IL114759A - Benzoxazole derivatives and pharmaceutical compositions containing them - Google Patents

Benzoxazole derivatives and pharmaceutical compositions containing them

Info

Publication number
IL114759A
IL114759A IL11475995A IL11475995A IL114759A IL 114759 A IL114759 A IL 114759A IL 11475995 A IL11475995 A IL 11475995A IL 11475995 A IL11475995 A IL 11475995A IL 114759 A IL114759 A IL 114759A
Authority
IL
Israel
Prior art keywords
pharmaceutical compositions
compositions containing
benzoxazole derivatives
benzoxazole
derivatives
Prior art date
Application number
IL11475995A
Other languages
English (en)
Other versions
IL114759A0 (en
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9415330A external-priority patent/GB9415330D0/en
Priority claimed from GBGB9425599.9A external-priority patent/GB9425599D0/en
Priority claimed from GBGB9509923.0A external-priority patent/GB9509923D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Priority to IL12552595A priority Critical patent/IL125525A/xx
Publication of IL114759A0 publication Critical patent/IL114759A0/xx
Publication of IL114759A publication Critical patent/IL114759A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IL11475995A 1994-07-29 1995-07-27 Benzoxazole derivatives and pharmaceutical compositions containing them IL114759A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL12552595A IL125525A (en) 1994-07-29 1995-07-27 Hydroxyalkylamine derivatives

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9415330A GB9415330D0 (en) 1994-07-29 1994-07-29 Novel compounds
GBGB9425599.9A GB9425599D0 (en) 1994-12-19 1994-12-19 Novel compounds
GBGB9509923.0A GB9509923D0 (en) 1995-05-17 1995-05-17 Novel compounds
PCT/GB1995/001323 WO1996004261A1 (en) 1994-07-29 1995-06-07 Benzoxazoles and pryridine derivatives useful in the treatment of the type ii diabetes

Publications (2)

Publication Number Publication Date
IL114759A0 IL114759A0 (en) 1995-12-31
IL114759A true IL114759A (en) 1999-10-28

Family

ID=27267309

Family Applications (3)

Application Number Title Priority Date Filing Date
IL11475995A IL114759A (en) 1994-07-29 1995-07-27 Benzoxazole derivatives and pharmaceutical compositions containing them
IL12552595A IL125525A (en) 1994-07-29 1995-07-27 Hydroxyalkylamine derivatives
IL12552598A IL125525A0 (en) 1994-07-29 1998-07-27 Hydroxyalkylamine derivatives

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL12552595A IL125525A (en) 1994-07-29 1995-07-27 Hydroxyalkylamine derivatives
IL12552598A IL125525A0 (en) 1994-07-29 1998-07-27 Hydroxyalkylamine derivatives

Country Status (16)

Country Link
EP (1) EP0772605A1 (no)
AP (1) AP776A (no)
BR (1) BR9508468A (no)
CA (1) CA2196079A1 (no)
CZ (1) CZ25497A3 (no)
DZ (1) DZ1916A1 (no)
FI (1) FI970357A (no)
HU (1) HUT76637A (no)
IL (3) IL114759A (no)
MA (1) MA23632A1 (no)
MX (1) MX9700763A (no)
NO (1) NO307827B1 (no)
OA (1) OA10470A (no)
PL (1) PL318766A1 (no)
SK (1) SK12297A3 (no)
WO (2) WO1996004261A1 (no)

Families Citing this family (64)

