IL112112A - Peptides with growth hormone releasing properties and pharmaceutical compositions containing them - Google Patents

Peptides with growth hormone releasing properties and pharmaceutical compositions containing them

Info

Publication number
IL112112A
IL112112A IL11211294A IL11211294A IL112112A IL 112112 A IL112112 A IL 112112A IL 11211294 A IL11211294 A IL 11211294A IL 11211294 A IL11211294 A IL 11211294A IL 112112 A IL112112 A IL 112112A
Authority
IL
Israel
Prior art keywords
growth hormone
peptides
pharmaceutical compositions
compositions containing
hormone releasing
Prior art date
Application number
IL11211294A
Other languages
English (en)
Other versions
IL112112A0 (en
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK143993A external-priority patent/DK143993D0/da
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of IL112112A0 publication Critical patent/IL112112A0/xx
Publication of IL112112A publication Critical patent/IL112112A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Psychiatry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL11211294A 1993-12-23 1994-12-22 Peptides with growth hormone releasing properties and pharmaceutical compositions containing them IL112112A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK143993A DK143993D0 (cs) 1993-12-23 1993-12-23
DK12194 1994-01-28
DK119194 1994-10-14

Publications (2)

Publication Number Publication Date
IL112112A0 IL112112A0 (en) 1995-03-15
IL112112A true IL112112A (en) 2000-06-29

Family

ID=27220421

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11211294A IL112112A (en) 1993-12-23 1994-12-22 Peptides with growth hormone releasing properties and pharmaceutical compositions containing them

Country Status (27)

Country Link
US (1) US5767085A (cs)
EP (1) EP0736039B1 (cs)
JP (1) JP3181918B2 (cs)
KR (1) KR100354897B1 (cs)
CN (1) CN1052731C (cs)
AT (1) ATE197158T1 (cs)
AU (1) AU689181B2 (cs)
BR (1) BR9408377A (cs)
CA (1) CA2179597A1 (cs)
CZ (1) CZ293113B6 (cs)
DE (1) DE69426206T2 (cs)
DK (1) DK0736039T3 (cs)
ES (1) ES2153469T3 (cs)
FI (1) FI962584A0 (cs)
GR (1) GR3035150T3 (cs)
HU (1) HU224345B1 (cs)
IL (1) IL112112A (cs)
MX (1) MX9500072A (cs)
NO (1) NO315561B1 (cs)
NZ (1) NZ277486A (cs)
PL (1) PL181280B1 (cs)
PT (1) PT736039E (cs)
RO (1) RO115635B1 (cs)
SG (1) SG55069A1 (cs)
SK (1) SK281963B6 (cs)
UA (1) UA42747C2 (cs)
WO (1) WO1995017423A1 (cs)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7094869B2 (en) 1994-11-16 2006-08-22 Genentech, Inc. Low molecular weight peptidomimetic growth hormone secretagogues

Families Citing this family (55)

