en) 2016-08-25 2021-05-04 The Government of the United States of Amercia as represented by the Secretary of Homeland Security Systems and methodologies for desigining simulant compounds
US10832800B2 (en) 2017-01-03 2020-11-10 International Business Machines Corporation Synthetic pathway engine
US10430395B2 (en) 2017-03-01 2019-10-01 International Business Machines Corporation Iterative widening search for designing chemical compounds
US10572545B2 (en) 2017-03-03 2020-02-25 Perkinelmer Informatics, Inc Systems and methods for searching and indexing documents comprising chemical information
UY37753A (es) 2017-06-02 2018-11-30 Amgen Inc Antagonistas de péptido pac1
WO2019006391A1 (en) * 2017-06-30 2019-01-03 Sri International REACTION SCREENING AND OPTIMIZATION APPARATUSES, AND ASSOCIATED METHODS
JP2020537668A (ja) 2017-10-18 2020-12-24 シーエスエル リミティド ヒト血清アルブミン変異体およびその使用
AU2018385757B2 (en) 2017-12-15 2023-10-19 Flagship Pioneering Innovations Vi, Llc Compositions comprising circular polyribonucleotides and uses thereof
KR102587959B1 (ko) 2018-01-17 2023-10-11 삼성전자주식회사 뉴럴 네트워크를 이용하여 화학 구조를 생성하는 장치 및 방법
US11087861B2 (en) * 2018-03-15 2021-08-10 International Business Machines Corporation Creation of new chemical compounds having desired properties using accumulated chemical data to construct a new chemical structure for synthesis
BR112020024767A2 (pt) * 2018-06-06 2021-03-23 Syngulon Sa engenharia de peptídeos antimicrobianos
GB201810944D0 (en) * 2018-07-04 2018-08-15 Univ Court Univ Of Glasgow Machine learning
RU2726899C2 (ru) * 2018-09-10 2020-07-16 Автономная некоммерческая образовательная организация высшего образования "Сколковский институт науки и технологий" Способ генерации случайной кристаллической структуры, использующий базу данных периодических сеток
JP7526195B2 (ja) 2019-03-01 2024-07-31 フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー ポリリボヌクレオチドの送達のための組成物、方法、及びキット
CA3131319A1 (en) 2019-03-25 2020-10-01 Avak Kahvejian Compositions comprising modified circular polyribonucleotides and uses thereof
WO2020236314A1 (en) * 2019-05-21 2020-11-26 The Regents Of The University Of Michigan Property modulation with chemical transformations
CA3140205A1 (en) 2019-06-14 2020-12-17 Alexandra Sophie DE BOER Circular rnas for cellular therapy
WO2020257727A1 (en) 2019-06-19 2020-12-24 Flagship Pioneering Innovations Vi, Llc Methods of dosing circular polyribonucleotides
US10515715B1 (en) 2019-06-25 2019-12-24 Colgate-Palmolive Company Systems and methods for evaluating compositions
EP4096681A1 (en) 2020-01-29 2022-12-07 Flagship Pioneering Innovations VI, LLC Delivery of compositions comprising circular polyribonucleotides
CA3217862A1 (en) 2021-05-05 2022-11-10 Radius Pharmaceuticals, Inc. Animal model having homologous recombination of mouse pth1 receptor
WO2023131726A1 (en) 2022-01-10 2023-07-13 The University Court Of The University Of Glasgow Autonomous exploration for the synthesis of chemical libraries
WO2023165898A1 (en) * 2022-03-03 2023-09-07 Cytiva Sweden Ab Method and device for synthesizing molecules
GB202209476D0 (en) 2022-06-28 2022-08-10 Univ Court Univ Of Glasgow Chemical synthesis platform

