IL105715A - 7b SUBSTITUTED-4-AZA-5a- ANDROSTAN-3-ONES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents

7b SUBSTITUTED-4-AZA-5a- ANDROSTAN-3-ONES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Info

Publication number
IL105715A
IL105715A IL105715A IL10571593A IL105715A IL 105715 A IL105715 A IL 105715A IL 105715 A IL105715 A IL 105715A IL 10571593 A IL10571593 A IL 10571593A IL 105715 A IL105715 A IL 105715A
Authority
IL
Israel
Prior art keywords
alkyl
substituted
aryl
unsubstituted
cycloalkyl
Prior art date
Application number
IL105715A
Other languages
English (en)
Other versions
IL105715A0 (en
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IL105715A0 publication Critical patent/IL105715A0/xx
Publication of IL105715A publication Critical patent/IL105715A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/80—Unsaturated compounds containing keto groups containing rings other than six-membered aromatic rings
    • C07C59/82—Unsaturated compounds containing keto groups containing rings other than six-membered aromatic rings the keto group being part of a ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL105715A 1992-05-20 1993-05-17 7b SUBSTITUTED-4-AZA-5a- ANDROSTAN-3-ONES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM IL105715A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US88657292A 1992-05-20 1992-05-20

Publications (2)

Publication Number Publication Date
IL105715A0 IL105715A0 (en) 1993-09-22
IL105715A true IL105715A (en) 1997-07-13

Family

ID=25389283

Family Applications (1)

Application Number Title Priority Date Filing Date
IL105715A IL105715A (en) 1992-05-20 1993-05-17 7b SUBSTITUTED-4-AZA-5a- ANDROSTAN-3-ONES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Country Status (14)