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DK0916651T3 (da) * 1996-04-04 2003-12-01 Sankyo Co Phenylalkylcarboxylsyrederivater
US6090839A (en) * 1996-12-23 2000-07-18 Merck & Co., Inc. Antidiabetic agents
US6160000A (en) * 1996-12-23 2000-12-12 Merck & Co., Inc. Antidiabetic agents based on aryl and heteroarylacetic acids
IL135177A0 (en) 1997-10-02 2001-05-20 Sankyo Co Amidocarboxylic acid derivatives and pharmaceutical compositions containing the same
US6444816B1 (en) 1997-10-27 2002-09-03 Dr. Reddy's Research Foundation Fused 7-oxo-pyrimidinyl compounds, preparation, composition and use thereof
MXPA00004036A (es) 1997-10-27 2006-05-24 Reddys Lab Ltd Dr Compuestos triciclicos novedosos y su uso en medicina; proceso para su preparacion y composiciones farmaceuticas que los contienen..
US6440961B1 (en) 1997-10-27 2002-08-27 Dr. Reddy's Research Foundation Tricyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them
WO1999019313A1 (en) * 1997-10-27 1999-04-22 Dr. Reddy's Research Foundation Novel tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them
CN1280574A (zh) * 1997-10-27 2001-01-17 雷迪研究基金会 新的杂环化合物及其在医药中的应用、它们的制备方法和含有它们的药物组合物
US6369067B1 (en) 1997-10-27 2002-04-09 Dr. Reddy's Research Foundation Monocyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them
US6265401B1 (en) 1997-10-27 2001-07-24 Reddy-Cheminor, Inc. Bicyclic compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them
CA2307068C (en) 1997-10-27 2007-04-10 Dr. Reddy's Research Foundation Bicyclic compounds, process for their preparation and pharmaceutical compositions containing them
NZ504106A (en) * 1998-05-27 2003-02-28 Dr Fused Oxazine, Thiazine and pipyridine compounds, process for their preparation and pharmaceutical compositions containing them
EP1113801A4 (en) 1998-09-17 2002-10-02 Bristol Myers Squibb Co METHOD FOR TREATING ATHEROSCLEROSIS WITH AN AP2 INHIBITOR OR COMBINATION
JP2002527516A (ja) * 1998-10-21 2002-08-27 ノボ ノルディスク アクティーゼルスカブ 新規化合物、それらの製造及び使用
JP2002527501A (ja) 1998-10-21 2002-08-27 ノボ ノルディスク アクティーゼルスカブ 新規化合物、その製造及び利用
AU6325799A (en) * 1998-10-21 2000-05-08 Dr. Reddy's Research Foundation New compounds, their preparation and use
EP1123279A1 (en) * 1998-10-21 2001-08-16 Novo Nordisk A/S New compounds, their preparation and use
US6300339B1 (en) 1998-10-21 2001-10-09 Novo Nordisk A/S Compounds, their preparation and use
AU6325899A (en) * 1998-10-21 2000-05-08 Dr. Reddy's Research Foundation New compounds, their preparation and use
US6214820B1 (en) 1998-10-21 2001-04-10 Novo Nordisk A/S Compounds, their preparation and use
US6365586B1 (en) 1998-10-21 2002-04-02 Novo Nordisk A/S Compounds, their preparation and use
EP1123268A1 (en) * 1998-10-21 2001-08-16 Novo Nordisk A/S New compounds, their preparation and use
US6468996B1 (en) 1998-10-21 2002-10-22 Novo Nordisk A/S Substituted hetero-polycyclic compounds as PPARα and PPARγ activators
US6248781B1 (en) 1998-10-21 2001-06-19 Novo Nordisk A/S Compounds useful in the treatment of conditions mediated by peroxisome proliferator-activated receptors (PPAR)
CN1323300A (zh) * 1998-10-29 2001-11-21 雷迪研究基金会 制备新的抗糖尿病剂的改进方法
US6531596B1 (en) 1998-10-29 2003-03-11 Dr. Reddy's Laboratories Ltd. Process for the preparation of new antidiabetic agents
WO2000063189A1 (en) * 1999-04-16 2000-10-26 Novo Nordisk A/S Crystalline r- guanidines, arginine or (l) -arginine (2s) -2- ethoxy -3-{4- [2-(10h -phenoxazin -10-yl)ethoxy]phenyl}propanoate
WO2000063209A1 (en) * 1999-04-20 2000-10-26 Novo Nordisk A/S New compounds, their preparation and use
US6972294B1 (en) 1999-04-20 2005-12-06 Novo Nordisk, A/S Compounds, their preparation and use
KR20020005703A (ko) * 1999-04-20 2002-01-17 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 신규한 화합물, 그의 제법 및 용도
EP1171431A1 (en) * 1999-04-20 2002-01-16 Novo Nordisk A/S Compounds, their preparation and use
US6274608B1 (en) 1999-04-20 2001-08-14 Novo Nordisk A/S Compounds, their preparation and use
US6369055B1 (en) 1999-04-20 2002-04-09 Novo Nordisk A/S Compounds, their preparation and use
US7414128B2 (en) 1999-04-20 2008-08-19 Dr. Reddy's Laboratories, Limited Crystalline R-guanidines, Arginine or (L)-Arginine (2S)-2-Ethoxy-3-{4-[2-(10H -phenoxazin-10-yl)ethoxy]phenyl}propanoate
KR100610578B1 (ko) 1999-04-28 2006-08-09 닥터 레디스 레보러터리즈 리미티드 치환된 이원 헤테로고리, 비만증 및 고콜레스테롤증치료제로서의 그 용도
CA2382966A1 (en) 1999-08-27 2001-03-08 Eli Lilly And Company Biaryl-oxa(thia)zole derivatives and their use as ppars modulators
HU230609B1 (hu) * 2000-01-19 2017-03-28 Cadila Healthcare Ltd. Hipolipidémiás és hipokoleszterinémiás hatású szubsztituált pirrolszármazékok, azokat tartalmazó gyógyszerkészítmények, eljárás előállításukra, köztitermékek és alkalmazásuk
WO2001055086A1 (en) * 2000-01-28 2001-08-02 Novo Nordisk A/S Alkynylsubstituted propionic acid derivatives and their use against diabetes and obesity
US6555577B1 (en) 2000-01-28 2003-04-29 Novo Nordisk A/S Compounds, their preparation and use
US6569901B2 (en) 2000-01-28 2003-05-27 Novo Nordisk A/S Alkynyl-substituted propionic acid derivatives, their preparation and use
US6509374B2 (en) 2000-04-17 2003-01-21 Novo Nordisk A/S Compounds, their preparation and use
US6908908B2 (en) 2000-05-12 2005-06-21 Ortho-Mcneil Pharmaceutical, Inc. Biologically active 4H-benzo [1,4] oxazin-3-ones
WO2001087860A2 (en) * 2000-05-12 2001-11-22 Ortho-Mcneil Pharmaceutical, Inc. Novel benzoxazinones as peroxisome proliferator activated receptor gamma modulators and method of treatment
EP1280783A2 (en) * 2000-05-12 2003-02-05 Ortho-McNeil Pharmaceutical, Inc. Methods of treatment using benzoxazinones as peroxisome proliferator activated receptor gamma modulators
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US7067530B2 (en) 2001-07-30 2006-06-27 Novo Nordisk A/S Compounds, their preparation and use
US6869967B2 (en) 2001-07-30 2005-03-22 Novo Nordisk A/S Peroxisome proliferator-activated receptor (PPAR) active vinyl carboxylic acid derivatives
US7220877B2 (en) 2001-10-17 2007-05-22 Novo Nordisk A/S Compounds, their preparation and use
JP2005518408A (ja) 2001-12-29 2005-06-23 ノボ　ノルディスク　アクティーゼルスカブ 異常脂肪血症を治療するための、ｇｌｐ−１化合物と他の薬物との組み合わせ使用
US7015345B2 (en) 2002-02-21 2006-03-21 Asahi Kasei Pharma Corporation Propionic acid derivatives
US7816385B2 (en) 2002-12-20 2010-10-19 High Point Pharmaceuticals, Llc Dimeric dicarboxylic acid derivatives, their preparation and use
US6653334B1 (en) 2002-12-27 2003-11-25 Kowa Co., Ltd. Benzoxazole compound and pharmaceutical composition containing the same
EP2154131A4 (en) * 2007-04-26 2011-09-21 Pharmafrontier Co Ltd INHIBITOR OF THE G-PROTEIN-COUPLED RECEPTOR AND PHARMACEUTICAL PRODUCT
WO2012104869A1 (en) 2011-01-31 2012-08-09 Cadila Healthcare Limited Treatment for lipodystrophy
KR101617812B1 (ko) 2013-04-22 2016-05-03 카딜라 핼쓰캐어 리미티드 비알콜성 지방간 질환을 위한 신규 조성물
US20160107989A1 (en) 2013-05-30 2016-04-21 Cadila Healthcare Limited A process for preparation of pyrroles having hypolipidemic hypocholesteremic activities
TW201513857A (zh) 2013-07-05 2015-04-16 Cadila Healthcare Ltd 協同性組成物
IN2013MU02470A (no) 2013-07-25 2015-06-26 Cadila Healthcare Ltd
US10112898B2 (en) 2013-09-06 2018-10-30 Cadila Healthcare Limited Process for the preparation of saroglitazar pharmaceutical salts
WO2017064635A2 (en) 2015-10-14 2017-04-20 Cadila Healthcare Limited Pyrrole compound, compositions and process for preparation thereof
JP6840853B2 (ja) 2016-12-09 2021-03-10 カディラ・ヘルスケア・リミテッド 原発性胆汁性胆管炎の治療