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61223941A (ja) 1985-03-29 1986-10-04 Kagaku Joho Kyokai 化学構造の検索方法
US4773099A (en) 1985-10-10 1988-09-20 The Palantir Corporation Pattern classification means for use in a pattern recognition system
US4908773A (en) 1987-04-06 1990-03-13 Genex Corporation Computer designed stabilized proteins and method for producing same
US4859736A (en) 1987-03-30 1989-08-22 Ciba-Geigy Corporation Synthetic polystyrene resin and its use in solid phase peptide synthesis
US4939666A (en) * 1987-09-02 1990-07-03 Genex Corporation Incremental macromolecule construction methods
US4935875A (en) 1987-12-02 1990-06-19 Data Chem, Inc. Chemical analyzer
JP2708456B2 (ja) * 1988-03-31 1998-02-04 武田薬品工業株式会社 自動合成装置
US5147608A (en) * 1988-04-29 1992-09-15 Millipore Corporation Apparatus and process for performing repetitive chemical processing
US5010175A (en) 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
EP0355628B1 (de) * 1988-08-24 1993-11-10 Siemens Aktiengesellschaft Verfahren zur chemischen Dekontamination der Oberfläche eines metallischen Bauteils einer Kernreaktoranlage
US5025388A (en) 1988-08-26 1991-06-18 Cramer Richard D Iii Comparative molecular field analysis (CoMFA)
US5095443A (en) * 1988-10-07 1992-03-10 Ricoh Company, Ltd. Plural neural network system having a successive approximation learning method
US5265030A (en) 1990-04-24 1993-11-23 Scripps Clinic And Research Foundation System and method for determining three-dimensional structures of proteins
US5723289A (en) 1990-06-11 1998-03-03 Nexstar Pharmaceuticals, Inc. Parallel selex
IE66205B1 (en) * 1990-06-14 1995-12-13 Paul A Bartlett Polypeptide analogs
US5650489A (en) * 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
US5167009A (en) 1990-08-03 1992-11-24 E. I. Du Pont De Nemours & Co. (Inc.) On-line process control neural network using data pointers
US5181259A (en) 1990-09-25 1993-01-19 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration General method of pattern classification using the two domain theory
US5155801A (en) 1990-10-09 1992-10-13 Hughes Aircraft Company Clustered neural networks
US5331573A (en) * 1990-12-14 1994-07-19 Balaji Vitukudi N Method of design of compounds that mimic conformational features of selected peptides
US5260882A (en) 1991-01-02 1993-11-09 Rohm And Haas Company Process for the estimation of physical and chemical properties of a proposed polymeric or copolymeric substance or material
US5499193A (en) 1991-04-17 1996-03-12 Takeda Chemical Industries, Ltd. Automated synthesis apparatus and method of controlling the apparatus
AU2408292A (en) 1991-07-11 1993-02-11 Regents Of The University Of California, The A method to identify protein sequences that fold into a known three-dimensional structure
JPH07117950B2 (ja) 1991-09-12 1995-12-18 株式会社エイ・ティ・アール視聴覚機構研究所 パターン認識装置およびパターン学習装置
US5270170A (en) * 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
US5240680A (en) * 1991-12-19 1993-08-31 Chiron Corporation Automated apparatus for use in peptide synthesis
US6037135A (en) 1992-08-07 2000-03-14 Epimmune Inc. Methods for making HLA binding peptides and their uses
DE69328640T2 (de) 1992-02-07 2000-09-28 Canon K.K., Tokio/Tokyo Verfahren und Einrichtung zur Mustererkennung
US5573905A (en) * 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US5288514A (en) * 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US5565325A (en) 1992-10-30 1996-10-15 Bristol-Myers Squibb Company Iterative methods for screening peptide libraries
JP2513395B2 (ja) 1992-11-09 1996-07-03 株式会社島津製作所 ペプチドアミド合成用リンカ―
WO1994028504A1 (en) 1993-05-21 1994-12-08 Arris Pharmaceutical A machine-learning approach to modeling biological activity for molecular design and to modeling other characteristics
US5703792A (en) 1993-05-21 1997-12-30 Arris Pharmaceutical Corporation Three dimensional measurement of molecular diversity
US5544352A (en) 1993-06-14 1996-08-06 Libertech, Inc. Method and apparatus for indexing, searching and displaying data
US5585277A (en) * 1993-06-21 1996-12-17 Scriptgen Pharmaceuticals, Inc. Screening method for identifying ligands for target proteins
ES2165880T3 (es) 1993-06-21 2002-04-01 Selectide Corp Conectores segmentables selectivamente basados en enlaces ester de acido iminodiacetico.
US5679582A (en) 1993-06-21 1997-10-21 Scriptgen Pharmaceuticals, Inc. Screening method for identifying ligands for target proteins
US5434796A (en) 1993-06-30 1995-07-18 Daylight Chemical Information Systems, Inc. Method and apparatus for designing molecules with desired properties by evolving successive populations
JPH0744514A (ja) * 1993-07-27 1995-02-14 Matsushita Electric Ind Co Ltd ニューラルネットの学習用データ縮約化方法
JP2948069B2 (ja) 1993-09-20 1999-09-13 株式会社日立製作所 化学分析装置
US5598510A (en) * 1993-10-18 1997-01-28 Loma Linda University Medical Center Self organizing adaptive replicate (SOAR)
JPH09511828A (ja) 1994-04-05 1997-11-25 ファーマジェニクス，インコーポレイテッド 化合物ライブラリー内の活性化合物の確認と識別
US5602938A (en) 1994-05-20 1997-02-11 Nippon Telegraph And Telephone Corporation Method of generating dictionary for pattern recognition and pattern recognition method using the same
US5549974A (en) 1994-06-23 1996-08-27 Affymax Technologies Nv Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof
EP0694855B1 (en) 1994-07-28 2002-05-02 International Business Machines Corporation Search/sort circuit for neural networks
US5463564A (en) 1994-09-16 1995-10-31 3-Dimensional Pharmaceuticals, Inc. System and method of automatically generating chemical compounds with desired properties
US5574844A (en) 1994-09-22 1996-11-12 International Business Machines Corporation Computer system and method for processing atomic data to calculate and exhibit the properties and structure of matter
US5553225A (en) 1994-10-25 1996-09-03 International Business Machines Corporation Method and apparatus for combining a zoom function in scroll bar sliders
US5712171A (en) 1995-01-20 1998-01-27 Arqule, Inc. Method of generating a plurality of chemical compounds in a spatially arranged array
US5807754A (en) 1995-05-11 1998-09-15 Arqule, Inc. Combinatorial synthesis and high-throughput screening of a Rev-inhibiting arylidenediamide array
US5602755A (en) 1995-06-23 1997-02-11 Exxon Research And Engineering Company Method for predicting chemical or physical properties of complex mixtures
US5811241A (en) 1995-09-13 1998-09-22 Cortech, Inc. Method for preparing and identifying N-substitued 1,4-piperazines and N-substituted 1,4-piperazinediones
US5734796A (en) * 1995-09-29 1998-03-31 Ai Ware, Inc. Self-organization of pattern data with dimension reduction through learning of non-linear variance-constrained mapping
US5712564A (en) 1995-12-29 1998-01-27 Unisys Corporation Magnetic ink recorder calibration apparatus and method
WO1997027559A1 (en) 1996-01-26 1997-07-31 Patterson David E Method of creating and searching a molecular virtual library using validated molecular structure descriptors
US6014661A (en) 1996-05-06 2000-01-11 Ivee Development Ab System and method for automatic analysis of data bases and for user-controlled dynamic querying
EP0818744A3 (en) 1996-07-08 1998-07-08 Proteus Molecular Design Limited Process for selecting candidate drug compounds
CA2269669A1 (en) 1996-11-04 1998-05-14 3-Dimensional Pharmaceuticals, Inc. System, method and computer program product for identifying chemical compounds having desired properties
US5861532A (en) 1997-03-04 1999-01-19 Chiron Corporation Solid-phase synthesis of N-alkyl amides
US5908960A (en) 1997-05-07 1999-06-01 Smithkline Beecham Corporation Compounds
US5933819C1 (en) 1997-05-23 2001-11-13 Scripps Research Inst Prediction of relative binding motifs of biologically active peptides and peptide mimetics
US6049797A (en) 1998-04-07 2000-04-11 Lucent Technologies, Inc. Method, apparatus and programmed medium for clustering databases with categorical attributes