* Cited by examiner, † Cited by third party
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JPH09505601A (ja) * 1993-11-24 1997-06-03 メルク エンド カンパニー インコーポレーテッド インドリル基含有化合物類および成長ホルモン放出を促進するためのそれらの使用
PL181286B1 (pl) * 1993-12-23 2001-07-31 Novo Nordisk As Zwiazki o wlasciwosciach uwalniania hormonu wzrostu i zawierajace je kompozycje farmaceutyczne PL PL PL PL PL PL PL PL
US5798337A (en) * 1994-11-16 1998-08-25 Genentech, Inc. Low molecular weight peptidomimetic growth hormone secretagogues
DE69633003T2 (de) * 1995-01-27 2005-08-18 Novo Nordisk A/S Verbindungen mit wachstumshormon-freisetzenden eigenschaften
AU711104B2 (en) * 1995-06-22 1999-10-07 Novo Nordisk A/S Compounds with growth hormone releasing properties
US6531314B1 (en) 1996-12-10 2003-03-11 Merck & Co., Inc. Growth hormone secretagogue receptor family
CA2240186A1 (en) 1995-12-13 1997-06-19 Merck & Co., Inc. Assays for growth hormone secretagogue receptors
GB2308362A (en) * 1995-12-19 1997-06-25 Lilly Industries Ltd Pharmaceutical indole derivatives
ES2323159T3 (es) * 1995-12-22 2009-07-07 Novo Nordisk A/S Compuestos con propiedades de liberacion de la hormona del crecimiento.
US6451970B1 (en) 1996-02-21 2002-09-17 Novo Nordisk A/S Peptide derivatives
CZ291982B6 (cs) * 1996-04-24 2003-06-18 Novo Nordisk A/S Diamidový derivát uvolňující růstový hormon, jeho použití, farmaceutické prostředky ho obsahující a způsob stimulace uvolňování růstového hormonu
US5919777A (en) * 1996-04-24 1999-07-06 Novo Nordisk A/S Compounds with growth hormone releasing properties
US5922770A (en) 1996-07-22 1999-07-13 Novo Nordisk A/S Compounds with growth hormone releasing properties
WO1998008492A1 (en) * 1996-08-29 1998-03-05 Novo Nordisk A/S Transdermal delivery of peptides
US6420518B1 (en) 1997-04-04 2002-07-16 Genetech, Inc. Insulin-like growth factor agonist molecules
US6121416A (en) 1997-04-04 2000-09-19 Genentech, Inc. Insulin-like growth factor agonist molecules
US6127341A (en) * 1997-06-20 2000-10-03 Novo Nordisk A/S Compounds with growth hormone releasing properties
EP1005484A1 (en) 1997-06-20 2000-06-07 Novo Nordisk A/S Compounds with growth hormone releasing properties
HUP0100777A3 (en) 1998-01-16 2001-12-28 Novo Nordisk As Tripeptides with growth hormone releasing properties, pharmaceutical compositions comprising thereof and their use
US6919315B1 (en) 1998-06-30 2005-07-19 Novo Nordisk A/S Compounds with growth hormone releasing properties
US6682908B1 (en) 1998-07-10 2004-01-27 Merck & Co., Inc. Mouse growth hormone secretagogue receptor
EP1097170A1 (en) 1998-07-13 2001-05-09 Merck & Co., Inc. Growth hormone secretagogue related receptors and nucleic acids
JP2002522058A (ja) 1998-08-10 2002-07-23 メルク・アンド・カンパニー・インコーポレーテッド イヌ成長ホルモン分泌促進物質受容体
US6696063B1 (en) 1998-12-30 2004-02-24 Applied Research Systems Ars Holding N.V. Treatment of HIV-associated dysmorphia/dysmetabolic syndrome (HADDS) with or without lipodystrophy
IL143866A0 (en) 1999-01-06 2002-04-21 Genentech Inc Insulin-like growth factor (igf) i mutant variants
JP2002542151A (ja) * 1999-02-18 2002-12-10 科研製薬株式会社 成長ホルモン分泌促進物質としての新規なアミド誘導体
WO2000074702A1 (en) * 1999-06-04 2000-12-14 Novo Nordisk A/S Compositions for the treatment of the catabolic state of prolonged critical illness
ES2301547T3 (es) 2000-05-16 2008-07-01 Genentech, Inc. Tratamiento de trastornos del cartilago.
ES2333097T3 (es) 2000-05-31 2010-02-17 Raqualia Pharma Inc Uso de secretagogos de la hormona de crecimiento para estimular la motilidad gastrointestinal.
TWI331922B (en) 2002-08-09 2010-10-21 Ipsen Pharma Sas Growth hormone releasing peptides
JP2007513065A (ja) * 2003-05-19 2007-05-24 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー 粒径が制御された酸化チタンを含むハードゼラチンカプセルおよびそれを製造する方法
US7476653B2 (en) 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
PT2274978E (pt) 2003-09-12 2015-07-09 Ipsen Biopharmaceuticals Inc Métodos para tratamento da deficiência do fator de crescimento de tipo insulina i (igf-i)
WO2005027913A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a growth hormone secretagogue
WO2005097261A1 (en) * 2004-03-30 2005-10-20 Sapphire Therapeutics, Inc. Method of reducing c-reactive protein using growth hormone secretagogues
UA87854C2 (en) 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
JP2008509930A (ja) * 2004-08-12 2008-04-03 サファイア セラピューティクス インコーポレイテッド 成長ホルモン分泌促進物質を利用して胃腸系の運動性を刺激する方法
CU23558A1 (es) 2006-02-28 2010-07-20 Ct Ingenieria Genetica Biotech Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento
US8536120B2 (en) * 2006-04-28 2013-09-17 The Administrators Of The Tulane Educational Fund Ghrelin/growth hormone releasing peptide/growth hormone secretatogue receptor antagonists and uses thereof
ES2602789T3 (es) 2007-02-09 2017-02-22 Ocera Therapeutics, Inc. Productos intermedios conectores para la síntesis de moduladores macrocíclicos del receptor de la grelina
AU2008216789A1 (en) * 2007-02-13 2008-08-21 Helsinn Therapeutics (U.S.), Inc. Method of treating cell proliferative disorders using growth hormone secretagogues
TWI429436B (zh) * 2007-04-10 2014-03-11 Helsinn Therapeutics Us Inc 使用生長激素促泌素治療或預防嘔吐之方法
EP2155769B1 (en) 2007-05-04 2012-06-27 Katholieke Universiteit Leuven KU Leuven Research & Development Tissue degeneration protection
CA2710039C (en) 2007-12-26 2018-07-03 Critical Outcome Technologies, Inc. Semicarbazones, thiosemicarbazones and related compounds and methods for treatment of cancer
EP3023426A1 (en) 2008-07-17 2016-05-25 Critical Outcome Technologies, Inc. Thiosemicarbazone inhibitor compounds and cancer treatment methods
UA105657C2 (uk) * 2009-02-27 2014-06-10 Хелсінн Терапьютікс (Ю.Ес.), Інк. Поліпшені способи лікування мігрені на основі анамореліну
US9724381B2 (en) 2009-05-12 2017-08-08 The Administrators Of The Tulane Educational Fund Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof
CN102481251A (zh) 2009-06-12 2012-05-30 赫尔辛医疗（美国）有限公司 伊帕瑞林双乙酸盐注射液和输注液
EP3235818A3 (en) 2010-04-01 2018-03-14 Critical Outcome Technologies, Inc. Compounds for the treatment of hiv
WO2013190520A2 (en) 2012-06-22 2013-12-27 The General Hospital Corporation Gh-releasing agents in the treatment of vascular stenosis and associated conditions
US9119832B2 (en) 2014-02-05 2015-09-01 The Regents Of The University Of California Methods of treating mild brain injury
AU2015265571A1 (en) 2014-05-30 2016-11-17 Pfizer Inc. Carbonitrile derivatives as selective androgen receptor modulators
US20170121385A1 (en) 2015-10-28 2017-05-04 Oxeia Biopharmaceuticals, Inc. Methods of treating neurodegenerative conditions
US12012467B2 (en) 2017-03-28 2024-06-18 Regents Of The University Of Michigan Small molecule DCN1 inhibitors and therapeutic methods using the same
WO2023275715A1 (en) 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators

Family Cites Families (10)

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US4223020A (en) * 1979-03-30 1980-09-16 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4223019A (en) * 1979-03-30 1980-09-16 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4228156A (en) * 1979-03-30 1980-10-14 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4410512A (en) * 1981-12-28 1983-10-18 Beckman Instruments, Inc. Combinations having synergistic pituitary growth hormone releasing activity
WO1983002272A1 (en) * 1981-12-28 1983-07-07 Beckman Instruments Inc Synthetic peptides having pituitary growth hormone releasing activity
US4803261A (en) * 1986-06-27 1989-02-07 The Administrators Of The Tulane Educational Fund Method for synthesizing a peptide containing a non-peptide
IL98910A0 (en) * 1990-07-24 1992-07-15 Polygen Holding Corp Polypeptide compounds having growth hormone releasing activity and pharmaceutical compositions containing them
US5663146A (en) * 1991-08-22 1997-09-02 Administrators Of The Tulane Educational Fund Polypeptide analogues having growth hormone releasing activity
JPH08502250A (ja) * 1992-09-25 1996-03-12 スミスクライン・ビーチャム・コーポレイション 成長ホルモン放出ペプチド
JPH09505601A (ja) * 1993-11-24 1997-06-03 メルク エンド カンパニー インコーポレーテッド インドリル基含有化合物類および成長ホルモン放出を促進するためのそれらの使用

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7094869B2 (en) 1994-11-16 2006-08-22 Genentech, Inc. Low molecular weight peptidomimetic growth hormone secretagogues

Also Published As

Publication number Publication date
SK281963B6 (sk) 2001-09-11
HUT73497A (en) 1996-08-28
KR100354897B1 (ko) 2003-01-06
WO1995017423A1 (en) 1995-06-29
NZ277486A (en) 1997-03-24
BR9408377A (pt) 1997-08-19
AU1272495A (en) 1995-07-10
GR3035150T3 (en) 2001-04-30
JPH09507217A (ja) 1997-07-22
AU689181B2 (en) 1998-03-26
EP0736039A1 (en) 1996-10-09
DE69426206T2 (de) 2001-05-17
IL112112A0 (en) 1995-03-15
ATE197158T1 (de) 2000-11-15
HU224345B1 (hu) 2005-08-29
FI962584L (fi) 1996-06-20
DK0736039T3 (da) 2001-02-12
CZ183496A3 (en) 1997-02-12
FI962584A7 (fi) 1996-06-20
MX9500072A (es) 1997-05-31
FI962584A0 (fi) 1996-06-20
PL315113A1 (en) 1996-10-14
SG55069A1 (en) 1998-12-21
CA2179597A1 (en) 1995-06-29
HU9501947D0 (en) 1995-11-28
US5767085A (en) 1998-06-16
RO115635B1 (ro) 2000-04-28
UA42747C2 (uk) 2001-11-15
EP0736039B1 (en) 2000-10-25
SK82096A3 (en) 1997-01-08
ES2153469T3 (es) 2001-03-01
CZ293113B6 (cs) 2004-02-18
PL181280B1 (pl) 2001-07-31
NO962665L (no) 1996-08-23
PT736039E (pt) 2001-04-30
DE69426206D1 (de) 2000-11-30
NO315561B1 (no) 2003-09-22
JP3181918B2 (ja) 2001-07-03
NO962665D0 (no) 1996-06-21
CN1052731C (zh) 2000-05-24
CN1138335A (zh) 1996-12-18

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