IL113084A - נגזרות של תיאוזולידין ואוקסאזולידין, תהליכים להכנתן ותכשירי רוקחות המכילים אותן - Google Patents
נגזרות של תיאוזולידין ואוקסאזולידין, תהליכים להכנתן ותכשירי רוקחות המכילים אותןInfo
- Publication number
- IL113084A IL113084A IL11308495A IL11308495A IL113084A IL 113084 A IL113084 A IL 113084A IL 11308495 A IL11308495 A IL 11308495A IL 11308495 A IL11308495 A IL 11308495A IL 113084 A IL113084 A IL 113084A
- Authority
- IL
- Israel
- Prior art keywords
- group
- formula
- carbon atoms
- preparation
- hydrogen atom
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5154194 | 1994-03-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL113084A0 IL113084A0 (en) | 1995-06-29 |
| IL113084A true IL113084A (he) | 1999-01-26 |
Family
ID=12889893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11308495A IL113084A (he) | 1994-03-23 | 1995-03-22 | נגזרות של תיאוזולידין ואוקסאזולידין, תהליכים להכנתן ותכשירי רוקחות המכילים אותן |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US5578620A (he) |
| EP (1) | EP0678511A3 (he) |
| KR (1) | KR950032187A (he) |
| CN (1) | CN1065532C (he) |
| AU (1) | AU682435B2 (he) |
| CA (1) | CA2145257A1 (he) |
| CZ (1) | CZ283938B6 (he) |
| FI (1) | FI951370A (he) |
| HU (1) | HUT71231A (he) |
| ID (1) | ID23600A (he) |
| IL (1) | IL113084A (he) |
| NO (1) | NO303782B1 (he) |
| NZ (1) | NZ270793A (he) |
| TW (1) | TW363959B (he) |
| ZA (1) | ZA952383B (he) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5925656A (en) * | 1995-04-10 | 1999-07-20 | Dr. Reddy's Research Foundation | Compounds having antidiabetic, hypolipidemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| IL118474A (he) * | 1995-06-01 | 2001-08-08 | Sankyo Co | נגזרות בנזימידאול ותכשירי רוקחות המכילים אותן |
| EP0783888A1 (en) * | 1995-12-26 | 1997-07-16 | Sankyo Company Limited | Use of troglitazone and related thiazolidinediones in the manufacture of a medicament for the treatment and prophylaxis of osteoporosis |
| DE69625795T2 (de) * | 1996-04-09 | 2003-08-14 | Reddys Lab Ltd Dr | Thiazolidinedionderivate mit antidiabetischen, hypolipidämischen und antihypertensiven Eigenschaften, Verfahren zu deren Herstellung und pharmazeutischen Zusammenstellungen, die sie enthalten |
| ZA973848B (en) * | 1996-05-06 | 1997-12-02 | Reddy Research Foundation | Novel heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them. |
| US5801173A (en) * | 1996-05-06 | 1998-09-01 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| ZA973850B (en) * | 1996-05-06 | 1997-12-02 | Reddy Research Foundation | Novel antidiabetic compounds having hypolipidaemic, anti-hypertensive properties, process for their preparation and pharmaceutical compositions containing them. |
| US5919782A (en) * | 1996-05-06 | 1999-07-06 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| US5885997A (en) * | 1996-07-01 | 1999-03-23 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| USRE39266E1 (en) * | 1996-07-01 | 2006-09-05 | Dr. Reddy's Laboratories, Limited | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| US6372750B2 (en) | 1996-07-01 | 2002-04-16 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases |
| US6114526A (en) * | 1996-07-01 | 2000-09-05 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| US5985884A (en) * | 1996-07-01 | 1999-11-16 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| ATE283704T1 (de) * | 1996-07-15 | 2004-12-15 | Sankyo Co | Pharmazeutische zusammensetzungen enthaltend cs- 866 und insulinresistenz verbesserndem mitteln und deren verwendung zur behandlung von arteriosklerose und xanthom |
| TW577875B (en) * | 1997-01-31 | 2004-03-01 | Shionogi & Co | Pyrrolidine derivatives with inhibitory activity for phospholipase A2 |
| US6011036A (en) * | 1997-04-15 | 2000-01-04 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic hypolipidemic antihypertensive properties process for their preparation and pharmaceutical compositions containing them |
| JP2001518069A (ja) * | 1997-05-02 | 2001-10-09 | ドクター・レディーズ・リサーチ・ファウンデーション | 低脂質性、抗高血圧性特性を有する新規な抗糖尿病化合物、それらの製造方法及びそれらを含有する薬学的組成物 |
| AU7109798A (en) * | 1997-12-02 | 1998-10-30 | Dr. Reddy's Research Foundation | Substituted thiazolidinedione and oxazolidinedione having antidiabetic, hypol ipidemia and antihypertensive properties |
| US6436914B1 (en) | 1998-06-30 | 2002-08-20 | Bristol-Myers Squibb Company | 2-hydroxy-3—(4-hydroxy-3-sulfonamidophenyl)—propylamines useful as beta 3 adrenergic agonists |
| JP4988128B2 (ja) * | 2000-07-13 | 2012-08-01 | イーライ リリー アンド カンパニー | β３アドレナリン作動性アゴニスト |
| US6514991B2 (en) | 2000-07-17 | 2003-02-04 | Wyeth | Phenyl-oxo-tetrahydroquinolin-3-yl beta-3 adrenergic receptor agonists |
| US6498170B2 (en) | 2000-07-17 | 2002-12-24 | Wyeth | Cyclamine sulfonamides as β-3 adrenergic receptor agonists |
| US6444685B1 (en) | 2000-07-17 | 2002-09-03 | Wyeth | N-(4-sulfonylaryl)Cyclylamine 2-hydroxyethylamines as beta-3 adrenergic receptor agonists |
| US6465501B2 (en) | 2000-07-17 | 2002-10-15 | Wyeth | Azolidines as β3 adrenergic receptor agonists |
| US6509358B2 (en) | 2000-07-17 | 2003-01-21 | Wyeth | Piperidino-phenyl amino squarate and thiadiazole dioxide beta-3 adrenergic receptor agonists |
| US6525202B2 (en) * | 2000-07-17 | 2003-02-25 | Wyeth | Cyclic amine phenyl beta-3 adrenergic receptor agonists |
| US6506901B2 (en) | 2000-07-17 | 2003-01-14 | Wyeth | Substituted 2-(S)-hydroxy-3-(piperidin-4-yl-methylamino)-propyl ethers and substituted 2-aryl-2-(R)-hydroxy-1-(piperidin-4-yl-methyl)-ethylamine β-3 adrenergic receptor agonists |
| US6395762B1 (en) | 2000-07-17 | 2002-05-28 | American Home Products Corporation | Phenyl amino squarate and thiadiazole dioxide beta-3 adrenergic receptor agonists |
| US6451814B1 (en) | 2000-07-17 | 2002-09-17 | Wyeth | Heterocyclic β-3 adrenergic receptor agonists |
| US6458817B1 (en) | 2000-07-17 | 2002-10-01 | Wyeth | Substituted arylsulfides, arylsulfoxides and arylsulfones as beta-3 adrenergic receptor agonists |
| US6410734B1 (en) * | 2000-07-17 | 2002-06-25 | Wyeth | 2-substituted thiazolidinones as beta-3 adrenergic receptor agonists |
| US6537994B2 (en) | 2000-07-17 | 2003-03-25 | Wyeth | Heterocyclic β3 adrenergic receptor agonists |
| CA2421594A1 (en) | 2000-11-10 | 2002-05-16 | John Arnold Werner | 3-substituted oxindole beta 3 agonists |
| WO2002094820A1 (en) * | 2001-05-23 | 2002-11-28 | Eli Lilly And Company | Crystalline salts of 2-(4-{2-[2-hydroxy-3-(2-thiophen-2-yl-phenoxy)-propylamino]-2-methyl-propyl}-phenoxy)-nicotinonitrile |
| ES2272749T3 (es) | 2001-08-14 | 2007-05-01 | Eli Lilly And Company | Derivados de indol como agonistas beta-3 adrenergicos para el tratamiento de diabetes tipo 2. |
