IL113112A - Pyridine substituted thiazolidinediones and pharmaceutical compositions comprising them - Google Patents
Pyridine substituted thiazolidinediones and pharmaceutical compositions comprising themInfo
- Publication number
- IL113112A IL113112A IL11311295A IL11311295A IL113112A IL 113112 A IL113112 A IL 113112A IL 11311295 A IL11311295 A IL 11311295A IL 11311295 A IL11311295 A IL 11311295A IL 113112 A IL113112 A IL 113112A
- Authority
- IL
- Israel
- Prior art keywords
- group
- alkyl
- cycloalkyl
- thiazolidinediones
- pharmaceutical compositions
- Prior art date
Links
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title abstract 4
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 title abstract 2
- 229940123464 Thiazolidinedione Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Chemical class 0.000 title 1
- 150000001467 thiazolidinediones Chemical class 0.000 title 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- 125000006701 (C1-C7) alkyl group Chemical group 0.000 abstract 3
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 1
- 125000005865 C2-C10alkynyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- -1 alpha -naphthyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000006267 biphenyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000002218 hypoglycaemic effect Effects 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 150000003548 thiazolidines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5719294 | 1994-03-28 | ||
| JP29517794 | 1994-11-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL113112A0 IL113112A0 (en) | 1995-06-29 |
| IL113112A true IL113112A (en) | 2000-06-01 |
Family
ID=26398213
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11311295A IL113112A (en) | 1994-03-28 | 1995-03-23 | Pyridine substituted thiazolidinediones and pharmaceutical compositions comprising them |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0751944B1 (cs) |
| KR (1) | KR100340615B1 (cs) |
| CN (1) | CN1045776C (cs) |
| AT (1) | ATE198200T1 (cs) |
| AU (1) | AU683739B2 (cs) |
| CA (1) | CA2186381A1 (cs) |
| CZ (1) | CZ282096A3 (cs) |
| DE (1) | DE69519666T2 (cs) |
| DK (1) | DK0751944T3 (cs) |
| ES (1) | ES2154727T3 (cs) |
| GR (1) | GR3035277T3 (cs) |
| HU (1) | HUT76062A (cs) |
| IL (1) | IL113112A (cs) |
| MX (1) | MX9604430A (cs) |
| NZ (1) | NZ282893A (cs) |
| PT (1) | PT751944E (cs) |
| RU (1) | RU2125053C1 (cs) |
| TW (1) | TW420669B (cs) |
| WO (1) | WO1995026347A1 (cs) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0749430T3 (da) * | 1994-03-08 | 2000-02-07 | American Home Prod | Thiazolidindion-derivater som antihyperglykæmiske midler |
| ZA973848B (en) * | 1996-05-06 | 1997-12-02 | Reddy Research Foundation | Novel heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them. |
| US5919782A (en) * | 1996-05-06 | 1999-07-06 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| US5889025A (en) * | 1996-05-06 | 1999-03-30 | Reddy's Research Foundation | Antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| USRE39266E1 (en) * | 1996-07-01 | 2006-09-05 | Dr. Reddy's Laboratories, Limited | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| US6114526A (en) * | 1996-07-01 | 2000-09-05 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| US6372750B2 (en) | 1996-07-01 | 2002-04-16 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases |
| CA2258949C (en) | 1996-07-01 | 2008-05-06 | Reddy-Cheminor, Inc. | Novel heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| US6313113B1 (en) | 1997-04-15 | 2001-11-06 | Reddy-Cheminor, Inc. | Heterocyclic compounds having antidiabetic, hypolipidemic and antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| US6011031A (en) * | 1997-05-30 | 2000-01-04 | Dr. Reddy's Research Foundation | Azolidinediones useful for the treatment of diabetes, dyslipidemia and hypertension: process for their preparation and pharmaceutical compositions containing them |
| US6756360B1 (en) | 1998-12-24 | 2004-06-29 | Metabasis Therapeutics, Inc. | Combination of FBPase inhibitors and insulin sensitizers for the treatment of diabetes |
| US7563774B2 (en) | 2000-06-29 | 2009-07-21 | Metabasis Therapeutics, Inc. | Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes |
| PT1339678E (pt) | 2000-11-27 | 2007-11-30 | Pfizer Prod Inc | Agonistas selectivos do receptor ep4 no tratamento de osteoporose |
| GB0122318D0 (en) * | 2001-09-14 | 2001-11-07 | Novartis Ag | Organic compounds |
