IL112677A - Pharmaceutical composition for treating autoimmune conditions comprising a therapeutically effective amount of IL-12 or of an IL-12 antagonist - Google Patents
Pharmaceutical composition for treating autoimmune conditions comprising a therapeutically effective amount of IL-12 or of an IL-12 antagonistInfo
- Publication number
- IL112677A IL112677A IL11267795A IL11267795A IL112677A IL 112677 A IL112677 A IL 112677A IL 11267795 A IL11267795 A IL 11267795A IL 11267795 A IL11267795 A IL 11267795A IL 112677 A IL112677 A IL 112677A
- Authority
- IL
- Israel
- Prior art keywords
- autoimmune
- antagonist
- pharmaceutical composition
- effective amount
- therapeutically effective
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/208—IL-12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Genetics & Genomics (AREA)
- Obesity (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21262994A | 1994-03-14 | 1994-03-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
IL112677A0 IL112677A0 (en) | 1995-05-26 |
IL112677A true IL112677A (en) | 2000-01-31 |
Family
ID=22791827
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL11267795A IL112677A (en) | 1994-03-14 | 1995-02-16 | Pharmaceutical composition for treating autoimmune conditions comprising a therapeutically effective amount of IL-12 or of an IL-12 antagonist |
Country Status (14)
Country | Link |
---|---|
US (1) | US6338848B1 (fr) |
EP (4) | EP2311484A1 (fr) |
JP (1) | JP3798426B2 (fr) |
AT (1) | ATE217533T1 (fr) |
AU (1) | AU689236B2 (fr) |
CA (1) | CA2185565C (fr) |
DE (1) | DE69526728T3 (fr) |
DK (1) | DK0750509T4 (fr) |
ES (1) | ES2173953T5 (fr) |
IL (1) | IL112677A (fr) |
PT (1) | PT750509E (fr) |
TW (1) | TW400233B (fr) |
WO (1) | WO1995024918A1 (fr) |
ZA (1) | ZA95960B (fr) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6683046B1 (en) | 1989-12-22 | 2004-01-27 | Hoffmann-La Roche Inc. | Purification and characterization of cytotoxic lymphocyte maturation factor and monoclonal antibodies thereto |
US6706264B1 (en) | 1994-03-14 | 2004-03-16 | Genetics Institute, Llc | Use of IL-12 antagonists in the treatment of conditions promoted by an increase in levels of IFN-y |
US20010055581A1 (en) * | 1994-03-18 | 2001-12-27 | Lawrence Tamarkin | Composition and method for delivery of biologically-active factors |
US5853697A (en) * | 1995-10-25 | 1998-12-29 | The United States Of America, As Represented By The Department Of Health & Human Services | Methods of treating established colitis using antibodies against IL-12 |
PT936923E (pt) * | 1996-11-15 | 2004-04-30 | Kennedy Inst Of Rheumatology | Supressao de tnfalfa e il-12 em terapia |
US6054487A (en) * | 1997-03-18 | 2000-04-25 | Basf Aktiengesellschaft | Methods and compositions for modulating responsiveness to corticosteroids |
US7229841B2 (en) | 2001-04-30 | 2007-06-12 | Cytimmune Sciences, Inc. | Colloidal metal compositions and methods |
US7026456B1 (en) | 1998-01-23 | 2006-04-11 | Hoffman-La Roche, Inc. | Antibodies against human IL-12 |
ATE357459T1 (de) * | 1998-01-23 | 2007-04-15 | Hoffmann La Roche | Antikörper gegen mensliches il-12 |
CA2353520C (fr) * | 1998-12-09 | 2006-04-25 | Protein Design Labs, Inc. | Modele animal du psoriasis destine a la prevention et au traitement du psoriasis humain |
