IL111581A - Cyclic amino acid derivatives pharmaceutical compositions containing them and process for their preparation - Google Patents

Cyclic amino acid derivatives pharmaceutical compositions containing them and process for their preparation

Info

Publication number
IL111581A
IL111581A IL11158194A IL11158194A IL111581A IL 111581 A IL111581 A IL 111581A IL 11158194 A IL11158194 A IL 11158194A IL 11158194 A IL11158194 A IL 11158194A IL 111581 A IL111581 A IL 111581A
Authority
IL
Israel
Prior art keywords
lower alkyl
compounds
carbocyclic
aryl
cycloalkyl
Prior art date
Application number
IL11158194A
Other languages
English (en)
Other versions
IL111581A0 (en
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/153,395 external-priority patent/US5432186A/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of IL111581A0 publication Critical patent/IL111581A0/xx
Publication of IL111581A publication Critical patent/IL111581A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)
IL11158194A 1993-11-16 1994-11-10 Cyclic amino acid derivatives pharmaceutical compositions containing them and process for their preparation IL111581A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/153,395 US5432186A (en) 1993-11-16 1993-11-16 Cyclic amino acid derivatives
US08/263,859 US5506244A (en) 1993-11-16 1994-06-22 Cyclic amino acid derivatives

Publications (2)

Publication Number Publication Date
IL111581A0 IL111581A0 (en) 1995-01-24
IL111581A true IL111581A (en) 1999-07-14

Family

ID=26850506

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11158194A IL111581A (en) 1993-11-16 1994-11-10 Cyclic amino acid derivatives pharmaceutical compositions containing them and process for their preparation

Country Status (19)

Country Link
US (1) US5668158A (no)
EP (1) EP0655461B1 (no)
JP (1) JP3647914B2 (no)
CN (1) CN1058019C (no)
AT (1) ATE193706T1 (no)
AU (1) AU687444B2 (no)
CA (1) CA2135711A1 (no)
CY (1) CY2234B1 (no)
DE (1) DE69424846T2 (no)
DK (1) DK0655461T3 (no)
ES (1) ES2148305T3 (no)
FI (1) FI118600B (no)
GR (1) GR3033829T3 (no)
HU (1) HU226300B1 (no)
IL (1) IL111581A (no)
NO (1) NO311224B1 (no)
NZ (1) NZ264913A (no)
PH (1) PH31056A (no)
PT (1) PT655461E (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1273455B (it) * 1995-01-27 1997-07-08 Zambon Spa Derivati tiolici ad attivita' inibitrice delle metallopeptidasi
JPH08325263A (ja) * 1995-05-31 1996-12-10 Sumitomo Metal Ind Ltd 新規２−アミノ−３−フェニルプロピオン酸誘導体
WO1997011717A1 (en) * 1995-09-27 1997-04-03 Novartis Ag Treatment of chronic progressive renal failure
EP0894003A4 (en) * 1996-04-12 2000-10-04 Bristol Myers Squibb Co N-FORMYL HYDROXYLAMINE-BASED COMPOUNDS SUITABLE AS INCEPTIENTS OF THE ACE ENZYME AND / OR ENDOPEPTIDASE NEP
US6777550B1 (en) 1996-04-12 2004-08-17 Bristol-Myers Squibb Company N-formyl hydroxylamine containing compounds useful as ACE inhibitors and/or NEP inhibitors
US6426354B1 (en) 1998-04-23 2002-07-30 Novartis Ag Certain heteroaryl substituted thiol inhibitors of endothelin-converting enzyme
US6423727B1 (en) 1998-04-23 2002-07-23 Novartis Ag Certain thiol inhibitors of endothelin-converting enzyme
EP1073674A1 (en) * 1998-04-23 2001-02-07 Novartis AG Thiol inhibitors of endothelin-converting enzyme
MXPA01009654A (es) * 1999-03-29 2002-05-14 Squibb Bristol Myers Co Uso de inhibidores de la vasopeptidasa para tratar la angina de pecho.
US6509330B2 (en) 2000-02-17 2003-01-21 Bristol-Myers Squibb Company Hydroxamic acid containing compounds useful as ACE inhibitors and/or NEP inhibotors
PT1430045E (pt) * 2001-09-21 2007-01-31 Novartis Ag Derivados de pirano como inibidores de ace e nep
TWI259079B (en) 2002-02-08 2006-08-01 Merck & Co Inc N-biphenyl(substituted methyl)aminocycloalkanecarboxamide derivatives
ES2256727T3 (es) 2002-02-08 2006-07-16 MERCK & CO., INC. Derivados de n-bifenilmetil aminocicloalcanocarboxamida.
US7045653B2 (en) 2002-12-23 2006-05-16 Pfizer, Inc. Pharmaceuticals
KR101406231B1 (ko) * 2007-01-10 2014-06-12 세츠코 다케다 메니에르병 치료약
CN105670160A (zh) * 2015-10-12 2016-06-15 陆思烨 一种防紫外抗老化电线电缆料及其制备方法
UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4093739A (en) * 1977-06-15 1978-06-06 Mead Johnson & Company Mercaptoacylamidobenzoyl glycine and mucolytic process
GB8820844D0 (en) * 1988-09-05 1988-10-05 Pfizer Ltd Therapeutic agents
GB9004260D0 (en) * 1990-02-26 1990-04-18 Pfizer Ltd Therapeutic agents
FR2679564A1 (fr) * 1991-07-23 1993-01-29 Inst Nat Sante Rech Med Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent.
US5208236A (en) * 1992-09-23 1993-05-04 Schering Corporation N-(acylaminomethyl)glutaryl amino acids and use

Also Published As

Publication number Publication date
DE69424846T2 (de) 2000-11-16
GR3033829T3 (en) 2000-10-31
NO944364L (no) 1995-05-18
NO944364D0 (no) 1994-11-15
DE69424846D1 (de) 2000-07-13
ATE193706T1 (de) 2000-06-15
FI945354A (fi) 1995-05-17
CY2234B1 (en) 2003-04-18
FI118600B (fi) 2008-01-15
IL111581A0 (en) 1995-01-24
ES2148305T3 (es) 2000-10-16
CA2135711A1 (en) 1995-05-17
DK0655461T3 (da) 2000-10-02
EP0655461B1 (en) 2000-06-07
PT655461E (pt) 2000-11-30
HU226300B1 (en) 2008-08-28
HUT71423A (en) 1995-11-28
HU9403276D0 (en) 1995-01-30
JPH07196685A (ja) 1995-08-01
PH31056A (en) 1998-02-03
AU7772994A (en) 1995-05-25
JP3647914B2 (ja) 2005-05-18
EP0655461A1 (en) 1995-05-31
CN1058019C (zh) 2000-11-01
NZ264913A (en) 1997-02-24
FI945354A0 (fi) 1994-11-14
CN1107857A (zh) 1995-09-06
NO311224B1 (no) 2001-10-29
AU687444B2 (en) 1998-02-26
US5668158A (en) 1997-09-16

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Legal Events

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FF Patent granted
KB Patent renewed
KB Patent renewed
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MM9K Patent not in force due to non-payment of renewal fees