| KR100674769B1 (ko) * | 2003-01-02 | 2007-02-28 | 에프. 호프만-라 로슈 아게 | 신규 씨비 1 수용체 역작용제 |
| EP2343303A1 (de) * | 2004-10-07 | 2011-07-13 | Boehringer Ingelheim International GmbH | PI3-Kinase Inhibitoren |
| RU2457207C2 (ru) * | 2006-03-24 | 2012-07-27 | Эррэй Биофарма Инк. | Активаторы глюкокиназы |
| CN101311167B (zh) * | 2007-05-25 | 2011-04-06 | 天津药物研究院 | 1-苯基咪唑烷-2,4-二酮类衍生物及其用途 |
| PL2516425T3 (pl) | 2009-12-23 | 2016-03-31 | Jasco Pharmaceuticals Llc | Inhibitory kinaz aminopirydynowych |
| EP2699569B1 (en) | 2011-04-22 | 2017-08-30 | Jasco Pharmaceuticals, LLC | Aminopyrimidine kinase inhibitors |
| KR101990605B1 (ko) | 2011-11-04 | 2019-06-18 | 자스코 파머수티컬스, 엘엘씨 | 아미노피리미딘 키나아제 억제제 |
| KR20160004272U (ko) | 2015-06-04 | 2016-12-14 | 심명보 | 걸이구가 구비된 케이블행거 |
| KR200488728Y1 (ko) | 2017-06-15 | 2019-03-11 | 심명보 | 걸이구가 구비된 케이블행거 |
| IL272246B2 (en) | 2017-07-28 | 2026-01-01 | Applied Therapeutics Inc | History of 2-(4-oxo/thioketone/azo-3-((substituted)benzo[d]thiazol-2-yl)methyl)- 3,4-dihydrothieno[3,4-d]pyridazin-1-yl)acetic acid for use as an aldose reductase inhibitor for the treatment of galactosemia or prevention of galactosemia-related complications |
| CA3132136A1 (en) | 2019-04-01 | 2020-10-08 | Andrew Wasmuth | Inhibitors of aldose reductase |
| JP2022531466A (ja) | 2019-05-07 | 2022-07-06 | ユニバーシティ オブ マイアミ | 遺伝性ニューロパチーおよび関連障害の処置および検出 |
| KR102433164B1 (ko) * | 2020-06-29 | 2022-08-18 | 한국전력공사 | 길이와 각도 조절이 가능한 케이블 행거 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5564586A (en) * | 1978-11-09 | 1980-05-15 | Takeda Chem Ind Ltd | Thiazolidine derivative |
| MX15171A (es) * | 1988-03-08 | 1993-05-01 | Pfizer | Derivados de tiazolidinodiona hipoglicemicos |
| WO1989008650A1 (en) * | 1988-03-08 | 1989-09-21 | Pfizer Inc. | Thiazolidinedione hypoglycemic agents |
| JPH065228A (ja) * | 1992-06-18 | 1994-01-14 | Mitsubishi Electric Corp | 偏向デバイス |
| TW245716B (cs) * | 1992-12-28 | 1995-04-21 | Takeda Pharm Industry Co | |
| KR960002625A (ko) * | 1994-06-17 | 1996-01-26 | 제임스 조셉 드롱 | 다층 레지스트의 플라즈마 에칭을 위한 방법 및 장치 |
-
1995
- 1995-03-23 TW TW084102837A patent/TW420669B/zh not_active IP Right Cessation
- 1995-03-23 IL IL11311295A patent/IL113112A/xx not_active IP Right Cessation
- 1995-03-27 NZ NZ282893A patent/NZ282893A/en unknown
- 1995-03-27 AT AT95913343T patent/ATE198200T1/de not_active IP Right Cessation
- 1995-03-27 CN CN95192264A patent/CN1045776C/zh not_active Expired - Fee Related
- 1995-03-27 EP EP95913343A patent/EP0751944B1/en not_active Expired - Lifetime
- 1995-03-27 CZ CZ962820A patent/CZ282096A3/cs unknown
- 1995-03-27 ES ES95913343T patent/ES2154727T3/es not_active Expired - Lifetime
- 1995-03-27 HU HU9602645A patent/HUT76062A/hu unknown
- 1995-03-27 AU AU20833/95A patent/AU683739B2/en not_active Ceased
- 1995-03-27 DK DK95913343T patent/DK0751944T3/da active
- 1995-03-27 MX MX9604430A patent/MX9604430A/es unknown
- 1995-03-27 RU RU96119770A patent/RU2125053C1/ru not_active IP Right Cessation
- 1995-03-27 CA CA002186381A patent/CA2186381A1/en not_active Abandoned
- 1995-03-27 WO PCT/JP1995/000560 patent/WO1995026347A1/en not_active Ceased
- 1995-03-27 KR KR1019960705283A patent/KR100340615B1/ko not_active Expired - Fee Related
- 1995-03-27 PT PT95913343T patent/PT751944E/pt unknown
- 1995-03-27 DE DE69519666T patent/DE69519666T2/de not_active Expired - Fee Related
-
2001
- 2001-01-18 GR GR20010400094T patent/GR3035277T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR970701716A (ko) | 1997-04-12 |
| KR100340615B1 (ko) | 2002-10-18 |
| DK0751944T3 (da) | 2001-01-08 |
| WO1995026347A1 (en) | 1995-10-05 |
| EP0751944B1 (en) | 2000-12-20 |
| MX9604430A (es) | 1997-12-31 |
| RU2125053C1 (ru) | 1999-01-20 |
| HU9602645D0 (en) | 1996-11-28 |
| NZ282893A (en) | 1997-07-27 |
| CN1045776C (zh) | 1999-10-20 |
| ATE198200T1 (de) | 2001-01-15 |
| TW420669B (en) | 2001-02-01 |
| PT751944E (pt) | 2001-03-30 |
| ES2154727T3 (es) | 2001-04-16 |
| IL113112A0 (en) | 1995-06-29 |
| CN1144526A (zh) | 1997-03-05 |
| HUT76062A (en) | 1997-06-30 |
| CZ282096A3 (en) | 1997-03-12 |
| DE69519666D1 (de) | 2001-01-25 |
| AU683739B2 (en) | 1997-11-20 |
| CA2186381A1 (en) | 1995-10-05 |
| DE69519666T2 (de) | 2001-04-26 |
| AU2083395A (en) | 1995-10-17 |
| EP0751944A1 (en) | 1997-01-08 |
| GR3035277T3 (en) | 2001-04-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| MM9K | Patent not in force due to non-payment of renewal fees |