IL114791A0 - 8-Fluoro-anthracyclines processes for their preparation and pharmaceutical compositions containing them - Google Patents

8-Fluoro-anthracyclines processes for their preparation and pharmaceutical compositions containing them

Info

Publication number
IL114791A0
IL114791A0 IL11479195A IL11479195A IL114791A0 IL 114791 A0 IL114791 A0 IL 114791A0 IL 11479195 A IL11479195 A IL 11479195A IL 11479195 A IL11479195 A IL 11479195A IL 114791 A0 IL114791 A0 IL 114791A0
Authority
IL
Israel
Prior art keywords
chosen
group
pct
anthracyclines
fluoro
Prior art date
Application number
IL11479195A
Other languages
English (en)
Original Assignee
Menarini Farma Ind
Bristol Myers Squibb Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Menarini Farma Ind, Bristol Myers Squibb Spa filed Critical Menarini Farma Ind
Publication of IL114791A0 publication Critical patent/IL114791A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/36—Quinones containing groups having oxygen atoms singly bound to carbon atoms the quinoid structure being part of a condensed ring system having four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/38—Quinones containing —CHO or non—quinoid keto groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL11479195A 1994-08-04 1995-07-31 8-Fluoro-anthracyclines processes for their preparation and pharmaceutical compositions containing them IL114791A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI941696A IT1271689B (it) 1994-08-04 1994-08-04 8-fluoro-antracicline, loro processi di preparazione e composizioni farmaceutiche che le contengono

Publications (1)

Publication Number Publication Date
IL114791A0 true IL114791A0 (en) 1995-11-27

Family

ID=11369446

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11479195A IL114791A0 (en) 1994-08-04 1995-07-31 8-Fluoro-anthracyclines processes for their preparation and pharmaceutical compositions containing them

Country Status (25)

Country Link
US (1) US5814608A (hu)
EP (1) EP0776328B1 (hu)
JP (1) JPH10503509A (hu)
AT (1) ATE172980T1 (hu)
AU (1) AU700929B2 (hu)
BG (1) BG101163A (hu)
BR (1) BR9508518A (hu)
CA (1) CA2196752A1 (hu)
CZ (1) CZ28097A3 (hu)
DE (1) DE69505828T2 (hu)
DK (1) DK0776328T3 (hu)
ES (1) ES2126923T3 (hu)
FI (1) FI970455A0 (hu)
HR (1) HRP950436A2 (hu)
HU (1) HUT76339A (hu)
IL (1) IL114791A0 (hu)
IT (1) IT1271689B (hu)
NO (1) NO305561B1 (hu)
NZ (1) NZ291426A (hu)
PL (1) PL319630A1 (hu)
RU (1) RU2146261C1 (hu)
SK (1) SK13797A3 (hu)
TJ (1) TJ245B (hu)
WO (1) WO1996004292A1 (hu)
ZA (1) ZA956480B (hu)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999058543A1 (en) * 1998-05-13 1999-11-18 Instytut Farmaceutyczny New n-alkyloxycarbonyl derivatives of monosaccharides l-acosamine and l-daunosamine
EP1976858B1 (en) * 2005-12-13 2016-01-06 Solux Corporation Method for preparing 4-demethyldaunorubicin
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
RU2642068C1 (ru) * 2017-04-26 2018-01-24 Федеральное государственное бюджетное учреждение науки Институт элементоорганических соединений им. А.Н. Несмеянова Российской академии наук (ИНЭОС РАН) N-пиперонильные производные даунорубицина, обладающие антипролиферативными свойствами

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA21995A1 (fr) * 1989-11-13 1991-07-01 Menarini Farma Ind Nouvelles fluoronaphthacenediones,leurs derives glycozyles et leurs procedes de fabrication .
IT1241927B (it) * 1990-05-14 1994-02-01 Menarini Farma Ind 3'-deamino-4'-deossi-4'-amino-8-fluoroantra- cicline processi per la loro preparazione e composizioni farmaceutiche che le contengono
PL297164A1 (hu) * 1990-06-11 1992-10-05 Iaf Biochem Int
IT1262565B (it) * 1993-09-30 1996-07-04 Menarini Farma Ind Disaccaridi di antracicline, loro processi di preparazione e composizioni farmaceutiche che li contengono.

Also Published As

Publication number Publication date
NZ291426A (en) 1998-05-27
ZA956480B (en) 1996-03-14
IT1271689B (it) 1997-06-04
ITMI941696A0 (it) 1994-08-04
CA2196752A1 (en) 1996-02-15
NO970059L (no) 1997-01-08
AU700929B2 (en) 1999-01-14
DE69505828T2 (de) 1999-05-20
RU2146261C1 (ru) 2000-03-10
TJ245B (en) 2001-08-06
EP0776328B1 (en) 1998-11-04
WO1996004292A1 (en) 1996-02-15
BR9508518A (pt) 1997-12-23
ATE172980T1 (de) 1998-11-15
FI970455A (fi) 1997-02-03
HUT76339A (en) 1997-08-28
ITMI941696A1 (it) 1996-02-04
JPH10503509A (ja) 1998-03-31
NO970059D0 (no) 1997-01-08
US5814608A (en) 1998-09-29
EP0776328A1 (en) 1997-06-04
NO305561B1 (no) 1999-06-21
ES2126923T3 (es) 1999-04-01
FI970455A0 (fi) 1997-02-03
PL319630A1 (en) 1997-08-18
BG101163A (en) 1997-09-30
CZ28097A3 (en) 1997-08-13
HRP950436A2 (en) 1997-10-31
SK13797A3 (en) 1997-07-09
AU3255395A (en) 1996-03-04
DE69505828D1 (de) 1998-12-10
DK0776328T3 (da) 1999-07-19

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