Country Link
US (1) US5710275A (fr)
EP (2) EP0572166B1 (fr)
JP (1) JPH06100587A (fr)
CN (1) CN1087092A (fr)
AT (2) ATE156838T1 (fr)
CA (1) CA2096616A1 (fr)
DE (2) DE69333317T2 (fr)
DK (1) DK0572166T3 (fr)
ES (2) ES2210336T3 (fr)
GR (1) GR3024884T3 (fr)
IL (1) IL105715A (fr)
MX (1) MX9302932A (fr)
WO (1) WO1993023420A1 (fr)
ZA (1) ZA933497B (fr)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993023051A1 (fr) * 1992-05-20 1993-11-25 Merck & Co., Inc. NOUVEAUX DERIVES 17-ESTER, AMIDE ET CETONE DE 3-OXO-4-AZASTEROIDES UTILISES COMME INHIBITEURS DE 5a-REDUCTASE
WO1993023420A1 (fr) * 1992-05-20 1993-11-25 Merck & Co., Inc. NOUVEAUX 4-AZA-5α-ANDROSTANE-3-ONES SUBSTITUES EN POSITION 7β EN TANT QU'INHIBITEURS DE LA 5α-REDUCTASE
DE69313114T2 (de) * 1992-05-20 1998-03-19 Merck & Co Inc NEUE DELTA-17 UND DELTA-20 UNGESÄTIGTE UND GESATIGTE 17--g(b)-SUBSTITUIERTE-4-AZA-5-g(a)-ANDROSTAN-3-ON VERBINDUNGEN ALS INHIBITOREN VON 5-ALPHA-REDUCTASE
WO1993023038A1 (fr) * 1992-05-20 1993-11-25 Merck & Co., Inc. INHIBITEURS DE 5α-REDUCTASE A BASE DE 4-AZASTEROIDES A SUBSTITUTION AMINO EN POSITION 17
DE69329149T2 (de) * 1992-05-20 2001-03-29 Merck & Co Inc 4-azasteroide als 5-alpha-reduktase
WO1993023039A1 (fr) * 1992-05-20 1993-11-25 Merck & Co., Inc. 4-aza-5a-androstan ones substituees utilisees en tant qu'inhibitors de la 5a-reductase
US5237064A (en) * 1992-05-20 1993-08-17 Merck & Co., Inc. Process for producing 7β-substituted-aza-5αandrostan-3-ones
AU5323694A (en) * 1992-10-06 1994-04-26 Merck & Co., Inc. 17beta -carboxanilides of 4-aza-5alpha-androstan-3-ones as 5alpha-reductase inhibitors
ES2158887T3 (es) * 1992-12-18 2001-09-16 Merck & Co Inc Procedimiento para tratar la prostatitis cronica con 17 beta-n-terc-butilcarbamoil-4-aza-5 alfa-androst-1-en-ona.
DE69405760T2 (de) * 1993-06-28 1998-04-09 Merck & Co Inc 4-aza-pregnan-5-alpha-reductase isozym 1 inhibitoren
US5438061A (en) * 1993-07-16 1995-08-01 Merck & Co., Inc. 7-substituted-δ4-6-azasteroid derivatives as 5α-reductase inhibitors
TW408127B (en) * 1993-09-17 2000-10-11 Glaxo Inc Androstenones
TW369521B (en) * 1993-09-17 1999-09-11 Smithkline Beecham Corp Androstenone derivative
CA2174234A1 (fr) * 1993-11-04 1995-05-11 Raman K. Bakshi Derives de 4-aza-steroide substitue en position 7 utilises comme inhibiteurs de 5-alpha-reductase
US5525608A (en) * 1994-04-20 1996-06-11 Merck & Co., Inc. 17b-aryl-4-aza-steroid derivatives useful as 5-alpha-reductase inhibitors
GB9415178D0 (en) * 1994-07-28 1994-09-21 Erba Carlo Spa 4-azasteroids with side-chain fluoroketones
US5470976A (en) * 1994-09-07 1995-11-28 Merck & Co., Inc. Process for the stereoselective reduction of steroid enelactams
US5817818A (en) * 1994-09-16 1998-10-06 Glaxo Wellcome Inc. Androstenones
US5541322A (en) * 1994-10-14 1996-07-30 Glaxo Wellcome Inc. Synthesis of 6-azaandrostenones
US5656613A (en) * 1995-01-04 1997-08-12 Merck & Co., Inc. Treatment of hyperandrogenic conditions
US5763361A (en) * 1995-10-23 1998-06-09 Merck & Co., Inc. 17-alkyl-7-substituted-4-aza steroid derivatives as 5-α-reductase inhibitors
WO1997015558A1 (fr) * 1995-10-23 1997-05-01 Merck & Co., Inc. Derives de steroides 17-alkyl-4-aza-7-substitues
US6365597B1 (en) 1996-02-14 2002-04-02 Aventis Pharmaceuticals Inc. 4-aza steroids
US5872126A (en) * 1996-09-06 1999-02-16 Merck & Co., Inc. Methods and compositions for treating preterm labor
CA2287924A1 (fr) * 1997-05-07 1998-11-12 Novopharm Limited 4-azasteroides
US5998427A (en) * 1998-05-14 1999-12-07 Glaxo Wellcome Inc. Androstenones
JP4563032B2 (ja) * 2002-01-15 2010-10-13 メルク・シャープ・エンド・ドーム・コーポレイション アンドロゲン受容体モジュレータとしての１７−ヒドロキシ−４−アザ−アンドロスタン−３−オン
EP1622567B1 (fr) * 2003-05-07 2013-07-24 Merck Sharp & Dohme Corp. Modulateurs du recepteur d'androgenes et leur methode d'utilisation
CN100528168C (zh) * 2003-06-30 2009-08-19 麦克公司 作为雄激素受体调节剂的17-乙酰氨基-4-氮杂甾类衍生物
JP2007521293A (ja) * 2003-06-30 2007-08-02 メルク　エンド　カムパニー　インコーポレーテッド アンドロゲン受容体モジュレータとしての１７−アセトアミド−４−アザステロイド誘導体
WO2005004807A2 (fr) * 2003-06-30 2005-01-20 Merck & Co., Inc. Derives de 17-acetamido-4-azasteroide servant de modulateurs du recepteur d'androgenes
US7482357B2 (en) 2003-06-30 2009-01-27 Merck & Co., Inc. 17-acetamido-4-azasteroid derivatives as androgen receptor modulators
CN1849120A (zh) * 2003-09-10 2006-10-18 默克公司 作为雄激素受体调节剂的17－杂环－4－氮杂甾类衍生物
AU2004272004B2 (en) 2003-09-10 2009-01-22 Merck Sharp & Dohme Corp. 17-heterocyclic-4-azasteroid derivatives as androgen receptor modulators
JP2007532550A (ja) * 2004-04-08 2007-11-15 メルク　エンド　カムパニー　インコーポレーテッド アンドロゲン受容体モジュレーターとしての１７−β−アセトアミド−４−アザステロイド
CN100355772C (zh) * 2005-12-28 2007-12-19 天津大学 具有5α－还原酶抑制活性的甾体化合物及其制备方法
WO2011131543A1 (fr) * 2010-04-20 2011-10-27 Syngenta Participations Ag Procédé de synthèse d'amides d'acide pyrazolecarboxylique
CN111175410A (zh) * 2020-02-12 2020-05-19 武汉大学 N-甲基苯乙胺及其同位素试剂在羧基化合物检测中的应用
CN117858887A (zh) * 2021-06-16 2024-04-09 拉瓦勒大学 17β-HSD7的新型抑制剂及其用途

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4377584A (en) * 1978-04-13 1983-03-22 Merck & Co., Inc. 4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors
AU527030B2 (en) * 1978-04-13 1983-02-10 Merck & Co., Inc. 4-aza-17-substituted-5a-androstan-3-ones
US4220775A (en) * 1979-03-15 1980-09-02 Merck & Co., Inc. Preparation of 4-aza-17-substituted-5α-androstan-3-ones useful as 5α-reductase inhibitors
ATE67503T1 (de) * 1984-02-27 1991-10-15 Merck & Co Inc 17-beta-substituierte-4-aza-5-alpha-androstenon und ihre anwendung als 5-alpha-reduktaseinhibitoren.
US5049562A (en) * 1984-02-27 1991-09-17 Merck & Co., Inc. 17β-acyl-4-aza-5α-androst-1-ene-3-ones as 5α-reductase inhibitors
US5138063A (en) * 1984-02-27 1992-08-11 Merck & Co., Inc. 17β-methoxycarbonyl-4-aza-androsten-1-en-3-ones
NZ211145A (en) * 1984-02-27 1988-10-28 Merck & Co Inc 4-aza-5-alpha-androst-1-en-3-ones and pharmaceutical compositions
US4760071A (en) * 1984-02-27 1988-07-26 Merck & Co., Inc. 17β-N-monosubstituted carbamoyl-4-aza-5α-androst-1-en-3-ones which are active as testosterone 5α-reductase inhibitors
US4859681A (en) * 1984-02-27 1989-08-22 Merck & Co., Inc. 17 α-Acyl-4-aza-5a-androst-1-en-3-ones as 5 alpha-reductase inhibitors
US4888336A (en) * 1987-01-28 1989-12-19 Smithkline Beckman Corporation Steroid 5-alpha-reductase inhibitors
US5026882A (en) * 1988-12-23 1991-06-25 Smithkline Beecham Corporation Phosphinic acid substituted steroids as inhibitors of steroid 5α-reductase
US5032586A (en) * 1989-08-24 1991-07-16 Smithkline Beecham Corporation 7-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-alpha reductase
US5300294A (en) * 1990-06-27 1994-04-05 Smithkline Beecham Corporation Method of treating prostatic adenocarcinoma
IE76452B1 (en) * 1990-10-29 1997-10-22 Sankyo Co Azasteroid compounds for the treatment of prostatic hypertrophy their preparation and use
CA2084799C (fr) * 1991-12-17 2003-01-28 Glenn J. Gormley Methode de prevention du carcinome prostatique a l'aide de 17 beta-n-monosubstitue-carbamyl-4-aza-5 alpha-androst-1 -en-3-ones
ATE165368T1 (de) * 1991-12-20 1998-05-15 Glaxo Wellcome Inc Inhibitoren von testosteron-5-alpha reductase.
US5215894A (en) * 1992-02-25 1993-06-01 Merck & Co., Inc. Biological process for producing 17β-N-monosubstituted carbamoyl-11-oxo-4-aza-5-α-androst-3-one testosterone-5-α reductase inhibitors
DE69313114T2 (de) * 1992-05-20 1998-03-19 Merck & Co Inc NEUE DELTA-17 UND DELTA-20 UNGESÄTIGTE UND GESATIGTE 17--g(b)-SUBSTITUIERTE-4-AZA-5-g(a)-ANDROSTAN-3-ON VERBINDUNGEN ALS INHIBITOREN VON 5-ALPHA-REDUCTASE
WO1993023419A1 (fr) * 1992-05-20 1993-11-25 Merck & Co., Inc. NOUVELLES 4-AZA-5α-CHOLESTAN-ONES SUBSTITUEES EN POSITION 7β ET UTILISEES COMME INHIBITEURS DE 5α-REDUCTASE
ATE195530T1 (de) * 1992-05-20 2000-09-15 Merck & Co Inc 17-ether und thioether von 4-aza-steroiden
WO1993023420A1 (fr) * 1992-05-20 1993-11-25 Merck & Co., Inc. NOUVEAUX 4-AZA-5α-ANDROSTANE-3-ONES SUBSTITUES EN POSITION 7β EN TANT QU'INHIBITEURS DE LA 5α-REDUCTASE
US5237064A (en) * 1992-05-20 1993-08-17 Merck & Co., Inc. Process for producing 7β-substituted-aza-5αandrostan-3-ones
WO1993023051A1 (fr) * 1992-05-20 1993-11-25 Merck & Co., Inc. NOUVEAUX DERIVES 17-ESTER, AMIDE ET CETONE DE 3-OXO-4-AZASTEROIDES UTILISES COMME INHIBITEURS DE 5a-REDUCTASE
KR950701527A (ko) * 1992-05-21 1995-04-28 라브리 페르낭 테스토스테론 5α 환원효소 활성 저해제(INHIBITORS OF TESTOSTERONE 5α-REDUCTASE ACTIVITY)
US5278159A (en) * 1992-10-06 1994-01-11 Merck & Co., Inc. Aryl ester derivatives of 3-oxo-4-aza-androstane 17-β-carboxylates as 5-α-reductase inhibitors
US5543417A (en) * 1994-10-21 1996-08-06 Merck & Co., Inc. Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents

Also Published As

Publication number Publication date
DE69313018T2 (de) 1998-02-19
DE69333317D1 (de) 2004-01-08
DE69333317T2 (de) 2004-08-19
ES2106965T3 (es) 1997-11-16
CA2096616A1 (fr) 1993-11-21
EP0778284B1 (fr) 2003-11-26
JPH06100587A (ja) 1994-04-12
GR3024884T3 (en) 1998-01-30
ATE156838T1 (de) 1997-08-15
EP0572166A1 (fr) 1993-12-01
ATE255125T1 (de) 2003-12-15
AU3869893A (en) 1993-11-25
ZA933497B (en) 1993-12-14
AU662224B2 (en) 1995-08-24
MX9302932A (es) 1995-01-31
IL105715A0 (en) 1993-09-22
CN1087092A (zh) 1994-05-25
EP0778284A3 (fr) 1997-08-13
EP0778284A2 (fr) 1997-06-11
EP0572166B1 (fr) 1997-08-13
ES2210336T3 (es) 2004-07-01
DK0572166T3 (da) 1997-09-01
DE69313018D1 (de) 1997-09-18
US5710275A (en) 1998-01-20
WO1993023420A1 (fr) 1993-11-25

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