EP1176140B1 (fr) | 1999-02-10 | 2004-12-29 | Mitsubishi Pharma Corporation | Composes amide et leur utilisation medicinale |
US6914128B1 (en) | 1999-03-25 | 2005-07-05 | Abbott Gmbh & Co. Kg | Human antibodies that bind human IL-12 and methods for producing |
AU2005200515B2 (en) * | 1999-03-25 | 2006-07-13 | AbbVie Deutschland GmbH & Co. KG | Human antibodies that bind human IL-12 and methods for producing |
TR200102715T2 (tr) * | 1999-03-25 | 2002-09-23 | Knoll Gmbh | Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler. |
US7883704B2 (en) | 1999-03-25 | 2011-02-08 | Abbott Gmbh & Co. Kg | Methods for inhibiting the activity of the P40 subunit of human IL-12 |
JP4676049B2 (ja) * | 1999-07-21 | 2011-04-27 | 生化学工業株式会社 | Il−12産生抑制剤 |
US6346247B1 (en) * | 1999-10-28 | 2002-02-12 | Promega Corporation | Prevention and treatment of autoimmune disease with luminally administered polyclonal antibodies |
US7115712B1 (en) | 1999-12-02 | 2006-10-03 | Maxygen, Inc. | Cytokine polypeptides |
US6902734B2 (en) * | 2000-08-07 | 2005-06-07 | Centocor, Inc. | Anti-IL-12 antibodies and compositions thereof |
US20040018195A1 (en) * | 2002-03-26 | 2004-01-29 | Griswold Don Edgar | Diabetes-related immunoglobulin derived proteins, compositions, methods and uses |
AU2004311630A1 (en) | 2003-12-02 | 2005-07-21 | Cytimmune Sciences, Inc. | Methods and compositions for the production of monoclonal antibodies |
GB0329146D0 (en) * | 2003-12-16 | 2004-01-21 | Glaxosmithkline Biolog Sa | Vaccine |
US20070178520A1 (en) * | 2004-02-27 | 2007-08-02 | Barbara Wolff-Winiski | Screening assay for modulators of interaction between interleukin-12 and/or -23 with their receptors |
US20060024725A1 (en) * | 2004-07-30 | 2006-02-02 | Robert Hussa | Oncofetal fibronectin as a marker for pregnancy-related indications |
CN101120087A (zh) | 2004-12-21 | 2008-02-06 | 森托科尔公司 | 抗-il-12抗体、表位、组合物、方法和用途 |
EP2500355A3 (fr) | 2005-08-19 | 2012-10-24 | Abbott Laboratories | Immunoglobuline à double domaine variable et ses utilisations |
US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
SG2014010029A (en) | 2005-08-19 | 2014-08-28 | Abbott Lab | Dual variable domain immunoglobin and uses thereof |
SG177982A1 (en) | 2007-01-16 | 2012-02-28 | Abbott Lab | Methods for treating psoriasis |
US8168760B2 (en) | 2007-03-29 | 2012-05-01 | Abbott Laboratories | Crystalline anti-human IL-12 antibodies |
EP2274333A4 (fr) | 2008-03-18 | 2011-06-15 | Abbott Lab | Procédé de traitement de psoriasis |
KR20110014607A (ko) | 2008-04-29 | 2011-02-11 | 아보트 러보러터리즈 | 이원 가변 도메인 면역글로불린 및 이의 용도 |
EP2297208A4 (fr) | 2008-06-03 | 2012-07-11 | Abbott Lab | Immunoglobulines à double domaine variable et leurs utilisations |
NZ589434A (en) | 2008-06-03 | 2012-11-30 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
CA2729949A1 (fr) | 2008-07-08 | 2010-01-14 | Abbott Laboratories | Immunoglobulines a double domaine variable de prostaglandine e2 et leurs utilisations |
US20110243938A1 (en) * | 2008-09-30 | 2011-10-06 | Baylor Research Intitute | Methods to Reduce B-Helper T Cells to Treat Autoimmune Diseases |
NZ592644A (en) * | 2008-11-28 | 2013-09-27 | Abbott Lab | Stable antibody compositions and methods for stabilizing same |
BR112012004710A2 (pt) | 2009-09-01 | 2016-08-16 | Abbott Lab | imunoglobulinas de domínio variável duplo e uso das mesmas |
