IL112088A - Stable stem cell factor formulations with improved stability and methods for their production - Google Patents
Stable stem cell factor formulations with improved stability and methods for their productionInfo
- Publication number
- IL112088A IL112088A IL11208894A IL11208894A IL112088A IL 112088 A IL112088 A IL 112088A IL 11208894 A IL11208894 A IL 11208894A IL 11208894 A IL11208894 A IL 11208894A IL 112088 A IL112088 A IL 112088A
- Authority
- IL
- Israel
- Prior art keywords
- scf
- formulations
- formulation
- lyophilized
- sucrose
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/172,507 US6288030B1 (en) | 1993-12-22 | 1993-12-22 | Stem cell factor formulations and methods |
Publications (2)
Publication Number | Publication Date |
---|---|
IL112088A0 IL112088A0 (en) | 1995-03-15 |
IL112088A true IL112088A (en) | 2001-04-30 |
Family
ID=22627993
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL11208894A IL112088A (en) | 1993-12-22 | 1994-12-20 | Stable stem cell factor formulations with improved stability and methods for their production |
Country Status (14)
Country | Link |
---|---|
US (4) | US6288030B1 (zh) |
EP (1) | EP0732935B1 (zh) |
CN (1) | CN1105575C (zh) |
AT (1) | ATE173402T1 (zh) |
AU (1) | AU696860B2 (zh) |
CA (1) | CA2182970C (zh) |
DE (1) | DE69414723T2 (zh) |
DK (1) | DK0732935T3 (zh) |
ES (1) | ES2123951T3 (zh) |
HK (1) | HK1008815A1 (zh) |
IL (1) | IL112088A (zh) |
NZ (1) | NZ278252A (zh) |
WO (1) | WO1995017206A1 (zh) |
ZA (1) | ZA9410189B (zh) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
GB9515839D0 (en) * | 1995-08-02 | 1995-10-04 | Q One Biotech Ltd | Feline stem cell factor |
TW518219B (en) * | 1996-04-26 | 2003-01-21 | Chugai Pharmaceutical Co Ltd | Erythropoietin solution preparation |
US6017876A (en) | 1997-08-15 | 2000-01-25 | Amgen Inc. | Chemical modification of granulocyte-colony stimulating factor (G-CSF) bioactivity |
US6541033B1 (en) | 1998-06-30 | 2003-04-01 | Amgen Inc. | Thermosensitive biodegradable hydrogels for sustained delivery of leptin |
US6420339B1 (en) | 1998-10-14 | 2002-07-16 | Amgen Inc. | Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility |
US6245740B1 (en) | 1998-12-23 | 2001-06-12 | Amgen Inc. | Polyol:oil suspensions for the sustained release of proteins |
US6500418B1 (en) * | 1999-02-12 | 2002-12-31 | The Washington University | Stimulating neutrophil function to treat inflammatory bowel disease |
US8106098B2 (en) | 1999-08-09 | 2012-01-31 | The General Hospital Corporation | Protein conjugates with a water-soluble biocompatible, biodegradable polymer |
US6472208B1 (en) * | 1999-12-13 | 2002-10-29 | Héma-Québec | Method of producing human IFN-α using sendai virus-infected hematopoietic stem cells |
US20080152629A1 (en) * | 2000-12-06 | 2008-06-26 | James Edinger | Placental stem cell populations |
CA2678490A1 (en) | 2000-12-06 | 2002-06-13 | Robert J. Hariri | Isolated placental perfusate and placental cells isolated therefrom |
US7311905B2 (en) * | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
JP2004528021A (ja) * | 2001-02-14 | 2004-09-16 | アンスロジェネシス コーポレーション | 分娩後の哺乳動物の胎盤、その使用およびそれに由来する胎盤幹細胞 |
US20030191056A1 (en) | 2002-04-04 | 2003-10-09 | Kenneth Walker | Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins |
JP3963786B2 (ja) * | 2002-06-11 | 2007-08-22 | 富士通株式会社 | 情報処理装置 |
BR0316695A (pt) * | 2002-11-26 | 2005-10-18 | Anthrogenesis Corp | Unidade citoterapêutica, kit para tratamento, método de tratamento de uma enfermidade, biblioteca de unidades citoterapêuticas e método de tratamento de um paciente |
BRPI0407427A (pt) * | 2003-02-13 | 2006-01-24 | Anthrogenesis Corp | Método para tratar um paciente e para tratar a mielodisplasia |
GB0321337D0 (en) * | 2003-09-11 | 2003-10-15 | Massone Mobile Advertising Sys | Method and system for distributing advertisements |
EP1694328A4 (en) * | 2003-12-02 | 2010-02-17 | Celgene Corp | METHOD AND COMPOSITIONS FOR THE TREATMENT AND SUPPLY OF HEMOGLOBINOPATHY AND ANEMIA |
WO2005067889A1 (en) | 2003-12-30 | 2005-07-28 | Durect Corporation | Polymeric implants, preferably containing a mixture of peg and plg, for controlled release of active agents, preferably a gnrh |
US20080311078A1 (en) | 2005-06-14 | 2008-12-18 | Gokarn Yatin R | Self-Buffering Protein Formulations |
US20070190047A1 (en) * | 2005-07-29 | 2007-08-16 | Amgen, Inc. | Formulations that inhibit protein aggregation |
PE20070771A1 (es) | 2005-10-13 | 2007-08-11 | Anthrogenesis Corp | Inmunomodulacion mediante el uso de celulas madres de la placenta |
CN101389754A (zh) | 2005-12-29 | 2009-03-18 | 人类起源公司 | 胎盘干细胞和第二来源干细胞的联合培养 |
ES2708933T3 (es) | 2005-12-29 | 2019-04-12 | Celularity Inc | Poblaciones de células madre placentarias |
AR059066A1 (es) | 2006-01-27 | 2008-03-12 | Amgen Inc | Combinaciones del inhibidor de la angiopoyetina -2 (ang2) y el inhibidor del factor de crecimiento endotelial vascular (vegf) |
EP1854478A1 (en) * | 2006-05-12 | 2007-11-14 | Cytos Biotechnology AG | Nicotine-carrier vaccine formulation |
PT2084268T (pt) * | 2006-10-23 | 2019-01-28 | Celularity Inc | Métodos e composições para o tratamento de defeitos ósseos com populações de células placentárias |
RS52921B (en) * | 2007-02-12 | 2014-02-28 | Anthrogenesis Corporation | TREATMENT OF INFLAMMATORY DISEASES USING PLACENTAL CELL CELLS |
US20100172830A1 (en) * | 2007-03-29 | 2010-07-08 | Cellx Inc. | Extraembryonic Tissue cells and method of use thereof |
TWM322542U (en) * | 2007-05-23 | 2007-11-21 | Universal Scient Ind Co Ltd | Testing machine |
US9200253B1 (en) | 2007-08-06 | 2015-12-01 | Anthrogenesis Corporation | Method of producing erythrocytes |
KR20190050867A (ko) * | 2007-09-26 | 2019-05-13 | 안트로제네시스 코포레이션 | 인간 태반 관류액으로부터의 혈관형성 세포 |
ES2530995T3 (es) | 2007-09-28 | 2015-03-09 | Anthrogenesis Corp | Supresión de tumor usando perfusato placentario humano y células asesinas naturales intermediarias que provienen de placenta humana |
NO2217329T3 (zh) * | 2007-11-07 | 2018-06-09 | ||
EP2329012B1 (en) * | 2008-08-20 | 2020-05-20 | Celularity, Inc. | Treatment of stroke using isolated placental cells |
NZ591292A (en) * | 2008-08-20 | 2012-10-26 | Anthrogenesis Corp | Improved cell composition and methods of making the same |
CA2734446C (en) * | 2008-08-22 | 2017-06-20 | Anthrogenesis Corporation | Methods and compositions for treatment of bone defects with placental cell populations |
JP5869342B2 (ja) | 2008-11-19 | 2016-02-24 | アンスロジェネシス コーポレーション | 羊膜由来接着細胞 |
NZ602569A (en) * | 2008-11-21 | 2014-03-28 | Anthrogenesis Corp | Treatment of diseases, disorders or conditions of the lung using placental cells |
NZ597436A (en) * | 2009-07-02 | 2014-08-29 | Anthrogenesis Corp | Method of producing erythrocytes without feeder cells |
EP3284818B1 (en) * | 2010-01-26 | 2022-03-09 | Celularity Inc. | Treatment of bone-related cancers using placental stem cells |
TW202011974A (zh) | 2010-04-07 | 2020-04-01 | 美商安瑟吉納西斯公司 | 利用胎盤幹細胞之血管新生 |
TW201138792A (en) | 2010-04-08 | 2011-11-16 | Anthrogenesis Corp | Treatment of sarcoidosis using placental stem cells |
WO2012009422A1 (en) | 2010-07-13 | 2012-01-19 | Anthrogenesis Corporation | Methods of generating natural killer cells |
MX349054B (es) | 2010-09-28 | 2017-07-07 | Aegerion Pharmaceuticals Inc | Leptinas altamente solubles. |
AR093183A1 (es) | 2010-12-31 | 2015-05-27 | Anthrogenesis Corp | Aumento de la potencia de celulas madre de placenta usando moleculas de arn moduladoras |
TWI602570B (zh) | 2011-06-01 | 2017-10-21 | 安瑟吉納西斯公司 | 使用胎盤幹細胞之疼痛治療 |
WO2013055476A1 (en) | 2011-09-09 | 2013-04-18 | Anthrogenesis Corporation | Treatment of amyotrophic lateral sclerosis using placental stem cells |
WO2014123879A1 (en) | 2013-02-05 | 2014-08-14 | Anthrogenesis Corporation | Natural killer cells from placenta |
EP4209499A1 (en) | 2015-08-13 | 2023-07-12 | Amgen Inc. | Charged depth filtration of antigen-binding proteins |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4165370A (en) | 1976-05-21 | 1979-08-21 | Coval M L | Injectable gamma globulin |
JPS5534001A (en) * | 1978-08-28 | 1980-03-10 | Noda Sangyo Kagaku Kenkyusho | Stabilization of sarcosine oxidase |
US4783441A (en) | 1979-04-30 | 1988-11-08 | Hoechst Aktiengesellschaft | Aqueous protein solutions stable to denaturation |
EP0035204B2 (en) | 1980-03-05 | 1991-05-22 | Miles Inc. | Pasteurized therapeutically active protein compositions |
JPS5874617A (ja) | 1981-10-28 | 1983-05-06 | Green Cross Corp:The | 人由来血液凝固第7因子含有水溶液の加熱処理方法 |
JPS58134991A (ja) * | 1981-12-28 | 1983-08-11 | Takeda Chem Ind Ltd | セラチオペプチタ−ゼの安定化法 |
JPS59134730A (ja) | 1983-01-20 | 1984-08-02 | Green Cross Corp:The | 血液凝固第8因子の加熱処理法 |
FI86885C (fi) | 1984-04-20 | 1992-10-26 | Genentech Inc | Foerfarande foer framstaellning av human rekombinantfaktor viii och nukleinsyrasekvenser och vektorer anvaend daertill |
SE8501050D0 (sv) | 1985-03-05 | 1985-03-05 | Kabivitrum Ab | Biologically active fragments of human antihemophilic factor and method for preparation thereof |
CA1292686C (en) | 1986-10-27 | 1991-12-03 | Ze'ev Shaked | Pharmaceutical compositions of recombinant interleukin-2 and formulation process |
NZ226170A (en) | 1987-09-18 | 1990-07-26 | Ethicon Inc | Stable freeze-dried pharmaceutical composition containing epidermal growth factor |
CA1329760C (en) * | 1987-10-29 | 1994-05-24 | Ted C. K. Lee | Plasma and recombinant protein formulations in high ionic strength media |
US4877608A (en) * | 1987-11-09 | 1989-10-31 | Rorer Pharmaceutical Corporation | Pharmaceutical plasma protein formulations in low ionic strength media |
US5096885A (en) | 1988-04-15 | 1992-03-17 | Genentech, Inc. | Human growth hormone formulation |
EP0381345B1 (en) | 1989-01-30 | 1994-07-13 | Corint, Ltd. | Aqueous liquid desmopressin-CMC pharmaceutical composition |
JPH02268681A (ja) * | 1989-04-07 | 1990-11-02 | Green Cross Corp:The | ウロキナーゼ前駆体の安定化方法及び乾燥製剤 |
CA2028848A1 (en) * | 1989-04-11 | 1990-10-12 | Tapan Audhya | Lyophilized peptide formulations |
WO1991005795A1 (en) | 1989-10-16 | 1991-05-02 | Amgen Inc. | Stem cell factor |
DE69034258D1 (de) | 1989-10-16 | 2008-09-18 | Amgen Inc | Stamzellfaktor |
SE465222C5 (sv) | 1989-12-15 | 1998-02-10 | Pharmacia & Upjohn Ab | Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning |
DE4001451A1 (de) | 1990-01-19 | 1991-08-01 | Octapharma Ag | Stabile injizierbare loesungen von faktor viii und faktor ix |
WO1992000376A1 (en) | 1990-06-25 | 1992-01-09 | Immunex Corporation | Mast cell growth factor |
EP0618807B1 (en) * | 1991-12-20 | 2002-11-13 | Novo Nordisk A/S | A stabilized pharmaceutical formulation comprising growth hormone and histidine |
US5192743A (en) | 1992-01-16 | 1993-03-09 | Genentech, Inc. | Reconstitutable lyophilized protein formulation |
SK282483B6 (sk) * | 1992-10-02 | 2002-02-05 | Genetics Institute, Inc. | Stabilná kompozícia koagulačného faktora VIII, spôsob jej prípravy a stabilizácie |
-
1993
- 1993-12-22 US US08/172,507 patent/US6288030B1/en not_active Expired - Fee Related
-
1994
- 1994-12-20 IL IL11208894A patent/IL112088A/en not_active IP Right Cessation
- 1994-12-21 AT AT95906058T patent/ATE173402T1/de not_active IP Right Cessation
- 1994-12-21 DK DK95906058T patent/DK0732935T3/da active
- 1994-12-21 AU AU14422/95A patent/AU696860B2/en not_active Ceased
- 1994-12-21 WO PCT/US1994/014739 patent/WO1995017206A1/en active IP Right Grant
- 1994-12-21 NZ NZ278252A patent/NZ278252A/en not_active IP Right Cessation
- 1994-12-21 ES ES95906058T patent/ES2123951T3/es not_active Expired - Lifetime
- 1994-12-21 ZA ZA9410189A patent/ZA9410189B/xx unknown
- 1994-12-21 CN CN94195012A patent/CN1105575C/zh not_active Expired - Fee Related
- 1994-12-21 DE DE69414723T patent/DE69414723T2/de not_active Expired - Lifetime
- 1994-12-21 EP EP95906058A patent/EP0732935B1/en not_active Expired - Lifetime
- 1994-12-21 CA CA002182970A patent/CA2182970C/en not_active Expired - Fee Related
-
1998
- 1998-06-29 US US09/106,891 patent/US5965522A/en not_active Expired - Fee Related
- 1998-07-31 HK HK98109572A patent/HK1008815A1/xx not_active IP Right Cessation
-
1999
- 1999-04-15 US US09/292,222 patent/US6020469A/en not_active Expired - Fee Related
-
2000
- 2000-12-20 US US09/748,592 patent/US20020013258A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0732935B1 (en) | 1998-11-18 |
US20020013258A1 (en) | 2002-01-31 |
CA2182970A1 (en) | 1995-06-29 |
NZ278252A (en) | 1998-04-27 |
ES2123951T3 (es) | 1999-01-16 |
WO1995017206A1 (en) | 1995-06-29 |
AU696860B2 (en) | 1998-09-17 |
DK0732935T3 (da) | 1999-08-02 |
AU1442295A (en) | 1995-07-10 |
CN1142771A (zh) | 1997-02-12 |
US5965522A (en) | 1999-10-12 |
DE69414723D1 (de) | 1998-12-24 |
EP0732935A1 (en) | 1996-09-25 |
HK1008815A1 (en) | 1999-05-21 |
CN1105575C (zh) | 2003-04-16 |
US6020469A (en) | 2000-02-01 |
IL112088A0 (en) | 1995-03-15 |
ATE173402T1 (de) | 1998-12-15 |
ZA9410189B (en) | 1995-08-25 |
US6288030B1 (en) | 2001-09-11 |
CA2182970C (en) | 2000-11-28 |
DE69414723T2 (de) | 1999-07-22 |
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Legal Events
Date | Code | Title | Description |
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FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |