ZA952383B - Thiazolidine and oxazolidine derivatives their preparation and their medical use - Google Patents

Thiazolidine and oxazolidine derivatives their preparation and their medical use

Info

Publication number
ZA952383B
ZA952383B ZA952383A ZA952383A ZA952383B ZA 952383 B ZA952383 B ZA 952383B ZA 952383 A ZA952383 A ZA 952383A ZA 952383 A ZA952383 A ZA 952383A ZA 952383 B ZA952383 B ZA 952383B
Authority
ZA
South Africa
Prior art keywords
thiazolidine
preparation
medical use
oxazolidine derivatives
oxazolidine
Prior art date
Application number
ZA952383A
Other languages
English (en)
Inventor
Takashi Fujita
Hiroaki Yanagisawa
Hiroyoshi Horikoshi
Kunio Wada
Takao Yoshioka
Toshihiko Fujiwara
Minoru Oguchi
Koichi Fujimoto
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of ZA952383B publication Critical patent/ZA952383B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
ZA952383A 1994-03-23 1995-03-23 Thiazolidine and oxazolidine derivatives their preparation and their medical use ZA952383B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5154194 1994-03-23

Publications (1)

Publication Number Publication Date
ZA952383B true ZA952383B (en) 1995-12-14

Family

ID=12889893

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA952383A ZA952383B (en) 1994-03-23 1995-03-23 Thiazolidine and oxazolidine derivatives their preparation and their medical use

Country Status (15)

Country Link
US (2) US5578620A (xx)
EP (1) EP0678511A3 (xx)
KR (1) KR950032187A (xx)
CN (1) CN1065532C (xx)
AU (1) AU682435B2 (xx)
CA (1) CA2145257A1 (xx)
CZ (1) CZ283938B6 (xx)
FI (1) FI951370A (xx)
HU (1) HUT71231A (xx)
ID (1) ID23600A (xx)
IL (1) IL113084A (xx)
NO (1) NO303782B1 (xx)
NZ (1) NZ270793A (xx)
TW (1) TW363959B (xx)
ZA (1) ZA952383B (xx)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5925656A (en) * 1995-04-10 1999-07-20 Dr. Reddy's Research Foundation Compounds having antidiabetic, hypolipidemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
IL118474A (en) * 1995-06-01 2001-08-08 Sankyo Co Benzimideol derivatives and pharmaceutical preparations containing them
EP0783888A1 (en) * 1995-12-26 1997-07-16 Sankyo Company Limited Use of troglitazone and related thiazolidinediones in the manufacture of a medicament for the treatment and prophylaxis of osteoporosis
EP0801063B1 (en) * 1996-04-09 2003-01-15 Dr. Reddy's Laboratories Ltd. Thiazolidinedione derivatives having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5919782A (en) * 1996-05-06 1999-07-06 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5801173A (en) * 1996-05-06 1998-09-01 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
ZA973850B (en) * 1996-05-06 1997-12-02 Reddy Research Foundation Novel antidiabetic compounds having hypolipidaemic, anti-hypertensive properties, process for their preparation and pharmaceutical compositions containing them.
US5889032A (en) * 1996-05-06 1999-03-30 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
USRE39266E1 (en) * 1996-07-01 2006-09-05 Dr. Reddy's Laboratories, Limited Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US5885997A (en) * 1996-07-01 1999-03-23 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
BR9711098B1 (pt) * 1996-07-01 2011-10-04 compostos heterocìclicos, processo para sua preparação e composições farmacêuticas contendo os mesmos e seu uso no tratamento de diabetes e doenças relacionadas.
US6114526A (en) 1996-07-01 2000-09-05 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6372750B2 (en) 1996-07-01 2002-04-16 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases
DE69731840T2 (de) * 1996-07-15 2005-08-04 Sankyo Co., Ltd. Pharmazeutische Zusammensetzungen enthaltend CS-866 und Insulinresistenz verbessernde Mittel und deren Verwendung zur Behandlung von Arteriosklerose und Xanthom
TW577875B (en) * 1997-01-31 2004-03-01 Shionogi & Co Pyrrolidine derivatives with inhibitory activity for phospholipase A2
US6313113B1 (en) 1997-04-15 2001-11-06 Reddy-Cheminor, Inc. Heterocyclic compounds having antidiabetic, hypolipidemic and antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
EP0981526B1 (en) * 1997-05-02 2004-02-25 Dr. Reddy's Laboratories Ltd. Novel antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
DE69824756T2 (de) * 1997-12-02 2005-07-14 Dr. Reddy's Laboratories Ltd. Substituierte thiazolidinedione und oxazolidinedione mit antidiabetischen,hypolipidämischen und antihypertensiven eigenschaften
US6436914B1 (en) 1998-06-30 2002-08-20 Bristol-Myers Squibb Company 2-hydroxy-3—(4-hydroxy-3-sulfonamidophenyl)—propylamines useful as beta 3 adrenergic agonists
SV2002000522A (es) * 2000-07-13 2002-10-24 Lilly Co Eli Agosnistas adrenergicos beta3 ref. x-13921
US6465501B2 (en) 2000-07-17 2002-10-15 Wyeth Azolidines as β3 adrenergic receptor agonists
US6410734B1 (en) 2000-07-17 2002-06-25 Wyeth 2-substituted thiazolidinones as beta-3 adrenergic receptor agonists
US6444685B1 (en) 2000-07-17 2002-09-03 Wyeth N-(4-sulfonylaryl)Cyclylamine 2-hydroxyethylamines as beta-3 adrenergic receptor agonists
US6514991B2 (en) 2000-07-17 2003-02-04 Wyeth Phenyl-oxo-tetrahydroquinolin-3-yl beta-3 adrenergic receptor agonists
US6525202B2 (en) * 2000-07-17 2003-02-25 Wyeth Cyclic amine phenyl beta-3 adrenergic receptor agonists
US6498170B2 (en) 2000-07-17 2002-12-24 Wyeth Cyclamine sulfonamides as β-3 adrenergic receptor agonists
US6451814B1 (en) 2000-07-17 2002-09-17 Wyeth Heterocyclic β-3 adrenergic receptor agonists
US6506901B2 (en) 2000-07-17 2003-01-14 Wyeth Substituted 2-(S)-hydroxy-3-(piperidin-4-yl-methylamino)-propyl ethers and substituted 2-aryl-2-(R)-hydroxy-1-(piperidin-4-yl-methyl)-ethylamine β-3 adrenergic receptor agonists
US6458817B1 (en) 2000-07-17 2002-10-01 Wyeth Substituted arylsulfides, arylsulfoxides and arylsulfones as beta-3 adrenergic receptor agonists
US6395762B1 (en) 2000-07-17 2002-05-28 American Home Products Corporation Phenyl amino squarate and thiadiazole dioxide beta-3 adrenergic receptor agonists
US6509358B2 (en) 2000-07-17 2003-01-21 Wyeth Piperidino-phenyl amino squarate and thiadiazole dioxide beta-3 adrenergic receptor agonists
US6537994B2 (en) 2000-07-17 2003-03-25 Wyeth Heterocyclic β3 adrenergic receptor agonists
JP2004513164A (ja) 2000-11-10 2004-04-30 イーライ・リリー・アンド・カンパニー ３−置換オキシインドールβ３アゴニスト
WO2002094820A1 (en) * 2001-05-23 2002-11-28 Eli Lilly And Company Crystalline salts of 2-(4-{2-[2-hydroxy-3-(2-thiophen-2-yl-phenoxy)-propylamino]-2-methyl-propyl}-phenoxy)-nicotinonitrile
ATE340794T1 (de) 2001-08-14 2006-10-15 Lilly Co Eli Indol derivate als beta-3-adrenerge agonisten zur behandlung von typ 2 diabetes
WO2003016276A2 (en) 2001-08-14 2003-02-27 Eli Lilly And Company 3-substituted oxindole beta-3 agonists
US7205407B2 (en) 2001-11-20 2007-04-17 Eli Lilly And Company 3-Substituted oxindole β3 agonists
AU2002353844A1 (en) 2001-11-20 2003-06-10 Eli Lilly And Company Beta 3 adrenergic agonists
AU2002357084A1 (en) 2002-01-11 2003-07-30 Eli Lilly And Company 2-oxo-benzimidazolyl substituted ethanolamine derivatives and their use as beta3 agonists
WO2006041921A2 (en) * 2004-10-05 2006-04-20 Auspex Pharmaceuticals, Inc. Preparation and uses of rhodanine derivatives
ES2394349B1 (es) 2012-08-29 2013-11-04 Fundación Centro Nacional De Investigaciones Cardiovasculares Carlos Iii Uso de agonistas selectivos de receptores beta-3 adrenérgicos para el tratamiento de hipertensión pulmonar

