IL106587A - Hybrid intrastromal corneal ring - Google Patents
Hybrid intrastromal corneal ringInfo
- Publication number
- IL106587A IL106587A IL106587A IL10658793A IL106587A IL 106587 A IL106587 A IL 106587A IL 106587 A IL106587 A IL 106587A IL 10658793 A IL10658793 A IL 10658793A IL 106587 A IL106587 A IL 106587A
- Authority
- IL
- Israel
- Prior art keywords
- ring
- polymer
- physiologically compatible
- inner portion
- additionally
- Prior art date
Links
- 229920000642 polymer Polymers 0.000 claims abstract description 114
- 210000004087 cornea Anatomy 0.000 claims description 25
- 229940079593 drug Drugs 0.000 claims description 23
- 239000003814 drug Substances 0.000 claims description 23
- -1 polyethylene Polymers 0.000 claims description 14
- 230000036571 hydration Effects 0.000 claims description 13
- 238000006703 hydration reaction Methods 0.000 claims description 13
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 13
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 13
- 239000000499 gel Substances 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 8
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 8
- 239000003124 biologic agent Substances 0.000 claims description 8
- 229920000669 heparin Polymers 0.000 claims description 8
- 229960002897 heparin Drugs 0.000 claims description 8
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 7
- 229920002674 hyaluronan Polymers 0.000 claims description 7
- 229960003160 hyaluronic acid Drugs 0.000 claims description 7
- 239000000017 hydrogel Substances 0.000 claims description 7
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 7
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 7
- 230000003527 anti-angiogenesis Effects 0.000 claims description 6
- 230000002927 anti-mitotic effect Effects 0.000 claims description 6
- 239000003080 antimitotic agent Substances 0.000 claims description 6
- 229960003957 dexamethasone Drugs 0.000 claims description 6
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims description 6
- 229920000098 polyolefin Polymers 0.000 claims description 6
- 229920001296 polysiloxane Polymers 0.000 claims description 6
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 6
- 239000004809 Teflon Substances 0.000 claims description 5
- 229920006362 Teflon® Polymers 0.000 claims description 5
- 239000003246 corticosteroid Substances 0.000 claims description 5
- 229960001334 corticosteroids Drugs 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- BFKJFAAPBSQJPD-UHFFFAOYSA-N tetrafluoroethene Chemical compound FC(F)=C(F)F BFKJFAAPBSQJPD-UHFFFAOYSA-N 0.000 claims description 5
- 102000008186 Collagen Human genes 0.000 claims description 4
- 108010035532 Collagen Proteins 0.000 claims description 4
- 229920002307 Dextran Polymers 0.000 claims description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 4
- 239000004698 Polyethylene Substances 0.000 claims description 4
- 239000004743 Polypropylene Substances 0.000 claims description 4
- 229920001436 collagen Polymers 0.000 claims description 4
- 229920001971 elastomer Polymers 0.000 claims description 4
- 239000000806 elastomer Substances 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 239000000314 lubricant Substances 0.000 claims description 4
- 229920001748 polybutylene Polymers 0.000 claims description 4
- 239000004417 polycarbonate Substances 0.000 claims description 4
- 229920000515 polycarbonate Polymers 0.000 claims description 4
- 229920000573 polyethylene Polymers 0.000 claims description 4
- 229920001155 polypropylene Polymers 0.000 claims description 4
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 claims description 3
- 230000008961 swelling Effects 0.000 claims description 3
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 2
- 235000010944 ethyl methyl cellulose Nutrition 0.000 claims description 2
- 150000004676 glycans Chemical class 0.000 claims description 2
- 235000011187 glycerol Nutrition 0.000 claims description 2
- 229920003087 methylethyl cellulose Polymers 0.000 claims description 2
- 229920001542 oligosaccharide Polymers 0.000 claims description 2
- 150000002482 oligosaccharides Chemical class 0.000 claims description 2
- 229920001282 polysaccharide Polymers 0.000 claims description 2
- 239000005017 polysaccharide Substances 0.000 claims description 2
- 230000002965 anti-thrombogenic effect Effects 0.000 claims 6
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 claims 2
- 239000003527 fibrinolytic agent Substances 0.000 claims 1
- 239000010410 layer Substances 0.000 description 33