RU2012114854A (ru) | 2009-09-14 | 2013-10-27 | Эбботт Лэборетриз | Способы лечения псориаза |
MX2012004415A (es) | 2009-10-15 | 2012-05-08 | Abbott Lab | Inmunoglobulinas de dominio variable doble y usos de las mismas. |
UY32979A (es) | 2009-10-28 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
WO2011051466A1 (fr) | 2009-11-02 | 2011-05-05 | Novartis Ag | Molécules de liaison anti-idiotypiques à base de fibronectine et leurs utilisations |
WO2012006500A2 (fr) | 2010-07-08 | 2012-01-12 | Abbott Laboratories | Anticorps monoclonaux contre la protéine de capside du virus de l'hépatite c |
UY33492A (es) | 2010-07-09 | 2012-01-31 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
AU2011285852B2 (en) | 2010-08-03 | 2014-12-11 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
PE20140229A1 (es) | 2010-08-26 | 2014-03-27 | Abbvie Inc | Inmunoglobulinas con dominio variable dual y usos de las mismas |
US8962317B2 (en) | 2010-09-28 | 2015-02-24 | Neumedicines, Inc. | Uses of IL-12 and the IL-12 receptor positive cell in tissue repair and regeneration |
CA2821976A1 (fr) | 2010-12-21 | 2012-09-13 | Abbvie Inc. | Immunoglobulines a double domaine variable et leurs utilisations |
CA2836473C (fr) | 2011-05-19 | 2020-07-14 | Rush University Medical Center | Monomere p40 il-12, anticorps monoclonal dirige contre l'homodimere p40 et combinaison des deux pour traiter une maladie autoimmune |
CA2843014C (fr) * | 2011-07-27 | 2020-01-21 | Neumedicines, Inc. | Utilisation d'il-12 pour generer de l'erythropoietine endogene |
AU2012362326A1 (en) | 2011-12-30 | 2014-07-24 | Abbvie Inc. | Dual variable domain immunoglobulins against IL-13 and/or IL-17 |
SG11201503412RA (en) | 2012-11-01 | 2015-05-28 | Abbvie Inc | Anti-vegf/dll4 dual variable domain immunoglobulins and uses thereof |
JP2016522793A (ja) | 2013-03-15 | 2016-08-04 | アッヴィ・インコーポレイテッド | IL−1βおよび/またはIL−17に対して指向された二重特異的結合タンパク質 |
WO2016094881A2 (fr) | 2014-12-11 | 2016-06-16 | Abbvie Inc. | Protéines de liaison à lrp-8 |
TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗vegf、pdgf及/或其受體之結合蛋白 |
US10765724B2 (en) | 2016-03-29 | 2020-09-08 | Janssen Biotech, Inc. | Method of treating psoriasis with increased interval dosing of anti-IL12/23 antibody |
TW201922780A (zh) * | 2017-09-25 | 2019-06-16 | 美商健生生物科技公司 | 以抗il12/il23抗體治療狼瘡之安全且有效之方法 |
EP3793521A4 (fr) | 2018-05-18 | 2022-02-23 | Janssen Biotech, Inc. | Méthode sûre et efficace de traitement du lupus avec un anticorps anti-il12/il23 |
CA3113837C (fr) | 2018-09-24 | 2022-07-12 | Janssen Biotech, Inc. | Methode sure et efficace de traitement de la rectocolite hemorragique avec un anticorps anti-il12/il23 |
CN113874073A (zh) | 2019-05-23 | 2021-12-31 | 詹森生物科技公司 | 用针对IL-23和TNFα的抗体的联合疗法治疗炎性肠病的方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5457038A (en) * | 1988-11-10 | 1995-10-10 | Genetics Institute, Inc. | Natural killer stimulatory factor |
ATE366311T1 (de) | 1989-12-22 | 2007-07-15 | Hoffmann La Roche | Zytotoxischer lymphozyten-reifefaktor 35kd untereinheit und monoklonale antikörper spezifisch dafür |
GB9207732D0 (en) * | 1992-04-06 | 1992-05-27 | Isis Innovation | Wound repair |
DE4315127A1 (de) * | 1993-05-07 | 1994-11-10 | Behringwerke Ag | Arzneimittel enthaltend die Untereinheit p40 von Interleukin-12 |
