AR018892A1 - Compuestos de aminotiazol carbono-sustituidos, utiles como inhibidores de quinasas dependientes de ciclinas y las composiciones farmaceuticas que lascontienen, metodo para el tratamiento de enfermedades proliferativas, inflamacion y artritis - Google Patents
Compuestos de aminotiazol carbono-sustituidos, utiles como inhibidores de quinasas dependientes de ciclinas y las composiciones farmaceuticas que lascontienen, metodo para el tratamiento de enfermedades proliferativas, inflamacion y artritisInfo
- Publication number
- AR018892A1 AR018892A1 ARP990102939A ARP990102939A AR018892A1 AR 018892 A1 AR018892 A1 AR 018892A1 AR P990102939 A ARP990102939 A AR P990102939A AR P990102939 A ARP990102939 A AR P990102939A AR 018892 A1 AR018892 A1 AR 018892A1
- Authority
- AR
- Argentina
- Prior art keywords
- heteroaryl
- cycloalkyl
- alkyl
- heterocycloalkylalkyl
- cycloalkylalkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
Se revelan compuestos aminotiazol carbono-sustituidos que tienen la formula (I) y las sales de los mismos aceptables farmacéuticamente. Lossustituyentes tienen los siguientes significados: R1 = R2, COR2, CONH2, CONR2R3, COOR3, o SO2R3; R2 = H, alquilo, cicloalquilo, heterocicloalquilo,cicloalquilalquilo, heterocicloalquilalquilo, arilo, heteroarilo, arilalquilo, heteroarilalquilo; R3 = alquilo, cicloalquilo, heterocicloalquilo,cicloalquilalquilo, heterocicloalquilalquilo, arilo, heteroarilo, arilalquilo, heteroarilalquilo; A = formula (II), en donde n = 0, 1, 2; m = 1, 2 perotanto n como m pueden ser 2, y X = O, NR12, S, o un enlace, o formula (III), en donde i, j = 0 o 1, pero no pueden ser ambos 1, e Y = alqueno sustituidoopcionalmente, alquilo, o cualesquiera de 2 átomos de carbono adyacentes de un anillo de cicloalquilo o cicloheteroalquilo de 3-7 átomos; R4 = alquilo,cicloalquilo, heterocicloalquilo, cicloalquilalquilo, heterocicloalquilalquilo, alquiloxicarbonilo, arilo, heteroarilo, arilalquilo, heteroarilalquilo,ariloxicarbonilo, o R9; R5, R6, R7, R8 = independientemente H, alquilo, cicloalquilo, heterocicloalquilo, cicloalquilalquilo, heterocicloalquilalquilo,arilo, heteroarilo, arilalquilo, heteroarilalquilo, halo, o hidroxi, alcoxi, amino NR16R17, tio o alquiltio con la condicion de que solamente uno detales grupos de heteroátomos está unido a cualquier átomo de carbon, o R5 = R6 = oxo, o R7 = R8 = oxo, cuando X = un enlace; R9 = formula (IV), en dondeZ = O, NR13,S; R10, R11 = independientemente H, alquilo, cicloalquilo, heterocicloalquilo, cicloalquilalquilo, heterocicloalquilalquilo, arilo,heteroarilo, arilalquilo, heteroarilalquilo, halo, hidroxi, alcoxi, alquilcarboniloxi, carboxi, alquiloxicarbonilo, amino, NR14R15, carbamoílo, ureido, tio,o alquiltio; R12 = H, alquilo, cicloalquilo, heterocicloalquilo, cicloalquilalquilo, heterocicloalquilalquilo, arilo, heteroarilo, arilalquilo,heteroarilalquilo, R13 = H, alquilo, cicloalquilo, heterocicloalquilo,cicloalquilalquilo, heterocicloalquilalquilo, arilo, heteroarilo, arilalquilo,
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8974798P | 1998-06-18 | 1998-06-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR018892A1 true AR018892A1 (es) | 2001-12-12 |
Family
ID=22219395
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP990102939A AR018892A1 (es) | 1998-06-18 | 1999-06-18 | Compuestos de aminotiazol carbono-sustituidos, utiles como inhibidores de quinasas dependientes de ciclinas y las composiciones farmaceuticas que lascontienen, metodo para el tratamiento de enfermedades proliferativas, inflamacion y artritis |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1087951B9 (es) |
JP (1) | JP2002518380A (es) |
AR (1) | AR018892A1 (es) |
AT (1) | ATE288904T1 (es) |
AU (1) | AU768751B2 (es) |
CA (1) | CA2332325A1 (es) |
DE (1) | DE69923681T2 (es) |
ES (1) | ES2237919T4 (es) |
WO (1) | WO1999065884A1 (es) |
Families Citing this family (64)
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GB9823871D0 (en) * | 1998-10-30 | 1998-12-23 | Pharmacia & Upjohn Spa | 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents |
WO2000035455A1 (en) * | 1998-12-15 | 2000-06-22 | Telik, Inc. | Heteroaryl-aryl ureas as igf-1 receptor antagonists |
UA71971C2 (en) * | 1999-06-04 | 2005-01-17 | Agoron Pharmaceuticals Inc | Diaminothiazoles, composition based thereon, a method for modulation of protein kinases activity, a method for the treatment of diseases mediated by protein kinases |
