IL104075A - Process for the preparation of a heterologous protein cleaved off a pro-sequence in a eukaryotic host cell - Google Patents
Process for the preparation of a heterologous protein cleaved off a pro-sequence in a eukaryotic host cellInfo
- Publication number
- IL104075A IL104075A IL10407592A IL10407592A IL104075A IL 104075 A IL104075 A IL 104075A IL 10407592 A IL10407592 A IL 10407592A IL 10407592 A IL10407592 A IL 10407592A IL 104075 A IL104075 A IL 104075A
- Authority
- IL
- Israel
- Prior art keywords
- pro
- sequence
- preparation
- host cell
- eukaryotic host
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 101710188975 Dibasic-processing endoprotease Proteins 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
- C12N9/60—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from yeast
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/04—Fusion polypeptide containing a localisation/targetting motif containing an ER retention signal such as a C-terminal HDEL motif
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Analytical Chemistry (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP91810984 | 1991-12-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
IL104075A0 IL104075A0 (en) | 1993-05-13 |
IL104075A true IL104075A (en) | 2003-01-12 |
Family
ID=8208912
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL10407592A IL104075A (en) | 1991-12-16 | 1992-12-13 | Process for the preparation of a heterologous protein cleaved off a pro-sequence in a eukaryotic host cell |
Country Status (17)
Country | Link |
---|---|
US (2) | US5501975A (fr) |
EP (1) | EP0548012B1 (fr) |
JP (1) | JP3305781B2 (fr) |
KR (1) | KR100270283B1 (fr) |
AT (1) | ATE157703T1 (fr) |
AU (1) | AU667852B2 (fr) |
CA (1) | CA2085308C (fr) |
DE (1) | DE69222013T2 (fr) |
DK (1) | DK0548012T3 (fr) |
ES (1) | ES2107520T3 (fr) |
FI (1) | FI105482B (fr) |
GR (1) | GR3025324T3 (fr) |
IL (1) | IL104075A (fr) |
MX (1) | MX9207291A (fr) |
NO (1) | NO308619B1 (fr) |
NZ (1) | NZ245469A (fr) |
ZA (1) | ZA929711B (fr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9404270D0 (en) * | 1994-03-05 | 1994-04-20 | Delta Biotechnology Ltd | Yeast strains and modified albumins |
US5807702A (en) * | 1995-02-27 | 1998-09-15 | Abbott Laboratories | Method for expressing phosphorylated recombinant human β-casein in a bacterial system |
NZ304538A (en) * | 1995-02-27 | 1999-08-30 | Abbott Lab | Process for producing a modified recombinant protein in a host cell comprising preparing a single vector encoding both the exogenous protein and an enzyme capable of modifying the exogenous protein |
US5710044A (en) * | 1995-02-27 | 1998-01-20 | Abbott Laboratories | Plasmid for expressing phosphorylated recombinant proteins in a bacterial system |
US5942254A (en) * | 1995-02-27 | 1999-08-24 | Abbott Laboratories | Phosphorylated recombinant human β-casein expressed in a bacterial system |
JPH11500920A (ja) * | 1995-02-27 | 1999-01-26 | アボツト・ラボラトリーズ | 修飾された組換えタンパク質を細菌系において発現させるプラスミド |
AT404838B (de) * | 1995-11-24 | 1999-03-25 | Immuno Ag | Herstellung von proteinen aus pro-proteinen durch fusionsproteine abgeleitet von furin oder furinanalogen |
FR2751000B1 (fr) | 1996-07-12 | 1998-10-30 | Inst Nat Sante Rech Med | Adn specifiques des bacteries de l'espece neisseria meningitidis, leurs procedes d'obtention et leurs applications biologiques |
WO2000028065A1 (fr) * | 1998-11-06 | 2000-05-18 | Novo Nordisk A/S | Technique de production du facteur vii |
EP2028275A3 (fr) * | 2000-06-30 | 2009-05-06 | VIB vzw | Modification de glycosylation de protéine dans pichia pastoris |
DE10221411B4 (de) * | 2002-05-14 | 2004-07-08 | GSF-Forschungszentrum für Umwelt und Gesundheit GmbH | Rekombinantes Fowlpox-Virus |
