IL106217A - Pharmaceutical compositions containing organic nitrites for vasodilator therapy - Google Patents
Pharmaceutical compositions containing organic nitrites for vasodilator therapyInfo
- Publication number
- IL106217A IL106217A IL106217A IL10621793A IL106217A IL 106217 A IL106217 A IL 106217A IL 106217 A IL106217 A IL 106217A IL 10621793 A IL10621793 A IL 10621793A IL 106217 A IL106217 A IL 106217A
- Authority
- IL
- Israel
- Prior art keywords
- nitrite
- dosage form
- nitrites
- composition
- organic
- Prior art date
Links
- 238000002560 therapeutic procedure Methods 0.000 title claims abstract description 29
- 229940124549 vasodilator Drugs 0.000 title claims abstract description 21
- 239000003071 vasodilator agent Substances 0.000 title claims abstract description 21
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 9
- 150000002826 nitrites Chemical class 0.000 title description 16
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 claims abstract description 63
- 206010019280 Heart failures Diseases 0.000 claims abstract description 46
- 206010007559 Cardiac failure congestive Diseases 0.000 claims abstract description 45
- 239000002552 dosage form Substances 0.000 claims abstract description 34
- 206010002383 Angina Pectoris Diseases 0.000 claims abstract description 26
- 239000002674 ointment Substances 0.000 claims abstract description 21
- 238000001990 intravenous administration Methods 0.000 claims abstract description 17
- 206010020772 Hypertension Diseases 0.000 claims abstract description 16
- 238000011161 development Methods 0.000 claims abstract description 12
- 230000007774 longterm Effects 0.000 claims abstract description 12
- 239000002775 capsule Substances 0.000 claims abstract description 7
- 201000001881 impotence Diseases 0.000 claims abstract description 6
- 208000023589 ischemic disease Diseases 0.000 claims abstract description 6
- 230000001225 therapeutic effect Effects 0.000 claims abstract 3
- 238000001802 infusion Methods 0.000 claims description 39
- -1 alkyl nitrites Chemical class 0.000 claims description 26
- 239000000203 mixture Substances 0.000 claims description 19
- APNSGVMLAYLYCT-UHFFFAOYSA-N isobutyl nitrite Chemical compound CC(C)CON=O APNSGVMLAYLYCT-UHFFFAOYSA-N 0.000 claims description 15
- OWFXIOWLTKNBAP-UHFFFAOYSA-N isoamyl nitrite Chemical compound CC(C)CCON=O OWFXIOWLTKNBAP-UHFFFAOYSA-N 0.000 claims description 12
- 239000003814 drug Substances 0.000 claims description 10
- 239000003826 tablet Substances 0.000 claims description 7
- 230000037317 transdermal delivery Effects 0.000 claims description 6
- 239000007894 caplet Substances 0.000 claims description 5
- DCUDQJHBYBOPCQ-UHFFFAOYSA-N (3-chloro-2,2-dimethylpropyl) nitrite Chemical compound ClCC(C)(C)CON=O DCUDQJHBYBOPCQ-UHFFFAOYSA-N 0.000 claims description 4
- UYFFAINCSURFJZ-UHFFFAOYSA-N 2-phenylethyl nitrite Chemical compound O=NOCCC1=CC=CC=C1 UYFFAINCSURFJZ-UHFFFAOYSA-N 0.000 claims description 4
- 206010002388 Angina unstable Diseases 0.000 claims description 4
- 208000007814 Unstable Angina Diseases 0.000 claims description 4
- KTQDPHRNUFXDJB-UHFFFAOYSA-N cyclohexylmethyl nitrite Chemical compound O=NOCC1CCCCC1 KTQDPHRNUFXDJB-UHFFFAOYSA-N 0.000 claims description 4
- 201000004332 intermediate coronary syndrome Diseases 0.000 claims description 4
- 229940100611 topical cream Drugs 0.000 claims 2
- 229940100640 transdermal system Drugs 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 14
- 238000012377 drug delivery Methods 0.000 abstract description 9
- 230000001684 chronic effect Effects 0.000 abstract description 8
- 208000007718 Stable Angina Diseases 0.000 abstract description 5
- 239000008280 blood Substances 0.000 abstract description 5
- 210000004369 blood Anatomy 0.000 abstract description 5
- 230000000699 topical effect Effects 0.000 abstract description 4
- 239000006189 buccal tablet Substances 0.000 abstract description 3
- 239000006071 cream Substances 0.000 abstract description 3
- 239000007935 oral tablet Substances 0.000 abstract description 3
- 239000007921 spray Substances 0.000 abstract description 3
- 239000006190 sub-lingual tablet Substances 0.000 abstract description 3
- 241000700159 Rattus Species 0.000 description 31
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 description 26
- 229960003711 glyceryl trinitrate Drugs 0.000 description 24
- 230000000694 effects Effects 0.000 description 23
- 239000000006 Nitroglycerin Substances 0.000 description 22
- 230000002861 ventricular Effects 0.000 description 15
- 238000011282 treatment Methods 0.000 description 12
- 230000000144 pharmacologic effect Effects 0.000 description 9
- 201000010099 disease Diseases 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 229940079593 drug Drugs 0.000 description 8
- 150000002823 nitrates Chemical class 0.000 description 8
- 229910002651 NO3 Inorganic materials 0.000 description 7
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 7
- 230000036772 blood pressure Effects 0.000 description 6
- 210000002216 heart Anatomy 0.000 description 6
- 230000009467 reduction Effects 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 206010019233 Headaches Diseases 0.000 description 5
- 230000002411 adverse Effects 0.000 description 5
- 210000003169 central nervous system Anatomy 0.000 description 5
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- 210000004351 coronary vessel Anatomy 0.000 description 4
- 150000002148 esters Chemical class 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 206010052804 Drug tolerance Diseases 0.000 description 3
- IOVCWXUNBOPUCH-UHFFFAOYSA-N Nitrous acid Chemical compound ON=O IOVCWXUNBOPUCH-UHFFFAOYSA-N 0.000 description 3
- 230000001276 controlling effect Effects 0.000 description 3
- 208000002173 dizziness Diseases 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 230000001435 haemodynamic effect Effects 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 210000004165 myocardium Anatomy 0.000 description 3
- 229940082615 organic nitrates used in cardiac disease Drugs 0.000 description 3
- 208000007530 Essential hypertension Diseases 0.000 description 2
- 206010061216 Infarction Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 206010030124 Oedema peripheral Diseases 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 208000001431 Psychomotor Agitation Diseases 0.000 description 2
- 206010037423 Pulmonary oedema Diseases 0.000 description 2
- 206010038743 Restlessness Diseases 0.000 description 2
- 241000283984 Rodentia Species 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 229960003116 amyl nitrite Drugs 0.000 description 2
- 230000004872 arterial blood pressure Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000011340 continuous therapy Methods 0.000 description 2
- 208000029078 coronary artery disease Diseases 0.000 description 2
- 230000034994 death Effects 0.000 description 2
- 231100000517 death Toxicity 0.000 description 2
- 150000002009 diols Chemical class 0.000 description 2
- 238000013265 extended release Methods 0.000 description 2
- BCQZXOMGPXTTIC-UHFFFAOYSA-N halothane Chemical compound FC(F)(F)C(Cl)Br BCQZXOMGPXTTIC-UHFFFAOYSA-N 0.000 description 2
- 229960003132 halothane Drugs 0.000 description 2
- 230000007574 infarction Effects 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- 229960000201 isosorbide dinitrate Drugs 0.000 description 2
- MOYKHGMNXAOIAT-JGWLITMVSA-N isosorbide dinitrate Chemical compound [O-][N+](=O)O[C@H]1CO[C@@H]2[C@H](O[N+](=O)[O-])CO[C@@H]21 MOYKHGMNXAOIAT-JGWLITMVSA-N 0.000 description 2
- 238000011866 long-term treatment Methods 0.000 description 2
- 230000002107 myocardial effect Effects 0.000 description 2
- 208000010125 myocardial infarction Diseases 0.000 description 2
- 208000031225 myocardial ischemia Diseases 0.000 description 2
- 239000006186 oral dosage form Substances 0.000 description 2
- 230000002085 persistent effect Effects 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 239000004800 polyvinyl chloride Substances 0.000 description 2
- LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 230000035488 systolic blood pressure Effects 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000005541 ACE inhibitor Substances 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 201000006474 Brain Ischemia Diseases 0.000 description 1
- 229940127291 Calcium channel antagonist Drugs 0.000 description 1
- 206010007572 Cardiac hypertrophy Diseases 0.000 description 1
- 208000006029 Cardiomegaly Diseases 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 206010008120 Cerebral ischaemia Diseases 0.000 description 1
- 206010008479 Chest Pain Diseases 0.000 description 1
- 206010008469 Chest discomfort Diseases 0.000 description 1
- 206010009192 Circulatory collapse Diseases 0.000 description 1
- 206010009866 Cold sweat Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 206010020565 Hyperaemia Diseases 0.000 description 1
- 206010020649 Hyperkeratosis Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010024264 Lethargy Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 206010073310 Occupational exposures Diseases 0.000 description 1
- 206010031127 Orthostatic hypotension Diseases 0.000 description 1
- 206010033546 Pallor Diseases 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 206010041277 Sodium retention Diseases 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 208000001871 Tachycardia Diseases 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000000862 absorption spectrum Methods 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 206010000891 acute myocardial infarction Diseases 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 description 1
- 230000003257 anti-anginal effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 210000001765 aortic valve Anatomy 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- YEESUBCSWGVPCE-UHFFFAOYSA-N azanylidyneoxidanium iron(2+) pentacyanide Chemical compound [Fe++].[C-]#N.[C-]#N.[C-]#N.[C-]#N.[C-]#N.N#[O+] YEESUBCSWGVPCE-UHFFFAOYSA-N 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000002876 beta blocker Substances 0.000 description 1
- 229940097320 beta blocking agent Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 239000000480 calcium channel blocker Substances 0.000 description 1
- 238000013131 cardiovascular procedure Methods 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000001447 compensatory effect Effects 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000035487 diastolic blood pressure Effects 0.000 description 1
- 230000003205 diastolic effect Effects 0.000 description 1
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 description 1
- 229960003529 diazepam Drugs 0.000 description 1
- 230000010339 dilation Effects 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 238000000921 elemental analysis Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 210000003191 femoral vein Anatomy 0.000 description 1
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 125000001188 haloalkyl group Chemical group 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 230000001077 hypotensive effect Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 210000004283 incisor Anatomy 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000003601 intercostal effect Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- YWXYYJSYQOXTPL-SLPGGIOYSA-N isosorbide mononitrate Chemical compound [O-][N+](=O)O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 YWXYYJSYQOXTPL-SLPGGIOYSA-N 0.000 description 1
- 229960003827 isosorbide mononitrate Drugs 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000005246 left atrium Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229960004027 molsidomine Drugs 0.000 description 1
- XLFWDASMENKTKL-UHFFFAOYSA-N molsidomine Chemical compound O1C(N=C([O-])OCC)=C[N+](N2CCOCC2)=N1 XLFWDASMENKTKL-UHFFFAOYSA-N 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 229960002460 nitroprusside Drugs 0.000 description 1
- 231100000675 occupational exposure Toxicity 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 210000004789 organ system Anatomy 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 238000006213 oxygenation reaction Methods 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 239000003961 penetration enhancing agent Substances 0.000 description 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
- 210000003516 pericardium Anatomy 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 230000037081 physical activity Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 208000005333 pulmonary edema Diseases 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 208000011818 severe chest pain Diseases 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000010288 sodium nitrite Nutrition 0.000 description 1
- 238000013222 sprague-dawley male rat Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000002889 sympathetic effect Effects 0.000 description 1
- 206010042772 syncope Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000006794 tachycardia Effects 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 239000003451 thiazide diuretic agent Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000013271 transdermal drug delivery Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 150000004072 triols Chemical class 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 230000000304 vasodilatating effect Effects 0.000 description 1
- 230000009724 venous congestion Effects 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 230000002618 waking effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/908,224 US5278192A (en) | 1992-07-02 | 1992-07-02 | Method of vasodilator therapy for treating a patient with a condition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL106217A0 IL106217A0 (en) | 1993-11-15 |
| IL106217A true IL106217A (en) | 1998-04-05 |
Family
ID=25425396
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL106217A IL106217A (en) | 1992-07-02 | 1993-07-02 | Pharmaceutical compositions containing organic nitrites for vasodilator therapy |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US5278192A (show.php) |
| EP (1) | EP0604642A1 (show.php) |
| JP (1) | JP2729333B2 (show.php) |
| KR (1) | KR0170789B1 (show.php) |
| CN (1) | CN1086997A (show.php) |
| AU (1) | AU667948B2 (show.php) |
| CA (1) | CA2116785C (show.php) |
| CZ (1) | CZ39894A3 (show.php) |
| HU (1) | HUT70501A (show.php) |
| IL (1) | IL106217A (show.php) |
| MX (1) | MX9303982A (show.php) |
| NO (1) | NO305886B1 (show.php) |
| NZ (1) | NZ254490A (show.php) |
| OA (1) | OA09890A (show.php) |
| PL (1) | PL302613A1 (show.php) |
| SK (1) | SK23594A3 (show.php) |
| TW (1) | TW261530B (show.php) |
| WO (1) | WO1994001103A1 (show.php) |
| ZA (1) | ZA934771B (show.php) |
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| US5278192A (en) * | 1992-07-02 | 1994-01-11 | The Research Foundation Of State University Of New York | Method of vasodilator therapy for treating a patient with a condition |
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1992
- 1992-07-02 US US07/908,224 patent/US5278192A/en not_active Expired - Fee Related
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1993
- 1993-06-30 WO PCT/US1993/006235 patent/WO1994001103A1/en not_active Ceased
- 1993-06-30 AU AU46587/93A patent/AU667948B2/en not_active Ceased
- 1993-06-30 NZ NZ254490A patent/NZ254490A/xx unknown
- 1993-06-30 KR KR1019940700689A patent/KR0170789B1/ko not_active Expired - Fee Related
- 1993-06-30 SK SK235-94A patent/SK23594A3/sk unknown
- 1993-06-30 US US08/199,280 patent/US5489610A/en not_active Expired - Fee Related
- 1993-06-30 CA CA002116785A patent/CA2116785C/en not_active Expired - Fee Related
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- 1993-06-30 HU HU9400627A patent/HUT70501A/hu unknown
- 1993-06-30 EP EP93916879A patent/EP0604642A1/en not_active Withdrawn
- 1993-06-30 JP JP6503397A patent/JP2729333B2/ja not_active Expired - Fee Related
- 1993-06-30 PL PL93302613A patent/PL302613A1/xx unknown
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- 1993-07-02 CN CN93116247A patent/CN1086997A/zh active Pending
- 1993-08-20 TW TW082106738A patent/TW261530B/zh active
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1994
- 1994-02-28 OA OA60477A patent/OA09890A/en unknown
- 1994-02-28 NO NO940691A patent/NO305886B1/no unknown
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| NZ254490A (en) | 1997-08-22 |
| EP0604642A1 (en) | 1994-07-06 |
| CA2116785C (en) | 1998-04-07 |
| US5489610A (en) | 1996-02-06 |
| PL302613A1 (en) | 1994-09-05 |
| NO940691D0 (no) | 1994-02-28 |
| CN1086997A (zh) | 1994-05-25 |
| NO940691L (no) | 1994-03-18 |
| AU4658793A (en) | 1994-01-31 |
| OA09890A (en) | 1994-09-15 |
| US5278192A (en) | 1994-01-11 |
| IL106217A0 (en) | 1993-11-15 |
| HU9400627D0 (en) | 1994-06-28 |
| JPH06510800A (ja) | 1994-12-01 |
| TW261530B (show.php) | 1995-11-01 |
| MX9303982A (es) | 1994-02-28 |
| WO1994001103A1 (en) | 1994-01-20 |
| KR0170789B1 (ko) | 1999-02-01 |
| NO305886B1 (no) | 1999-08-16 |
| AU667948B2 (en) | 1996-04-18 |
| ZA934771B (en) | 1994-01-20 |
| SK23594A3 (en) | 1994-08-10 |
| CZ39894A3 (en) | 1994-11-16 |
| HUT70501A (en) | 1995-10-30 |
| JP2729333B2 (ja) | 1998-03-18 |
| CA2116785A1 (en) | 1994-01-20 |
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