ES2251395T3 (es) * | 1999-07-26 | 2006-05-01 | Banyu Pharmaceutical Co., Ltd. | Derivados de biarilureas. |
JP2001106673A (ja) * | 1999-07-26 | 2001-04-17 | Banyu Pharmaceut Co Ltd | ビアリールウレア誘導体 |
US6114365A (en) * | 1999-08-12 | 2000-09-05 | Pharmacia & Upjohn S.P.A. | Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents |
ATE309241T1 (de) * | 1999-09-10 | 2005-11-15 | Merck & Co Inc | Tyrosin kinase inhibitoren |
AU2001230026A1 (en) * | 2000-02-04 | 2001-08-14 | Novo-Nordisk A/S | 2,4-diaminothiazole derivatives |
WO2001079198A1 (en) | 2000-04-18 | 2001-10-25 | Agouron Pharmaceuticals, Inc. | Pyrazoles for inhibiting protein kinase |
AU2001252562A1 (en) * | 2000-04-28 | 2001-11-12 | Toshiharu Suzuki | Medicinal compositions for suppressing beta-amyloid production |
SE0001899D0 (sv) | 2000-05-22 | 2000-05-22 | Pharmacia & Upjohn Ab | New compounds |
CN100457753C (zh) * | 2000-07-26 | 2009-02-04 | 布里斯托尔-迈尔斯斯奎布公司 | 依赖细胞周期蛋白的激酶的n-[5-[[[5-烷基-2-唑基]甲基]硫代]-2-噻唑基]甲酰胺抑制剂 |
US6645990B2 (en) | 2000-08-15 | 2003-11-11 | Amgen Inc. | Thiazolyl urea compounds and methods of uses |
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DE60117605T2 (de) | 2000-12-21 | 2006-12-07 | Bristol-Myers Squibb Co. | Thiazolyl-inhibitoren von tyrosinkinasen der tec-familie |
CA2735478C (en) * | 2001-01-26 | 2014-07-08 | Chugai Seiyaku Kabushiki Kaisha | Malonyl-coa decarboxylase inhibitors useful as metabolic modulators |
US7709510B2 (en) | 2001-02-20 | 2010-05-04 | Chugai Seiyaku Kabushiki Kaisha | Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators |
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ES2255621T3 (es) * | 2001-06-22 | 2006-07-01 | MERCK & CO., INC. | Inhibidores de tirosina quinasa. |
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KR101244517B1 (ko) | 2008-01-11 | 2013-03-18 | 에프. 호프만-라 로슈 아게 | 아밀로이드 베타에 대한 조절제 |
CA2713716A1 (en) | 2008-02-22 | 2009-08-27 | F. Hoffmann-La Roche Ag | Modulators for amyloid beta |
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Family Cites Families (6)
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US3169954A (en) * | 1962-08-06 | 1965-02-16 | Eastman Kodak Co | Monoazo thiazole dyestuffs |
DE3418376A1 (de) * | 1984-05-17 | 1985-11-21 | Bayer Ag, 5090 Leverkusen | Zwischenprodukte sowie verfahren zur herstellung von zwischenprodukten fuer die synthese von cephalosporinen |
FR2612187B1 (fr) * | 1987-03-12 | 1989-07-21 | Sanofi Sa | Derives du thiazole actifs sur le systeme cholinergique, leur procede de preparation et compositions pharmaceutiques en contenant |
TW513418B (en) * | 1996-07-31 | 2002-12-11 | Otsuka Pharma Co Ltd | Thiazole derivatives, their production and use |
GB9823873D0 (en) * | 1998-10-30 | 1998-12-30 | Pharmacia & Upjohn Spa | 2-ureido-thiazole derivatives,process for their preparation,and their use as antitumour agents |
GB9823871D0 (en) * | 1998-10-30 | 1998-12-23 | Pharmacia & Upjohn Spa | 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents |
-
1999
- 1999-06-11 JP JP2000554710A patent/JP2002518380A/ja not_active Withdrawn
- 1999-06-11 CA CA002332325A patent/CA2332325A1/en not_active Abandoned
- 1999-06-11 AT AT99927401T patent/ATE288904T1/de not_active IP Right Cessation
- 1999-06-11 WO PCT/US1999/013034 patent/WO1999065884A1/en active IP Right Grant
- 1999-06-11 AU AU44311/99A patent/AU768751B2/en not_active Ceased
- 1999-06-11 DE DE69923681T patent/DE69923681T2/de not_active Expired - Fee Related
- 1999-06-11 EP EP99927401A patent/EP1087951B9/en not_active Expired - Lifetime
- 1999-06-11 ES ES99927401T patent/ES2237919T4/es not_active Expired - Lifetime
- 1999-06-18 AR ARP990102939A patent/AR018892A1/es unknown
Also Published As
Publication number | Publication date |
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DE69923681D1 (de) | 2005-03-17 |
EP1087951B9 (en) | 2006-09-13 |
AU768751B2 (en) | 2004-01-08 |
EP1087951A4 (en) | 2002-08-14 |
JP2002518380A (ja) | 2002-06-25 |
EP1087951A1 (en) | 2001-04-04 |
AU4431199A (en) | 2000-01-05 |
DE69923681T2 (de) | 2006-01-12 |
WO1999065884A1 (en) | 1999-12-23 |
ES2237919T4 (es) | 2007-05-01 |
CA2332325A1 (en) | 1999-12-23 |
ES2237919T3 (es) | 2005-08-01 |
ATE288904T1 (de) | 2005-02-15 |
EP1087951B1 (en) | 2005-02-09 |
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