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US5089514A (en) * 1990-06-14 1992-02-18 Pfizer Inc. 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
SK695A3 (en) * 1992-07-03 1995-07-11 Smithkline Beecham Plc Heterocyclic compounds method of their production and using

Also Published As

Publication number Publication date
IL125525A0 (en) 1999-03-12
HUT76637A (en) 1997-10-28
WO1996004261A1 (en) 1996-02-15
MA23632A1 (fr) 1996-04-01
NO970373L (no) 1997-03-18
NO970373D0 (no) 1997-01-28
WO1996004260A1 (en) 1996-02-15
EP0772605A1 (en) 1997-05-14
OA10470A (en) 2002-04-08
IL114759A0 (en) 1995-12-31
MX9700763A (es) 1997-05-31
DZ1916A1 (fr) 2002-02-17
SK12297A3 (en) 1997-08-06
CA2196079A1 (en) 1996-02-15
CZ25497A3 (en) 1997-09-17
NO307827B1 (no) 2000-06-05
IL125525A (en) 2000-02-29
FI970357A0 (fi) 1997-01-28
FI970357A (fi) 1997-03-26
AP9700918A0 (en) 1997-01-31
AP776A (en) 1999-10-28
PL318766A1 (en) 1997-07-07
BR9508468A (pt) 1997-11-25

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