IL109337A0 - Indole derivatives for use in migraine - Google Patents
Indole derivatives for use in migraineInfo
- Publication number
- IL109337A0 IL109337A0 IL10933794A IL10933794A IL109337A0 IL 109337 A0 IL109337 A0 IL 109337A0 IL 10933794 A IL10933794 A IL 10933794A IL 10933794 A IL10933794 A IL 10933794A IL 109337 A0 IL109337 A0 IL 109337A0
- Authority
- IL
- Israel
- Prior art keywords
- pct
- migraine
- date oct
- indole derivatives
- sec
- Prior art date
Links
- 208000019695 Migraine disease Diseases 0.000 title abstract 2
- 206010027599 migraine Diseases 0.000 title abstract 2
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 150000002475 indoles Chemical class 0.000 title 1
- -1 3,5-disubstituted indole compounds Chemical class 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939308360A GB9308360D0 (en) | 1993-04-22 | 1993-04-22 | Indoles |
| GB939324433A GB9324433D0 (en) | 1993-11-27 | 1993-11-27 | Indoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL109337A0 true IL109337A0 (en) | 1994-07-31 |
Family
ID=26302791
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10933794A IL109337A0 (en) | 1993-04-22 | 1994-04-18 | Indole derivatives for use in migraine |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5607960A (de) |
| EP (1) | EP0695301B1 (de) |
| JP (1) | JP2802169B2 (de) |
| KR (1) | KR960701865A (de) |
| CN (1) | CN1121348A (de) |
| AT (1) | ATE144773T1 (de) |
| AU (1) | AU6567094A (de) |
| BR (1) | BR9406481A (de) |
| CA (1) | CA2157397C (de) |
| CZ (1) | CZ274595A3 (de) |
| DE (1) | DE69400824T2 (de) |
| DK (1) | DK0695301T3 (de) |
| ES (1) | ES2094653T3 (de) |
| FI (1) | FI954944A7 (de) |
| GR (1) | GR3021804T3 (de) |
| HU (1) | HUT73807A (de) |
| IL (1) | IL109337A0 (de) |
| NO (1) | NO954168D0 (de) |
| NZ (1) | NZ265269A (de) |
| PL (1) | PL311204A1 (de) |
| WO (1) | WO1994024127A1 (de) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5559246A (en) * | 1990-10-15 | 1996-09-24 | Pfizer Inc. | Indole derivatives |
| US5607951A (en) * | 1990-10-15 | 1997-03-04 | Pfizer Inc | Indole derivatives |
| US5578612A (en) * | 1990-10-15 | 1996-11-26 | Pfizer Inc. | Indole derivatives |
| US5545644A (en) * | 1990-10-15 | 1996-08-13 | Pfizer Inc. | Indole derivatives |
| US5559129A (en) * | 1990-10-15 | 1996-09-24 | Pfizer Inc | Indole derivatives |
| DK0716649T3 (da) * | 1993-08-31 | 1999-02-08 | Pfizer | 5-Arylindolderivater |
| GB9417310D0 (en) * | 1994-08-27 | 1994-10-19 | Pfizer Ltd | Therapeutic agents |
| GB9420503D0 (en) * | 1994-10-11 | 1994-11-23 | Pfizer Ltd | Therapeutic agents |
| GB9420529D0 (en) | 1994-10-12 | 1994-11-30 | Pfizer Ltd | Indoles |
| NZ305166A (en) * | 1995-03-20 | 1998-12-23 | Lilly Co Eli | 5-substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1h-indoles; preparation and medicaments |
| US8022095B2 (en) | 1996-08-16 | 2011-09-20 | Pozen, Inc. | Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs |
| US5872145A (en) * | 1996-08-16 | 1999-02-16 | Pozen, Inc. | Formulation of 5-HT agonist and NSAID for treatment of migraine |
| US6586458B1 (en) | 1996-08-16 | 2003-07-01 | Pozen Inc. | Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs |
| WO1998011895A1 (en) * | 1996-09-18 | 1998-03-26 | Eli Lilly And Company | A method for the prevention of migraine |
| EP0944595B1 (de) * | 1996-11-26 | 2003-10-01 | NPS Allelix Corp. | 5-cyclo-indolverbindungen als 5-ht1d rezeptor liganden |
| US5998462A (en) * | 1996-12-16 | 1999-12-07 | Allelix Biopharmaceuticals Inc. | 5-alkyl indole compounds |
| US5856510A (en) * | 1996-12-16 | 1999-01-05 | Allelix Biopharmaceuticals Inc. | 5-alkenyl and 5-alkynyl indole compounds |
| GB9705035D0 (en) * | 1997-03-11 | 1997-04-30 | Pharmacia & Upjohn Spa | Indolyl-pyrrolydenemethylpyrrole derivatives and process for their preparation |
| EP0875513A1 (de) * | 1997-04-14 | 1998-11-04 | Eli Lilly And Company | Substituierte heteroaromatische 5-HT1F Agoniste |
| WO1999007700A1 (en) * | 1997-08-09 | 1999-02-18 | Smithkline Beecham Plc | Bicyclic compounds as ligands for 5-ht1 receptors |
| US7189753B1 (en) | 1997-11-06 | 2007-03-13 | Cady Roger K | Preemptive prophylaxis of migraine |
| US6310066B1 (en) | 1998-04-29 | 2001-10-30 | American Home Products Corp. | Antipsychotic indolyl derivatives |
| US6204274B1 (en) | 1998-04-29 | 2001-03-20 | American Home Products Corporation | Indolyl derivatives as serotonergic agents |
| US6066637A (en) * | 1998-06-19 | 2000-05-23 | American Home Products Corporation | Indolyl derivatives as serotonergic agents |
| AU4961499A (en) * | 1998-06-26 | 2000-01-17 | Eli Lilly And Company | 5-HT1f agonists |
| US5994352A (en) * | 1998-11-13 | 1999-11-30 | Pfizer Inc. | 5-arylindole derivatives |
| UA73995C2 (en) | 2000-07-21 | 2005-10-17 | Lundbeck & Co As H | Indole derivatives being useful for the treatment of cns disorders,, a pharmaceutical composition and a method for treatment |
| US6489512B1 (en) | 2002-06-21 | 2002-12-03 | Rhodia Chirex Inc. | Method for making aryl hydrazines and substituted indoles |
| KR20050085472A (ko) * | 2002-12-10 | 2005-08-29 | 메르크 파텐트 게엠베하 | 인돌 유도체 및 ５-ｈｔ 리간드로서의 이의 용도 |
| EP1572647B1 (de) * | 2002-12-20 | 2016-09-21 | Basf Se | Herstellung von aminen und deren zwischenverbindungen |
| WO2004060355A1 (en) * | 2002-12-26 | 2004-07-22 | Pozen Inc. | Multilayer Dosage Forms Containing NSAIDs and Triptans |
| JP2006527195A (ja) * | 2003-06-06 | 2006-11-30 | グラクソ グループ リミテッド | トリプタンおよびｎｓａｉｄを含む組成物 |
| US20050245540A1 (en) * | 2003-12-09 | 2005-11-03 | Fujisawa Pharmaceutical Co., Ltd. | New methods |
| WO2005066157A1 (en) * | 2004-01-02 | 2005-07-21 | Suven Life Sciences | 3-(pyrolidin-3-l) indoles as 5-ht6 receptor modulators |
| GB0807772D0 (en) * | 2008-04-29 | 2008-06-04 | Lectus Therapeutics Ltd | Calcium ion modulators and uses thereof |
| FR2953720B1 (fr) * | 2009-12-11 | 2012-05-11 | Oreal | Utilisation de derives de benzyloxy-ethylamines comme conservateur, |
| CN104557957B (zh) * | 2013-10-09 | 2017-04-19 | 华东师范大学 | 螺‑氧化吲哚环氧乙烷衍生物的合成方法 |
| MX2022009528A (es) * | 2020-02-04 | 2022-11-14 | Mindset Pharma Inc | Derivados de 3-pirrolidina-indol como agentes psicodélicos serotoninérgicos para el tratamiento de trastornos del snc. |