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5522636A (en) * 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative
CA1262729A (en) * 1983-10-19 1989-11-07 Leo Alig Phenoxypropanolamines
GB8528633D0 (en) * 1985-11-21 1985-12-24 Beecham Group Plc Compounds
US4968707A (en) * 1987-06-10 1990-11-06 Pfizer Inc. Oxazolidin-2-one derivatives as hypoglycemic agents
US5260445A (en) * 1987-09-04 1993-11-09 Beecham Group P.L.C. 2,4-thiazolidinediones
GB9017218D0 (en) * 1990-08-06 1990-09-19 Beecham Group Plc Novel compounds
GB9023584D0 (en) * 1990-10-30 1990-12-12 Beecham Group Plc Novel compounds
GB9023583D0 (en) * 1990-10-30 1990-12-12 Beecham Group Plc Novel compounds
JP3053490B2 (ja) * 1991-02-25 2000-06-19 杏林製薬株式会社 チアゾリジン−２，４−ジオン誘導体とその塩及び製造法
FR2680512B1 (fr) * 1991-08-20 1995-01-20 Adir Nouveaux derives de 2,4-thiazolidinedione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
NO179246C (no) * 1991-11-20 1996-09-04 Sankyo Co Aromatiske amino-alkoholderivater og mellomprodukter til fremstilling derav
EP0590793B1 (en) * 1992-08-31 1999-10-13 Sankyo Company Limited Oxazolidine derivatives having anti-diabetic and anti-obesity properties, their preparation and their therapeutic uses
JPH072848A (ja) * 1993-04-23 1995-01-06 Sankyo Co Ltd モルホリンおよびチオモルホリン誘導体

Also Published As

Publication number Publication date
IL113084A (en) 1999-01-26
FI951370A (fi) 1995-09-24
CN1132750A (zh) 1996-10-09
NO951095L (no) 1995-09-25
CA2145257A1 (en) 1995-09-24
US5578620A (en) 1996-11-26
TW363959B (en) 1999-07-11
CN1065532C (zh) 2001-05-09
AU1501695A (en) 1995-10-05
HU9500849D0 (en) 1995-05-29
CZ73995A3 (en) 1995-12-13
AU682435B2 (en) 1997-10-02
EP0678511A3 (en) 1998-06-10
CZ283938B6 (cs) 1998-07-15
ID23600A (id) 1995-11-30
IL113084A0 (en) 1995-06-29
US5688823A (en) 1997-11-18
HUT71231A (en) 1995-11-28
FI951370A0 (fi) 1995-03-23
NO951095D0 (no) 1995-03-22
NO303782B1 (no) 1998-08-31
EP0678511A2 (en) 1995-10-25
NZ270793A (en) 1996-02-27
KR950032187A (ko) 1995-12-20

Similar Documents

Publication Publication Date Title
ZA952383B (en) Thiazolidine and oxazolidine derivatives their preparation and their medical use
IL115717A0 (en) Heterocyclic compounds and their preparation and use
AU3391395A (en) Morpholine derivatives and their use as therapeutic agents
IL114795A0 (en) N-benzylindole- and benmzopyrazole derivatives their preparation and use
IL113844A (en) N-(alpha-ETHYLBENZYL)-3-HYDROXY-2-PHENYLQUINOLINE-4-CARBOXAMIDE AND ITS USE IN THE PREPARATION OF MEDICAMENTS
HUP9904361A3 (en) Use of isobutylgaba and its derivatives for the treatment of pain
AU2505795A (en) 1-arylpyrimidine derivatives and pharmaceutical use thereof
EP0788489A4 (en) HETEROCYCLIC COMPOUNDS AND THEIR USE
TW294963U (en) Disposable diaper
HK1010681A1 (en) Disposable diaper
IL116525A0 (en) Piperazinedione derivatives their preparation and use
EP0482649A3 (en) Cm-chitin derivatives and use thereof
GB9414157D0 (en) Medical use
HK1014938A1 (en) Oxazolidinone derivatives, their preparation and therapeutical use
IL128902A0 (en) N-(2-benzothiazolyl)-1-piperidineethanamine derivatives their preparation and their use in therapy
IL114490A0 (en) Heterocyclic compounds their preparation and their use
HU9603133D0 (en) Thiadiazoles and their use as antipicornaviral agents
HU9204072D0 (en) Terazole derivatives and medical preparatives containing them
ZA924038B (en) New oxazole derivatives and their preparation and use
NO953002L (no) Anvendelse av eliprodil og enantiomerer derav for fremstilling av medisinske preparater
NO953003D0 (no) Anvendelse av ifenprodil og diastereoisomerer derav for fremstilling av medisinske preparater
AU1745092A (en) Thiazolidine derivatives and their use in therapy
GB9026257D0 (en) Thiazole derivatives and their preparation
GB9412618D0 (en) Cytotoxic agent and its use
EP0715840A3 (en) Disposable diaper