CA2125763C (fr) * | 1993-07-02 | 2007-08-28 | Maurice Kent Gately | Homodimere p40 de l'interleukine-12 |
US5536657A (en) * | 1993-07-19 | 1996-07-16 | Hoffmann-La Roche Inc. | Recombinant DNA encoding human receptor for interleukin-12 |
EP0638644A1 (fr) * | 1993-07-19 | 1995-02-15 | F. Hoffmann-La Roche Ag | Récepteurs de l'interleukine 12 et anticorps |
US5853721A (en) * | 1995-01-31 | 1998-12-29 | Hoffmann-La Roche Inc. | Antibody to interleukin-12 receptor |
DK0929578T3 (da) * | 1996-02-09 | 2003-08-25 | Abbott Lab Bermuda Ltd | Humane antistoffer, der binder human TNFalfa |
US5969102A (en) * | 1997-03-03 | 1999-10-19 | St. Jude Children's Research Hospital | Lymphocyte surface receptor that binds CAML, nucleic acids encoding the same and methods of use thereof |
BR9810409A (pt) * | 1997-03-18 | 2000-08-22 | Basf Ag | Métodos e composições para a modulação de responsividade a corticosteróides |
US6054487A (en) * | 1997-03-18 | 2000-04-25 | Basf Aktiengesellschaft | Methods and compositions for modulating responsiveness to corticosteroids |
ATE357459T1 (de) * | 1998-01-23 | 2007-04-15 | Hoffmann La Roche | Antikörper gegen mensliches il-12 |
US8700033B2 (en) | 2008-08-22 | 2014-04-15 | International Business Machines Corporation | Dynamic access to radio networks |
CN102377479B (zh) | 2010-08-11 | 2015-01-21 | 华为技术有限公司 | 数据同步方法及系统、光网络单元 |
-
1995
- 1995-02-07 ZA ZA95960A patent/ZA95960B/xx unknown
- 1995-02-14 TW TW084101380A patent/TW400233B/zh not_active IP Right Cessation
- 1995-02-16 IL IL11267795A patent/IL112677A/xx not_active IP Right Cessation
- 1995-03-07 WO PCT/US1995/002550 patent/WO1995024918A1/fr active IP Right Grant
- 1995-03-07 EP EP10184543A patent/EP2311484A1/fr not_active Withdrawn
- 1995-03-07 DE DE69526728T patent/DE69526728T3/de not_active Expired - Lifetime
- 1995-03-07 EP EP10156687A patent/EP2201959A3/fr not_active Withdrawn
- 1995-03-07 ES ES95912666T patent/ES2173953T5/es not_active Expired - Lifetime
- 1995-03-07 EP EP95912666A patent/EP0750509B2/fr not_active Expired - Lifetime
- 1995-03-07 CA CA002185565A patent/CA2185565C/fr not_active Expired - Lifetime
- 1995-03-07 EP EP01117762A patent/EP1179348A3/fr not_active Withdrawn
- 1995-03-07 AU AU19749/95A patent/AU689236B2/en not_active Expired
- 1995-03-07 JP JP52404495A patent/JP3798426B2/ja not_active Expired - Lifetime
- 1995-03-07 AT AT95912666T patent/ATE217533T1/de active
- 1995-03-07 DK DK95912666T patent/DK0750509T4/da active
- 1995-03-07 PT PT95912666T patent/PT750509E/pt unknown
-
2000
- 2000-02-25 US US09/513,380 patent/US6338848B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE217533T1 (de) | 2002-06-15 |
JP3798426B2 (ja) | 2006-07-19 |
CA2185565C (fr) | 2009-02-03 |
US6338848B1 (en) | 2002-01-15 |
JPH09510444A (ja) | 1997-10-21 |
EP0750509B1 (fr) | 2002-05-15 |
DE69526728T2 (de) | 2002-11-21 |
EP0750509A1 (fr) | 1997-01-02 |
DE69526728D1 (de) | 2002-06-20 |
AU1974995A (en) | 1995-10-03 |
CA2185565A1 (fr) | 1995-09-21 |
EP2311484A1 (fr) | 2011-04-20 |
EP0750509B2 (fr) | 2006-06-14 |
DK0750509T3 (da) | 2002-07-08 |
AU689236B2 (en) | 1998-03-26 |
ZA95960B (en) | 1995-10-10 |
TW400233B (en) | 2000-08-01 |
EP1179348A3 (fr) | 2003-12-03 |
EP2201959A3 (fr) | 2011-03-16 |
EP1179348A2 (fr) | 2002-02-13 |