| IL326081A (en) * | 2023-07-24 | 2026-03-01 | Innovstone Therapeutics Ltd | 5-HT2A receptor agonists, process for their preparation and uses |
| WO2025104491A1 (en) * | 2023-11-14 | 2025-05-22 | Mindset Pharma Inc. | Indole derivatives as serotonergic agents useful for the treatment of disorders related thereto |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8530507D0 (en) * | 1985-12-11 | 1986-01-22 | Glaxo Group Plc | Chemical compounds |
| GB8719167D0 (en) * | 1987-08-13 | 1987-09-23 | Glaxo Group Ltd | Chemical compounds |
| PL170330B1 (pl) * | 1990-10-15 | 1996-11-29 | Pfizer | Sposób wytwarzania nowych pochodnych indolu PL PL PL PL PL PL |
-
1994
- 1994-04-11 AT AT94913573T patent/ATE144773T1/de not_active IP Right Cessation
- 1994-04-11 HU HU9501920A patent/HUT73807A/hu unknown
- 1994-04-11 CZ CZ952745A patent/CZ274595A3/cs unknown
- 1994-04-11 CN CN94191850A patent/CN1121348A/zh active Pending
- 1994-04-11 AU AU65670/94A patent/AU6567094A/en not_active Abandoned
- 1994-04-11 NZ NZ265269A patent/NZ265269A/en unknown
- 1994-04-11 PL PL94311204A patent/PL311204A1/xx unknown
- 1994-04-11 DE DE69400824T patent/DE69400824T2/de not_active Expired - Fee Related
- 1994-04-11 CA CA002157397A patent/CA2157397C/en not_active Expired - Fee Related
- 1994-04-11 JP JP6522726A patent/JP2802169B2/ja not_active Expired - Fee Related
- 1994-04-11 ES ES94913573T patent/ES2094653T3/es not_active Expired - Lifetime
- 1994-04-11 EP EP94913573A patent/EP0695301B1/de not_active Expired - Lifetime
- 1994-04-11 US US08/532,573 patent/US5607960A/en not_active Expired - Fee Related
- 1994-04-11 DK DK94913573.5T patent/DK0695301T3/da active
- 1994-04-11 BR BR9406481A patent/BR9406481A/pt not_active Application Discontinuation
- 1994-04-11 WO PCT/EP1994/001121 patent/WO1994024127A1/en not_active Ceased
- 1994-04-11 KR KR1019950704623A patent/KR960701865A/ko not_active Ceased
- 1994-04-18 IL IL10933794A patent/IL109337A0/xx unknown
-
1995
- 1995-10-17 FI FI954944A patent/FI954944A7/fi not_active Application Discontinuation
- 1995-10-19 NO NO954168A patent/NO954168D0/no unknown
-
1996
- 1996-11-28 GR GR960403195T patent/GR3021804T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2802169B2 (ja) | 1998-09-24 |
| DE69400824D1 (de) | 1996-12-05 |
| ATE144773T1 (de) | 1996-11-15 |
| EP0695301A1 (de) | 1996-02-07 |
| NO954168L (no) | 1995-10-19 |
| KR960701865A (ko) | 1996-03-28 |
| CZ274595A3 (en) | 1996-03-13 |
| EP0695301B1 (de) | 1996-10-30 |
| DK0695301T3 (da) | 1996-12-09 |
| NO954168D0 (no) | 1995-10-19 |
| CA2157397C (en) | 1999-07-06 |
| JPH08507083A (ja) | 1996-07-30 |
| CN1121348A (zh) | 1996-04-24 |
| HUT73807A (en) | 1996-09-30 |
| FI954944A0 (fi) | 1995-10-17 |
| AU6567094A (en) | 1994-11-08 |
| WO1994024127A1 (en) | 1994-10-27 |
| ES2094653T3 (es) | 1997-01-16 |
| DE69400824T2 (de) | 1997-03-13 |
| PL311204A1 (en) | 1996-02-05 |
| CA2157397A1 (en) | 1994-10-27 |
| HU9501920D0 (en) | 1995-09-28 |
| US5607960A (en) | 1997-03-04 |
| NZ265269A (en) | 1996-09-25 |
| BR9406481A (pt) | 1996-01-09 |
| FI954944A7 (fi) | 1995-10-17 |
| GR3021804T3 (en) | 1997-02-28 |
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