| DE60211199T2 (de) | 2001-08-14 | 2007-02-01 | Eli Lilly And Co., Indianapolis | 3-substituierte oxindol-beta-3-agonisten |
| ATE297925T1 (de) | 2001-11-20 | 2005-07-15 | Lilly Co Eli | 3-substituierte oxindol beta 3 agonisten |
| JP2005518357A (ja) | 2001-11-20 | 2005-06-23 | イーライ・リリー・アンド・カンパニー | ベータ３アドレナリンアゴニスト |
| US7009060B2 (en) | 2002-01-11 | 2006-03-07 | Eli Lilly And Company | 2-oxo-benzimidazolyl substituted ethanolamine derivatives and their use as β3 agonists |
| WO2006041921A2 (en) * | 2004-10-05 | 2006-04-20 | Auspex Pharmaceuticals, Inc. | Preparation and uses of rhodanine derivatives |
| ES2394349B1 (es) | 2012-08-29 | 2013-11-04 | Fundación Centro Nacional De Investigaciones Cardiovasculares Carlos Iii | Uso de agonistas selectivos de receptores beta-3 adrenérgicos para el tratamiento de hipertensión pulmonar |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5522636A (en) * | 1978-08-04 | 1980-02-18 | Takeda Chem Ind Ltd | Thiazoliding derivative |
| CA1262729A (en) * | 1983-10-19 | 1989-11-07 | Leo Alig | Phenoxypropanolamines |
| GB8528633D0 (en) * | 1985-11-21 | 1985-12-24 | Beecham Group Plc | Compounds |
| US4968707A (en) * | 1987-06-10 | 1990-11-06 | Pfizer Inc. | Oxazolidin-2-one derivatives as hypoglycemic agents |
| US5260445A (en) * | 1987-09-04 | 1993-11-09 | Beecham Group P.L.C. | 2,4-thiazolidinediones |
| GB9017218D0 (en) * | 1990-08-06 | 1990-09-19 | Beecham Group Plc | Novel compounds |
| GB9023584D0 (en) * | 1990-10-30 | 1990-12-12 | Beecham Group Plc | Novel compounds |
| GB9023583D0 (en) * | 1990-10-30 | 1990-12-12 | Beecham Group Plc | Novel compounds |
| JP3053490B2 (ja) * | 1991-02-25 | 2000-06-19 | 杏林製薬株式会社 | チアゾリジン−２，４−ジオン誘導体とその塩及び製造法 |
| FR2680512B1 (fr) * | 1991-08-20 | 1995-01-20 | Adir | Nouveaux derives de 2,4-thiazolidinedione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| NO179246C (no) * | 1991-11-20 | 1996-09-04 | Sankyo Co | Aromatiske amino-alkoholderivater og mellomprodukter til fremstilling derav |
| ZA936324B (en) * | 1992-08-31 | 1994-03-22 | Sankyo Co | Oxazolidine derivatives having anti-diabetic and anti-obesity properties their preparation and their therapeutic uses |
| JPH072848A (ja) * | 1993-04-23 | 1995-01-06 | Sankyo Co Ltd | モルホリンおよびチオモルホリン誘導体 |
-
1995
- 1995-03-22 NO NO951095A patent/NO303782B1/no not_active IP Right Cessation
- 1995-03-22 IL IL11308495A patent/IL113084A/he not_active IP Right Cessation
- 1995-03-22 CA CA002145257A patent/CA2145257A1/en not_active Abandoned
- 1995-03-22 TW TW084102774A patent/TW363959B/zh active
- 1995-03-23 KR KR1019950006242A patent/KR950032187A/ko not_active Application Discontinuation
- 1995-03-23 HU HU9500849A patent/HUT71231A/hu unknown
- 1995-03-23 ZA ZA952383A patent/ZA952383B/xx unknown
- 1995-03-23 NZ NZ270793A patent/NZ270793A/en unknown
- 1995-03-23 ID IDP990567D patent/ID23600A/id unknown
- 1995-03-23 AU AU15016/95A patent/AU682435B2/en not_active Ceased
- 1995-03-23 CN CN95104547A patent/CN1065532C/zh not_active Expired - Lifetime
- 1995-03-23 US US08/410,033 patent/US5578620A/en not_active Expired - Fee Related
- 1995-03-23 CZ CZ95739A patent/CZ283938B6/cs unknown
- 1995-03-23 EP EP95301922A patent/EP0678511A3/en not_active Withdrawn
- 1995-03-23 FI FI951370A patent/FI951370A/fi unknown
-
1996