WO1995024918A1 (fr) | 1995-09-21 |
DK0750509T4 (da) | 2006-10-16 |
PT750509E (pt) | 2002-08-30 |
EP2201959A2 (fr) | 2010-06-30 |
ES2173953T3 (es) | 2002-11-01 |
DE69526728T3 (de) | 2007-01-04 |
IL112677A0 (en) | 1995-05-26 |
ES2173953T5 (es) | 2007-03-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL112677A (en) | Pharmaceutical composition for treating autoimmune conditions comprising a therapeutically effective amount of IL-12 or of an IL-12 antagonist | |
ATE411029T1 (de) | Estrogene als antimitotika | |
UA37244C2 (uk) | Спосіб лікування або профілактики клінічних розладів, виліковних прогестероном, у пацієнтів жіночої статі | |
DK0754048T3 (da) | Behandling af partielt væksthormon-insentivitetssyndrom | |
GB2063671B (en) | Composition for the treatment of keratin fibred based on amphoteric polymers and cationic polymers | |
AU2840789A (en) | Continuous release pharmaceutical compositions | |
DK0610595T3 (da) | Sammensætning af L-DOPA-estere | |
CA2116559A1 (fr) | Traitement pour prevenir la perte de et/ou augmenter la masse osseuse des maladies metaboliques des os | |
WO1994007535A3 (fr) | Interleukine-8 marquee et ses utilisations medicales | |
WO1997003188A3 (fr) | Utilisation de mp52 ou de mp121 pour la therapie et la prophylaxie de maladies du systeme nerveux | |
DK0763361T3 (da) | Mycobacterium vaccae til behandling af langsigtede autoimmune tilstande | |
JPS55113865A (en) | Leveling aging method for age hardening type titanium alloy member | |
CA2023560A1 (fr) | Anilides de l'acide 5-methyle-isoxazole-4-carboxylique et anilides de l'acide 2-hydroxyethylidene-cyano acetique pour le traitement des affections oculaires | |
JPS6425717A (en) | Method and apparatus for preventing organic nitric acid ester resistance | |
BE893492A (fr) | Procede de preparation d'esters d'acides apovincaminiques, esters ainsi obtenus et compositions pharmaceutiques prepares avec ces esters | |
OA08298A (fr) | Nouvelles N-(aminométhyl-5 oxazolin-2 yl-2) N'-phénylurées, leur méthode de préparation ainsi que leur application thérapeutique. | |
WO1989005146A3 (fr) | Methode de traitement de la dyslipidemie chez les etres humains | |
Shimoda et al. | Follow-up Study of Splinting for Pollux Rigidus | |
FR2703680B1 (fr) | Structure cristalline d'halogénure de 2-amino-5-nitropyridinium, procédé de préparation desdites structures cristallines, et dispositif à effet électrooptique comportant de telles structures. | |
Dixon | The age of Cimon: the Delian League's foundation and early history | |
FR2696180B1 (fr) | Nouvelles céphalosporines comportant en position 7, un radical benzyloxyimino substitué, leur procédé de préparation et leur application comme médicaments. | |
Pashchenko | The Effect of Strain Rate on Uniform Elongation of a Low Carbon Steel | |
Ebihara | Clinical study on immunologic abnormalities and autoimmune diseases associated with pneumoconiosis.(Rep. 3). Four cases of RA, three cases of PSS and one case of adjuvant disease. | |
JPS5451910A (en) | Soaking method | |
PT74021A (en) | Process for preparing polymers for controlling body weight of animals and pharmaceutical compositions thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
HC | Change of name of proprietor(s) | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
EXP | Patent expired |