ATE235556T1 - Schimmel-protease - Google Patents

Schimmel-protease

Info

Publication number
ATE235556T1
ATE235556T1 AT94810616T AT94810616T ATE235556T1 AT E235556 T1 ATE235556 T1 AT E235556T1 AT 94810616 T AT94810616 T AT 94810616T AT 94810616 T AT94810616 T AT 94810616T AT E235556 T1 ATE235556 T1 AT E235556T1
Authority
AT
Austria
Prior art keywords
protease
aspergillus
preparation
mutant strain
aspartic
Prior art date
Application number
AT94810616T
Other languages
English (en)
Inventor
Frank Buxton
Gabor Jarai
Jacob Visser
Original Assignee
Novartis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Pharma Gmbh filed Critical Novartis Pharma Gmbh
Application granted granted Critical
Publication of ATE235556T1 publication Critical patent/ATE235556T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
    • C12N9/62—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from Aspergillus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT94810616T 1993-11-03 1994-10-25 Schimmel-protease ATE235556T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP93810764 1993-11-03

Publications (1)

Publication Number Publication Date
ATE235556T1 true ATE235556T1 (de) 2003-04-15

Family

ID=8215057

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94810616T ATE235556T1 (de) 1993-11-03 1994-10-25 Schimmel-protease

Country Status (18)

Country Link
US (2) US5674728A (de)
EP (1) EP0655497B1 (de)
JP (1) JP3727678B2 (de)
KR (1) KR100378507B1 (de)
AT (1) ATE235556T1 (de)
AU (1) AU688379B2 (de)
CA (1) CA2134863C (de)
CY (1) CY2471B1 (de)
DE (1) DE69432336T2 (de)
DK (1) DK0655497T3 (de)
ES (1) ES2196019T3 (de)
FI (1) FI119060B (de)
HU (1) HU220360B (de)
IL (2) IL168245A (de)
NO (1) NO315330B1 (de)
NZ (1) NZ264839A (de)
PT (1) PT655497E (de)
ZA (1) ZA948619B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997020921A1 (en) * 1995-12-07 1997-06-12 Novo Nordisk A/S Selective inactivation of enzyme activities
EP0866872A1 (de) * 1995-12-15 1998-09-30 Novo Nordisk A/S Ein pilz, bei dem die gene area. pepc und / oder pepe inaktiviert wurden
JP2000511429A (ja) * 1996-06-05 2000-09-05 ギスト ブロカデス ベスローテン フェンノートシャップ 真菌メタロプロテアーゼ遺伝子
DK0956338T3 (da) * 1996-09-19 2006-05-08 Novozymes As Værtsceller og fremgangsmåder til produktion af proteiner
ATE517988T1 (de) * 2001-02-23 2011-08-15 Dsm Ip Assets Bv Neue gene, die neue proteolytische enzyme codieren
US7323327B2 (en) * 2001-02-23 2008-01-29 Dsm Ip Assets B.V. Genes encoding novel proteolytic enzymes
AU2006202723B2 (en) * 2001-02-23 2008-06-26 Dsm Ip Assets B.V. Novel genes encoding novel proteolytic enzymes
US20090253173A1 (en) * 2008-04-08 2009-10-08 Danisco Us Inc., Genencor Division Filamentous fungi with inactivated protease genes for altered protein production
FI121712B (fi) * 2009-04-30 2011-03-15 Ab Enzymes Oy Uusi sieniperäinen proteaasi ja sen käyttö
RU2645252C2 (ru) 2012-01-05 2018-02-19 Глюкос Финланд Ой Клетка нитчатых грибов с дефицитом протеаз и способы ее применения
US9695454B2 (en) 2012-05-23 2017-07-04 Glykos Finland Oy Production of fucosylated glycoproteins
CA2916905A1 (en) 2013-07-10 2015-01-15 Novartis Ag Multiple proteases deficient filamentous fungal cells and methods of use thereof
CN108064266A (zh) 2014-07-21 2018-05-22 格利科斯芬兰公司 在丝状真菌中具有哺乳动物样n-聚糖的糖蛋白的制备
CN106222096B (zh) * 2016-08-18 2018-02-23 滨州学院 一株塔宾曲霉菌ct1及其在盐碱地解磷方面的应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8415186D0 (en) * 1984-06-14 1984-07-18 Ciba Geigy Ag Polypeptides
US4885249A (en) * 1984-12-05 1989-12-05 Allelix, Inc. Aspergillus niger transformation system
GB8521496D0 (en) * 1985-08-29 1985-10-02 Ciba Geigy Ag Repressible yeast promoters
GB8702475D0 (en) * 1987-02-04 1987-03-11 Ciba Geigy Ag Expression system
EP0304486A4 (en) * 1987-03-12 1990-12-05 Genex Corporation Production of bioadhesive precursor protein analogs by genetically-engineered organisms
US4871824A (en) * 1987-03-13 1989-10-03 Minnesota Mining And Manufacturing Company Variably crosslinked polymeric supports
US5252726A (en) * 1987-09-04 1993-10-12 Novo Nordisk A/S Promoters for use in aspergillus
CA1333777C (en) * 1988-07-01 1995-01-03 Randy M. Berka Aspartic proteinase deficient filamentous fungi
ES2063162T5 (es) * 1988-07-28 2002-11-16 Novartis Ag Nuevo sistema de expresion.
EP0421919A3 (en) * 1989-09-02 1992-04-15 Ciba-Geigy Ag Polygalacturonase encoding fungal expression system
CA2032035C (en) * 1990-01-29 2001-08-14 Leendert Hendrik De Graaff Fungal expression system
EP0578746B1 (de) * 1991-04-01 2002-07-03 Merck & Co., Inc. Gene, die die proteolytische aktivitaet von pichia beeinflussen und deren verwendung
DK47493D0 (da) * 1993-04-27 1993-04-27 Novo Nordisk As Fremgangsmaade til fremstilling af ost

Also Published As

Publication number Publication date
JPH07213286A (ja) 1995-08-15
NZ264839A (en) 1996-03-26
HUT69954A (en) 1995-09-28
US5756338A (en) 1998-05-26
ES2196019T3 (es) 2003-12-16
KR950014309A (ko) 1995-06-15
DE69432336T2 (de) 2003-12-04
NO944181D0 (no) 1994-11-02
CY2471B1 (en) 2005-06-03
NO315330B1 (no) 2003-08-18
HU220360B (hu) 2001-12-28
IL111482A0 (en) 1995-01-24
DE69432336D1 (de) 2003-04-30
HU9403136D0 (en) 1994-12-28
US5674728A (en) 1997-10-07
AU7751494A (en) 1995-05-18
KR100378507B1 (ko) 2003-09-19
EP0655497A2 (de) 1995-05-31
PT655497E (pt) 2003-07-31
FI945163A0 (fi) 1994-11-02
AU688379B2 (en) 1998-03-12
EP0655497A3 (de) 1997-05-07
ZA948619B (en) 1995-06-27
IL168245A (en) 2009-12-24
JP3727678B2 (ja) 2005-12-14
NO944181L (no) 1995-05-04
IL111482A (en) 2005-08-31
CA2134863A1 (en) 1995-05-04
DK0655497T3 (da) 2003-07-21
EP0655497B1 (de) 2003-03-26
FI119060B (fi) 2008-07-15
FI945163A (fi) 1995-05-04
CA2134863C (en) 2008-12-30

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