IL113084A - Derivatives of thiazolidine and oxazolidine, processes for their preparation and pharmaceutical preparations containing them - Google Patents
Derivatives of thiazolidine and oxazolidine, processes for their preparation and pharmaceutical preparations containing themInfo
- Publication number
- IL113084A IL113084A IL11308495A IL11308495A IL113084A IL 113084 A IL113084 A IL 113084A IL 11308495 A IL11308495 A IL 11308495A IL 11308495 A IL11308495 A IL 11308495A IL 113084 A IL113084 A IL 113084A
- Authority
- IL
- Israel
- Prior art keywords
- group
- formula
- carbon atoms
- preparation
- hydrogen atom
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5154194 | 1994-03-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL113084A0 IL113084A0 (en) | 1995-06-29 |
| IL113084A true IL113084A (en) | 1999-01-26 |
Family
ID=12889893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11308495A IL113084A (en) | 1994-03-23 | 1995-03-22 | Derivatives of thiazolidine and oxazolidine, processes for their preparation and pharmaceutical preparations containing them |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US5578620A (sv) |
| EP (1) | EP0678511A3 (sv) |
| KR (1) | KR950032187A (sv) |
| CN (1) | CN1065532C (sv) |
| AU (1) | AU682435B2 (sv) |
| CA (1) | CA2145257A1 (sv) |
| CZ (1) | CZ283938B6 (sv) |
| FI (1) | FI951370A (sv) |
| HU (1) | HUT71231A (sv) |
| ID (1) | ID23600A (sv) |
| IL (1) | IL113084A (sv) |
| NO (1) | NO303782B1 (sv) |
| NZ (1) | NZ270793A (sv) |
| TW (1) | TW363959B (sv) |
| ZA (1) | ZA952383B (sv) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5925656A (en) * | 1995-04-10 | 1999-07-20 | Dr. Reddy's Research Foundation | Compounds having antidiabetic, hypolipidemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| CZ293016B6 (cs) * | 1995-06-01 | 2004-01-14 | Sankyo Company Limited | Benzimidazolové deriváty a farmaceutické prostředky s jejich obsahem |
| EP0783888A1 (en) * | 1995-12-26 | 1997-07-16 | Sankyo Company Limited | Use of troglitazone and related thiazolidinediones in the manufacture of a medicament for the treatment and prophylaxis of osteoporosis |
| EP0801063B1 (en) * | 1996-04-09 | 2003-01-15 | Dr. Reddy's Laboratories Ltd. | Thiazolidinedione derivatives having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| US5919782A (en) * | 1996-05-06 | 1999-07-06 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| US5889032A (en) * | 1996-05-06 | 1999-03-30 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| ZA973850B (en) * | 1996-05-06 | 1997-12-02 | Reddy Research Foundation | Novel antidiabetic compounds having hypolipidaemic, anti-hypertensive properties, process for their preparation and pharmaceutical compositions containing them. |
| US5801173A (en) * | 1996-05-06 | 1998-09-01 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| US5885997A (en) * | 1996-07-01 | 1999-03-23 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| US6114526A (en) | 1996-07-01 | 2000-09-05 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| KR100579765B1 (ko) * | 1996-07-01 | 2006-12-28 | 닥터 레디스 레보러터리즈 리미티드 | 신규헤테로고리형화합물의제조방법,이를함유하는약제조성물및당뇨병및이와관련된질병의치료에있어서그의용도 |
| USRE39266E1 (en) * | 1996-07-01 | 2006-09-05 | Dr. Reddy's Laboratories, Limited | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| US6372750B2 (en) | 1996-07-01 | 2002-04-16 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases |
| DE69734405T2 (de) * | 1996-07-15 | 2006-08-03 | Sankyo Co., Ltd. | Verwendung von CS-866 (Olmersartan) zur Herstellung eines Medikaments für die Behandlung von Arteriosklerose |
| TW577875B (en) * | 1997-01-31 | 2004-03-01 | Shionogi & Co | Pyrrolidine derivatives with inhibitory activity for phospholipase A2 |
| US6011036A (en) | 1997-04-15 | 2000-01-04 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic hypolipidemic antihypertensive properties process for their preparation and pharmaceutical compositions containing them |
| WO1997041119A1 (en) * | 1997-05-02 | 1997-11-06 | Dr. Reddy's Research Foundation | Novel antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| AU7109798A (en) * | 1997-12-02 | 1998-10-30 | Dr. Reddy's Research Foundation | Substituted thiazolidinedione and oxazolidinedione having antidiabetic, hypol ipidemia and antihypertensive properties |
| US6436914B1 (en) | 1998-06-30 | 2002-08-20 | Bristol-Myers Squibb Company | 2-hydroxy-3—(4-hydroxy-3-sulfonamidophenyl)—propylamines useful as beta 3 adrenergic agonists |
| HUP0301329A2 (hu) | 2000-07-13 | 2003-08-28 | Eli Lilly And Co. | Béta3 Adrenergiás agonisták, valamint ezen vegyületeket tartalmazó gyógyászati készítmények és eljárás e vegyületek előállítására |
| US6458817B1 (en) | 2000-07-17 | 2002-10-01 | Wyeth | Substituted arylsulfides, arylsulfoxides and arylsulfones as beta-3 adrenergic receptor agonists |
| US6395762B1 (en) | 2000-07-17 | 2002-05-28 | American Home Products Corporation | Phenyl amino squarate and thiadiazole dioxide beta-3 adrenergic receptor agonists |
| US6537994B2 (en) | 2000-07-17 | 2003-03-25 | Wyeth | Heterocyclic β3 adrenergic receptor agonists |
| US6410734B1 (en) * | 2000-07-17 | 2002-06-25 | Wyeth | 2-substituted thiazolidinones as beta-3 adrenergic receptor agonists |
| US6451814B1 (en) | 2000-07-17 | 2002-09-17 | Wyeth | Heterocyclic β-3 adrenergic receptor agonists |
| US6506901B2 (en) | 2000-07-17 | 2003-01-14 | Wyeth | Substituted 2-(S)-hydroxy-3-(piperidin-4-yl-methylamino)-propyl ethers and substituted 2-aryl-2-(R)-hydroxy-1-(piperidin-4-yl-methyl)-ethylamine β-3 adrenergic receptor agonists |
| US6498170B2 (en) | 2000-07-17 | 2002-12-24 | Wyeth | Cyclamine sulfonamides as β-3 adrenergic receptor agonists |
| US6444685B1 (en) | 2000-07-17 | 2002-09-03 | Wyeth | N-(4-sulfonylaryl)Cyclylamine 2-hydroxyethylamines as beta-3 adrenergic receptor agonists |
| US6514991B2 (en) | 2000-07-17 | 2003-02-04 | Wyeth | Phenyl-oxo-tetrahydroquinolin-3-yl beta-3 adrenergic receptor agonists |
| US6509358B2 (en) | 2000-07-17 | 2003-01-21 | Wyeth | Piperidino-phenyl amino squarate and thiadiazole dioxide beta-3 adrenergic receptor agonists |
| US6525202B2 (en) * | 2000-07-17 | 2003-02-25 | Wyeth | Cyclic amine phenyl beta-3 adrenergic receptor agonists |
| US6465501B2 (en) | 2000-07-17 | 2002-10-15 | Wyeth | Azolidines as β3 adrenergic receptor agonists |
| JP2004513164A (ja) | 2000-11-10 | 2004-04-30 | イーライ・リリー・アンド・カンパニー | ３−置換オキシインドールβ３アゴニスト |
| WO2002094820A1 (en) * | 2001-05-23 | 2002-11-28 | Eli Lilly And Company | Crystalline salts of 2-(4-{2-[2-hydroxy-3-(2-thiophen-2-yl-phenoxy)-propylamino]-2-methyl-propyl}-phenoxy)-nicotinonitrile |
| EP1444224B1 (en) | 2001-08-14 | 2006-05-03 | Eli Lilly And Company | 3-substituted oxindole beta-3 agonists |
| ATE340794T1 (de) | 2001-08-14 | 2006-10-15 | Lilly Co Eli | Indol derivate als beta-3-adrenerge agonisten zur behandlung von typ 2 diabetes |
| US7205407B2 (en) | 2001-11-20 | 2007-04-17 | Eli Lilly And Company | 3-Substituted oxindole β3 agonists |
| DE60225174T2 (de) | 2001-11-20 | 2009-02-12 | Eli Lilly And Co., Indianapolis | Beta-3 adrenergische agonisten |
| EP1467733A1 (en) | 2002-01-11 | 2004-10-20 | Eli Lilly And Company | 2-oxo-benzimidazolyl substituted ethanolamine derivatives and their use as beta3 agonists |
| WO2006041921A2 (en) * | 2004-10-05 | 2006-04-20 | Auspex Pharmaceuticals, Inc. | Preparation and uses of rhodanine derivatives |
| ES2394349B1 (es) | 2012-08-29 | 2013-11-04 | Fundación Centro Nacional De Investigaciones Cardiovasculares Carlos Iii | Uso de agonistas selectivos de receptores beta-3 adrenérgicos para el tratamiento de hipertensión pulmonar |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5522636A (en) * | 1978-08-04 | 1980-02-18 | Takeda Chem Ind Ltd | Thiazoliding derivative |
| CA1262729A (en) * | 1983-10-19 | 1989-11-07 | Leo Alig | Phenoxypropanolamines |
| GB8528633D0 (en) * | 1985-11-21 | 1985-12-24 | Beecham Group Plc | Compounds |
| US4968707A (en) * | 1987-06-10 | 1990-11-06 | Pfizer Inc. | Oxazolidin-2-one derivatives as hypoglycemic agents |
| US5260445A (en) * | 1987-09-04 | 1993-11-09 | Beecham Group P.L.C. | 2,4-thiazolidinediones |
| GB9017218D0 (en) * | 1990-08-06 | 1990-09-19 | Beecham Group Plc | Novel compounds |
| GB9023583D0 (en) * | 1990-10-30 | 1990-12-12 | Beecham Group Plc | Novel compounds |
| GB9023584D0 (en) * | 1990-10-30 | 1990-12-12 | Beecham Group Plc | Novel compounds |
| JP3053490B2 (ja) * | 1991-02-25 | 2000-06-19 | 杏林製薬株式会社 | チアゾリジン−２，４−ジオン誘導体とその塩及び製造法 |
| FR2680512B1 (fr) * | 1991-08-20 | 1995-01-20 | Adir | Nouveaux derives de 2,4-thiazolidinedione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| NO179246C (no) * | 1991-11-20 | 1996-09-04 | Sankyo Co | Aromatiske amino-alkoholderivater og mellomprodukter til fremstilling derav |
| EP0590793B1 (en) * | 1992-08-31 | 1999-10-13 | Sankyo Company Limited | Oxazolidine derivatives having anti-diabetic and anti-obesity properties, their preparation and their therapeutic uses |
| JPH072848A (ja) * | 1993-04-23 | 1995-01-06 | Sankyo Co Ltd | モルホリンおよびチオモルホリン誘導体 |
-
1995
- 1995-03-22 TW TW084102774A patent/TW363959B/zh active
- 1995-03-22 CA CA002145257A patent/CA2145257A1/en not_active Abandoned
- 1995-03-22 NO NO951095A patent/NO303782B1/no not_active IP Right Cessation
- 1995-03-22 IL IL11308495A patent/IL113084A/en not_active IP Right Cessation
- 1995-03-23 EP EP95301922A patent/EP0678511A3/en not_active Withdrawn
- 1995-03-23 ID IDP990567D patent/ID23600A/id unknown
- 1995-03-23 FI FI951370A patent/FI951370A/sv unknown
- 1995-03-23 NZ NZ270793A patent/NZ270793A/en unknown
- 1995-03-23 ZA ZA952383A patent/ZA952383B/xx unknown
- 1995-03-23 KR KR1019950006242A patent/KR950032187A/ko not_active Application Discontinuation
- 1995-03-23 CZ CZ95739A patent/CZ283938B6/cs unknown
- 1995-03-23 CN CN95104547A patent/CN1065532C/zh not_active Expired - Lifetime
- 1995-03-23 AU AU15016/95A patent/AU682435B2/en not_active Ceased
- 1995-03-23 HU HU9500849A patent/HUT71231A/hu unknown
- 1995-03-23 US US08/410,033 patent/US5578620A/en not_active Expired - Fee Related
-
1996
- 1996-02-21 US US08/604,702 patent/US5688823A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| FI951370A0 (sv) | 1995-03-23 |
| HU9500849D0 (en) | 1995-05-29 |
| CN1065532C (zh) | 2001-05-09 |
| ID23600A (id) | 1995-11-30 |
| EP0678511A2 (en) | 1995-10-25 |
| AU1501695A (en) | 1995-10-05 |
| NO951095D0 (no) | 1995-03-22 |
| AU682435B2 (en) | 1997-10-02 |
| CZ283938B6 (cs) | 1998-07-15 |
| NO951095L (no) | 1995-09-25 |
| US5688823A (en) | 1997-11-18 |
| FI951370A (sv) | 1995-09-24 |
| CZ73995A3 (en) | 1995-12-13 |
| CN1132750A (zh) | 1996-10-09 |
| KR950032187A (ko) | 1995-12-20 |
| ZA952383B (en) | 1995-12-14 |
| CA2145257A1 (en) | 1995-09-24 |
| TW363959B (en) | 1999-07-11 |
| US5578620A (en) | 1996-11-26 |
| NZ270793A (en) | 1996-02-27 |
| EP0678511A3 (en) | 1998-06-10 |
| HUT71231A (en) | 1995-11-28 |
| IL113084A0 (en) | 1995-06-29 |
| NO303782B1 (no) | 1998-08-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5688823A (en) | Thiazolidine and oxazolidine derivatives their preparation and their medical use | |
| RU2151145C1 (ru) | Промежуточное соединение для получения гетероциклических соединений, обладающих антидиабетической активностью | |
| EP0543662B1 (en) | Aromatic amino-alcohol derivatives having anti-diabetic and anti-obesity properties, their preparation and their therapeutic uses | |
| US5436257A (en) | Oxazolidine derivatives having anti-diabetic and anti-obesity properties, their preparation and their therapeutic uses | |
| DE69723869T2 (de) | Heterozyklische verbindungen, verfahren zu ihrer herstellung, pharmazeutische zusammensetzungen die diese enthalten und ihre anwendung in der behandlung von diabetis und verwandten krankheiten | |
| US6288095B1 (en) | Compounds | |
| RU2456276C2 (ru) | Бензимидазольные производные, фармацевтическая композиция на их основе и способы их применения | |
| HRP20040810A2 (en) | Thiazole and oxazole derivatives that modulate ppar activity | |
| HU211901A9 (en) | Oxazolidine derivative and pharmaceutically acceptable salt thereof | |
| WO2007081091A1 (en) | Rhodandse derivarives, a process for the preparation thereof and pharmaceutical composition containing the same | |
| AU765005B2 (en) | Polymorph of 5-(4-(2- (N-methyl-N-( 2-pyridyl)amino) ethoxy)benzyl) thiazolidine-2,4-dione, maleic acid salt | |
| US6686475B2 (en) | Compounds | |
| US20120184544A1 (en) | Substituted benzamide derivatives as glucokinase (gk) activators | |
| JP2007210974A (ja) | 置換されたウレア化合物を含有する医薬 | |
| US8450494B2 (en) | Disubstituted benzamide derivatives as glucokinase (GK) activators | |
| RU2118319C1 (ru) | Производные тиазолидина, фармацевтическая композиция, обладающая гипогликемической и гиполипемической активностью и активностью ингибирования альдозоредуктазы, и способ лечения и профилактики заболеваний млекопитающих | |
| JPH09221481A (ja) | 芳香族化合物を含有する医薬 | |
| JPH07330710A (ja) | 芳香族化合物 | |
| EP0894089B9 (en) | Novel heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them | |
| EP1325000B1 (en) | A thiazolidinedione derivative and its use as antidiabetic | |
| US20040214866A1 (en) | Sodium salts of 5-'4-'2-(N-methyl-N-(2-pyridyl)amino)ethoxy!benzyl!thiazolidine-2, 4-dione |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |