EP0894003A4 - N-formyl hydroxylamine containing compounds useful as ace inhibitors and/or nep inhibitors - Google Patents

N-formyl hydroxylamine containing compounds useful as ace inhibitors and/or nep inhibitors

Info

Publication number
EP0894003A4
EP0894003A4 EP97917889A EP97917889A EP0894003A4 EP 0894003 A4 EP0894003 A4 EP 0894003A4 EP 97917889 A EP97917889 A EP 97917889A EP 97917889 A EP97917889 A EP 97917889A EP 0894003 A4 EP0894003 A4 EP 0894003A4
Authority
EP
European Patent Office
Prior art keywords
inhibitors
containing compounds
compounds useful
nep
formyl hydroxylamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97917889A
Other languages
German (de)
French (fr)
Other versions
EP0894003A1 (en
Inventor
Jeffrey A Robl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of EP0894003A1 publication Critical patent/EP0894003A1/en
Publication of EP0894003A4 publication Critical patent/EP0894003A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
EP97917889A 1996-04-12 1997-04-07 N-formyl hydroxylamine containing compounds useful as ace inhibitors and/or nep inhibitors Withdrawn EP0894003A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1629596P 1996-04-12 1996-04-12
PCT/US1997/005744 WO1997038705A1 (en) 1996-04-12 1997-04-07 N-formyl hydroxylamine containing compounds useful as ace inhibitors and/or nep inhibitors
US16295P 2007-12-21

Publications (2)

Publication Number Publication Date
EP0894003A1 EP0894003A1 (en) 1999-02-03
EP0894003A4 true EP0894003A4 (en) 2000-10-04

Family

ID=21776392

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97917889A Withdrawn EP0894003A4 (en) 1996-04-12 1997-04-07 N-formyl hydroxylamine containing compounds useful as ace inhibitors and/or nep inhibitors

Country Status (5)

Country Link
EP (1) EP0894003A4 (en)
JP (1) JP2000511882A (en)
AU (1) AU715451B2 (en)
CA (1) CA2251292A1 (en)
WO (1) WO1997038705A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6635632B1 (en) 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
NZ505675A (en) * 1998-02-07 2002-11-26 British Biotech Pharm N-alkylamide substituted hydroxamic acid derivatives are used as antibacterial agents
US6569851B1 (en) 1998-06-22 2003-05-27 Elan Pharmaceutials, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6509331B1 (en) 1998-06-22 2003-01-21 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6774125B2 (en) 1998-06-22 2004-08-10 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6528505B1 (en) 1998-06-22 2003-03-04 Elan Pharmaceuticals, Inc. Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6958330B1 (en) 1998-06-22 2005-10-25 Elan Pharmaceuticals, Inc. Polycyclic α-amino-ε-caprolactams and related compounds
US6552013B1 (en) 1998-06-22 2003-04-22 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
GB9827805D0 (en) * 1998-12-16 1999-02-10 British Biotech Pharm Antibacterial agents
GB9907055D0 (en) 1999-03-29 1999-05-19 British Biotech Pharm Antibacterial agents
ATE293600T1 (en) * 1999-08-10 2005-05-15 Vernalis Oxford Ltd ANTIBACTERIAL AGENTS
US6509330B2 (en) 2000-02-17 2003-01-21 Bristol-Myers Squibb Company Hydroxamic acid containing compounds useful as ACE inhibitors and/or NEP inhibotors
DE10020818A1 (en) * 2000-04-28 2001-10-31 Degussa 2,6-diamino-6-methyl-heptanoic acid and derivatives, process for their preparation and their use
WO2016191178A1 (en) 2015-05-22 2016-12-01 Biotheryx, Inc. Compounds targeting proteins, compositions, methods, and uses thereof
WO2017201069A1 (en) 2016-05-18 2017-11-23 Biotheryx, Inc. Oxoindoline derivatives as protein function modulators
WO2018170199A1 (en) * 2017-03-16 2018-09-20 Celgene Car Llc Forms and compositions of a mk2 inhibitor

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0236872A2 (en) * 1986-03-11 1987-09-16 F. Hoffmann-La Roche Ag Hydroxyl amine derivatives, their preparation and use as medicaments
EP0524553A1 (en) * 1991-07-23 1993-01-27 Institut National De La Sante Et De La Recherche Medicale (Inserm) Acylmercaptoalkanoyldipeptides, methods of preparation and their therapeutic use
EP0599444A1 (en) * 1992-05-18 1994-06-01 E.R. SQUIBB & SONS, INC. Dual action inhibitors
EP0655461A1 (en) * 1993-11-16 1995-05-31 Ciba-Geigy Ag Cyclic amino acid derivatives having ACE and NEP inhibiting activity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4539150A (en) * 1983-06-29 1985-09-03 Mitsui Toatsu Chemicals, Inc. Benzothiazepine derivatives and their methods of preparation
US5552400A (en) * 1994-06-08 1996-09-03 Sterling Winthrop Inc. Fused-bicyclic lactams as interleukin-1β converting enzyme inhibitors

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0236872A2 (en) * 1986-03-11 1987-09-16 F. Hoffmann-La Roche Ag Hydroxyl amine derivatives, their preparation and use as medicaments
EP0524553A1 (en) * 1991-07-23 1993-01-27 Institut National De La Sante Et De La Recherche Medicale (Inserm) Acylmercaptoalkanoyldipeptides, methods of preparation and their therapeutic use
EP0599444A1 (en) * 1992-05-18 1994-06-01 E.R. SQUIBB & SONS, INC. Dual action inhibitors
EP0655461A1 (en) * 1993-11-16 1995-05-31 Ciba-Geigy Ag Cyclic amino acid derivatives having ACE and NEP inhibiting activity

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
FOURNIE-ZALUSKI M -C ET AL: "NEW BIDENTATES AS FULL INHIBITORS OF ENKEPHALIN-DEGRADING ENZYMES: SYNTHESIS AND ANALGESIC PROPERTIES", JOURNAL OF MEDICINAL CHEMISTRY,US,AMERICAN CHEMICAL SOCIETY. WASHINGTON, vol. 28, no. 9, 1985, pages 1158 - 1169, XP000906979, ISSN: 0022-2623 *
NISHINO E.A.: "DESIGN OF POTENT REVERSIBLE INHIBITORS OF THERMOLYSIN. PEPTIDES CONTAINING ZINC COORDINATING LIGANDS AND THEIR USE IN AFFINITY CHROMATOGRAPHY", BIOCHEMISTRY, vol. 18, no. 20, 1979, EASTON, PA US, pages 4340 - 4347, XP002144002 *
See also references of WO9738705A1 *
WELLER E.A.: "Design of conformationally constrained angiotensin-converting-enzyme inhibitors", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 125, no. 1, 1984, ORLANDO, FL US, pages 82 - 89, XP000915405 *

Also Published As

Publication number Publication date
EP0894003A1 (en) 1999-02-03
AU715451B2 (en) 2000-02-03
WO1997038705A1 (en) 1997-10-23
JP2000511882A (en) 2000-09-12
AU2609497A (en) 1997-11-07
CA2251292A1 (en) 1997-10-23

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