IL114866A - Process for the preparation of the (-)-N-methyl-N-[4-(4-phenyl-4-acetylaminopiperidin-1-yl)-2-(3,4-dichlorophenyl)butyl]benzamide - Google Patents

Process for the preparation of the (-)-N-methyl-N-[4-(4-phenyl-4-acetylaminopiperidin-1-yl)-2-(3,4-dichlorophenyl)butyl]benzamide

Info

Publication number
IL114866A
IL114866A IL11486695A IL11486695A IL114866A IL 114866 A IL114866 A IL 114866A IL 11486695 A IL11486695 A IL 11486695A IL 11486695 A IL11486695 A IL 11486695A IL 114866 A IL114866 A IL 114866A
Authority
IL
Israel
Prior art keywords
preparation
benzamide
dichlorophenyl
phenyl
methyl
Prior art date
Application number
IL11486695A
Other languages
English (en)
Other versions
IL114866A0 (en
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of IL114866A0 publication Critical patent/IL114866A0/xx
Publication of IL114866A publication Critical patent/IL114866A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/01Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/41Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by carboxyl groups, other than cyano groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56Nitrogen atoms
    • C07D211/58Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL11486695A 1994-08-24 1995-08-08 Process for the preparation of the (-)-N-methyl-N-[4-(4-phenyl-4-acetylaminopiperidin-1-yl)-2-(3,4-dichlorophenyl)butyl]benzamide IL114866A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/294,035 US5512680A (en) 1993-02-26 1994-08-24 Process for the preparation of an optically pure aminoalcohol

Publications (2)

Publication Number Publication Date
IL114866A0 IL114866A0 (en) 1995-12-08
IL114866A true IL114866A (en) 1999-12-22

Family

ID=23131621

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11486695A IL114866A (en) 1994-08-24 1995-08-08 Process for the preparation of the (-)-N-methyl-N-[4-(4-phenyl-4-acetylaminopiperidin-1-yl)-2-(3,4-dichlorophenyl)butyl]benzamide

Country Status (24)

Country Link
US (2) US5512680A (cs)
EP (1) EP0698601B1 (cs)
JP (1) JP3037592B2 (cs)
KR (1) KR100275978B1 (cs)
AT (1) ATE172964T1 (cs)
AU (1) AU685971B2 (cs)
BR (1) BR9503776A (cs)
CA (1) CA2156764C (cs)
CZ (1) CZ289654B6 (cs)
DE (1) DE69505756T2 (cs)
DK (1) DK0698601T3 (cs)
ES (1) ES2125574T3 (cs)
FI (1) FI116221B (cs)
HU (1) HU218485B (cs)
IL (1) IL114866A (cs)
MY (1) MY116365A (cs)
NO (1) NO305167B1 (cs)
NZ (1) NZ272827A (cs)
PL (1) PL182914B1 (cs)
RU (1) RU2097376C1 (cs)
SI (1) SI0698601T1 (cs)
SK (1) SK281454B6 (cs)
TW (1) TW410223B (cs)
ZA (1) ZA957025B (cs)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2792835B3 (fr) * 1999-04-27 2001-05-25 Sanofi Sa Utilisation du saredutant pour la preparation de medicaments utiles dans le traitement ou la prevention de l'ensemble des troubles de l'humeur, des troubles de l'adaptation ou des troubles mixtes anxiete-depression
WO2007020079A2 (en) * 2005-08-17 2007-02-22 Synthon B.V. Orally disintegratable simvastatin tablets
JP2009191006A (ja) * 2008-02-14 2009-08-27 Sumitomo Chemical Co Ltd 光学活性な4−アミノ−3−(3,4−ジクロロフェニル)ブタン−1−オールの製造方法およびその中間体
US20180208544A1 (en) 2015-07-13 2018-07-26 Piramal Enterprises Limited An improved process for the preparation of baclofen and its intermediate

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE903957A1 (en) 1989-11-06 1991-05-08 Sanofi Sa Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present
IL99320A (en) 1990-09-05 1995-07-31 Sanofi Sa Arylalkylamines, their preparation and pharmaceutical preparations containing them
FR2676054B1 (fr) 1991-05-03 1993-09-03 Sanofi Elf Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2688219B1 (fr) 1992-03-03 1994-07-08 Sanofi Elf Sels d'ammonium quaternaires de composes aromatiques amines, leur preparation et compositions pharmaceutiques les contenant.
US5391819A (en) * 1992-09-30 1995-02-21 Merck & Co., Inc. Process of making chiral 2-aryl-1,4-butanediamine derivatives as useful neurokinin-A antagonists
FR2701946B1 (fr) * 1993-02-26 1995-05-24 Sanofi Elf Procédé pour la préparation d'un aminoalcool optiquement pur.

Also Published As

Publication number Publication date
EP0698601B1 (en) 1998-11-04
JP3037592B2 (ja) 2000-04-24
AU3021695A (en) 1996-03-07
CZ289654B6 (cs) 2002-03-13
CZ216495A3 (en) 1996-03-13
IL114866A0 (en) 1995-12-08
ZA957025B (en) 1996-03-26
CA2156764A1 (en) 1996-02-25
NO953313D0 (no) 1995-08-23
FI116221B (fi) 2005-10-14
SK103095A3 (en) 1996-03-06
FI953994A0 (fi) 1995-08-24
AU685971B2 (en) 1998-01-29
DE69505756D1 (de) 1998-12-10
JPH08176108A (ja) 1996-07-09
PL182914B1 (pl) 2002-04-30
PL310155A1 (en) 1996-03-04
NO953313L (no) 1996-02-26
RU2097376C1 (ru) 1997-11-27
KR100275978B1 (ko) 2000-12-15
US5512680A (en) 1996-04-30
DK0698601T3 (da) 1999-07-19
DE69505756T2 (de) 1999-05-27
HU9502481D0 (en) 1995-10-30
ATE172964T1 (de) 1998-11-15
FI953994A (fi) 1996-02-25
SK281454B6 (sk) 2001-03-12
US5780666A (en) 1998-07-14
HUT74184A (en) 1996-11-28
HU218485B (hu) 2000-09-28
ES2125574T3 (es) 1999-03-01
EP0698601A1 (en) 1996-02-28
CA2156764C (en) 2006-06-13
NZ272827A (en) 1997-11-24
KR960007562A (ko) 1996-03-22
MY116365A (en) 2004-01-31
SI0698601T1 (en) 1999-04-30
NO305167B1 (no) 1999-04-12
BR9503776A (pt) 1996-04-16
TW410223B (en) 2000-11-01

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Legal Events

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FF Patent granted
KB Patent renewed
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HC Change of name of proprietor(s)
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MM9K Patent not in force due to non-payment of renewal fees