IL113491A - Cyclodextrin hybridization compounds of N morpholino - N - nitrosoaminoacetonitrile, their preparation and pharmaceutical preparations containing them - Google Patents

Cyclodextrin hybridization compounds of N morpholino - N - nitrosoaminoacetonitrile, their preparation and pharmaceutical preparations containing them

Info

Publication number
IL113491A
IL113491A IL11349195A IL11349195A IL113491A IL 113491 A IL113491 A IL 113491A IL 11349195 A IL11349195 A IL 11349195A IL 11349195 A IL11349195 A IL 11349195A IL 113491 A IL113491 A IL 113491A
Authority
IL
Israel
Prior art keywords
sin
cyclodextrin
complexes
acid anions
group
Prior art date
Application number
IL11349195A
Other languages
English (en)
Hebrew (he)
Other versions
IL113491A0 (en
Original Assignee
Therabel Ind Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Therabel Ind Sa filed Critical Therabel Ind Sa
Publication of IL113491A0 publication Critical patent/IL113491A0/xx
Publication of IL113491A publication Critical patent/IL113491A/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Detergent Compositions (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL11349195A 1994-04-26 1995-04-25 Cyclodextrin hybridization compounds of N morpholino - N - nitrosoaminoacetonitrile, their preparation and pharmaceutical preparations containing them IL113491A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9401183A HU218280B (en) 1994-04-26 1994-04-26 Cyclodextrin inclusion complexes containing sin-1a which are stable intheir solid state, process for their preparation and pharmaceutical compositions containing the comlexes

Publications (2)

Publication Number Publication Date
IL113491A0 IL113491A0 (en) 1995-07-31
IL113491A true IL113491A (en) 2002-03-10

Family

ID=10985114

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11349195A IL113491A (en) 1994-04-26 1995-04-25 Cyclodextrin hybridization compounds of N morpholino - N - nitrosoaminoacetonitrile, their preparation and pharmaceutical preparations containing them

Country Status (32)

Country Link
US (1) US5698535A (fi)
EP (1) EP0705255B1 (fi)
JP (1) JP3434828B2 (fi)
KR (1) KR960703404A (fi)
CN (1) CN1060164C (fi)
AT (1) ATE197708T1 (fi)
AU (1) AU694219B2 (fi)
BG (1) BG61974B1 (fi)
BR (1) BR9506155A (fi)
CA (1) CA2163539C (fi)
CZ (1) CZ316395A3 (fi)
DE (1) DE69519463T2 (fi)
DK (1) DK0705255T3 (fi)
ES (1) ES2153897T3 (fi)
FI (1) FI956156A0 (fi)
GR (1) GR3035356T3 (fi)
HR (1) HRP950249A2 (fi)
HU (1) HU218280B (fi)
IL (1) IL113491A (fi)
LT (1) LT4167B (fi)
LV (1) LV11543B (fi)
MD (1) MD1419G2 (fi)
NO (1) NO311030B1 (fi)
NZ (1) NZ285149A (fi)
PL (1) PL312183A1 (fi)
PT (1) PT705255E (fi)
RO (1) RO114449B1 (fi)
RU (1) RU2136698C1 (fi)
SI (1) SI0705255T1 (fi)
SK (1) SK155195A3 (fi)
WO (1) WO1995029172A1 (fi)
YU (1) YU25995A (fi)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6143746A (en) * 1994-01-21 2000-11-07 Icos Corporation Tetracyclic cyclic GMP-specific phosphodiesterase inhibitors, process of preparation and use
US6602860B1 (en) * 1999-11-12 2003-08-05 Josef Pitha Crystalline mixtures of partial methyl ethers of beta-cyclodextrin and related compounds
FR2805462B1 (fr) * 2000-02-24 2003-08-15 Therabel Res Nouvelle forme galenique orale a liberation prolongee de la molsidomine
TWI321054B (en) 2000-12-19 2010-03-01 California Inst Of Techn Compositions containing inclusion complexes
EP1219306A1 (en) * 2000-12-29 2002-07-03 Nicox S.A. Compositions comprising cyclodextrins and NO- releasing drugs
EP1534340B1 (en) 2002-09-06 2011-11-16 Cerulean Pharma Inc. Cyclodextrin-based polymers for delivering the therapeutic agents covalently bound thereto
CN1717209A (zh) * 2002-10-09 2006-01-04 植入疗法公司 以环糊精为基础的材料、其相关的组合物和用途
US20080176958A1 (en) 2007-01-24 2008-07-24 Insert Therapeutics, Inc. Cyclodextrin-based polymers for therapeutics delivery
BR112012012210B8 (pt) * 2009-11-23 2021-05-25 Cerulean Pharma Inc conjugado de (cdp)-taxano de polímero contendo ciclodextrina, composição, composição farmacêutica, forma de dosagem, kit e uso de um conjugado de cdp-taxano
US20140094432A1 (en) 2012-10-02 2014-04-03 Cerulean Pharma Inc. Methods and systems for polymer precipitation and generation of particles
US10793327B2 (en) 2017-10-09 2020-10-06 Terumo Bct Biotechnologies, Llc Lyophilization container and method of using same
CA3130670A1 (en) 2019-03-14 2020-09-17 Terumo Bct Biotechnologies, Llc Lyophilization loading tray assembly and system
WO2022016343A1 (zh) * 2020-07-20 2022-01-27 深圳迈瑞生物医疗电子股份有限公司 一种组合物的血小板解聚用途、解聚试剂及解聚方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5208233A (en) * 1989-09-15 1993-05-04 The United States Of America As Represented By The Department Of Health And Human Services Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof
US5039705A (en) * 1989-09-15 1991-08-13 The United States Of America As Represented By The Department Of Health And Human Services Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof
US5212204A (en) * 1989-10-18 1993-05-18 The United States Of America As Represented By The Department Of Health And Human Services Antihypertensive compositions and use thereof
HU211648A9 (en) * 1990-03-28 1995-12-28 Chinoin Gyogyszer Es Vegyeszet Inclusion complexes of 3-morpholino-sydnonimine or its salts or its tautomer isomer, process for the preparation thereof, and pharmaceutical compositions containing the same
CA2119572C (en) * 1991-09-24 2005-07-05 Larry Kay Keefer Oxygen substituted derivatives of nucleophile-nitric oxide adducts as nitric oxide donor prodrugs
US5389675A (en) * 1992-03-27 1995-02-14 The United States Of America As Represented By The Department Of Health And Human Services Mixed ligand metal complexes of nitric oxide-nucleophile adducts useful as cardiovascular agents