- 210000001508 eye Anatomy 0.000 description 31
- 210000001525 retina Anatomy 0.000 description 10
- 239000000463 material Substances 0.000 description 9
- 238000000034 method Methods 0.000 description 8
- 238000003780 insertion Methods 0.000 description 7
- 230000037431 insertion Effects 0.000 description 7
- 201000009310 astigmatism Diseases 0.000 description 6
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 description 4
- 210000004240 ciliary body Anatomy 0.000 description 4
- 238000002513 implantation Methods 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 210000003683 corneal stroma Anatomy 0.000 description 3
- 238000004132 cross linking Methods 0.000 description 3
- 210000000981 epithelium Anatomy 0.000 description 3
- 230000004305 hyperopia Effects 0.000 description 3
- 201000006318 hyperopia Diseases 0.000 description 3
- 208000001491 myopia Diseases 0.000 description 3
- 230000004379 myopia Effects 0.000 description 3
- 206010020675 Hypermetropia Diseases 0.000 description 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 2
- 230000004308 accommodation Effects 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 210000005252 bulbus oculi Anatomy 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 210000003161 choroid Anatomy 0.000 description 2
- 230000001886 ciliary effect Effects 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 210000002919 epithelial cell Anatomy 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000007943 implant Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 description 2
- 210000004129 prosencephalon Anatomy 0.000 description 2
- 210000001747 pupil Anatomy 0.000 description 2
- 210000003786 sclera Anatomy 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 210000004127 vitreous body Anatomy 0.000 description 2
- MNIQECRMTVGZBM-UHFFFAOYSA-N 3-(1-methylpyrrolidin-2-yl)pyridine;7h-purin-6-amine Chemical compound NC1=NC=NC2=C1NC=N2.CN1CCCC1C1=CC=CN=C1 MNIQECRMTVGZBM-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 229920002527 Glycogen Polymers 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000446313 Lamella Species 0.000 description 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
- BAWFJGJZGIEFAR-NNYOXOHSSA-O NAD(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-O 0.000 description 1
- 208000037273 Pathologic Processes Diseases 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
- 208000013521 Visual disease Diseases 0.000 description 1
- 238000002679 ablation Methods 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000004480 accommodation of the lens Effects 0.000 description 1
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 1
- 229960004373 acetylcholine Drugs 0.000 description 1
- 230000010398 acute inflammatory response Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 210000002159 anterior chamber Anatomy 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 210000004045 bowman membrane Anatomy 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 210000000795 conjunctiva Anatomy 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 210000002555 descemet membrane Anatomy 0.000 description 1
- 229960002086 dextran Drugs 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 210000003038 endothelium Anatomy 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 210000000887 face Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 229940096919 glycogen Drugs 0.000 description 1
- 230000004402 high myopia Effects 0.000 description 1
- 229920001477 hydrophilic polymer Polymers 0.000 description 1
- 229920001600 hydrophobic polymer Polymers 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 210000001328 optic nerve Anatomy 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000009054 pathological process Effects 0.000 description 1
- 108091008695 photoreceptors Proteins 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 229920005573 silicon-containing polymer Polymers 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 239000013306 transparent fiber Substances 0.000 description 1
- 208000029257 vision disease Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
- A61F2/147—Implants to be inserted in the stroma for refractive correction, e.g. ring-like implants
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Prostheses (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Eye Examination Apparatus (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92716592A | 1992-08-07 | 1992-08-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL106587A0 IL106587A0 (en) | 1993-12-08 |
| IL106587A true IL106587A (en) | 1998-03-10 |
Family
ID=25454311
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL106587A IL106587A (en) | 1992-08-07 | 1993-08-04 | Hybrid intrastromal corneal ring |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US5888243A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0653926B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JPH08500035A (cg-RX-API-DMAC7.html) |
| CN (1) | CN1083345A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE179585T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU4997393A (cg-RX-API-DMAC7.html) |
| BR (1) | BR9306848A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2141850A1 (cg-RX-API-DMAC7.html) |
| DE (1) | DE69324811T2 (cg-RX-API-DMAC7.html) |
| DK (1) | DK0653926T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2133411T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL106587A (cg-RX-API-DMAC7.html) |
| SG (2) | SG89316A1 (cg-RX-API-DMAC7.html) |
| TW (1) | TW294594B (cg-RX-API-DMAC7.html) |
| WO (1) | WO1994003129A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (117)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6966927B1 (en) | 1992-08-07 | 2005-11-22 | Addition Technology, Inc. | Hybrid intrastromal corneal ring |
| DE69433625T2 (de) * | 1993-08-02 | 2005-02-03 | Addition Technology, Inc., Des Plaines | Zusammenlegbarer, intrastromaler, kornealer einsatz aus mehreren segmenten |
| SG52643A1 (en) | 1993-08-02 | 1998-09-28 | Keravision Inc | Segmented preformed intrastromal corneal insert |
| US6331188B1 (en) | 1994-08-31 | 2001-12-18 | Gore Enterprise Holdings, Inc. | Exterior supported self-expanding stent-graft |
| US6015429A (en) | 1994-09-08 | 2000-01-18 | Gore Enterprise Holdings, Inc. | Procedures for introducing stents and stent-grafts |
| JPH11507269A (ja) * | 1995-06-07 | 1999-06-29 | ケラビジョン，インコーポレイテッド | 基質内角膜半径方向挿入物および挿入方法 |
| US6042605A (en) | 1995-12-14 | 2000-03-28 | Gore Enterprose Holdings, Inc. | Kink resistant stent-graft |
| AU1413797A (en) | 1995-12-14 | 1997-07-03 | Prograft Medical, Inc. | Stent-graft deployment apparatus and method |
| EP0957825A1 (en) * | 1996-06-26 | 1999-11-24 | Jürgen Henning | Corneal insert, instrument of insertion of the same and method of correcting the refractive power of an eye |
| US5733334A (en) * | 1996-12-09 | 1998-03-31 | Microoptix | Method and apparatus for adjusting corneal curvature |
| FR2757064B1 (fr) * | 1996-12-13 | 2000-02-04 | Ioltechnologie Production | Lentille intraoculaire contenant un medicament relargable |
| US6352561B1 (en) | 1996-12-23 | 2002-03-05 | W. L. Gore & Associates | Implant deployment apparatus |
| US6551350B1 (en) | 1996-12-23 | 2003-04-22 | Gore Enterprise Holdings, Inc. | Kink resistant bifurcated prosthesis |
| IL121417A0 (en) * | 1997-07-28 | 1998-01-04 | Israel Henry M | Intraocular ring |
| US6991650B2 (en) | 1997-10-08 | 2006-01-31 | Refocus Ocular, Inc. | Scleral expansion device having duck bill |
| AU4980199A (en) * | 1998-07-08 | 2000-02-01 | Sunsoft Corporation | Interpenetrating polymer network hydrophilic hydrogels for contact lens |
| EP1173790A2 (en) | 1999-03-01 | 2002-01-23 | Boston Innovative Optics, Inc. | System and method for increasing the depth of focus of the human eye |
| US6543453B1 (en) * | 1999-05-06 | 2003-04-08 | Sciencevision L.L.C. | Methods of refractive correction of the eye |
| US6632905B2 (en) | 1999-09-02 | 2003-10-14 | Alcon Universal Ltd. | Covalently-bound, hydrophilic coating compositions for surgical implants |
| EP1207808B1 (en) | 1999-09-02 | 2005-01-12 | Alcon Inc. | Hydrophobically-bound, hydrophilic coating compositions for surgical implants |
| US6723815B2 (en) | 1999-09-02 | 2004-04-20 | Alcon, Inc. | Covalently-bound, hydrophilic coating compositions for surgical implants |
| US7008396B1 (en) | 1999-09-03 | 2006-03-07 | Restorvision, Inc. | Ophthalmic device and method of manufacture and use |
| BR0000016A (pt) | 2000-01-06 | 2001-08-14 | Ferrara Ophthalmics Ltda | Dispositivo para implante intracorneano e processo para tratamento de deformidades da córnea |
| US6228113B1 (en) | 2000-01-10 | 2001-05-08 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Intracorneal astigmatic onlay |
| US7635388B1 (en) * | 2000-05-04 | 2009-12-22 | Tyler Thomas D | Device and method for incremental correction of sight disorders and occular diseases |
| US6511508B1 (en) * | 2000-08-04 | 2003-01-28 | Environmental Robots, Inc. | Surgical correction of human eye refractive errors by active composite artificial muscle implants |
| US7060094B2 (en) | 2000-08-07 | 2006-06-13 | Ophthalmotronics, Inc. | Accommodating zonular mini-bridge implants |
| US8647612B2 (en) * | 2008-03-05 | 2014-02-11 | Encore Health, Llc | Dithiol compounds, derivatives, and treatment of presbyopia |
| US20050112113A1 (en) * | 2000-08-16 | 2005-05-26 | Till Jonathan S. | Presbyopia treatment by lens alteration |
| US7914815B2 (en) * | 2000-08-16 | 2011-03-29 | Encore Health, Llc | Method for delivery of pharmaceuticals for treating or preventing presbyopia |
| US7935332B2 (en) * | 2000-08-16 | 2011-05-03 | Encore Health, Llc | Presbyopia treatment by lens alteration |
| US8697109B2 (en) | 2000-08-16 | 2014-04-15 | Encore Health, Llc | Caged mercaptan and seleno-mercaptan compounds and methods of using them |
| US6923955B2 (en) * | 2000-08-16 | 2005-08-02 | Newlens, Llc | Presbyopia treatment by lens alteration |
| JP2004526467A (ja) | 2000-09-12 | 2004-09-02 | アナメッド インク． | 移植片のパッケージおよび取扱のためのシステムおよび使用方法 |
| US8668735B2 (en) | 2000-09-12 | 2014-03-11 | Revision Optics, Inc. | Corneal implant storage and delivery devices |
| US6543610B1 (en) * | 2000-09-12 | 2003-04-08 | Alok Nigam | System for packaging and handling an implant and method of use |
| EP1370204B1 (en) | 2001-02-23 | 2006-08-30 | Refocus Ocular, Inc. | System for making incisions for scleral eye implants |
| US20060241750A1 (en) * | 2001-05-22 | 2006-10-26 | Ras Holding Corp | Scleral expansion device having duck bill |
| WO2003020190A2 (en) * | 2001-08-31 | 2003-03-13 | Duckworth & Kent Limited | Ophthalmic devices and procedures |
| GB0121168D0 (en) * | 2001-08-31 | 2001-10-24 | Duckworth & Kent Ltd | Ophthalmic devices and procedures |
| US6623522B2 (en) * | 2001-11-07 | 2003-09-23 | Alok Nigam | Myopic corneal ring with central accommodating portion |
| US20040002756A1 (en) * | 2002-05-09 | 2004-01-01 | Georges Baikoff | Corrective element for presbyopia |
| ES2368711T3 (es) | 2002-05-20 | 2011-11-21 | Refocus Group, Inc. | Sistema y procedimiento para determinar una posición para un bolsillo en la esclerótica para una prótesis escleral. |
| FR2844703B1 (fr) * | 2002-09-25 | 2005-07-08 | Alain Nicolas Gilg | Dispositif intraoculaire pour restaurer l'accommodation de l'oeil atteint de presbytie |
| WO2004041323A2 (en) * | 2002-10-30 | 2004-05-21 | Yablon, Jay, R. | Improved endocapsular tension ring and method of implanting same |
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1993
- 1993-08-04 AU AU49973/93A patent/AU4997393A/en not_active Abandoned
- 1993-08-04 AT AT93919882T patent/ATE179585T1/de not_active IP Right Cessation
- 1993-08-04 SG SG200000322D patent/SG89316A1/en unknown
- 1993-08-04 ES ES93919882T patent/ES2133411T3/es not_active Expired - Lifetime
- 1993-08-04 DK DK93919882T patent/DK0653926T3/da active
- 1993-08-04 JP JP6505546A patent/JPH08500035A/ja active Pending
- 1993-08-04 CA CA002141850A patent/CA2141850A1/en not_active Abandoned
- 1993-08-04 SG SG1996008605A patent/SG48274A1/en unknown
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- 1993-08-04 EP EP93919882A patent/EP0653926B1/en not_active Expired - Lifetime
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- 1993-08-04 BR BR9306848A patent/BR9306848A/pt not_active Application Discontinuation
- 1993-08-04 WO PCT/US1993/007339 patent/WO1994003129A1/en not_active Ceased
- 1993-08-07 CN CN93109648A patent/CN1083345A/zh active Pending
- 1993-08-11 TW TW082106420A patent/TW294594B/zh active
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1995
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- 1995-06-06 US US08/467,618 patent/US6214044B1/en not_active Expired - Fee Related
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1997
- 1997-11-21 US US08/976,378 patent/US6096076A/en not_active Expired - Fee Related
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| SG48274A1 (en) | 1998-04-17 |
| BR9306848A (pt) | 1998-12-08 |
| DE69324811T2 (de) | 1999-09-16 |
| ATE179585T1 (de) | 1999-05-15 |
| JPH08500035A (ja) | 1996-01-09 |
| TW294594B (cg-RX-API-DMAC7.html) | 1997-01-01 |
| SG89316A1 (en) | 2002-06-18 |
| EP0653926B1 (en) | 1999-05-06 |
| DE69324811D1 (de) | 1999-06-10 |
| CN1083345A (zh) | 1994-03-09 |
| EP0653926A1 (en) | 1995-05-24 |
| IL106587A0 (en) | 1993-12-08 |
| US5888243A (en) | 1999-03-30 |
| CA2141850A1 (en) | 1994-02-17 |
| AU4997393A (en) | 1994-03-03 |
| ES2133411T3 (es) | 1999-09-16 |
| EP0653926A4 (en) | 1995-08-09 |
| US6096076A (en) | 2000-08-01 |
| DK0653926T3 (da) | 1999-11-01 |
| WO1994003129A1 (en) | 1994-02-17 |
| US6214044B1 (en) | 2001-04-10 |
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