IL109602A - Urethanes and ureas that induce cytokine production process for their preparation and pharmaceutical compositions containing them - Google Patents

Urethanes and ureas that induce cytokine production process for their preparation and pharmaceutical compositions containing them

Info

Publication number
IL109602A
IL109602A IL10960294A IL10960294A IL109602A IL 109602 A IL109602 A IL 109602A IL 10960294 A IL10960294 A IL 10960294A IL 10960294 A IL10960294 A IL 10960294A IL 109602 A IL109602 A IL 109602A
Authority
IL
Israel
Prior art keywords
urethanes
pharmaceutical compositions
cytokine production
ureas
preparation
Prior art date
Application number
IL10960294A
Other languages
English (en)
Other versions
IL109602A0 (en
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of IL109602A0 publication Critical patent/IL109602A0/xx
Publication of IL109602A publication Critical patent/IL109602A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
IL10960294A 1993-05-12 1994-05-09 Urethanes and ureas that induce cytokine production process for their preparation and pharmaceutical compositions containing them IL109602A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/063,174 US5312831A (en) 1993-05-12 1993-05-12 Urethanes and ureas that induce cytokine production

Publications (2)

Publication Number Publication Date
IL109602A0 IL109602A0 (en) 1994-08-26
IL109602A true IL109602A (en) 2000-06-01

Family

ID=22047440

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10960294A IL109602A (en) 1993-05-12 1994-05-09 Urethanes and ureas that induce cytokine production process for their preparation and pharmaceutical compositions containing them

Country Status (26)

Country Link
US (6) US5312831A (fr)
EP (1) EP0652228B1 (fr)
JP (1) JP3583469B2 (fr)
KR (1) KR100296543B1 (fr)
CN (1) CN1094943C (fr)
AT (1) ATE144533T1 (fr)
AU (1) AU669064B2 (fr)
CA (1) CA2123261A1 (fr)
CZ (1) CZ290445B6 (fr)
DE (1) DE69400798T2 (fr)
DK (1) DK0652228T3 (fr)
ES (1) ES2094004T3 (fr)
FI (1) FI942186A (fr)
GR (1) GR3022253T3 (fr)
HU (1) HU219768B (fr)
IL (1) IL109602A (fr)
NO (1) NO311223B1 (fr)
NZ (1) NZ260507A (fr)
PH (1) PH30182A (fr)
PL (1) PL179984B1 (fr)
RU (1) RU2135515C1 (fr)
SG (1) SG43071A1 (fr)
SI (1) SI0652228T1 (fr)
SK (1) SK281120B6 (fr)
TW (1) TW380129B (fr)
ZA (1) ZA943266B (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE1007183A3 (fr) * 1993-06-18 1995-04-18 Solvay Ureines derivees d'alpha, omega-diaminoacides et procede pour leur preparation.
EP0809492A4 (fr) * 1995-02-17 2007-01-24 Smithkline Beecham Corp Antagonistes des recepteurs d'il-8
US6005008A (en) * 1996-02-16 1999-12-21 Smithkline Beecham Corporation IL-8 receptor antagonists
US6211373B1 (en) 1996-03-20 2001-04-03 Smithkline Beecham Corporation Phenyl urea antagonists of the IL-8 receptor
US6262113B1 (en) 1996-03-20 2001-07-17 Smithkline Beecham Corporation IL-8 receptor antagonists
EP0912505A4 (fr) * 1996-06-27 2001-10-24 Smithkline Beecham Corp Antagonistes des recepteurs d'il-8
AU3499497A (en) 1996-06-27 1998-01-14 Smithkline Beecham Corporation Il-8 receptor antagonists
EP0939634A4 (fr) * 1996-08-15 2001-02-21 Smithkline Beecham Corp Antagonistes du recepteur il-8
WO1999050238A1 (fr) * 1998-03-26 1999-10-07 Santen Pharmaceutical Co., Ltd. Nouveaux derives d'uree
US7465754B1 (en) 1999-09-15 2008-12-16 Wyeth Method of potentiating chemotherapy and treating solid tumors
US7332158B2 (en) 2002-05-29 2008-02-19 Demao Yang Compositions and treatments for myelosuppression by ex vivo activated immune cells
US7048922B2 (en) * 2002-05-29 2006-05-23 Demao Yang Stimulation of hematopoiesis by ex vivo activated immune cells
AR041834A1 (es) * 2002-10-29 2005-06-01 Smithkline Beecham Corp Compuesto de difenilurea sustituido con sulfonamida, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion
US20060057121A1 (en) * 2004-09-10 2006-03-16 Demao Yang Compositions and treatments using ex vivo activated cells for myelosuppressed patients
DK2009992T3 (da) * 2006-04-21 2012-08-13 Glaxosmithkline Llc Il-8 receptor-antagonister
CA2650007A1 (fr) * 2006-04-21 2007-11-01 Smithkline Beecham Corporation Antagonistes du recepteur de l'il-8
AR061571A1 (es) * 2006-06-23 2008-09-03 Smithkline Beecham Corp Compuesto sal del acido toluenosulfonico de 4-{[6-cloro-3-({[(2- cloro-3-fluorofenil) amino]carbonil} amino)- 2- hidroxifenil]sulfonil] -1- piperazinacarbxilato de 1.1-dimetiletilo, composicion farmaceutica que lo comprende su uso para la fabricacion de un medicamento combinacion farmaceutica con un
WO2013149025A1 (fr) * 2012-03-30 2013-10-03 Givaudan, S., A. Dérivés de n-acyl sérine comme composés d'arôme alimentaire
EP2830439B1 (fr) 2012-03-30 2020-11-04 Givaudan SA Dérivés n-acyl gaba pour l'amélioration du profil aromatique de compositions alimentaires
SG11201405409PA (en) 2012-03-30 2014-11-27 Givaudan Sa N-acylated 1 - aminocycloalkyl carboxylic acids as food flavouring compounds
BR112014023941B1 (pt) 2012-03-30 2020-07-14 Givaudan S.A. Composição flavorizante em pó, bem como composições comestíveis de petisco e refresco em pó compreendendo a mesma
CN104219964B (zh) 2012-03-30 2016-09-21 奇华顿股份有限公司 作为食品加香化合物的n-酰基脯氨酸衍生物
US10836712B2 (en) 2012-03-30 2020-11-17 Givaudan S.A. Organic compounds
JP6248091B2 (ja) 2012-03-30 2017-12-13 ジボダン エス エー 食品フレーバー付与化合物としてのガンマアミノ酪酸およびベータアラニンのｎ−アシル誘導体
CA2868058C (fr) 2012-03-30 2019-12-17 Givaudan S.A. Derives n-acyles de methionine comme composes d'arome alimentaire
US10537127B2 (en) 2013-10-02 2020-01-21 Givaudan S.A. Organic compounds
EP3057445B1 (fr) 2013-10-02 2018-07-04 Givaudan SA Composés organiques présentant des propriétés de modification du goût
WO2015050535A1 (fr) 2013-10-02 2015-04-09 Givaudan S.A. Composés organiques
CN105636459A (zh) 2013-10-02 2016-06-01 奇华顿股份有限公司 有机化合物
WO2015050538A1 (fr) 2013-10-02 2015-04-09 Givaudan S.A. Composés organiques
GB201317424D0 (en) * 2013-10-02 2013-11-13 Givaudan Sa Improvements in or relating to organic compounds
US11122826B2 (en) 2013-10-02 2021-09-21 Givaudan Sa Organic compounds
US20160227825A1 (en) 2013-10-02 2016-08-11 Givaudan Sa Organic Compounds having Taste-Modifying Properties
MX2020002010A (es) 2017-08-21 2020-07-13 Celgene Corp Procesos para la preparacion de 4,5-diamino-5-oxopentanoato de (s)-terc-butilo.
CN109601739B (zh) * 2019-01-17 2022-10-14 河南湾流生物科技有限公司 一种复合氨基酸饲料添加剂及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2033906B (en) * 1978-10-19 1982-12-01 Anvar Water-soluble compounds derived from extracts of streptomyces stimulosus process for their production and compositions containing them
US4725582A (en) * 1978-11-14 1988-02-16 Fujisawa Pharmaceutical Company, Ltd. Peptide, process for preparation thereof and use thereof
US4349466A (en) * 1978-11-14 1982-09-14 Fujisawa Pharmaceutical Co Peptide, process for preparation thereof and use thereof
FR2460290A1 (fr) * 1979-06-29 1981-01-23 Rhone Poulenc Ind Nouveaux tetra- ou pentapeptides, leur preparation et les medicaments qui les contiennent
CA2116684A1 (fr) * 1991-09-27 1993-04-01 Robert G. Kilbourn Acides amines contenant des formulations parenterales pour le traitement de l'hypotension et d'autres pathologies apparentees