Also Published As

Publication number Publication date
JPH09503546A (ja) 1997-04-08
AU694219B2 (en) 1998-07-16
EP0705255A1 (en) 1996-04-10
CN1128028A (zh) 1996-07-31
AU2415995A (en) 1995-11-16
PL312183A1 (en) 1996-04-01
NO311030B1 (no) 2001-10-01
HRP950249A2 (en) 1997-10-31
HU218280B (en) 2000-07-28
RU2136698C1 (ru) 1999-09-10
HU9401183D0 (en) 1994-07-28
ATE197708T1 (de) 2000-12-15
BG100313A (bg) 1996-07-31
RO114449B1 (ro) 1999-04-30
CA2163539A1 (en) 1995-11-02
GR3035356T3 (en) 2001-05-31
MD1419F2 (en) 2000-02-29
BR9506155A (pt) 1996-04-16
LV11543A (lv) 1996-10-20
WO1995029172A1 (en) 1995-11-02
CZ316395A3 (en) 1996-05-15
SK155195A3 (en) 1997-05-07
FI956156A (fi) 1995-12-20
NO955283L (no) 1995-12-22
MD1419G2 (ro) 2000-11-30
NZ285149A (en) 1998-06-26
FI956156A0 (fi) 1995-12-20
KR960703404A (ko) 1996-08-17
ES2153897T3 (es) 2001-03-16
BG61974B1 (bg) 1998-11-30
MD950440A (en) 1997-10-31
NO955283D0 (no) 1995-12-22
EP0705255B1 (en) 2000-11-22
IL113491A0 (en) 1995-07-31
HUT70750A (en) 1995-10-30
DK0705255T3 (da) 2000-12-11
PT705255E (pt) 2001-05-31
CN1060164C (zh) 2001-01-03
DE69519463T2 (de) 2001-06-28
DE69519463D1 (de) 2000-12-28
LT95133A (en) 1996-10-25
YU25995A (sh) 1998-08-14
LT4167B (en) 1997-06-25
US5698535A (en) 1997-12-16
LV11543B (en) 1996-12-20
CA2163539C (en) 2003-04-01
JP3434828B2 (ja) 2003-08-11
SI0705255T1 (en) 2001-04-30

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Legal Events

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