- 1996-02-21 US US08/604,702 patent/US5688823A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| HUT71231A (en) | 1995-11-28 |
| AU1501695A (en) | 1995-10-05 |
| CN1132750A (zh) | 1996-10-09 |
| US5688823A (en) | 1997-11-18 |
| ID23600A (id) | 1995-11-30 |
| HU9500849D0 (en) | 1995-05-29 |
| KR950032187A (ko) | 1995-12-20 |
| NO951095D0 (no) | 1995-03-22 |
| CN1065532C (zh) | 2001-05-09 |
| NZ270793A (en) | 1996-02-27 |
| FI951370A0 (fi) | 1995-03-23 |
| CZ283938B6 (cs) | 1998-07-15 |
| CZ73995A3 (en) | 1995-12-13 |
| FI951370A (fi) | 1995-09-24 |
| CA2145257A1 (en) | 1995-09-24 |
| NO951095L (no) | 1995-09-25 |
| NO303782B1 (no) | 1998-08-31 |
| US5578620A (en) | 1996-11-26 |
| AU682435B2 (en) | 1997-10-02 |
| EP0678511A2 (en) | 1995-10-25 |
| EP0678511A3 (en) | 1998-06-10 |
| TW363959B (en) | 1999-07-11 |
| ZA952383B (en) | 1995-12-14 |
| IL113084A0 (en) | 1995-06-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5688823A (en) | Thiazolidine and oxazolidine derivatives their preparation and their medical use | |
| RU2151145C1 (ru) | Промежуточное соединение для получения гетероциклических соединений, обладающих антидиабетической активностью | |
| EP0543662B1 (en) | Aromatic amino-alcohol derivatives having anti-diabetic and anti-obesity properties, their preparation and their therapeutic uses | |
| US5436257A (en) | Oxazolidine derivatives having anti-diabetic and anti-obesity properties, their preparation and their therapeutic uses | |
| DE69723869T2 (de) | Heterozyklische verbindungen, verfahren zu ihrer herstellung, pharmazeutische zusammensetzungen die diese enthalten und ihre anwendung in der behandlung von diabetis und verwandten krankheiten | |
| US6288095B1 (en) | Compounds | |
| RU2456276C2 (ru) | Бензимидазольные производные, фармацевтическая композиция на их основе и способы их применения | |
| HRP20040810A2 (en) | Thiazole and oxazole derivatives that modulate ppar activity | |
| HU211901A9 (en) | Oxazolidine derivative and pharmaceutically acceptable salt thereof | |
| IE59335B1 (en) | Benzoxazole derivatives and preparation thereof | |
| WO2007081091A1 (en) | Rhodandse derivarives, a process for the preparation thereof and pharmaceutical composition containing the same | |
| AU765005B2 (en) | Polymorph of 5-(4-(2- (N-methyl-N-( 2-pyridyl)amino) ethoxy)benzyl) thiazolidine-2,4-dione, maleic acid salt | |
| EP2354137A1 (en) | Urea derivatives, methods for their manufacture, and uses thereof | |
| US6686475B2 (en) | Compounds | |
| JP2007210974A (ja) | 置換されたウレア化合物を含有する医薬 | |
| US8450494B2 (en) | Disubstituted benzamide derivatives as glucokinase (GK) activators | |
| US20120184544A1 (en) | Substituted benzamide derivatives as glucokinase (gk) activators | |
| RU2118319C1 (ru) | Производные тиазолидина, фармацевтическая композиция, обладающая гипогликемической и гиполипемической активностью и активностью ингибирования альдозоредуктазы, и способ лечения и профилактики заболеваний млекопитающих | |
| JPH09221481A (ja) | 芳香族化合物を含有する医薬 | |
| JPH07330710A (ja) | 芳香族化合物 | |
| EP0894089B1 (en) | Novel heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them | |
| EP1325000B1 (en) | A thiazolidinedione derivative and its use as antidiabetic | |
| US20040214866A1 (en) | Sodium salts of 5-'4-'2-(N-methyl-N-(2-pyridyl)amino)ethoxy!benzyl!thiazolidine-2, 4-dione |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |