ZA956480B - 8-fluoro-anthracyclines processes for their preparation and pharmaceutical compositions containing them - Google Patents

8-fluoro-anthracyclines processes for their preparation and pharmaceutical compositions containing them

Info

Publication number
ZA956480B
ZA956480B ZA956480A ZA956480A ZA956480B ZA 956480 B ZA956480 B ZA 956480B ZA 956480 A ZA956480 A ZA 956480A ZA 956480 A ZA956480 A ZA 956480A ZA 956480 B ZA956480 B ZA 956480B
Authority
ZA
South Africa
Prior art keywords
chosen
group
pct
anthracyclines
fluoro
Prior art date
Application number
ZA956480A
Other languages
English (en)
Inventor
Fabio Animati
Federico Arcamone
Giuseppe Giannini
Paolo Lombardi
Edith Monteagudo
Original Assignee
Menarini Farma Ind
Bristol Myers Squibb Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Menarini Farma Ind, Bristol Myers Squibb Spa filed Critical Menarini Farma Ind
Publication of ZA956480B publication Critical patent/ZA956480B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/36—Quinones containing groups having oxygen atoms singly bound to carbon atoms the quinoid structure being part of a condensed ring system having four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/38—Quinones containing —CHO or non—quinoid keto groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ZA956480A 1994-08-04 1995-08-03 8-fluoro-anthracyclines processes for their preparation and pharmaceutical compositions containing them ZA956480B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI941696A IT1271689B (it) 1994-08-04 1994-08-04 8-fluoro-antracicline, loro processi di preparazione e composizioni farmaceutiche che le contengono

Publications (1)

Publication Number Publication Date
ZA956480B true ZA956480B (en) 1996-03-14

Family

ID=11369446

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA956480A ZA956480B (en) 1994-08-04 1995-08-03 8-fluoro-anthracyclines processes for their preparation and pharmaceutical compositions containing them

Country Status (25)

Country Link
US (1) US5814608A (xx)
EP (1) EP0776328B1 (xx)
JP (1) JPH10503509A (xx)
AT (1) ATE172980T1 (xx)
AU (1) AU700929B2 (xx)
BG (1) BG101163A (xx)
BR (1) BR9508518A (xx)
CA (1) CA2196752A1 (xx)
CZ (1) CZ28097A3 (xx)
DE (1) DE69505828T2 (xx)
DK (1) DK0776328T3 (xx)
ES (1) ES2126923T3 (xx)
FI (1) FI970455A (xx)
HR (1) HRP950436A2 (xx)
HU (1) HUT76339A (xx)
IL (1) IL114791A0 (xx)
IT (1) IT1271689B (xx)
NO (1) NO305561B1 (xx)
NZ (1) NZ291426A (xx)
PL (1) PL319630A1 (xx)
RU (1) RU2146261C1 (xx)
SK (1) SK13797A3 (xx)
TJ (1) TJ245B (xx)
WO (1) WO1996004292A1 (xx)
ZA (1) ZA956480B (xx)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999058543A1 (en) * 1998-05-13 1999-11-18 Instytut Farmaceutyczny New n-alkyloxycarbonyl derivatives of monosaccharides l-acosamine and l-daunosamine
WO2007070820A2 (en) * 2005-12-13 2007-06-21 Solux Corporation Method for preparing 4-demethyldaunorubicin
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
RU2642068C1 (ru) * 2017-04-26 2018-01-24 Федеральное государственное бюджетное учреждение науки Институт элементоорганических соединений им. А.Н. Несмеянова Российской академии наук (ИНЭОС РАН) N-пиперонильные производные даунорубицина, обладающие антипролиферативными свойствами

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA21995A1 (fr) * 1989-11-13 1991-07-01 Menarini Farma Ind Nouvelles fluoronaphthacenediones,leurs derives glycozyles et leurs procedes de fabrication .
IT1241927B (it) * 1990-05-14 1994-02-01 Menarini Farma Ind 3'-deamino-4'-deossi-4'-amino-8-fluoroantra- cicline processi per la loro preparazione e composizioni farmaceutiche che le contengono
WO1991019725A2 (en) * 1990-06-11 1991-12-26 Biochem Pharma Inc. Heterocyclic anthracyclione and anthracycline analogs
IT1262565B (it) * 1993-09-30 1996-07-04 Menarini Farma Ind Disaccaridi di antracicline, loro processi di preparazione e composizioni farmaceutiche che li contengono.

Also Published As

Publication number Publication date
HRP950436A2 (en) 1997-10-31
ATE172980T1 (de) 1998-11-15
DE69505828D1 (de) 1998-12-10
EP0776328A1 (en) 1997-06-04
SK13797A3 (en) 1997-07-09
BG101163A (en) 1997-09-30
FI970455A0 (fi) 1997-02-03
IL114791A0 (en) 1995-11-27
ITMI941696A1 (it) 1996-02-04
HUT76339A (en) 1997-08-28
NO970059D0 (no) 1997-01-08
US5814608A (en) 1998-09-29
NO970059L (no) 1997-01-08
CA2196752A1 (en) 1996-02-15
WO1996004292A1 (en) 1996-02-15
JPH10503509A (ja) 1998-03-31
EP0776328B1 (en) 1998-11-04
NO305561B1 (no) 1999-06-21
AU3255395A (en) 1996-03-04
NZ291426A (en) 1998-05-27
AU700929B2 (en) 1999-01-14
RU2146261C1 (ru) 2000-03-10
IT1271689B (it) 1997-06-04
DK0776328T3 (da) 1999-07-19
TJ245B (en) 2001-08-06
ES2126923T3 (es) 1999-04-01
DE69505828T2 (de) 1999-05-20
FI970455A (fi) 1997-02-03
BR9508518A (pt) 1997-12-23
ITMI941696A0 (it) 1994-08-04
CZ28097A3 (en) 1997-08-13
PL319630A1 (en) 1997-08-18

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