US20040117874A1 (en) * | 2002-10-15 | 2004-06-17 | Jianjun Yang | Methods for accumulating translocated proteins |
US7507573B2 (en) | 2003-11-14 | 2009-03-24 | Vib, Vzw | Modification of protein glycosylation in methylotrophic yeast |
JP5112064B2 (ja) * | 2004-05-21 | 2013-01-09 | エムオー バイオ ラボラトリーズ インコーポレイテッド | 環境サンプルおよび生物学的サンプル中の核酸から夾雑物を除去するためのキットおよび方法 |
US20080082338A1 (en) * | 2006-09-29 | 2008-04-03 | O'neil Michael P | Systems and methods for secure voice identification and medical device interface |
JP6742729B2 (ja) | 2013-03-06 | 2020-08-19 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーGlaxoSmithKline LLC | 宿主細胞および使用方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0205404B1 (fr) * | 1985-06-11 | 1992-07-15 | Ciba-Geigy Ag | Interférons hybrides |
US5391485A (en) * | 1985-08-06 | 1995-02-21 | Immunex Corporation | DNAs encoding analog GM-CSF molecules displaying resistance to proteases which cleave at adjacent dibasic residues |
FI100106B (fi) * | 1986-12-05 | 1997-09-30 | Novartis Ag | Menetelmä plasminogeenin yksisäikeisen yhdistelmäaktivaattorin valmist amiseksi |
JP2643968B2 (ja) * | 1988-02-03 | 1997-08-25 | サントリー株式会社 | Kex2エンドプロテアーゼ及びその製造方法 |
-
1992
- 1992-12-08 AT AT92810964T patent/ATE157703T1/de active
- 1992-12-08 EP EP92810964A patent/EP0548012B1/fr not_active Expired - Lifetime
- 1992-12-08 ES ES92810964T patent/ES2107520T3/es not_active Expired - Lifetime
- 1992-12-08 DE DE69222013T patent/DE69222013T2/de not_active Expired - Lifetime
- 1992-12-08 DK DK92810964.4T patent/DK0548012T3/da active
- 1992-12-10 AU AU30071/92A patent/AU667852B2/en not_active Expired
- 1992-12-13 IL IL10407592A patent/IL104075A/xx not_active IP Right Cessation
- 1992-12-14 NZ NZ245469A patent/NZ245469A/en unknown
- 1992-12-14 FI FI925678A patent/FI105482B/fi not_active IP Right Cessation
- 1992-12-14 CA CA002085308A patent/CA2085308C/fr not_active Expired - Lifetime
- 1992-12-14 KR KR1019920024117A patent/KR100270283B1/ko not_active IP Right Cessation
- 1992-12-15 JP JP33410492A patent/JP3305781B2/ja not_active Expired - Lifetime
- 1992-12-15 ZA ZA929711A patent/ZA929711B/xx unknown
- 1992-12-15 MX MX9207291A patent/MX9207291A/es unknown
- 1992-12-15 NO NO924847A patent/NO308619B1/no not_active IP Right Cessation
-
1994
- 1994-10-24 US US08/328,961 patent/US5501975A/en not_active Expired - Lifetime
-
1995
- 1995-06-05 US US08/462,397 patent/US5618690A/en not_active Expired - Lifetime
-
1997
- 1997-11-07 GR GR970402966T patent/GR3025324T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
CA2085308C (fr) | 2003-12-02 |
DE69222013T2 (de) | 1998-01-29 |
AU667852B2 (en) | 1996-04-18 |
FI925678A (fi) | 1993-06-17 |
EP0548012A1 (fr) | 1993-06-23 |
JPH06197787A (ja) | 1994-07-19 |
KR930013115A (ko) | 1993-07-21 |
ES2107520T3 (es) | 1997-12-01 |
ZA929711B (en) | 1993-06-16 |
FI925678A0 (fi) | 1992-12-14 |
IL104075A0 (en) | 1993-05-13 |
NO924847D0 (no) | 1992-12-15 |
DE69222013D1 (de) | 1997-10-09 |
MX9207291A (es) | 1993-07-01 |
KR100270283B1 (ko) | 2000-11-01 |
AU3007192A (en) | 1993-06-17 |
ATE157703T1 (de) | 1997-09-15 |
DK0548012T3 (da) | 1998-04-14 |
NZ245469A (en) | 1995-03-28 |
GR3025324T3 (en) | 1998-02-27 |
NO924847L (no) | 1993-06-17 |
EP0548012B1 (fr) | 1997-09-03 |
US5618690A (en) | 1997-04-08 |
FI105482B (fi) | 2000-08-31 |
NO308619B1 (no) | 2000-10-02 |
US5501975A (en) | 1996-03-26 |
CA2085308A1 (fr) | 1993-06-17 |
JP3305781B2 (ja) | 2002-07-24 |
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Legal Events
Date | Code | Title | Description |
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FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
EXP | Patent expired |