Also Published As

Publication number Publication date
HUT77914A (hu) 1998-10-28
US5684711A (en) 1997-11-04
US20030033088A1 (en) 2003-02-13
US5463564A (en) 1995-10-31
AU3628095A (en) 1996-03-29
IL115292A0 (en) 1995-12-31
AU688598B2 (en) 1998-03-12
TW420779B (en) 2001-02-01
US5901069A (en) 1999-05-04
JPH10505832A (ja) 1998-06-09
US6434490B1 (en) 2002-08-13
EP0781436A4 (en) 1999-08-25
CA2199264A1 (en) 1996-03-21
EP0781436A1 (en) 1997-07-02
US5574656A (en) 1996-11-12
WO1996008781A1 (en) 1996-03-21

Similar Documents

Publication Publication Date Title
IL115292A (en) Computer based system and method of automatically generating chemical compounds
EP0727734A4 (en) METHOD FOR GENERATING OPERATION BUTTON FOR COMPUTER PROCESS, DATA PROVISION METHOD BY OPERATION BUTTON AND DISPLAY METHOD
FI20090384A (fi) Menetelmä modifioidun G-CSF-polypeptidin valmistamiseksi
TW242678B (en) Multiple instruction set mapping
DE69331025D1 (de) System und Verfahren für Rechnerschnittstellen
CA2221032A1 (en) Method for preparing blend products
HK1099095A1 (en) An apparatus and a system for performing operations of multimedia applications and a method for performing the same
WO1994022078A3 (en) Apparatus and method for a relocatable file format
HU890958D0 (en) Quick immunoselective cloning process
TW325536B (en) Method and apparatus for accessing a register in a data processing system
ATE256093T1 (de) Verfahren zur hydrofluorierung von chlorierten kohlenwasserstoffen
EP0299301A3 (en) Data processing method
EP0645685A3 (en) Control method for an online computer for implementing and readressing a translated program from the collection of programs stored in memory.
PL308742A1 (en) Method of recombining and host cell for producing xylythol
CA2134347A1 (en) Thiazole or imidazole derivatives as maillard reaction inhibitors
PL316532A1 (en) Data processing system and way of its operation
WO1997036227A3 (en) Method and computer system for processing a set of data elements on a sequential processor
TW357312B (en) Method and apparatus for locating specific information from a plurality of information
NO943005D0 (no) Fremgangsmåte ved prosessering av seismikk-data
EP0438016A3 (en) Method for cursor control of scrolling movements on certain computer workstations
Keung et al. The solution of a multi-objective tool selection model using the GA approach
EP0317478A3 (en) Dynamically adaptive environment for computer programs
AU6071194A (en) Apparatus for processing information by executing an operation selected from data processing operations in accordance with a coordinate value
NO990556D0 (no) Prosess og reaktor for utf°relse av en eksoterm reaksjon
NO305550B1 (no) FremgangsmÕte og innretning for utvinning av vinylklorid

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed