IL106459A - Nitrogen mustard based prodrugs, process for their preparation and pharmaceutical compositions thereof particularly in combination with carboxypeptidase g2-a5b7 antibody conjugates for cancer therapy - Google Patents

Nitrogen mustard based prodrugs, process for their preparation and pharmaceutical compositions thereof particularly in combination with carboxypeptidase g2-a5b7 antibody conjugates for cancer therapy

Info

Publication number
IL106459A
IL106459A IL106459A IL10645993A IL106459A IL 106459 A IL106459 A IL 106459A IL 106459 A IL106459 A IL 106459A IL 10645993 A IL10645993 A IL 10645993A IL 106459 A IL106459 A IL 106459A
Authority
IL
Israel
Prior art keywords
compound
vas
formula
bis
group
Prior art date
Application number
IL106459A
Other languages
English (en)
Other versions
IL106459A0 (en
Original Assignee
Zeneca Limited And Cancer Rese
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929215636A external-priority patent/GB9215636D0/en
Priority claimed from GB939310884A external-priority patent/GB9310884D0/en
Application filed by Zeneca Limited And Cancer Rese filed Critical Zeneca Limited And Cancer Rese
Publication of IL106459A0 publication Critical patent/IL106459A0/xx
Publication of IL106459A publication Critical patent/IL106459A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
    • A61K47/6899—Antibody-Directed Enzyme Prodrug Therapy [ADEPT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/54—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/51—Y being a hydrogen or a carbon atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nanotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Seasonings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
IL106459A 1992-07-23 1993-07-22 Nitrogen mustard based prodrugs, process for their preparation and pharmaceutical compositions thereof particularly in combination with carboxypeptidase g2-a5b7 antibody conjugates for cancer therapy IL106459A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929215636A GB9215636D0 (en) 1992-07-23 1992-07-23 Chemical compounds
GB939310884A GB9310884D0 (en) 1993-05-26 1993-05-26 Chemical compounds

Publications (2)

Publication Number Publication Date
IL106459A0 IL106459A0 (en) 1994-11-11
IL106459A true IL106459A (en) 1998-02-08

Family

ID=26301303

Family Applications (1)

Application Number Title Priority Date Filing Date
IL106459A IL106459A (en) 1992-07-23 1993-07-22 Nitrogen mustard based prodrugs, process for their preparation and pharmaceutical compositions thereof particularly in combination with carboxypeptidase g2-a5b7 antibody conjugates for cancer therapy

Country Status (24)

Country Link
US (6) US5405990A (cs)
EP (1) EP0651740B1 (cs)
JP (1) JP3541037B2 (cs)
KR (1) KR100268654B1 (cs)
AT (1) ATE172450T1 (cs)
AU (1) AU681349B2 (cs)
CA (1) CA2101104C (cs)
CZ (1) CZ287028B6 (cs)
DE (1) DE69321729T2 (cs)
DK (1) DK0651740T3 (cs)
ES (1) ES2123662T3 (cs)
FI (1) FI115048B (cs)
GB (1) GB9314960D0 (cs)
HU (1) HUT69288A (cs)
IL (1) IL106459A (cs)
MY (1) MY111635A (cs)
NZ (1) NZ254864A (cs)
PH (1) PH30004A (cs)
PL (1) PL174617B1 (cs)
RU (1) RU2129542C1 (cs)
SK (1) SK281338B6 (cs)
TW (1) TW272971B (cs)
WO (1) WO1994002450A1 (cs)
ZW (1) ZW9293A1 (cs)

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US6765019B1 (en) 1999-05-06 2004-07-20 University Of Kentucky Research Foundation Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids
GB0001653D0 (en) * 2000-01-26 2000-03-15 Astrazeneca Uk Ltd Chemical compound
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AU7570201A (en) * 2000-07-26 2002-02-05 Riley Patrick Anthony Phenylethylamine derivatives and their use in the treatment of melanoma
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RU2181261C1 (ru) * 2000-10-27 2002-04-20 Кировская государственная медицинская академия Способ определения контактной поверхности тупого твердого предмета при ударе по волосистой части головы
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RU2231063C2 (ru) * 2001-10-04 2004-06-20 Войсковая часть 61469 Способ оценки проницаемости иприта через защитные материалы
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EP2283869A3 (en) 2002-07-15 2012-06-27 Board of Regents, The University of Texas System Selected antibodies and duramycin peptides binding to anionic phospholipids and aminophospholipids and their use in the treatment of viral infections and cancer
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BRPI0510909A2 (pt) * 2004-05-19 2008-12-16 Medarex Inc composto de ligaÇço fÁrmaco-ligante citotàxico, formulaÇço farmacÊutica, mÉtodo para matar uma cÉlula e mÉtodo para retardar ou interromper o crescimento de tumor
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TWI412367B (zh) 2006-12-28 2013-10-21 Medarex Llc 化學鏈接劑與可裂解基質以及其之綴合物
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CA2938919C (en) 2014-02-28 2020-12-29 Hangzhou Dac Biotech Co., Ltd Charged linkers and their uses for conjugation
CN108449940B (zh) 2015-07-12 2021-06-08 杭州多禧生物科技有限公司 与细胞结合分子的共轭偶联的桥连接体
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GB9314960D0 (en) 1992-07-23 1993-09-01 Zeneca Ltd Chemical compounds

Also Published As

Publication number Publication date
RU2129542C1 (ru) 1999-04-27
US6277880B1 (en) 2001-08-21
CA2101104A1 (en) 1994-01-24
JP3541037B2 (ja) 2004-07-07
FI115048B (fi) 2005-02-28
AU681349B2 (en) 1997-08-28
HUT69288A (en) 1995-09-28
DK0651740T3 (da) 1999-06-28
RU95105246A (ru) 1997-04-27
MY111635A (en) 2000-10-31
HU9500145D0 (en) 1995-03-28
DE69321729D1 (de) 1998-11-26
FI950230L (fi) 1995-01-19
ZW9293A1 (en) 1994-03-30
GB9314960D0 (en) 1993-09-01
US5660829A (en) 1997-08-26
US5405990A (en) 1995-04-11
CZ15195A3 (en) 1995-11-15
AU4715693A (en) 1994-02-14
EP0651740A1 (en) 1995-05-10
ATE172450T1 (de) 1998-11-15
EP0651740B1 (en) 1998-10-21
CA2101104C (en) 2007-01-23
NZ254864A (en) 1996-11-26
SK281338B6 (sk) 2001-02-12
FI950230A0 (fi) 1995-01-19
JPH07509461A (ja) 1995-10-19
KR100268654B1 (ko) 2000-10-16
DE69321729T2 (de) 1999-03-18
US5714148A (en) 1998-02-03
IL106459A0 (en) 1994-11-11
PL174617B1 (pl) 1998-08-31
WO1994002450A1 (en) 1994-02-03
CZ287028B6 (en) 2000-08-16
US5587161A (en) 1996-12-24
US5958971A (en) 1999-09-28
PL307226A1 (en) 1995-05-15
PH30004A (en) 1996-10-29
SK6995A3 (en) 1995-07-11
ES2123662T3 (es) 1999-01-16
HK1002683A1 (en) 1998-09-11
TW272971B (cs) 1996-03-21

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