Also Published As

Publication number Publication date
CN1100413A (zh) 1995-03-22
SI0652228T1 (en) 1997-10-31
JP3583469B2 (ja) 2004-11-04
ZA943266B (en) 1995-01-12
IL109602A0 (en) 1994-08-26
CN1094943C (zh) 2002-11-27
SK281120B6 (sk) 2000-12-11
EP0652228A1 (fr) 1995-05-10
US5658945A (en) 1997-08-19
KR100296543B1 (ko) 2001-11-22
EP0652228B1 (fr) 1996-10-23
HUT67038A (en) 1995-01-30
US5633280A (en) 1997-05-27
SK49194A3 (en) 1995-02-08
ES2094004T3 (es) 1997-01-01
CA2123261A1 (fr) 1994-11-13
HU9401444D0 (en) 1994-08-29
SG43071A1 (en) 1997-10-17
PL179984B1 (pl) 2000-11-30
FI942186A (fi) 1994-11-13
JPH07179414A (ja) 1995-07-18
AU669064B2 (en) 1996-05-23
US5545662A (en) 1996-08-13
FI942186A0 (fi) 1994-05-11
US5602275A (en) 1997-02-11
NO311223B1 (no) 2001-10-29
RU2135515C1 (ru) 1999-08-27
NZ260507A (en) 1996-02-27
CZ98194A3 (en) 1994-12-15
CZ290445B6 (cs) 2002-07-17
DK0652228T3 (da) 1996-11-25
HU219768B (hu) 2001-07-30
NO941786D0 (no) 1994-05-11
TW380129B (en) 2000-01-21
DE69400798D1 (de) 1996-11-28
AU6304394A (en) 1994-11-17
DE69400798T2 (de) 1997-03-13
PH30182A (en) 1997-01-21
US5616612A (en) 1997-04-01
NO941786L (no) 1994-11-14
ATE144533T1 (de) 1996-11-15
US5312831A (en) 1994-05-17
GR3022253T3 (en) 1997-04-30

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees